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MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIP RVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVL ATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAV FADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSEN LPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSV SLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1372 | - | - | 100% (393) | hypothetical protein Rv1372 |
| M. tuberculosis H37Rv | Rv1665 | pks11 | 3e-34 | 28.89% (360) | chalcone synthase |
| M. tuberculosis H37Rv | Rv1660 | pks10 | 8e-30 | 26.89% (357) | chalcone synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1406 | - | 0.0 | 100.00% (393) | hypothetical protein Mb1406 |
| M. gilvum PYR-GCK | Mflv_5140 | - | 1e-35 | 28.81% (361) | chalcone/stilbene synthase domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1141c | - | 5e-08 | 27.00% (200) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. marinum M | MMAR_2190 | - | 1e-174 | 79.90% (393) | chalcone/stilbene synthase |
| M. avium 104 | MAV_3105 | - | 1e-30 | 26.61% (357) | Pks11 protein |
| M. smegmatis MC2 155 | MSMEG_0808 | - | 3e-37 | 29.20% (363) | chalcone synthase Pks10 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1775 | - | 1e-173 | 79.39% (393) | chalcone/stilbene synthase |
| M. vanbaalenii PYR-1 | Mvan_1196 | - | 3e-31 | 27.02% (359) | chalcone/stilbene synthase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1372|M.tuberculosis_H37Rv MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQS
Mb1406|M.bovis_AF2122/97 MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQS
MMAR_2190|M.marinum_M MSTAAEGGAIRRAGHEPRYDLAQLPPAPPTTVAVIEGMATGAPQRVVAQA
MUL_1775|M.ulcerans_Agy99 MSTAAEGGAICRAGHEPRYDLAQLPPAPPTTVAVIEGMATGAPQRVVAQA
Mflv_5140|M.gilvum_PYR-GCK ------------------------MTDVHTPVSVIAGVQGALPPHRYSQA
Mvan_1196|M.vanbaalenii_PYR-1 ---------------------------MNDRISVIAGVQGALPPYRYSQA
MAV_3105|M.avium_104 -------------------------------MSVIAGVFGAVPPHRYSQR
MSMEG_0808|M.smegmatis_MC2_155 ---------------------MENTAFTPSGTCTIAGVHGVLPPHRYTQA
MAB_1141c|M.abscessus_ATCC_199 ----------------------------MTDIAEITGIN-KIGLLSLGAY
. * *:
Rv1372|M.tuberculosis_H37Rv DAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPA
Mb1406|M.bovis_AF2122/97 DAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPA
MMAR_2190|M.marinum_M DAAARVSELFVDPQQRERISRIYDKTRIDTRRMAVDPLDDEFDEFRREPA
MUL_1775|M.ulcerans_Agy99 DAAARVSELFVDPQQRERISRIYDKTRIDTRRMAVDPLDDEFDEFRREPA
Mflv_5140|M.gilvum_PYR-GCK EVTDAFLAAPAFAEVGDLLRSLHTNAKVDARHLVLP------LEQYPDLL
Mvan_1196|M.vanbaalenii_PYR-1 EITERFVAVPAFAELEDVVRGLHKHAKVDARHFVLP------MDRYPTLV
MAV_3105|M.avium_104 EITDEIVKFPALREHEEVVRRLHAAAKVNSRHFVLP------LQQYHSLT
MSMEG_0808|M.smegmatis_MC2_155 EVTEALLDLPGYADFEGIVRSLHKSAKVNSRYLTLP------LEEYAALD
MAB_1141c|M.abscessus_ATCC_199 RPERVVTNDEICERIESSDEWIYTRTGIKTRRFAAD--------------
. :: : : :* :.
Rv1372|M.tuberculosis_H37Rv TIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPG
Mb1406|M.bovis_AF2122/97 TIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPG
MMAR_2190|M.marinum_M TIRDRMNLFYQHAVPLAVDVAARALDGLPYAPDEIGQLVFVTSTGFIAPG
MUL_1775|M.ulcerans_Agy99 TIRDRMNLFYQHAVPLAVDVAARALDGLPYAPDEIGQLVFVTSTGFIAPG
Mflv_5140|M.gilvum_PYR-GCK DFGDANDLYIHHAVELGCQALTAALDEAGLAPSDLDVIMSTTVTGIAVPS
Mvan_1196|M.vanbaalenii_PYR-1 DFGETNDLYLEHSLDLACEALTAALDEAGLGPRDLDMIMTTTVTGIAVPS
MAV_3105|M.avium_104 DFGEVNEIFIDKAVQIGCDALLGALDEAGLRPQDIDMIATTTVTGVAVPS
MSMEG_0808|M.smegmatis_MC2_155 DFGETNGLFIEHATELGCAALTGALDEAGLRPEDVDLIITTTVTGAVVPS
MAB_1141c|M.abscessus_ATCC_199 ---------EETAQTLAIEAGRKAIANALLTGAEIDAVIVATSTHYLQTP
. : :. . *: ::. : .* * .
Rv1372|M.tuberculosis_H37Rv VDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVV
Mb1406|M.bovis_AF2122/97 VDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVV
MMAR_2190|M.marinum_M VDVEIVKQLGLPRSISRVVVNFMGCAAAMNAIRTATNYVRAHPSMKALVV
MUL_1775|M.ulcerans_Agy99 VDVEIVKQLGLPRSISRVVVNFMGCAAAMNAIRTATNYVRAHPSMKALVV
Mflv_5140|M.gilvum_PYR-GCK LDARIAAKLGLRPDVRRVPLFGLGCVAGAAGIARMHDYLRGAPGHVAALI
Mvan_1196|M.vanbaalenii_PYR-1 LDARIADRLGLRPDVRRVPLFGLGCVAGAAGIARMHDYLRGAPDHIAALV
MAV_3105|M.avium_104 LDARIAGRLGLRPDVRRVPLFGLGCAAGAAGVGRLHDYLRGAPDGVAALV
MSMEG_0808|M.smegmatis_MC2_155 LDARIAGRVGLRPDVRRVPIFGLGCVAGAAGVARLNDYLRGAPDKVAVLV
MAB_1141c|M.abscessus_ATCC_199 ASAPAVATALGAQGVPAFDLS-AGCAGFGYAVGVAGDMIRGGSASKVLVI
.. . .: . : **.. .: : :*. . . ::
Rv1372|M.tuberculosis_H37Rv CIELCSVNA-VFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVV
Mb1406|M.bovis_AF2122/97 CIELCSVNA-VFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVV
MMAR_2190|M.marinum_M CIELSSVNA-VFADDINDVVIHSLFGDGCGALVIGASQVQQPLPAGNVVI
MUL_1775|M.ulcerans_Agy99 CIELSSVNA-VFADDINDVVIHSLFGDGCGALVIGASQAQQPLPAGNVVI
Mflv_5140|M.gilvum_PYR-GCK SVELCSLTRPALAPTIGSLVGSALFGDGAAAVVAVGEERAGHIRASGPDV
Mvan_1196|M.vanbaalenii_PYR-1 SVELCSLTYPAVEPTMASLVGSALFGDGAAAVIAVGAERAETIGATGPEV
MAV_3105|M.avium_104 SVELCSLTFPTVKPTVSGLVGTAMFGDGAAAVVAVGDRRAERLGATGPDI
MSMEG_0808|M.smegmatis_MC2_155 SVELCSLTH-KHTPSMPTLVAGALFGDGASAVVAVGAGRAEQLDPIGPDV
MAB_1141c|M.abscessus_ATCC_199 GSEKLSPAL-----DMTDRGNCFIFGDGAGAVVVG-ETAEQGIGPTVWGS
* * : :****..*:: : .
Rv1372|M.tuberculosis_H37Rv RSSFSQLLDNTEDGIVLGVNHNG-----ITCELSENLPGYIFSGVAPVVT
Mb1406|M.bovis_AF2122/97 RSSFSQLLDNTEDGIVLGVNHNG-----ITCELSENLPGYIFSGVAPVVT
MMAR_2190|M.marinum_M RSSFSQLLDDSEDGIVLGVNHDG-----ITCELSENLPSYIYRSVDPVVA
MUL_1775|M.ulcerans_Agy99 RSSFSQLLDDSEDGIVLGVNHDG-----ITCELSENLPSYIYRSVDPVVA
Mflv_5140|M.gilvum_PYR-GCK LDSRSRMYPDSLDIMGWSVNHNG-----FQLVLSPELPALIERYLPDDMA
Mvan_1196|M.vanbaalenii_PYR-1 LDTRSRMYPDSLDTMGWRVGASG-----FQLILSPNLPELIERYLADDMA
MAV_3105|M.avium_104 LDSRSRLYPETLHIMGWNIGSAG-----MQLVMSPELPAVVEKHLADDVT
MSMEG_0808|M.smegmatis_MC2_155 LDSRSHLYPDSLHAMGWDIGTKG-----FEIVLSAEVPGFVGRYLGDDVT
MAB_1141c|M.abscessus_ATCC_199 DGSQSNAIRQDIDWMDFAAAPDPEGPRPYLRIEGTSVFRWAAFEMGKVGQ
.: *. : . : . .: :
Rv1372|M.tuberculosis_H37Rv EMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARF
Mb1406|M.bovis_AF2122/97 EMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARF
MMAR_2190|M.marinum_M EMLRDNGLSKADIDLWAIHPGGPKIIEQSARSLGIPVGRAVQSWDVLAQF
MUL_1775|M.ulcerans_Agy99 EMLRDNGLSKADIDLWAIHPGGPKIIEQSARSLGIPVGRAVQSWDVLAQF
Mflv_5140|M.gilvum_PYR-GCK SFLGEHDLGIGDIATWVSHPGGPKVLEAIASALDLPDDALELSWRSLAEI
Mvan_1196|M.vanbaalenii_PYR-1 GFLGAHDLQIGDIAAWVSHPGGPKVMEAISETLGLPDDALDLAWRSLAEV
MAV_3105|M.avium_104 GFLAAHGLTTGDVGAWITHPAGPKVITAIAATLDLPAEAHELTWRSLGEV
MSMEG_0808|M.smegmatis_MC2_155 EFLGEHGVATDDVSAWVSHPGGPKVIEAIIETLDLPSDALDLTWQSLAEV
MAB_1141c|M.abscessus_ATCC_199 RAMEAAKVGPEQIDVFVPHQANTRINELLAKNLHLRADAVIAN--DIEHT
: : :: : * ...:: * : : .
Rv1372|M.tuberculosis_H37Rv GNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR-
Mb1406|M.bovis_AF2122/97 GNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR-
MMAR_2190|M.marinum_M GNMLSVSLIFVLEMMVAQAESDKPISTGVAFAFAPGVTVEGMLFDIIRR-
MUL_1775|M.ulcerans_Agy99 GNMLSVSLIFVLEMMVAQAESDKPISTGVAFAFAPGVTVEGMLFDIIRR-
Mflv_5140|M.gilvum_PYR-GCK GNLSSSSVLHILRDTIAKKPPAA--TPGLLMAMGPGFCSELVLLRWH---
Mvan_1196|M.vanbaalenii_PYR-1 GNLSSSSVLHVLRDTRAKKPPAG--TPGLLMAMGPGFCSELVLLRWR---
MAV_3105|M.avium_104 ANLSSASVLHILRDTIAKPPPAG--SPALMLAVGPGFGSELVLLRWH---
MSMEG_0808|M.smegmatis_MC2_155 GNLSSSSVLHVLRDTIRKRPPAG--TPGVLMAMGPGFCSELVLLRWR---
MAB_1141c|M.abscessus_ATCC_199 GNTSAASVPLAMETLLSTG-AAKPGDLALLIGYGAGLSYAAQVVRMPPVP
.* : *: :. . .: :. ..*. :.
Rv1372|M.tuberculosis_H37Rv --
Mb1406|M.bovis_AF2122/97 --
MMAR_2190|M.marinum_M --
MUL_1775|M.ulcerans_Agy99 --
Mflv_5140|M.gilvum_PYR-GCK --
Mvan_1196|M.vanbaalenii_PYR-1 --
MAV_3105|M.avium_104 --
MSMEG_0808|M.smegmatis_MC2_155 --
MAB_1141c|M.abscessus_ATCC_199 FE