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MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVLPLQQYPSLTDFGDANE IFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVA GAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGG PDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGG PKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEKRPPSGSAGLMLAMGPGFCTELVLL RWR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1665 | pks11 | - | 100% (353) | Possible chalcone synthase pks11 |
| M. tuberculosis H37Rv | Rv1660 | pks10 | e-153 | 74.15% (352) | chalcone synthase |
| M. tuberculosis H37Rv | Rv1372 | - | 3e-34 | 28.89% (360) | hypothetical protein Rv1372 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1693 | pks11 | 0.0 | 100.00% (353) | chalcone synthase |
| M. gilvum PYR-GCK | Mflv_5140 | - | 1e-141 | 67.90% (352) | chalcone/stilbene synthase domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1141c | - | 4e-06 | 25.70% (284) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. marinum M | MMAR_2474 | pks11_1 | 1e-174 | 84.38% (352) | chalcone synthase, Pks11_1 |
| M. avium 104 | MAV_3105 | - | 1e-157 | 76.70% (352) | Pks11 protein |
| M. smegmatis MC2 155 | MSMEG_0808 | - | 1e-135 | 65.14% (350) | chalcone synthase Pks10 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1656 | pks11 | 1e-174 | 84.38% (352) | chalcone synthase, Pks11 |
| M. vanbaalenii PYR-1 | Mvan_1196 | - | 1e-140 | 66.86% (353) | chalcone/stilbene synthase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1665|M.tuberculosis_H37Rv ----------MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRR
Mb1693|M.bovis_AF2122/97 ----------MSVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRR
MMAR_2474|M.marinum_M ----------MSVIAGVFGALPPHRYSQSEITEAFLEFPGLQEHEEIVRR
MUL_1656|M.ulcerans_Agy99 ----------MSVIAGVFGALPPHRYSQSEITESFLEFPGLQEHEEIVRR
MAV_3105|M.avium_104 ----------MSVIAGVFGAVPPHRYSQREITDEIVKFPALREHEEVVRR
Mflv_5140|M.gilvum_PYR-GCK ---MTDVHTPVSVIAGVQGALPPHRYSQAEVTDAFLAAPAFAEVGDLLRS
Mvan_1196|M.vanbaalenii_PYR-1 ------MNDRISVIAGVQGALPPYRYSQAEITERFVAVPAFAELEDVVRG
MSMEG_0808|M.smegmatis_MC2_155 MENTAFTPSGTCTIAGVHGVLPPHRYTQAEVTEALLDLPGYADFEGIVRS
MAB_1141c|M.abscessus_ATCC_199 ----------MTDIAEITGIN----------KIGLLSLGAYRP-ERVVTN
** : * . :: . ::
Rv1665|M.tuberculosis_H37Rv LHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDD
Mb1693|M.bovis_AF2122/97 LHAAAKVNGRHLVLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDD
MMAR_2474|M.marinum_M MHAAAKVNSRQFVLPIEQYPALTDFGDANEIFIEKAVDLGIEALMGALDE
MUL_1656|M.ulcerans_Agy99 MHAAAKVNSRQFVLPIEQYPALTDFGDTNEIFIEKAVDLGIEALMGALDE
MAV_3105|M.avium_104 LHAAAKVNSRHFVLPLQQYHSLTDFGEVNEIFIDKAVQIGCDALLGALDE
Mflv_5140|M.gilvum_PYR-GCK LHTNAKVDARHLVLPLEQYPDLLDFGDANDLYIHHAVELGCQALTAALDE
Mvan_1196|M.vanbaalenii_PYR-1 LHKHAKVDARHFVLPMDRYPTLVDFGETNDLYLEHSLDLACEALTAALDE
MSMEG_0808|M.smegmatis_MC2_155 LHKSAKVNSRYLTLPLEEYAALDDFGETNGLFIEHATELGCAALTGALDE
MAB_1141c|M.abscessus_ATCC_199 DEICERIESSDEWIYTRTGIKTRRFAADEETAQTLAIEAGRKAIANALLT
. :::. : *. : : : . *: **
Rv1665|M.tuberculosis_H37Rv ANLRPSDIDMIATATVTG-VAVPSLDARIAGRLGLRPDVRRMPLFGL--G
Mb1693|M.bovis_AF2122/97 ANLRPSDIDMIATATVTG-VAVPSLDARIAGRLGLRPDVRRMPLFGL--G
MMAR_2474|M.marinum_M AGLTPQDIDLIITTTVTG-VAVPSLDARIAGRLGLRPDVRRMPLFGL--G
MUL_1656|M.ulcerans_Agy99 AGLTPQDIDLIITTTVTG-VAVPSLDARIAGRLGLRPDVRRMPLFGL--G
MAV_3105|M.avium_104 AGLRPQDIDMIATTTVTG-VAVPSLDARIAGRLGLRPDVRRVPLFGL--G
Mflv_5140|M.gilvum_PYR-GCK AGLAPSDLDVIMSTTVTG-IAVPSLDARIAAKLGLRPDVRRVPLFGL--G
Mvan_1196|M.vanbaalenii_PYR-1 AGLGPRDLDMIMTTTVTG-IAVPSLDARIADRLGLRPDVRRVPLFGL--G
MSMEG_0808|M.smegmatis_MC2_155 AGLRPEDVDLIITTTVTG-AVVPSLDARIAGRVGLRPDVRRVPIFGL--G
MAB_1141c|M.abscessus_ATCC_199 G----AEIDAVIVATSTHYLQTPASAPAVATALGAQG----VPAFDLSAG
. ::* : :* * .*: . :* :* : :* *.* *
Rv1665|M.tuberculosis_H37Rv CVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTAL
Mb1693|M.bovis_AF2122/97 CVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKPTVSSLVGTAL
MMAR_2474|M.marinum_M CVAGAAGVARLHDYLRGAPDGVAVLIAVELCSLTYPAVKPTVSGIVGTAL
MUL_1656|M.ulcerans_Agy99 CVAGAAGVARLHDYLRGAPDGVAVLIAVELCSLTYPAVKPTVSGIVGTAL
MAV_3105|M.avium_104 CAAGAAGVGRLHDYLRGAPDGVAALVSVELCSLTFPTVKPTVSGLVGTAM
Mflv_5140|M.gilvum_PYR-GCK CVAGAAGIARMHDYLRGAPGHVAALISVELCSLTRPALAPTIGSLVGSAL
Mvan_1196|M.vanbaalenii_PYR-1 CVAGAAGIARMHDYLRGAPDHIAALVSVELCSLTYPAVEPTMASLVGSAL
MSMEG_0808|M.smegmatis_MC2_155 CVAGAAGVARLNDYLRGAPDKVAVLVSVELCSLTH-KHTPSMPTLVAGAL
MAB_1141c|M.abscessus_ATCC_199 CAGFGYAVGVAGDMIRGGSASKVLVIGSEKLSPALDMTDRGN-----CFI
*.. . .:. * :**.. . ::. * * : :
Rv1665|M.tuberculosis_H37Rv FGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVG----
Mb1693|M.bovis_AF2122/97 FGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVG----
MMAR_2474|M.marinum_M FGDGAAAVVAVGDRRAEQIRAGGPDILDSRSRLYPESLDIMGWDVG----
MUL_1656|M.ulcerans_Agy99 FGDGAAAVVAVGDRRAEQIRAGGPDILDSRSRLYPESLDIMGWDVG----
MAV_3105|M.avium_104 FGDGAAAVVAVGDRRAERLGATGPDILDSRSRLYPETLHIMGWNIG----
Mflv_5140|M.gilvum_PYR-GCK FGDGAAAVVAVGEERAGHIRASGPDVLDSRSRMYPDSLDIMGWSVN----
Mvan_1196|M.vanbaalenii_PYR-1 FGDGAAAVIAVGAERAETIGATGPEVLDTRSRMYPDSLDTMGWRVG----
MSMEG_0808|M.smegmatis_MC2_155 FGDGASAVVAVGAGRAEQLDPIGPDVLDSRSHLYPDSLHAMGWDIG----
MAB_1141c|M.abscessus_ATCC_199 FGDGAG-AVVVGETAEQGIGPTVWGSDGSQSNAIRQDIDWMDFAAAPDPE
*****. .:.** : . .::* : :. *.:
Rv1665|M.tuberculosis_H37Rv -SHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPK
Mb1693|M.bovis_AF2122/97 -SHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPK
MMAR_2474|M.marinum_M -SHGLQLRLAPELTNLIEEYLPDDVDAFLAMHDLTKNDIGAWVSHPGGPK
MUL_1656|M.ulcerans_Agy99 -SHGLQLRLAPELTNLIEEYLPDDVDAFLAMHDLTKNDIGAWVSHPGGPK
MAV_3105|M.avium_104 -SAGMQLVMSPELPAVVEKHLADDVTGFLAAHGLTTGDVGAWITHPAGPK
Mflv_5140|M.gilvum_PYR-GCK -HNGFQLVLSPELPALIERYLPDDMASFLGEHDLGIGDIATWVSHPGGPK
Mvan_1196|M.vanbaalenii_PYR-1 -ASGFQLILSPNLPELIERYLADDMAGFLGAHDLQIGDIAAWVSHPGGPK
MSMEG_0808|M.smegmatis_MC2_155 -TKGFEIVLSAEVPGFVGRYLGDDVTEFLGEHGVATDDVSAWVSHPGGPK
MAB_1141c|M.abscessus_ATCC_199 GPRPYLRIEGTSVFRWAAFEMGKVGQRAMEAAKVGPEQIDVFVPHQANTR
...: : . : : :: .::.* ...:
Rv1665|M.tuberculosis_H37Rv VIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG
Mb1693|M.bovis_AF2122/97 VIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG
MMAR_2474|M.marinum_M VLDAITNSLGLPSDALELTWRSLGEIGNLSSASVLHILRDTIAK-VPPSG
MUL_1656|M.ulcerans_Agy99 VLDAIANSLGLPSDALELTWRSLGEIGNLSSASVLRILRDTIAK-VPPSG
MAV_3105|M.avium_104 VITAIAATLDLPAEAHELTWRSLGEVANLSSASVLHILRDTIAK-PPPAG
Mflv_5140|M.gilvum_PYR-GCK VLEAIASALDLPDDALELSWRSLAEIGNLSSSSVLHILRDTIAK-KPPAA
Mvan_1196|M.vanbaalenii_PYR-1 VMEAISETLGLPDDALDLAWRSLAEVGNLSSSSVLHVLRDTRAK-KPPAG
MSMEG_0808|M.smegmatis_MC2_155 VIEAIIETLDLPSDALDLTWQSLAEVGNLSSSSVLHVLRDTIRK-RPPAG
MAB_1141c|M.abscessus_ATCC_199 INELLAKNLHLRADAVIAN--DIEHTGNTSAASVPLAMETLLSTGAAKPG
: : * * :* .: . .* *::*: :. . . ..
Rv1665|M.tuberculosis_H37Rv SAGLMLAMGPGFCTELVLLRWR-----
Mb1693|M.bovis_AF2122/97 SAGLMLAMGPGFCTELVLLRWR-----
MMAR_2474|M.marinum_M SPGLMLAMGPGFCAELVLLRWH-----
MUL_1656|M.ulcerans_Agy99 SPGLMLAMGPGFCAELVLLRWH-----
MAV_3105|M.avium_104 SPALMLAVGPGFGSELVLLRWH-----
Mflv_5140|M.gilvum_PYR-GCK TPGLLMAMGPGFCSELVLLRWH-----
Mvan_1196|M.vanbaalenii_PYR-1 TPGLLMAMGPGFCSELVLLRWR-----
MSMEG_0808|M.smegmatis_MC2_155 TPGVLMAMGPGFCSELVLLRWR-----
MAB_1141c|M.abscessus_ATCC_199 DLALLIGYGAGLSYAAQVVRMPPVPFE
.:::. *.*: ::*