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MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAADEVSTAVAALFSQHAQGYQAAAAQVA AFHSRFVQALTAGAGAYAFAEAANASPLQSAMGAVSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGS GGNGAPGAAGQSGGNGGSAGLWGNGGAGGAGGSGGAAGGNGGNGGWLFGAGGTGGIGGTGAPGAMGGTGG NGGNGALLIGGGGLGGAGGMGGTGGGTGGTGGNGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGG NGGAGGLFMNGGDGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGHGGAGGMGGQG GTGGMGGAGGDGTTVIAAGTGGEGGTGGAAGAGGAAGARGALTSGGLAGGVGAGGTGGTGGTGGNGADAA AVVGFGANGDPGFAGGKGGNGGIGGAAVTGGVAGDGGTGGKGGTGGAGGAGNDAGSTGNPGGKGGDGGIG GAGGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGADNTLNPDTPGGAGEPGGAGGAGGAGGAA GGPGGTGGTGGNGGNGGNGGNGGNGGNGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAGSQ GTGGVGGDGGAGGNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGANGGTGGSGGNGGDGGAGG IGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAGGAGGQGGNAGQGGAGGAGGNAVIPGDGVGK APHGDAGGSGGDGGKGGQGGSGGTGGSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNGGNAG DGGNGGNAGAGGNGGSGDFGGNTTSGASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGGNGGNGGNGGDG GNGAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTGGNAGSQGIGGDGGNGGDGGKG GDGADAVNVVFMPTEPQAATGTAGSAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTN ANDGTATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGGQFGAGGNGGAGGSVTD GSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGG SGGNGGNAGGGGANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGTGGVGSVGA AGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGDGGNGVIAGGGGTGGNGGASGAGGAGGTGGF AGNGNAGGNGGTGGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3507 | PE_PGRS53 | - | 100% (1381) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 0.0 | 52.87% (1481) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 47.51% (1724) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3537 | PE_PGRS53 | 0.0 | 85.81% (1424) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.28% (816) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 3e-12 | 38.54% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 3e-54 | 31.68% (565) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_4995 | - | 0.0 | 65.39% (1433) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 9e-26 | 48.37% (153) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-177 | 42.37% (1081) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 2e-47 | 42.20% (282) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 45.90% (1231) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 46.42% (881) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3507|M.tuberculosis_H37Rv MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAADEVSTA
Mb3537|M.bovis_AF2122/97 MSFVLVSPETVAAVATDLKRIGASLAHENASAAASTTAVVSAAADEVSTA
MMAR_4995|M.marinum_M MSYLIVAPEAMTAAAGDLAGIGSSVAAANAAAAGPTTAMLTAAADEVSTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 -----MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAA
MUL_4367|M.ulcerans_Agy99 MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGVLPAAGDEVSAA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv VAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQS
Mb3537|M.bovis_AF2122/97 VAALFSQHAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQS
MMAR_4995|M.marinum_M IAAFFSAHAADYQRLAGQAAALHTQLERVLSAGAVAYAAAETTGTSPLQL
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------MMFLAPPGGPGPISAAIQLTSTGSEA
MSMEG_0868|M.smegmatis_MC2_155 LAPESPLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNT
MUL_4367|M.ulcerans_Agy99 IAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQE
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv AMG----AVSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGSGGNGAP
Mb3537|M.bovis_AF2122/97 AMG----AVSASAQTLLSRPLIGNGANATTPGGNGGDGGWLFGSGGNGAP
MMAR_4995|M.marinum_M AIN----AVSAPAQSLLARPIIGNGANATTPGGNGGDGGWLFGSGGNGAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------MVTFGGG
Mvan_1264|M.vanbaalenii_PYR-1 TEP--------------------------------------WYVVSFGGS
MSMEG_0868|M.smegmatis_MC2_155 TDQPTSDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTT
MUL_4367|M.ulcerans_Agy99 LEQQALGVVNAPSMALFGRPSIGNGVDGVAGTGQAGGAGGILWGNGGNGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv GAAGQ--------------------------------SGGNGGSAGLWGN
Mb3537|M.bovis_AF2122/97 GAAGQ--------------------------------SGGNGGSAGLWGN
MMAR_4995|M.marinum_M GAAGQ--------------------------------AGGSGGSAGLLGN
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATPTP----------------------------------------TSLGA
Mvan_1264|M.vanbaalenii_PYR-1 GAPTP----------------------------------------NNLAA
MSMEG_0868|M.smegmatis_MC2_155 LIPNAPTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVAS
MUL_4367|M.ulcerans_Agy99 LGAAG-------------------------------ANGGAGGSAGLIGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv GGAGGAGGSGG--------------AAGGNGGNGGWLFGAGGTGGIGGTG
Mb3537|M.bovis_AF2122/97 GGAGGAGGSGG--------------AAGGNGGNGGWLFGAGGTGGIGGTG
MMAR_4995|M.marinum_M GGAGGAGGTGG--------------ARGGNGGSGGLLFGGGGIGGTGGTG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AAVDLS------------------------GTSCG----------LICNG
Mvan_1264|M.vanbaalenii_PYR-1 SLVDLS------------------------GTSCG----------LICNG
MSMEG_0868|M.smegmatis_MC2_155 AVLDPTQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNG
MUL_4367|M.ulcerans_Agy99 GGVGGAG------------------GVGAAGMTGGSGGAGGGGGWLWGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------------MS
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv APGA-MGGTGGNGGNGALLIGGGGLGGAGGMGGTGGGTGG--TGGNGGNG
Mb3537|M.bovis_AF2122/97 APGA-MGGTGGNGGNGALLIGGGGLGGAGGMGGTGGGTGG--TGGNGGNG
MMAR_4995|M.marinum_M AAGAGMGGMGGNGGSGSWLIGGGGAGGAGGIGGTGGGTGG--VGGTGGDA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK QDG---TGQN-----GGILFGNGGSGWNSDVVGMDGGNGG----------
Mvan_1264|M.vanbaalenii_PYR-1 QDG---TGQN-----GGILFGNGGSGWNSEIAGVSGGNGG----------
MSMEG_0868|M.smegmatis_MC2_155 ING---TADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGG----------
MUL_4367|M.ulcerans_Agy99 GSGG-AAGAGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAGDQGVSG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 IIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVG----------
MAV_4827|M.avium_104 ---------------MNIVLGVSMAPSSIQMVVLEGEYAD----------
Rv3507|M.tuberculosis_H37Rv ALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGNGGAGGLFMNGGDGGAG
Mb3537|M.bovis_AF2122/97 ALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGNGGAGGLFMNGGDGGAG
MMAR_4995|M.marinum_M GWLVGAGGSGGSGGIGATGTGSGGAAGNG---GNGGAGGLFMNGGDGGAG
TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGGRTGLFSKLSRGGDGGDG
Mflv_5091|M.gilvum_PYR-GCK ----NGGLFGGNGGNG----GNGLGGGNGGNGGNAGAFALFGNGGNGGNG
Mvan_1264|M.vanbaalenii_PYR-1 ----NAGLFGGNGGNG----GNGLGSGDGGNGGDAGLFSLFGRGGNGGNG
MSMEG_0868|M.smegmatis_MC2_155 ----NAGLFG-NGGNG----GVGWAGLDGGNGGSGG--LLMGIGGAGGAG
MUL_4367|M.ulcerans_Agy99 VAPGEAGAVGFAGGAG----GAGGAGGNGVGGGVNGAGGAGGAGGVGGGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----AVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPS
MAV_4827|M.avium_104 ------------GATVEEDAIDVTGADDAATASAPDRVISAILGTREGAA
Rv3507|M.tuberculosis_H37Rv GQGGDGAAGDAAASAGGTGGK-GGQGGDGGTGGAGGAGPVLFGHGGAGGM
Mb3537|M.bovis_AF2122/97 GQGGDGAAGDAAASAGGTGGK-GGQGGDGGTGGAGGAGPVLFGHGGAGGM
MMAR_4995|M.marinum_M GQGGDGAAGAAAAAAGGTGGD-GGLGGNGGAGGAGGGGPVLFGHGGAGGL
TH_3810|M.thermoresistible__bu GLG-------------GNGGHGGGTGIIS--------------------L
Mflv_5091|M.gilvum_PYR-GCK GVGVVGATGAVG--APGVAGATGATGVTSGVVGGNGEDAVGYGATGAAGA
Mvan_1264|M.vanbaalenii_PYR-1 GVGIAGATGAVG--APGVAGATGATGVTSNVTGGNGADAVGYGATGAAGA
MSMEG_0868|M.smegmatis_MC2_155 GVGADGTSAHVDGGTGGTGGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGA
MUL_4367|M.ulcerans_Agy99 GAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGTGGAAGVAGTGGDGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLL
MAV_4827|M.avium_104 DAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNV
Rv3507|M.tuberculosis_H37Rv GGQGGTGGMGGAGG-----------DGTTVIAAGTGGEGGTGGAAGAGGA
Mb3537|M.bovis_AF2122/97 GGQGGTGGMGGAGG-----------DGTTVIAAGTGGEGGTG--------
MMAR_4995|M.marinum_M GGQGGTGGIGGTGG-----------AGTTSIAAGTGGNGGAGGAAGGGGT
TH_3810|M.thermoresistible__bu LSLAGNGGNGG---------------NGYRTTDNNALDGGHGG-------
Mflv_5091|M.gilvum_PYR-GCK AGAAGAAGAAG--------------AVGSAGAAGEAGETGTWG-------
Mvan_1264|M.vanbaalenii_PYR-1 AGAAGAAGKAG--------------AVGSAGTAGSAGAPGVWG-------
MSMEG_0868|M.smegmatis_MC2_155 AGAAGNGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQS-----
MUL_4367|M.ulcerans_Agy99 DGGAGGAGSDAS------------LAGQAGFAGGSGGAGGVGGSA-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 DLSFGDLQFGNR--------------DTTAIGDGAVAVGGSNSGP-----
MAV_4827|M.avium_104 GGAMGYERTAVLLVEP----------DTATLAVVETSDGSIPDVY-----
Rv3507|M.tuberculosis_H37Rv AGARGALTSGGLAGGVGAGGTGGTGGTGGNGADAAAVVGFGANGDPGFAG
Mb3537|M.bovis_AF2122/97 ----------------------GTGGTGGNGADAAAVVGFGANGDPGFAG
MMAR_4995|M.marinum_M AGAAGPLTNAGLAGGFGTGGTGGTGGTGGAGAPGIDGAALGEGGTNGYIG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------NAGLPGKAGDAGGAG----------------AVG
Mvan_1264|M.vanbaalenii_PYR-1 ----------------NAGLPGAAGAAGGAG----------------AIG
MSMEG_0868|M.smegmatis_MC2_155 ----------------TAAGPGKGGGGGGGGGGAILIGANGGTVDGHAIG
MUL_4367|M.ulcerans_Agy99 ----------------GAGGVNGSGGDGGAG----------------AAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv GKGGNGGIGGAAVTGGVAGDGGTGGKGGTGGAGGAGN---DAGSTGNPGG
Mb3537|M.bovis_AF2122/97 GKGGNGGIGGAAVTGGVAGDGGTGGKGGTGGAGGAGN---DAGSTGNPGG
MMAR_4995|M.marinum_M GNGGNGGAGGAALGGGAAGDGGQGGHGGAGGMGGAGANGITGGGVTGAGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AAGAAG------TVGTAGATGGTG--------------------------
Mvan_1264|M.vanbaalenii_PYR-1 TAGVAG------AAGTAGATGGTG--------------------------
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEG-----------TA
MUL_4367|M.ulcerans_Agy99 GAGGAS--ATVAGSGGVGGDGGAGG------------------------A
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------I
MAV_4827|M.avium_104 ------------------------------------------------KQ
Rv3507|M.tuberculosis_H37Rv KGGDGGIGGAGGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGA
Mb3537|M.bovis_AF2122/97 KGGDGGIGGAGGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGA
MMAR_4995|M.marinum_M NGGDGGQGGEPGTGGAAGSGGGGQTGSLGIGGTGGHGGAGGDGTPGGNGA
TH_3810|M.thermoresistible__bu NGGNVGFFSLFNLGG--------------------AGGWGGSG-------
Mflv_5091|M.gilvum_PYR-GCK TGANGGAGGVGGVGGTGAAG--------------AAGGAGGLG-------
Mvan_1264|M.vanbaalenii_PYR-1 VGGNGGAGQAGGIGGTGAAG--------------AAGQAGTAG-------
MSMEG_0868|M.smegmatis_MC2_155 TGGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDG-------
MUL_4367|M.ulcerans_Agy99 AGGGVGAASLGGDGGHAGAG--------------GAGGEGLSGGF-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ASGQGSTAVNGDVRDSNIIN---------------ADHGSNVG-------
MAV_4827|M.avium_104 QIRAESYGDAAGQLSAMVAG--------------LEKLESLPG-------
Rv3507|M.tuberculosis_H37Rv DN----TLNPDTPGGAGEPGGAGGAGGAGGAAG--GPGGTGGTGGNGGNG
Mb3537|M.bovis_AF2122/97 DN----TLNPDTPGGAGEPGGAGGAGGAGGAAG--GPGGTGGTGGNGGN-
MMAR_4995|M.marinum_M AGPTAGTGDPGVDGGAGGNGGAGGQGGSNGTGGDGGTGGSGATGGDGGTG
TH_3810|M.thermoresistible__bu -----------------VDG------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------------ETGTTGGAGGVGGQ-------------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------ETGVTGGVGGIGGQ-------------------
MSMEG_0868|M.smegmatis_MC2_155 -----------------IDGGTGGAGGMGEIYS-----------------
MUL_4367|M.ulcerans_Agy99 -----------------NTGAAGGIGGAGGAG------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------VDQSQTRVGG-----------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv3507|M.tuberculosis_H37Rv GNGGNGGNGGNGGNGGNAGNNSTNAPVGGEGGAGGDGGAGGAGGAAN-GG
Mb3537|M.bovis_AF2122/97 -----------------AGNNSTNAPVGGEGGAGGDGGAGGAGGAAN-GG
MMAR_4995|M.marinum_M G----------------AGTATDAGGTGGQGGVGGAGGAPGAAGLAGTGG
TH_3810|M.thermoresistible__bu --------------------------VDVVGGNP----------------
Mflv_5091|M.gilvum_PYR-GCK ------------------GTAGGTGGVGGIGGAGSTGAVGGVGGKG----
Mvan_1264|M.vanbaalenii_PYR-1 ------------------GTEGGTGGVGGVGGVGATGGAGGVGGKG----
MSMEG_0868|M.smegmatis_MC2_155 ------------------GADGEATGISAGGDGGSATGADSLGGRGGTSW
MUL_4367|M.ulcerans_Agy99 ------------------GTGGDSGGVGGVNGDGGAGGGGGRGGDGGSST
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------------DYTNVSGHGSADIDKSVTVVDDHSQRNT
MAV_4827|M.avium_104 -------------------------GLLLVGSGVDVAPLKQVLQTTTFLD
Rv3507|M.tuberculosis_H37Rv TAGSQG--------------TGGVGGDGGAGGNGGGGKAGTG--------
Mb3537|M.bovis_AF2122/97 TAGSQG--------------TGGVGGDGGAGGNGGGGKAGTG--------
MMAR_4995|M.marinum_M QAGNEG--------------VGGNGGQGGHGGAGGNGVDGAD--------
TH_3810|M.thermoresistible__bu --------------------------DGGTPG------------------
Mflv_5091|M.gilvum_PYR-GCK IQGGQG-------------LQGGKGGDGGAGGKGGDADSMGS--------
Mvan_1264|M.vanbaalenii_PYR-1 IQGGQG-------------LQGGQGGDGGTGGTGGDATSMGE--------
MSMEG_0868|M.smegmatis_MC2_155 VQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATG
MUL_4367|M.ulcerans_Agy99 STSGVG-------------GAGGAGGNGGNAGFGVSAGGTGG--------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 TNINDS-------------FNTDRSTNIGSGNTTNTEIGSHN--------
MAV_4827|M.avium_104 VSVAEE---------------PETALARGAALAAANAPLFAS--------
Rv3507|M.tuberculosis_H37Rv NSGNFGVDGEAGFSGGAGGNGGVGGAAGANGG--------TGGSGGNGGD
Mb3537|M.bovis_AF2122/97 NSGNFGVDGEAGFSGGAGGNGGVGGAAGANGG--------TGGSGGNGGD
MMAR_4995|M.marinum_M ANVFTGDNGGDGTAGGKGGDGGAGGAAGANGG--------TGGGGGIGGG
TH_3810|M.thermoresistible__bu ------------AHGESHTPGVYTDRQ-----------------------
Mflv_5091|M.gilvum_PYR-GCK ----------AGATGGKGGNGGNGGRGGLFG---------------KGGN
Mvan_1264|M.vanbaalenii_PYR-1 ----------AGATGGKGGNGGNGGRGSLFG---------------RGGN
MSMEG_0868|M.smegmatis_MC2_155 NTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGN
MUL_4367|M.ulcerans_Agy99 ---------SAGDGGAGGGAGGVDGVGGASG---------------NGGA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------QANIGTSTSAGGSAAVGGNAG-------------------
MAV_4827|M.avium_104 ----------STAALAYAQDPGTGAVDQYSLP------------------
Rv3507|M.tuberculosis_H37Rv GGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAG-----
Mb3537|M.bovis_AF2122/97 GGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAGGAGGN
MMAR_4995|M.marinum_M GGVGGDGGNGGSGNTGTSSAPAGGTGGIGGTGADGGAGGNGGAAGGAGGT
TH_3810|M.thermoresistible__bu --------------------------------GEDGEDGTGTGIGGRGGN
Mflv_5091|M.gilvum_PYR-GCK AGNGAD----------------------GGTGGAGGAGGTGG-TGGAGGT
Mvan_1264|M.vanbaalenii_PYR-1 AGNGGN----------------------GGTGGNGGNGGTGG-TGGNGGT
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGD
MUL_4367|M.ulcerans_Agy99 AGAGGAG---------------GSGIGAGIDGGAGGAGGTGGAAGFPGGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------LAGNAGLAGNAGLAGNAGLAGNA
MAV_4827|M.avium_104 ---------------------------DYLYVPVDPEPGDDELAYSAVGE
Rv3507|M.tuberculosis_H37Rv -GAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGDAGGSGGDGGKGGQG
Mb3537|M.bovis_AF2122/97 GGAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGGAGGSGGDGGKGGQG
MMAR_4995|M.marinum_M GGQGGTGGGAGKGGTGGAGGAAVTPGLGIGDEPAGGTGGTGGHGGTGGHG
TH_3810|M.thermoresistible__bu GG---------------------------------SSSGTHPMAEDG---
Mflv_5091|M.gilvum_PYR-GCK GG----------------------------------TGGTGGIGGAGSTG
Mvan_1264|M.vanbaalenii_PYR-1 GG----------------------------------TGGTGGIGGAGSTG
MSMEG_0868|M.smegmatis_MC2_155 GAGASVWKANGQHSTG-----------------QTDTGGNGGRGGDGGTF
MUL_4367|M.ulcerans_Agy99 GTTG-----------------------------AWGTGGAGGAGGAGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 G-----------------------------------LAGNAGLAGNAGLA
MAV_4827|M.avium_104 ED----------------------------------AESPTVVIEKLFLP
Rv3507|M.tuberculosis_H37Rv GSGGTGGSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNGGNA
Mb3537|M.bovis_AF2122/97 GSGGTGGSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNGGNA
MMAR_4995|M.marinum_M GTGGAAGNGG--AGGAGGQAGDGGSGGEGGDGGTGAQGTTVSLPGSGGNA
TH_3810|M.thermoresistible__bu -----EHVKA--LDGRPGLD--------GGNGSHG---------GNGGHG
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGG--TGGTGGTG------GTGGTGGTG---------GTGGKG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGG--TGGTGGTG------GTGGTGGTG---------GTGGKG
MSMEG_0868|M.smegmatis_MC2_155 VNAGANGNGG--AGGAGGVSE-----GEGGTGGHG---------GDGGRG
MUL_4367|M.ulcerans_Agy99 DHGGVGVNPG--DSGTAGWAG-----GAGGAGGAGGSAAFNGVNGAGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAG--LAGNAGLAG-----NAGLAGNAG-------LAGNAGLA
MAV_4827|M.avium_104 EDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIG--------IRTTGTV
Rv3507|M.tuberculosis_H37Rv GDGGNGG---------------------------NAGAGGNGGSGDFGGN
Mb3537|M.bovis_AF2122/97 GDGGNGGGGGAGGTGGDGATGTPAG---NGGNGGNAGDGGNGGSGDFGGN
MMAR_4995|M.marinum_M GNGGNAGGGGVGGTGGAGATGAPAGRGGTGGNGGNAGAGGKGGAGAFGGA
TH_3810|M.thermoresistible__bu GRGGFLGIGGSG---------------------------GWGGHGGNGGD
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG------------------------GDGGTGGTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG------------------------GTGGTGGTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVG--------------------LGNGGKGGNGGNGGN
MUL_4367|M.ulcerans_Agy99 GNGGAGGGGGAGASG--------------------IGAGVAGGDGGTGGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAG------------------------NAGLAGNAGLAGN
MAV_4827|M.avium_104 ALQPTPNQHLIVP------------------------TEQAPAPPPVQAS
Rv3507|M.tuberculosis_H37Rv TTS----GASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGGNGG----NG
Mb3537|M.bovis_AF2122/97 TTS----GASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGG---------
MMAR_4995|M.marinum_M GSSPGFLSPAGNGGAGGDAGTAAAGGDGGAGGAGPSGGNGGTGG----NG
TH_3810|M.thermoresistible__bu -----------TDADGGNGGDG---------------GNGGSAG------
Mflv_5091|M.gilvum_PYR-GCK G---------GTGGTGGTGGAG-----------DGTGGTGGTGG----TG
Mvan_1264|M.vanbaalenii_PYR-1 G---------GTGGTGGTGGAG-----------DGLGGTGGTGG----TG
MSMEG_0868|M.smegmatis_MC2_155 GGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADG
MUL_4367|M.ulcerans_Agy99 GGAAGTGGAAGTGGTGGAAGAAG---------SAGDGGAGGAGG-AGDDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------AGLAGNAGLAGNAG------------LAGNAGLAG------
MAV_4827|M.avium_104 APQ------PKISVPEPVAAPKP--------LSPPVAAPLPAAP------
Rv3507|M.tuberculosis_H37Rv GNGGDGGNGAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAG--
Mb3537|M.bovis_AF2122/97 -NGGDGGNGAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAG--
MMAR_4995|M.marinum_M GHGGNGGNGAEGAIGAQFVPASSLPTPSGGAGGDGGNGSNGGAPGAGG--
TH_3810|M.thermoresistible__bu ---------------------------RGGTGGLRGVFGINGGNG-----
Mflv_5091|M.gilvum_PYR-GCK GQGGQGGQGG-----------------TGGTGGQGG-LGGGGGTG-----
Mvan_1264|M.vanbaalenii_PYR-1 GFGGQGGQGG-----------------TGGTGGQGG-LGGVGGTG-----
MSMEG_0868|M.smegmatis_MC2_155 HRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATI
MUL_4367|M.ulcerans_Agy99 SAGVVSGDPG-----------------TAGKAGGAGGAGGVGGNGVAG--
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------------------------NAAVAGNAAVAGNAAVAG-----
MAV_4827|M.avium_104 ---------------------------PPAAPPLPEAPPIPAAPPVVP--
Rv3507|M.tuberculosis_H37Rv -----APGPTTGGNAGSQGIGGDGGNGGDGGKGGDGADAVNVVFMPTEPQ
Mb3537|M.bovis_AF2122/97 -----APGPTTGGNAGSQGIGGDGGNGGDGGKGGDGADAVNVVFMPTEPQ
MMAR_4995|M.marinum_M -----SAGAGTGGSTGGQGTGGDGGNGGNGGNGADGANAVNIAFTPNEPQ
TH_3810|M.thermoresistible__bu -------------------RAGLGGRGXXXXGG-----------------
Mflv_5091|M.gilvum_PYR-GCK ------------------GQGGTGGTGGQGGTG-----------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------------GTGGTGGTGGQGGTG-----------------
MSMEG_0868|M.smegmatis_MC2_155 VAYNVVQANPQASGTATDGHGGSGINGGHGGNG-----------------
MUL_4367|M.ulcerans_Agy99 ------------------GVNGSGGAGGAGGAG-----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------NAAVGGVLNTGVSG-----------------
MAV_4827|M.avium_104 ------------------VPVVVPPVPVPVPVR-----------------
Rv3507|M.tuberculosis_H37Rv AATGTAGSAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTG
Mb3537|M.bovis_AF2122/97 AATGTAGSAGDPTGGNGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTG
MMAR_4995|M.marinum_M ATAGNPGGSG-ITGEIGGSGTNGS-----PATLPTTQVQQGGDGGAGGTG
TH_3810|M.thermoresistible__bu -----------------------------------------GVGAAVRSG
Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------GTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------GTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 -----------------------------------------GQGTIEANG
MUL_4367|M.ulcerans_Agy99 -----------------------------------------GTGGAGASG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------AIGGSSHVG
MAV_4827|M.avium_104 ----------------------------------------IPVPDPVSPP
Rv3507|M.tuberculosis_H37Rv STNANDGTATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNG
Mb3537|M.bovis_AF2122/97 STNANDGTATGGKGGEGGVGSILGGPGGNGGTGGNASATGTNGVANAGNG
MMAR_4995|M.marinum_M TNAANNEVATGGEGGTGGTG-SAGGPGGDGGVGGDASETGTDGVAVGGQG
TH_3810|M.thermoresistible__bu ---------------NGVFS----GGGGTPSAG-----------------
Mflv_5091|M.gilvum_PYR-GCK --------GTGGAGGDGGLG----GLGGFGGSG-----------------
Mvan_1264|M.vanbaalenii_PYR-1 --------GTGGAGGDGGLG----GLGGFGGVG-----------------
MSMEG_0868|M.smegmatis_MC2_155 PSAVASGIGAGGNGGDGIDG----GLGGNGGDG-----------------
MUL_4367|M.ulcerans_Agy99 -------VPASVDGGDGGAG----GAGGAAGTG-----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---------GAINESLGGSG----SVGGSTAVG-----------------
MAV_4827|M.avium_104 QLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVP----------------
Rv3507|M.tuberculosis_H37Rv GKGGDGGQFGAGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPAG
Mb3537|M.bovis_AF2122/97 GKGGDGGQFGAGGNGGAGGSVTDGSAGSTAGNGGNGGNATNGTIAGQPAG
MMAR_4995|M.marinum_M GQGGAGGQFGGGGNGGDGGNVTAGSAGSTAGNGGNGGNANNGTIEGSPAG
TH_3810|M.thermoresistible__bu FGVPTTIQFPAGSCTSRAVSREG------------------------IMP
Mflv_5091|M.gilvum_PYR-GCK GTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAG
MSMEG_0868|M.smegmatis_MC2_155 VVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLG
MUL_4367|M.ulcerans_Agy99 GSGGSAGNTGAGGAGGAGGAGGSAASTGVNGDGGAGG----AGGVGGLGG
MLBr_01183|M.leprae_Br4923 --MPLFLNAEPQALTAAANTLEG------------------------LSA
MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGG--------STAVG
MAV_4827|M.avium_104 -QSPPQHQTPPGEGTPPKPDGPG------------------------NYG
Rv3507|M.tuberculosis_H37Rv GNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGGSGGNGGN
Mb3537|M.bovis_AF2122/97 GNGSAGGKGGDGGNIAAGATGTAGNGGNGGNGNDGAVNAGTGGSGGNGGN
MMAR_4995|M.marinum_M GNGSAGGDGGDGGDVASGATGTAGTGGTGGAGNDGTINAGTGGNGGAGGR
TH_3810|M.thermoresistible__bu SSRAASARAG---------------------------------------A
Mflv_5091|M.gilvum_PYR-GCK ATGAAGASGGKGAQGATGAQGATG------------------AQGATG-A
Mvan_1264|M.vanbaalenii_PYR-1 VTGASGASGGKGAQGATGAQGATG------------------AQGATG-A
MSMEG_0868|M.smegmatis_MC2_155 GNATGTATAGKGGEASNGGVAGNGG------------NALVMAAGTTGVA
MUL_4367|M.ulcerans_Agy99 DSAATAGGGGAGGDGGKGGAGGAG----------------VNGVGGGDGG
MLBr_01183|M.leprae_Br4923 ATVASNAAAAQ-------------------------------------LT
MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGGVSTGVGVGSHVGGG-------------------------I
MAV_4827|M.avium_104 GGHVPTPGAGGSGGSGGGHVPTPG-------------------------A
..
Rv3507|M.tuberculosis_H37Rv AGGGGANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNG
Mb3537|M.bovis_AF2122/97 AGGGGANGGDGGAGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNG
MMAR_4995|M.marinum_M AGSGGANGGNGGTGGTGGDGGKGGGGAVGGSGGDGGDGGINNGAGANGNG
TH_3810|M.thermoresistible__bu ACASSTSRSRRSFCCSRA--------------------------------
Mflv_5091|M.gilvum_PYR-GCK TGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NG
Mvan_1264|M.vanbaalenii_PYR-1 TGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NG
MSMEG_0868|M.smegmatis_MC2_155 TGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNG
MUL_4367|M.ulcerans_Agy99 KGGTGGAGGAGGAGSDGIIPSNGGLGGNGGNGGNGGQAFGDGVGGAGGIG
MLBr_01183|M.leprae_Br4923 TEIAPPAADDVSILLAHFFSGHG-------------RQYQAHASQGATNH
MAB_4284c|M.abscessus_ATCC_199 SESLGGSGSVGGSTAVGGGAHTG------------VGGGVNTGVGVGSHV
MAV_4827|M.avium_104 GGSGGSGGGHVPTPGTGGPGGTG------------GSGGGHVPTPGAGTP
Rv3507|M.tuberculosis_H37Rv GNGGTGGVGSVGAAGGDGGNGGTGGFAGFGG-TAGNGGSGGTGGAGGDGG
Mb3537|M.bovis_AF2122/97 GNGGTGGVGSVGAAGGDGGNGGTGGFAGFGG-TAGNGGSGGTGGAGGDGG
MMAR_4995|M.marinum_M GGGGTGGTGSIGAAGGNGGQGGSGGAAGSGGGTAGNGGAGGVGGAGGTGG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAG
MSMEG_0868|M.smegmatis_MC2_155 GNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDG
MUL_4367|M.ulcerans_Agy99 GKGGNAAIGTIVINGGVGGAGG-----SGGLGGATEDGVGGVG-CAGGAG
MLBr_01183|M.leprae_Br4923 QDLIQSLLTSSSAYAG--------------TETANHDSL-----------
MAB_4284c|M.abscessus_ATCC_199 GGGISESLGGSGSVGGSTAVGG------GAHTSAINDALGGSGSVGGSTA
MAV_4827|M.avium_104 GGSGGGHLPFPGAGSTPGGSGG------------GHLPTPGAGTPGGGLG
Rv3507|M.tuberculosis_H37Rv TGGDGGNG---VIAGGGGTGGNG---GASGAGGAGGTGGFAGNGNAGGNG
Mb3537|M.bovis_AF2122/97 TGGGGGNGGTGVIAGGGGTGGNG---GASGAGGAGGTGGFAGNGNAGGNG
MMAR_4995|M.marinum_M VGGGGGDGGAGALAGTGGTGGSGGTGGASGAGGSGGGGGLSGSGQSGANG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAGG-----------AGGEGGEGG-DGGKGGAGAE--------GGAGGGG
Mvan_1264|M.vanbaalenii_PYR-1 GAGG-----------AGGEGGEGG-AGGAGGDGSE--------GGAGGSG
MSMEG_0868|M.smegmatis_MC2_155 GNGGNTSVWKSGGQTADGEHNTGG-NGGNGGDGSEPGPGGNGAGGAGGNG
MUL_4367|M.ulcerans_Agy99 GNGGRGDMLFTVGGSGGTGGDGGG-GGSASGSGTGGSGGTGGVGGIGGDG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VGGGAHTSAINESMNSSINASHSSSMNESFG-------------------
MAV_4827|M.avium_104 GFGG-----------GHAPAPGGG--------------------------
Rv3507|M.tuberculosis_H37Rv G----TGGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA-----
Mb3537|M.bovis_AF2122/97 G----TGGASEDGDNGNAGSGATGGTGGNGGTGGDGGAAGLGGVA-----
MMAR_4995|M.marinum_M G----TGGASQEGQDGQASTDSDGGAGGAGGTGGSGGAAGAGGQA-----
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----GAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD------
Mvan_1264|M.vanbaalenii_PYR-1 -----GAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-------
MSMEG_0868|M.smegmatis_MC2_155 -----GTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP------
MUL_4367|M.ulcerans_Agy99 KLGGFGGDGGDGGDGGFGVIGGQGGGGGFGGLGGTGAGGAPSDKGINGEP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----SSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH---------
MAV_4827|M.avium_104 -----LGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK----------
Rv3507|M.tuberculosis_H37Rv ----
Mb3537|M.bovis_AF2122/97 ----
MMAR_4995|M.marinum_M ----
TH_3810|M.thermoresistible__bu ----
Mflv_5091|M.gilvum_PYR-GCK ----
Mvan_1264|M.vanbaalenii_PYR-1 ----
MSMEG_0868|M.smegmatis_MC2_155 ----
MUL_4367|M.ulcerans_Agy99 GNPG
MLBr_01183|M.leprae_Br4923 ----
MAB_4284c|M.abscessus_ATCC_199 ----
MAV_4827|M.avium_104 ----