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MSGVIAALDTLTAAATDVAGLGAAINAANAAAAVSTTRLMAAAGDEVSAAIAALFSDHALQYQAVSAEAV AFHGRFVQALTGGVQMYAAAETANTASLQTLGQDLLGMVNAPAAAVLGRPLIGNGTNGAPGSGDAGGPGG LLFGNGGNGGSGSAGMAGGAGGSAGLIGNGGAGGAGGADAAGGPGGAGGWLWGGGGAGGLGGAASGAGNG GAGGAGGAGGAFIAIGGVGGDGGAASSGTGGVGGAGGNADGLIVSLGGAGGHGGDATTGIGGAGGAGGMA TARIPAGINFNVGGAGGHGGAGATGGAGGGGGSAYSGYVGIAFGQGGAGGIGGAASTGMAGAGGSGGSCV AFDFVGFAAAHGGAGGTGGAATGVGATAGAAGSGGLGVAIVGSGVGGVGGVGGAATGAGATAAAGGAGGL GLAAVGSGTGGAGGAGGVGAGTGGAGGAGAHGFGLLSGTAGAGGAGGAASAGTGGAGGLGGTGFGLIAAG GDGGGAGTGVGSNGGDGGGGGGAHAVLAAIAGSGGQGQAGTSGFGGFGGSGGSAESLFFSIGGAGGAGGD ASTGGGGLGGNGGVAVAHSPIGIDIGIGGAGGHGGSGTSGADGGAGGVSISEGIFAIDVNLGGAGGDGGT ATTGTAGSGGNGGFVENFDFFGFGVAHGGDGGSGGAASGAGGIGGAGGNGGSGTTPLFGAYSGGAGGDGG AATGTGGAGGNGGAGGAASGLGVGIGGAGGHGGAAPTGNGGSGGAGAGGLGLIGAGGNGGDAGAGVAAAD GGDGGNAGLVINGTYEASPYGNGGNGGNGVNGGSGGKGGSAGQVGGTPGQNGSP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0492 | - | - | 100% (824) | PE-PGRS family protein |
| M. marinum M | MMAR_5344 | - | 0.0 | 48.89% (853) | PE-PGRS family protein |
| M. marinum M | MMAR_0609 | - | 0.0 | 47.77% (919) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0857c | PE_PGRS14 | 0.0 | 57.95% (837) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-136 | 44.14% (768) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv0834c | PE_PGRS14 | 0.0 | 59.95% (884) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 4e-13 | 45.45% (88) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 9e-47 | 34.92% (461) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 1e-20 | 41.27% (189) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-121 | 41.03% (797) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 7e-37 | 39.03% (310) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1155 | - | 0.0 | 77.54% (846) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-131 | 45.12% (738) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0492|M.marinum_M --------------------------------------------------
MUL_1155|M.ulcerans_Agy99 --------------------------------------------------
Mb0857c|M.bovis_AF2122/97 --------------------------------------------------
Rv0834c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0492|M.marinum_M ---------------------MSGVIAALDTLTAAATDVAGLG-------
MUL_1155|M.ulcerans_Agy99 ---------------------MSGVIAALDTLTAAATDVAGLG-------
Mb0857c|M.bovis_AF2122/97 ---------------------MSFVIAAPDLVAMATEDLAGIG-------
Rv0834c|M.tuberculosis_H37Rv ---------------------MSFVIAAPDLVAMATEDLAGIG-------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0492|M.marinum_M -------------------------------------AAINAANAAAAVS
MUL_1155|M.ulcerans_Agy99 -------------------------------------AAINAANAAAAVS
Mb0857c|M.bovis_AF2122/97 -------------------------------------ASLTAANAAAAVP
Rv0834c|M.tuberculosis_H37Rv -------------------------------------ASLTAANAAAAVP
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS
MMAR_0492|M.marinum_M TTRLMAAAG------------------------------DEVSAAIAALF
MUL_1155|M.ulcerans_Agy99 TTRLMAAAG------------------------------DEVSADIAALF
Mb0857c|M.bovis_AF2122/97 TSGLLAAAG------------------------------DEVSAAIAALF
Rv0834c|M.tuberculosis_H37Rv TSGLLAAAG------------------------------DEVSAAIAALF
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------MSIIDFIL
MAV_4827|M.avium_104 ----------------------------------------IQMVVLEGEY
MMAR_0492|M.marinum_M SDHALQYQAVSAEAVAFHGRFVQALTGGVQMYAAAETANTASLQTLGQDL
MUL_1155|M.ulcerans_Agy99 SDHALQYQAVSAEAVAFHGRFVQALTGGVQMYAAAETANTASLQTLGQDL
Mb0857c|M.bovis_AF2122/97 SSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQTLEQGL
Rv0834c|M.tuberculosis_H37Rv SSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQTLEQGL
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGY
MAV_4827|M.avium_104 ADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIG
MMAR_0492|M.marinum_M LGMVNAPAAAVLGRPLIGNGTNGAPGSGDAGGPGGLLFGNGGNGGSGSAG
MUL_1155|M.ulcerans_Agy99 LGMVNALAAAVLGRPLIGNGTNGAPGSGDAGGPGGLLFGNGGNGGSGSAG
Mb0857c|M.bovis_AF2122/97 LGAINAPAAALSGRPFIGNGTNGAPGTGEAGGPGGWLLGNGGNGGSGAPG
Rv0834c|M.tuberculosis_H37Rv LGAINAPAAALSGRPFIGNGTNGAPGTGEAGGPGGWLLGNGGNGGSGAPG
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_3810|M.thermoresistible__bu ------------------------------------------------VD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 QSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDT
MAV_4827|M.avium_104 VTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTA
MMAR_0492|M.marinum_M MAGGAGGSAG---LIGNGGAGGAGGADAAGGPGGAGGWLWGGGGAG----
MUL_1155|M.ulcerans_Agy99 MAGGAGGSAG---LIGNGGAGGAGGADAAGGPGGAGGWLWGGGGAG----
Mb0857c|M.bovis_AF2122/97 QTGGAGGAAG---LLGHGGTGGAGGTGASGGKGGTGGWLWGSGGAGGAGG
Rv0834c|M.tuberculosis_H37Rv QTGGAGGAAG---LLGHGGTGGAGGTGASGGKGGTGGWLWGSGGAGGAGG
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATG--A
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATG--A
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGG--G
TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGG--G
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DFASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIG--
MAV_4827|M.avium_104 VLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAG---
MMAR_0492|M.marinum_M ---------------------GLGGAASGAGNGGAGGAGGAG-----GAF
MUL_1155|M.ulcerans_Agy99 ---------------------GLGGPASGAGNGGAGGAGGAG-----GAF
Mb0857c|M.bovis_AF2122/97 SGGGSGGAGGNALMFGIGGNGGAGGAASGVGNGGVGGAGGAG-----GAL
Rv0834c|M.tuberculosis_H37Rv SGGGSGGAGGNALMFGIGGNGGAGGAASGVGNGGVGGAGGAG-----GAL
Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
TH_3810|M.thermoresistible__bu TGIIS--------------------LLSLAGNGGNGG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------DGAVAVGGSNSGPIAS-------------
MAV_4827|M.avium_104 ----------------------LEKLESLPGGLLLVG-------------
MMAR_0492|M.marinum_M IAIGGVGGDGGAASSGTGGVGGAGGNADGLIVSLGG--------------
MUL_1155|M.ulcerans_Agy99 IAIGGVGGDGGAASSGIGGVGGAGGNADGLIVSLGG--------------
Mb0857c|M.bovis_AF2122/97 VAIGGAGGAGGAATTGTGGAGGAGSNALGLFLGLGG--------------
Rv0834c|M.tuberculosis_H37Rv VAIGGAGGAGGAATTGTGGAGGAGSNALGLFLGLGG--------------
Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
TH_3810|M.thermoresistible__bu --NGYRTTDNNALDGGHGG-------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -GQGSTAVNGDVRDSNIINADHGSNVGVDQSQTRVG--------------
MAV_4827|M.avium_104 SGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAAL--------------
MMAR_0492|M.marinum_M ------------------AGGHGGDATTG---------------IGGAGG
MUL_1155|M.ulcerans_Agy99 ------------------VGGHGGDATTG---------------IGGAGG
Mb0857c|M.bovis_AF2122/97 ------------------SGGQGGDSAMG---------------SGGAGG
Rv0834c|M.tuberculosis_H37Rv ------------------SGGQGGDSAMG---------------SGGAGG
Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
TH_3810|M.thermoresistible__bu --------------------------------------------NGGNVG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------GDYTNVSGHG--------------SADIDKS
MAV_4827|M.avium_104 --------------------------------------------AAANAP
MMAR_0492|M.marinum_M AGGMATARIPAGIN-------------FNVGGAGGHGGAGATGGAGGGGG
MUL_1155|M.ulcerans_Agy99 AGGMATARIPAGIN-------------FNVGGAGGHGGAGATGGAGGGGG
Mb0857c|M.bovis_AF2122/97 AGGSGGAASPFGID-------------IGIGGAGGHGGAGTNGGAGGAGG
Rv0834c|M.tuberculosis_H37Rv AGGSGGAASPFGID-------------IGIGGAGGHGGAGTNGGAGGAGG
Mflv_5091|M.gilvum_PYR-GCK AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
TH_3810|M.thermoresistible__bu FFSLFNLGG--------------------AGGWGGSGVDG----------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTN--------------INDSFNTDRSTNIGSGNTTNTE
MAV_4827|M.avium_104 LFASSTAALAYAQD----------------PGTGAVDQYSLPDYLYVPVD
MMAR_0492|M.marinum_M SAYSG--YVGIAFGQGGAGGIGGAASTGMAG-------------------
MUL_1155|M.ulcerans_Agy99 SAYSG--YVGIAFGQGGAGGIGGAASTGMAG-------------------
Mb0857c|M.bovis_AF2122/97 AGGSSGTVFALDLSWGGAGGNGGAATTGTGG-------------------
Rv0834c|M.tuberculosis_H37Rv AGGSSGTVFALDLSWGGAGGNGGAATTGTGG-------------------
Mflv_5091|M.gilvum_PYR-GCK Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1 Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
TH_3810|M.thermoresistible__bu -----------VDVVGGNP-------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 IGSHNQANIGTSTSAGGSAAVGGNAGLAGNAG------------------
MAV_4827|M.avium_104 PEPGDDELAYSAVGEEDAESPTVVIEKLFLP-------------------
MMAR_0492|M.marinum_M -----------AGGSGGSCVAFDFVGFA------------------AAHG
MUL_1155|M.ulcerans_Agy99 -----------AGGSGGSCVAFDFVGFA------------------AAHG
Mb0857c|M.bovis_AF2122/97 -----------AGGTGGFAVAPDFIGFG------------------AAYG
Rv0834c|M.tuberculosis_H37Rv -----------AGGTGGFAVAPDFIGFG------------------AAYG
Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
TH_3810|M.thermoresistible__bu -----------DGGTPG------------------------------AHG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------LAGNAGLAGNAGLAGNAG----------------LAGNA
MAV_4827|M.avium_104 ------------EDSEPRRRPVLLVGSG--------------------LA
MMAR_0492|M.marinum_M GAGGTGGAATGVGATAG---------------------------------
MUL_1155|M.ulcerans_Agy99 GAGGTGGAATGVGATAG---------------------------------
Mb0857c|M.bovis_AF2122/97 GAGGLGGAATGAGGTGG---------------------------------
Rv0834c|M.tuberculosis_H37Rv GAGGLGGAATGAGGTGG---------------------------------
Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
TH_3810|M.thermoresistible__bu ESHTPGVYTDRQ--------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGN---------------------------------
MAV_4827|M.avium_104 VVGISAVLALEIALAIG---------------------------------
MMAR_0492|M.marinum_M -------------AAGSGGLGVAIVGSGVGGVGGVGG----AATGAG---
MUL_1155|M.ulcerans_Agy99 -------------AAGSGGLGVAIVGSGVGGVGGVGG----AATGAG---
Mb0857c|M.bovis_AF2122/97 -------------TGGVGAGGFAALGVGVGGAGGAGG----AATETGGIG
Rv0834c|M.tuberculosis_H37Rv -------------TGGVGAGGFAALGVGVGGAGGAGG----AATETGGIG
Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAGGTGG-------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNGGTGG-------------
MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWK-------
TH_3810|M.thermoresistible__bu -----------------GEDGEDGTGTGIGGRGGNGG-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------AGLAGNAGLAGNAGLAGNAGLAGN-------------
MAV_4827|M.avium_104 -------------IRTTGTVALQPTPNQHLIVPTEQAP------------
MMAR_0492|M.marinum_M ----------------------ATAAAGGAGGLG---LAAVGSGTGGAGG
MUL_1155|M.ulcerans_Agy99 ----------------------ATAAAGGAGGLG---LAAVGSGTGGAG-
Mb0857c|M.bovis_AF2122/97 GAGGLGVGLLGGAGGAGGPGGAASAGSGGHGGTGGDALGLIGAGIGGVGG
Rv0834c|M.tuberculosis_H37Rv GAGGLGVGLLGGAGGAGGPGGAASAGSGGHGGTGGDALGLIGAGIGGVGG
Mflv_5091|M.gilvum_PYR-GCK -----------------------TGGTGGIGGAGSTGGTGGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 -----------------------TGGTGGIGGAGSTGGTGGTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 ------------ANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGG
TH_3810|M.thermoresistible__bu ----------------------SSSGTHPMAEDG--------EHVKALDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------AGLAGNAGLAGNAGLAGNAGLAGNAGLAG
MAV_4827|M.avium_104 ----------------------APPPVQASAPQPKISVPEPVAAPKPLSP
MMAR_0492|M.marinum_M AGGVGAGTGGAGGAGAHGFGLLSGTAGAGGAGGAASAGTGGAGGLGGTGF
MUL_1155|M.ulcerans_Agy99 -------------------------------------------GLGGTGF
Mb0857c|M.bovis_AF2122/97 VGGAATDTGGNGGAGGSGTGLLGGVGGAGGHGGGASVGTGGSGGAGGDGF
Rv0834c|M.tuberculosis_H37Rv VGGAATDTGGNGGAGGSGTGLLGGVGGAGGHGGGASVGTGGSGGAGGDGF
Mflv_5091|M.gilvum_PYR-GCK TGGTG-GTGGTGGTGGTG-------------GKGGTGGTGGAGGTG----
Mvan_1264|M.vanbaalenii_PYR-1 TGGTG-GTGGTGGTGGTG-------------GKGGTGGTGGDGGTG----
MSMEG_0868|M.smegmatis_MC2_155 AGGVSEGEGGTGGHGGDG-------------GRGGDGALGGNGGTGGVGL
TH_3810|M.thermoresistible__bu RPGLD---GGNGSHGGNG-------------GHGGRGGFLGIGGSG----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAG-----------NAGLAGNAAVAGNAAVAG-NA
MAV_4827|M.avium_104 PVAAPLPAAPPPAAPPLP-------------EAPPIPAAPPVVPVPVVVP
MMAR_0492|M.marinum_M GLIAAGGDGGGAGTG----------VGSNGGDGGGG----GGAHAVLAAI
MUL_1155|M.ulcerans_Agy99 GLIAAGGDGGGAGTG----------VGSNGGDGGGG----GGAHAVLAAI
Mb0857c|M.bovis_AF2122/97 GFVGAGGNGGNAGTG----------VGVNGANGGNG----GSATGALAAV
Rv0834c|M.tuberculosis_H37Rv GFVGAGGNGGNAGTG----------VGVNGANGGNG----GSATGALAAV
Mflv_5091|M.gilvum_PYR-GCK GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGT
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGL
MSMEG_0868|M.smegmatis_MC2_155 GNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTAT
TH_3810|M.thermoresistible__bu ---GWGGHGGNGGD-----------TDADGGNGGDG--------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AVAGNAAVGGVLNTG---------VSGAIGGSSHVG-------GAINESL
MAV_4827|M.avium_104 PVPVPVPVRIPVPDP----------VSPPQLLAPPR-------LSVPQPV
MMAR_0492|M.marinum_M AGSGGQGQ--------AGTSGFGG----------------FGGSGGSAES
MUL_1155|M.ulcerans_Agy99 AGSGGQGQ--------AGTSGFGG----------------FGGSGGSAES
Mb0857c|M.bovis_AF2122/97 GGAGAAGG--------DATSGTGG----------------FGGAGGSARG
Rv0834c|M.tuberculosis_H37Rv GGAGAAGG--------DATSGTGG----------------FGGAGGSARG
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGG----TGGQGGQGGQGG-----------------TGGTGGQGG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGG----TGGFGGQGGQGG-----------------TGGTGGQGG
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGG
TH_3810|M.thermoresistible__bu -GNGGSAG---------------------------------RGGTGGLRG
MLBr_01183|M.leprae_Br4923 ------------------------------------------------MP
MAB_4284c|M.abscessus_ATCC_199 GGSGSVGG----------STAVGG------------------GAHTGVGG
MAV_4827|M.avium_104 QPPVRVPQ--------PPSPPQVG------------------GTVPQSPP
MMAR_0492|M.marinum_M LFFSIGGAG-----------------------GAGGDASTGGGGLGGNGG
MUL_1155|M.ulcerans_Agy99 LFFSIGGAG-----------------------GAGGDASTGGGGLGGNGG
Mb0857c|M.bovis_AF2122/97 LIFALGGAG-----------------------AAGGDASTGVGGPGGPGG
Rv0834c|M.tuberculosis_H37Rv LIFALGGAG-----------------------AAGGDASTGVGGPGGPGG
Mflv_5091|M.gilvum_PYR-GCK -LGGGGGTG-----------------------GQGGTGGTGGQGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 -LGGVGGTG-----------------------GTGGTGGTGGQGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 TLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQG
TH_3810|M.thermoresistible__bu VFGINGGNG------------------------RAGLGGRGXXXXGGGVG
MLBr_01183|M.leprae_Br4923 LFLNAEPQA----------------------------LTAAANTLEGLSA
MAB_4284c|M.abscessus_ATCC_199 GVSTGVGVG-----------------------SHVGGGISESLGGSGSVG
MAV_4827|M.avium_104 QHQTPPGEG-------------------------TPPKPDGPGNYGGGHV
. *
MMAR_0492|M.marinum_M VAVAHSPIG--IDIGIGGAGGHGGSGTSGADGGAGGVSISEGIFAIDVNL
MUL_1155|M.ulcerans_Agy99 VAVAHSPIG--IDIGIGGAGGHGGSGTSGADGGAGGVSISEGIFAIDVNL
Mb0857c|M.bovis_AF2122/97 TGTASSPFG--IAIAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGF
Rv0834c|M.tuberculosis_H37Rv TGTASSPFG--IAIAIGGAGAQGGAGTSGATGGAGGDGVFEGIAVLGLGF
Mflv_5091|M.gilvum_PYR-GCK GTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGST
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTG--------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGST
MSMEG_0868|M.smegmatis_MC2_155 TIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSAT
TH_3810|M.thermoresistible__bu AAVRSG---------------NGVFSGGGGTPSAGFGVPTTIQFPAGSCT
MLBr_01183|M.leprae_Br4923 ATVASN------------AAAAQLTTEIAPPAADDVSILLAHFFSGHGRQ
MAB_4284c|M.abscessus_ATCC_199 GSTAVG---------------GGAHTGVGGGVSTGVGVGSHVGGGISESL
MAV_4827|M.avium_104 PTPGAG-------------GSGGSGGGHVPTPGAGGSGGSGGGHVPTPGT
. . .
MMAR_0492|M.marinum_M GGAGGDGGTATTGTAGSGGNGGFVEN----FDFFGFGVAHGGDGGSGGAA
MUL_1155|M.ulcerans_Agy99 GGAGGDGGTATTGTAGSGGNGGFVEN----FDFFGFGVAHGGDGGSGGAA
Mb0857c|M.bovis_AF2122/97 GGAAGAGG-AATGDGATGGAGGFGGAGAGIANFLGFSVLHGGAGGAGGTA
Rv0834c|M.tuberculosis_H37Rv GGAAGAGG-AATGDGATGGAGGFGGAGAGIANFLGFSVLHGGAGGAGGTA
Mflv_5091|M.gilvum_PYR-GCK GGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQG
Mvan_1264|M.vanbaalenii_PYR-1 GGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQG
MSMEG_0868|M.smegmatis_MC2_155 GTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEA
TH_3810|M.thermoresistible__bu SRAVSREG------------------------IMPSSRAASARAG-----
MLBr_01183|M.leprae_Br4923 YQAHASQG--------------------------ATNHQDLIQS------
MAB_4284c|M.abscessus_ATCC_199 GGSGSVGGSTAVGGGAHTGVGGGVNTGVGVGSHVGGGISESLGG------
MAV_4827|M.avium_104 GGPGGTGG-------------------------SGGGHVP----------
. . *
MMAR_0492|M.marinum_M SG--------------------AGGIGGAGGNGGSGTTPLFG--------
MUL_1155|M.ulcerans_Agy99 SG--------------------AGGIGGAGGNGGSGTTPLFG--------
Mb0857c|M.bovis_AF2122/97 TG--------------------TGGNGGAGGGGGLSSPVILG--------
Rv0834c|M.tuberculosis_H37Rv TG--------------------TGGNGGAGGGGGLSSPVILG--------
Mflv_5091|M.gilvum_PYR-GCK ATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG----
Mvan_1264|M.vanbaalenii_PYR-1 ATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG----
MSMEG_0868|M.smegmatis_MC2_155 SNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSN
TH_3810|M.thermoresistible__bu ----------------------AACASSTSRSRRSFCCSRA---------
MLBr_01183|M.leprae_Br4923 ---------------------LLTSSSAYAGTETANHDSL----------
MAB_4284c|M.abscessus_ATCC_199 ----------------------SGSVGGSTAVGGGAHTSAIN--------
MAV_4827|M.avium_104 ----------------------TPGAGTPGGSGGGHLPFPGAG-------
MMAR_0492|M.marinum_M -----AYSGGAGGDGGAATG-TGGAGGNGGAGGAASGLGVGIGGAGGHGG
MUL_1155|M.ulcerans_Agy99 -----AYSGGAGGDGGAATG-TGGAGGNGVAGGAASGLGVGIGGAGGHGG
Mb0857c|M.bovis_AF2122/97 -----IGIG-----------------------------------------
Rv0834c|M.tuberculosis_H37Rv -----IGIGGAGGDGGGALGVLGGMGGDGGDGGEAVAVGIAVGGAGGAGG
Mflv_5091|M.gilvum_PYR-GCK -------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG------
Mvan_1264|M.vanbaalenii_PYR-1 -------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG------
MSMEG_0868|M.smegmatis_MC2_155 IAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANS
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MMAR_0492|M.marinum_M AAPTGNGGSGGAGAGGLGLIGAGGNGG------------DAGAGVAAADG
MUL_1155|M.ulcerans_Agy99 AAPTGNGGSGGAGAGGLGLIGAGGNGGGAGAGGAGGNGGDAGAGVAAADG
Mb0857c|M.bovis_AF2122/97 -------GAGGNGGDALGLVGVGGNGG------------NAGTGFGANTG
Rv0834c|M.tuberculosis_H37Rv AAPTGNGGAGGNGGDALGLVGVGGNGG------------NAGTGFGANTG
Mflv_5091|M.gilvum_PYR-GCK --AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDGG
Mvan_1264|M.vanbaalenii_PYR-1 --AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAGG
MSMEG_0868|M.smegmatis_MC2_155 SAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---DALGGSGSVGGSTAVGGGAHTSAIN----------ESMNSSINASHS
MAV_4827|M.avium_104 ------STPGGSGGGHLPTPGAGTPGG----------------GLGGFGG
MMAR_0492|M.marinum_M GDGGNAGLVINGTYEASPYGNGGNGGNGVNGGSGGKGGSAGQVGGTPGQN
MUL_1155|M.ulcerans_Agy99 GDGGNAGLVINGTYEASPYGNGGN---GVNGGSGGKGGSAGQVGGTPGQN
Mb0857c|M.bovis_AF2122/97 GNGGDTTIVVNGMLAPSTLGYGGNG---VNGGAGGTGGKAGVFG-APGQN
Rv0834c|M.tuberculosis_H37Rv GNGGDTTIVVNGMLAPSTLGYGGNGGNGVNGGAGGTGGKAGVFG-APGQN
Mflv_5091|M.gilvum_PYR-GCK KGGAGAEGGAGGGGGAGGSGAGGAG-------GAGGSGGSGGSGGSGGSG
Mvan_1264|M.vanbaalenii_PYR-1 AGGDGSEGGAGGSGGAGGSGTGGAG-------GAGGSGGSGGSGGAGGSG
MSMEG_0868|M.smegmatis_MC2_155 NGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SSMNESFGSSMGSHGAAGTGFEAQG-------HAQGHASETAHTTLPGAE
MAV_4827|M.avium_104 GHAPAPGGGLGGGGGHAPAPGGGLG-------GFGGGHSGGGLGGLGGGH
MMAR_0492|M.marinum_M GSP--------
MUL_1155|M.ulcerans_Agy99 GSP--------
Mb0857c|M.bovis_AF2122/97 GLP--------
Rv0834c|M.tuberculosis_H37Rv GLP--------
Mflv_5091|M.gilvum_PYR-GCK GAAGDSDD---
Mvan_1264|M.vanbaalenii_PYR-1 GAAGDSD----
MSMEG_0868|M.smegmatis_MC2_155 GTAGTTGANNP
TH_3810|M.thermoresistible__bu -----------
MLBr_01183|M.leprae_Br4923 -----------
MAB_4284c|M.abscessus_ATCC_199 HH---------
MAV_4827|M.avium_104 K----------