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APFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFAQPSVLAAAATDLAGIGSAINQATAAVA APTTGLAAAAADEVSTALATLFGAYGQQFQAISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEAT AGLFKPTSPPVLPPMFNQNTAIIMGGTGSPIPTPSYVNAITTLFIDPVVSNPVVKALVTPEELYPITGVK SLPFQTSVQLGLQILDGAIWEQINAGNHVTVFGYSQSAVIASLEMQHLISLGPNAPSPSQLNFILIGNEM NPNGGILARIPGLNVTTLGLPFYGATPDNPYPTTTYTLEYDGFADFPRYPLNVLSDINAVFGILTVHTTY ADLTPAQIASATQLPTQGTTSNTYYIIETEHLPLLAPLRAIPVIGPPLAALVEPNLEVIVNLGYGDPRFG YSTSPANVPTPFGLFPDVPASVVADALVAGTQQGVNDFMVELPAALNTLPQTPMPAFPPYVPTLLPPPPP PQPATLINIADTFASVVSTGYSILLPTADLGLAFVTILPAYDLTLFVNQLAAGNLRAAIELPLAATIGLA ALGGMIEFIAIVVTLADITQQLQSFSI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0151c | PE1 | - | 100% (588) | PE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0152c | PE2 | e-126 | 54.08% (466) | PE family protein |
| M. tuberculosis H37Rv | Rv1800 | PPE28 | e-112 | 42.27% (563) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0156c | PE1 | 0.0 | 99.83% (588) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 2e-32 | 34.19% (310) | hypothetical protein Mflv_1918 |
| M. leprae Br4923 | MLBr_01183 | - | 1e-12 | 37.50% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 4e-27 | 30.38% (316) | PE/PPE family protein |
| M. marinum M | MMAR_0372 | - | 0.0 | 72.94% (547) | PE family protein |
| M. avium 104 | MAV_1346 | - | 3e-17 | 40.83% (120) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 3e-41 | 32.11% (383) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 8e-43 | 38.73% (284) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-130 | 49.34% (533) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 1e-35 | 32.17% (286) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0151c|M.tuberculosis_H37Rv MAPFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFAQPSVLA
Mb0156c|M.bovis_AF2122/97 MAPFGFTPKARHNRGVALRSTYRLDRWVMGPVDKEGWGLSYVFAQPSVLA
MMAR_0372|M.marinum_M --------------------------------------MSYVVAQPPAIA
MUL_0967|M.ulcerans_Agy99 ------------------------------------MAVIDLLASPQAMT
Mflv_1918|M.gilvum_PYR-GCK -------------------------------------------MGKGDFG
MSMEG_5455|M.smegmatis_MC2_155 -------------------------------------------MGRLLHS
TH_3724|M.thermoresistible__bu -----------------------------------------------VVA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 --------------------------------------------MRRRLR
MAB_4141|M.abscessus_ATCC_1997 ------------------------------------------MAGQYSVP
Rv0151c|M.tuberculosis_H37Rv AAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQF
Mb0156c|M.bovis_AF2122/97 AAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQF
MMAR_0372|M.marinum_M AAATELTGIGSALSEATAAAAGPTTAILSAAADEVSTAIAQLLGTFGAEY
MUL_0967|M.ulcerans_Agy99 ATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVSEAIATLFDNYAQGY
Mflv_1918|M.gilvum_PYR-GCK LKASEFTGR------SSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWVF
MSMEG_5455|M.smegmatis_MC2_155 LSTAFLVFV------AVVVLCVSTS-------------------------
TH_3724|M.thermoresistible__bu VGALTWGGX------GVASPAGQPE-------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 SAAWGLLSLVIAVLFAWGSVVTSTS-------------------------
MAB_4141|M.abscessus_ATCC_1997 GKRHSLRRYVATITAVAATCTVLAP-------------------------
Rv0151c|M.tuberculosis_H37Rv QAISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALV--QEATAGLFKPT
Mb0156c|M.bovis_AF2122/97 QAISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALV--QEATAGLFKPT
MMAR_0372|M.marinum_M QGISTQLAAFHAQIAQRLATVANYYINAEEINNAALL--EEATAGLYSPN
MUL_0967|M.ulcerans_Agy99 QAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKALAGLTEPVANLFAPV
Mflv_1918|M.gilvum_PYR-GCK ARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMG-------GTFHPL
MSMEG_5455|M.smegmatis_MC2_155 -------------------MPTAAHLLLNHPHALVIG-------GTGTPV
TH_3724|M.thermoresistible__bu --------------------RAAALRLTATADAIIMP-------GTKIGY
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 ---------------------------AGAGTALVMG-------GNGHPL
MAB_4141|M.abscessus_ATCC_1997 -------------------LAMESRTIASTLASYVIG-------------
Rv0151c|M.tuberculosis_H37Rv SP------PVLPPMFN------QNTAIIMGGTGSPIPTPSYVNAITTLFI
Mb0156c|M.bovis_AF2122/97 SP------PVLPPMFN------QNTAIIMGGTGSPIPTPSYVNAITTLFI
MMAR_0372|M.marinum_M SP------PTVPAVFN------DYVAIAMGGTGTPIPSTSYLDAVNTLYI
MUL_0967|M.ulcerans_Agy99 LSGPESVAASATALLSGAPLKPVEAALILSESGVPTPSASYISDVYTKYV
Mflv_1918|M.gilvum_PYR-GCK TGP---------------------------RDSPEFVTAYLDNAVDNQIS
MSMEG_5455|M.smegmatis_MC2_155 P-------------------------------PPEYVNGQTDNYIGAEFP
TH_3724|M.thermoresistible__bu IP------------------------------SQDEFTAYATAVIGATAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 SVP---------------------------QDTPDYINKYVTAADDAFIA
MAB_4141|M.abscessus_ATCC_1997 ---------------------------------IGGNNDGASANIPRKLG
Rv0151c|M.tuberculosis_H37Rv DP-VVSNPV-VKALVTPEELYPITGVKSLPFQTSVQLGLQILDGAIWEQI
Mb0156c|M.bovis_AF2122/97 DP-VVSNPV-VKALVTPEELYPITGVKSLPFQTSVQLGLQILDGAIWEQI
MMAR_0372|M.marinum_M QH-IAPGAI-AKALFTPEQLYPITGVKSLPFQTSVQEGLKILDISIWNEI
MUL_0967|M.ulcerans_Agy99 EPNFPSATA-PQGVSTPNGLYPFTGIKDLSLDISLARGATILNDAILQQL
Mflv_1918|M.gilvum_PYR-GCK AAYGYAVTN-AVAVYTPEEFFPLGG---LTFDDSVAEGLANLGRCLRAEP
MSMEG_5455|M.smegmatis_MC2_155 GEYRYAVH-------TPQNFWPVYGS--MSFDESTVAGLAALQAEMAKEG
TH_3724|M.thermoresistible__bu APGAVDYLG------VPGEFWPATGLDSLTFDASVAXGQAMLTPMVDGAI
MLBr_01183|M.leprae_Br4923 -----------------MPLFLNAEPQALTAAANTLEGLSAATVASNAAA
MAV_1346|M.avium_104 -----------------MS-FVTTRPEALLAVASMLEGLGSSMDAQNAAA
Mvan_4726|M.vanbaalenii_PYR-1 PSGLCGPQCSLVATYTPAQIRFVNGIFDMTYDESVAVGQANLNDCIQGSD
MAB_4141|M.abscessus_ATCC_1997 GAYSVDYHP----VSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIVTAG
. *
Rv0151c|M.tuberculosis_H37Rv N-------------------AGNHVTVFGYSQSAVIASLEMQHLISLGPN
Mb0156c|M.bovis_AF2122/97 N-------------------AGNHVTVFGYSQSAVIASLEMQHLISLGPN
MMAR_0372|M.marinum_M N-------------------AGNHVTVFGYSQSAVIASLEMQHFISLGPN
MUL_0967|M.ulcerans_Agy99 AAL----------------PAGSSVAVLGYSQSAVLSSRVMPKLLAEG--
Mflv_1918|M.gilvum_PYR-GCK GCVFNADPAVAARVGTVAPRHDDTFVVFGYSQSAAVASLLKRQLIDAP--
MSMEG_5455|M.smegmatis_MC2_155 -------------------HFGSPLVILGYSSSTRILTADKNRRIAD---
TH_3724|M.thermoresistible__bu ES-------------------DTPIVVFGHSQSAVIATKEKQRLLAEYPD
MLBr_01183|M.leprae_Br4923 A-----------------------------QLTTEIAP------------
MAV_1346|M.avium_104 A-----------------------------APTTSIAP------------
Mvan_4726|M.vanbaalenii_PYR-1 CTATLAPYSETG----PHTVADSTYVIYAYSQSATVAANQKLQLIAHP--
MAB_4141|M.abscessus_ATCC_1997 N---------------------QPITIVGYSLGAVVVSKSHSDLLQRYP-
: : .
Rv0151c|M.tuberculosis_H37Rv APSPSQLNFILIGNEMNPNGGILARIPGLNVTTLGLPFYGATPD-----N
Mb0156c|M.bovis_AF2122/97 APSPSQLNFILIGNEMNPNGGILARIPGLNVTTLGLPFYGATPD-----N
MMAR_0372|M.marinum_M APDPSQINFILTGNEMNPNGGILARIPGLNVASLGLPFYGATPD-----N
MUL_0967|M.ulcerans_Agy99 -VTSSQVNFVLLGNPMNPNGGVLARFPDLTLPSLGFTFYGATPD-----N
Mflv_1918|M.gilvum_PYR-GCK GPEPAATTFMLAANPMRPNGGVLGRFPALTIPILGITFHGATPTAG-VDG
MSMEG_5455|M.smegmatis_MC2_155 GDYAVDINYVLVSDVAKGNGGVMARFPGWHIPILGVTFDGATRTDS-DGY
TH_3724|M.thermoresistible__bu PDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVTFNGATPAPA-DG-
MLBr_01183|M.leprae_Br4923 --PAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTS----SS
MAV_1346|M.avium_104 --AAADEVSALQAAQFSAYGTWYQQVSAQAKAIHQTLVQNLDTN----AD
Mvan_4726|M.vanbaalenii_PYR-1 --VASTVSFLLVANPNRPDGGILERFVGAYIPLLGITFNGSTPTFSPQPR
MAB_4141|M.abscessus_ATCC_1997 -GGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIESNGAWEP-----D
: . * . .
Rv0151c|M.tuberculosis_H37Rv PYPTTTYTLEYDGFA-DFPRYPLNVLSDINAVFGILTVHTTYADLTP---
Mb0156c|M.bovis_AF2122/97 PYPTTTYTLEYDGFA-DFPRYPLNVLSDINAVFGILTVHTTYADLTP---
MMAR_0372|M.marinum_M PYYTTTYTLEYDGFA-DFPRYPLNVLSDVNAVFGILTVHRTYPDLTP---
MUL_0967|M.ulcerans_Agy99 AFPTVSYTLEYDGFA-DFPRYPINLLADINAVMGIPFVHADYQDLTQ---
Mflv_1918|M.gilvum_PYR-GCK AYRTVDVVRQYDGLGGDFPVRPLNLLATVNALLGYGIMHGETVDVPF---
MSMEG_5455|M.smegmatis_MC2_155 AFDTKSISFVHDGWS-DFPVYPLNVLALANAVAGIAVLHPTYPELDR---
TH_3724|M.thermoresistible__bu PFDSYDVAREFDGWA-DFPRYPLNLVATANAILGIYYLHGGYYELLTENP
MLBr_01183|M.leprae_Br4923 AYAGTETAN------------------------------HDSL-------
MAV_1346|M.avium_104 SYGATEAANRVNTSAAALQGLAPNVIPNAAPAADPPPAGTTSLGTSI---
Mvan_4726|M.vanbaalenii_PYR-1 PLTTVDVARQYDGWA-DFPTNPLNLLADLNAIMGTILLHPNYSDAGT---
MAB_4141|M.abscessus_ATCC_1997 QFKTKVINTEYDTYG-DFPAYFNPLALANSIAAIQYAHPDAYYDRIDPAA
Rv0151c|M.tuberculosis_H37Rv AQIASATQLPTQGTTSNTYYIIETEHLPLLAPL--RAIPVIGPPLAALVE
Mb0156c|M.bovis_AF2122/97 AQIASATQLPTQGTTSNTYYIIETEHLPLLAPL--RAIPVIGPPLAALVE
MMAR_0372|M.marinum_M EQIASATLLPTEGPTTGTYYMIRTENLPLLDPV--RAIPVIGEPLAALVQ
MUL_0967|M.ulcerans_Agy99 AQLDSAVQLPTEGPTQSTYYMIPTEHLPLLAPL--RFIPYVGDPLAELLE
Mflv_1918|M.gilvum_PYR-GCK -----AQARFQGREGDTDYYLIGTDLLPLLQPL--LLF-VPRPILSALDA
MSMEG_5455|M.smegmatis_MC2_155 -----PDLVPVGSTGDTEYFVIGTDIMPLLMPL--ETIGVPRPILLAVDE
TH_3724|M.thermoresistible__bu DILDDPERTIVQQYGDTTYYLIRTEQLPLLRPL--RDLGVPEEFVDALEP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------GWAQNVGAAASDFITLGEG--QFAPVPGAAGIPNFN
Mvan_4726|M.vanbaalenii_PYR-1 -------PQLQGQYQDSTYYLIPAPITPVLVPL--TWVPIVGKPLAIALD
MAB_4141|M.abscessus_ATCC_1997 LDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAIE
Rv0151c|M.tuberculosis_H37Rv PNLEVIVNLGYGDPRFGYSTSPANVPTP-FGLFPDVPASVVADALVAGTQ
Mb0156c|M.bovis_AF2122/97 PNLEVIVNLGYGDPRFGYSTSPANVPTP-FGLFPDVPASVVADALVAGTQ
MMAR_0372|M.marinum_M PDLKVLVNLGYGDPNYGYSTSPANVPTP-FGLFPDVSLQVVADALVAGTH
MUL_0967|M.ulcerans_Agy99 PNLRVLVNFGYGDPAYGYDTGPANVPTP-FGLFPPVSPLTVAEHLAAGTQ
Mflv_1918|M.gilvum_PYR-GCK P-LRVLVEDAYDRDAGPGDPTTARWWPV-KDFAGTAAKLIASVPVAVDNL
MSMEG_5455|M.smegmatis_MC2_155 P-LRVLVEAGYRRDIAPGAPTPARLIPI-VNPITLTRNFIAAIPVGVDDA
TH_3724|M.thermoresistible__bu Y-VRRIVDLGYDRNTPYGEPAPVRVLPP-LTPAPG--------PATQHNA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 PGLTAATTAGPPAPAAPAAAAGAPVLAS-MGRGPSIGGLSVPPSWAPGGV
Mvan_4726|M.vanbaalenii_PYR-1 PAVRVLVEMGYDRTVNPGQPTPARYLYV-PNLIKAALNFAMAIPTGWDDA
MAB_4141|M.abscessus_ATCC_1997 PTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNV
Rv0151c|M.tuberculosis_H37Rv QGVNDFMVELPA----------------------------ALNTLPQTPM
Mb0156c|M.bovis_AF2122/97 QGVNDFMVELPA----------------------------ALNTLPQTPM
MMAR_0372|M.marinum_M QGINDFGAALPT----------------------------ALSTTPQIAP
MUL_0967|M.ulcerans_Agy99 QGIVNSGAALQAQGPPSI----------------------PLSDIAHTLT
Mflv_1918|M.gilvum_PYR-GCK TEGFGLGRVLGTPVPGVFGVGG-----------------PDLPDVDEGGA
MSMEG_5455|M.smegmatis_MC2_155 MEELGHGRPLGTQPSGVFGVGGEDTELKGLPAGVISLAKPTLPVSSHTTV
TH_3724|M.thermoresistible__bu GQGITVASATSTP-------------------------------DKRTPV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 APAANATPAQLVG----------------------------------AGF
Mvan_4726|M.vanbaalenii_PYR-1 ISYLTGDPDCRPFHTTVPASPFG-VGGPPVYTGAIDPYGEPTPYLAPPVE
MAB_4141|M.abscessus_ATCC_1997 ENGLAGATPKQSASPEKPASPPVPQPGPTNPGS--ATTQIPAPEAPTPSV
Rv0151c|M.tuberculosis_H37Rv PAFPPYVPTLLPPPPPPQP----------ATLINIADTFASVVSTGYSIL
Mb0156c|M.bovis_AF2122/97 PAFPPYVPTLLPPPPPPQP----------ATLINIADTFASVVSTGYSIL
MMAR_0372|M.marinum_M LEFPPYVQSVLPPAPPPMP----------ATPINIANTLASVVSTGYSVL
MUL_0967|M.ulcerans_Agy99 ANPPWAGTPALPPSTSPASSIEDFILAVQAANSSISRGFVKTLSTAYATL
Mflv_1918|M.gilvum_PYR-GCK VTSDIDEDAVAQRDSASSTERSA---PAEESRSAVGGADSDGRDDVVDPE
MSMEG_5455|M.smegmatis_MC2_155 VEKTERKDLAKPAAEPEPVVEDE---PAVEDETPVADTKKASPKPLRPKV
TH_3724|M.thermoresistible__bu VEAPVEE---PPVQTGRSTLKRE---KPVSARHLVRNSLRAVPGLRRGEP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 TSAAPDTAPVTAVPGGVPS---------MATAGRGGYGLGAPRYGVKPTV
Mvan_4726|M.vanbaalenii_PYR-1 THGEAAPGSGSPAAHPAGTEPPETVTFSPTTESTPSTLLPETPAESEDMP
MAB_4141|M.abscessus_ATCC_1997 VSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTP
Rv0151c|M.tuberculosis_H37Rv LPTADLGLAFVTI----------------LPAYDLTLFVNQLAAGNLRAA
Mb0156c|M.bovis_AF2122/97 LPTADLGLAFVTI----------------LPAYDLTLFVNQLAAGNLRAA
MMAR_0372|M.marinum_M LPTADIGLGFVTS----------------LPAYNLTLFLSQLAQGDLRAA
MUL_0967|M.ulcerans_Agy99 LPTTDIASELVFT----------------LPSYNLNLFL----DGVIQAI
Mflv_1918|M.gilvum_PYR-GCK PAAPEAETSEAET----------------VTETEADD---------ADDA
MSMEG_5455|M.smegmatis_MC2_155 RGPISFDAPKLPT----------------IRKATGDRPLKRLLSALTPKR
TH_3724|M.thermoresistible__bu AATPTPDVTPDVT----------------PDAPAGQP-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 MPKPAI--------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 PDFVENDTPDSDE----------------VSPTEDDALKDTETINESQDG
MAB_4141|M.abscessus_ATCC_1997 PPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSV
Rv0151c|M.tuberculosis_H37Rv IELPLAATIGLAALGGMIEFIAIVVTLADITQQLQSFSI------
Mb0156c|M.bovis_AF2122/97 IELPLAATIGLAALGGMIEFIAIVVTLADITQQLQSFSI------
MMAR_0372|M.marinum_M IELPLAATFGLGALGGMIEFIAVMEAAAEIAQDLQSLYL------
MUL_0967|M.ulcerans_Agy99 NGQPIGD--------------------------------------
Mflv_1918|M.gilvum_PYR-GCK DDGADADDEDIDADGADADGEDTAGNTAEAA--------------
MSMEG_5455|M.smegmatis_MC2_155 PKPASSHDAGPAAGNKDTDNADKPAARADDAA-------------
TH_3724|M.thermoresistible__bu -EPAEPNESAAPPAAAEADDASE----------------------
MLBr_01183|M.leprae_Br4923 ---------------------------------------------
MAV_1346|M.avium_104 ---------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 PTESASGVSGEDAADADSRSADADSLSADAGDSAPADAAAADTAA
MAB_4141|M.abscessus_ATCC_1997 PGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA--