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ISFVIAAPEAIAAAATDLASIGSTIGAANAAAAANTTAVLAAGADQVSVAIAAAFGAHGQAYQALSAQAA TFHIQFVQALTAGAGSYAAAEAASAASITSPLLDAINAPFLAALGRPLIGNGADGAPGTGAAGGAGGLLF GNGGAGGSGAPGGAGGLLFGNGGAGGPGASGGALG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0742 | PE_PGRS8 | - | 100% (175) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0278c | PE_PGRS3 | 4e-66 | 75.43% (175) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv1818c | PE_PGRS33 | 6e-64 | 73.48% (181) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0763 | PE_PGRS8 | 5e-92 | 100.00% (172) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 4e-13 | 35.93% (167) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 5e-15 | 39.58% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_0664 | - | 4e-07 | 34.44% (90) | PE family protein |
| M. marinum M | MMAR_0608 | - | 2e-65 | 70.97% (186) | PE-PGRS family protein |
| M. avium 104 | MAV_1346 | - | 4e-20 | 38.73% (173) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_3202 | - | 1e-10 | 50.67% (75) | hypothetical protein MSMEG_3202 |
| M. thermoresistible (build 8) | TH_3810 | - | 4e-09 | 47.54% (61) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0570 | - | 2e-57 | 65.59% (186) | PE_PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_3865 | - | 5e-16 | 56.76% (74) | hypothetical protein Mvan_3865 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M --------------------------------------------------
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK MVTFGGGATPTPTSLGAAAVDLSGTSCGLICNGQDGTGQNGGILFGNGGS
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 ---MTKHQRLTSAVAASIVATAGVAVSQAPAPASTGTPTAHQTPTSTSTP
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------MSFVIAAPEAIAAAATDLASIGSTIGAANAAAAANT
Mb0763|M.bovis_AF2122/97 -----------------MIAAPEAIAAAATDLASIGSTIGAANAAAAANT
MMAR_0608|M.marinum_M --------------MSFVITAPEALTAAATDLASLGSTIGAANAAAVAPT
MUL_0570|M.ulcerans_Agy99 --------------MSFVITAPEALTAAATDLASLGSTIGAANAAAVAPT
Mflv_5091|M.gilvum_PYR-GCK GWNSDVVGMDGGNGGNGGLFG--GNGGNGGNGLGGGNGGNGGNAGAFALF
TH_3810|M.thermoresistible__bu ------VDGDGGSGGRTGLFSKLSRGGDGGDGGLGGNGGHGGGTGIISLL
MSMEG_3202|M.smegmatis_MC2_155 RWLTVTSTPEGAPATPNALYGAILPSTSPGSVTSTGSGIGHREPGISGSP
Mvan_3865|M.vanbaalenii_PYR-1 --------------MIDRLLALLRPTSRVSLLSPTGAFLG----------
MLBr_01183|M.leprae_Br4923 -------------MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLT
MAV_1346|M.avium_104 -------------MS-FVTTRPEALLAVASMLEGLGSSMDAQNAAAAAPT
MAB_0664|M.abscessus_ATCC_1997 -------------MS--LNVVPEGLTAASAAVEALTARLAAVNAAAAPVI
Rv0742|M.tuberculosis_H37Rv TAVLAAGADQVS--------------------------------------
Mb0763|M.bovis_AF2122/97 TAVLAAGADQVS--------------------------------------
MMAR_0608|M.marinum_M TAVLAAGADEVS--------------------------------------
MUL_0570|M.ulcerans_Agy99 TAVLAAGADEVS--------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNGGVGVVGATGAVGAPGVAGATGATGVTSGVVGGNGEDAVGYG
TH_3810|M.thermoresistible__bu SLAGNGGNGGN------------------------------------GYR
MSMEG_3202|M.smegmatis_MC2_155 AFTAVRAVRPGSSTARLVFAPKTSTSGTALTVTPIAVGMVGNAKVTVAVD
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 TEIAPPAADDVS--------------------------------------
MAV_1346|M.avium_104 TSIAPAAADEVS--------------------------------------
MAB_0664|M.abscessus_ATCC_1997 GAVMPPAADPVS--------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M --------------------------------------------------
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATGAAGAAGAAGAAGAAGAVGSAGAAGEAGETGTWGNAGLPGKAGDAGGA
TH_3810|M.thermoresistible__bu TTDNN---------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 SSGRP---------------------------------------------
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M --------------------------------------------------
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAVGAAGAAGTVGTAGATGGTGTGANGGAGGVGGVGGTGAAGAAGGAGGL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M --------------------------------------------------
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GETGTTGGAGGVGGQGTAGGTGGVGGIGGAGSTGAVGGVGGKGIQGGQGL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv ----------------------VAIAAAFGAHGQAYQALSAQAATFHIQF
Mb0763|M.bovis_AF2122/97 ----------------------VAIAAAFGAHGQAYQALSAQAATFHIQF
MMAR_0608|M.marinum_M ----------------------AAVAALFDAQGQAYQLLSARAATFHEQF
MUL_0570|M.ulcerans_Agy99 ----------------------AAVAAMFDAQGQAYQLLSARAAAFHEQF
Mflv_5091|M.gilvum_PYR-GCK QGGKGGDGGAGGKGGDADSMGSAGATGGKGGNGGNGGRGGLFGKGGNAGN
TH_3810|M.thermoresistible__bu -----------------------ALDGGHGGNGGNVGFFSLFN-------
MSMEG_3202|M.smegmatis_MC2_155 ---------------------MIGPGGWLIGNGIEPGQNGGLLIGNGADG
Mvan_3865|M.vanbaalenii_PYR-1 ---------------------LIGPGGLLIGNGVLPGQNGGLLIGNGADG
MLBr_01183|M.leprae_Br4923 ----------------------ILLAHFFSGHGRQYQAHASQGATNHQDL
MAV_1346|M.avium_104 ----------------------ALQAAQFSAYGTWYQQVSAQAKAIHQTL
MAB_0664|M.abscessus_ATCC_1997 ----------------------MQSAALFSAHGLERTGAGARAAYELGRS
. * .
Rv0742|M.tuberculosis_H37Rv VQALTAGAGSYAAAEAASAAS------------ITSPLLDAINAPFLAAL
Mb0763|M.bovis_AF2122/97 VQALTAGAGSYAAAEAASAAS------------ITSPLLDAINAPFLAAL
MMAR_0608|M.marinum_M LQALSGGGASYAAAEAAAVS----------------PLLDAINAPVLAAT
MUL_0570|M.ulcerans_Agy99 LQALSGGGASYAAGEAAAVS----------------PLLDAINAPVLADT
Mflv_5091|M.gilvum_PYR-GCK GADGGTGGAGGAGGTGGTGGAGGTGGTGGTGGIGGAGSTGGTGGTGGTGG
TH_3810|M.thermoresistible__bu --------LGGAGGWGGSG-------------VDGVDVVGGNP-DGGTPG
MSMEG_3202|M.smegmatis_MC2_155 GP-------GQKGGNGGFLLG--------NGGRGGDGLAGVNGGRAGDGG
Mvan_3865|M.vanbaalenii_PYR-1 APGVLPGEAGGKGGNGGLLMG--------NGGAGGAGAPGVAGGAGGAGG
MLBr_01183|M.leprae_Br4923 IQSLLTSSSAYAGTETAN--------------------------------
MAV_1346|M.avium_104 VQNLDTNADSYGATEAANRVN--------------TSAAALQGLAPNVIP
MAB_0664|M.abscessus_ATCC_1997 GVGATEAAASYTVGDIQA--------------------------------
.
Rv0742|M.tuberculosis_H37Rv GRPLIGNGAD------------------------GAP-------------
Mb0763|M.bovis_AF2122/97 GRPLIGNGAD------------------------GAP-------------
MMAR_0608|M.marinum_M GRPLIGNGANGAPGTGADGGAAGWLIGNGGAGGSGTPGTAS--------V
MUL_0570|M.ulcerans_Agy99 GRPLIGNGAN--------GGAAGWLIGNGGAGGSGTPGTAS--------V
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGTGGTGGTGGKGGTGGTGGAGGTGGDGGTGGTGGTGGTG
TH_3810|M.thermoresistible__bu AHGESHTPGVYTD--RQGEDGEDGTG--TGIGGRGGNGGSS---------
MSMEG_3202|M.smegmatis_MC2_155 NAGLLGNGGDGGNSVGGVEGANGGNAGLIGNGGKGGDGSPNVISNGAHIA
Mvan_3865|M.vanbaalenii_PYR-1 NGGFFAGNG--------------------GAGGAGGNGS---TVNGPTSG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 NAAPAADPPP----------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --GTGAAGGAGGLLFGNGGAGGSG---------APGG------AGGLL--
Mb0763|M.bovis_AF2122/97 --GTGAAGGAGGLLFGNGGAGGSG---------APGG------AGGLL--
MMAR_0608|M.marinum_M AGGNGGNGGAGGLLFGTGGAGGAGGTASSLVGAIPGGNGGYGGDGGLL--
MUL_0570|M.ulcerans_Agy99 AGGNGGNGGAGGLLFGTGGAGGAGGTASSLVGAIPGGNGGYGGDGGLL--
Mflv_5091|M.gilvum_PYR-GCK --GTGGTGGTGGAGDGTGGTGGTGGTGGQGGQGGQGGTGGTGGQGGLGGG
TH_3810|M.thermoresistible__bu ------SGTHPMAEDGEHVKALDGRPGLDGGNGSHGGNGGHGGRGGFLGI
MSMEG_3202|M.smegmatis_MC2_155 NAGRGGNGGNGGLLVGSGGDGGRGGDGDGEGPETAGSHGADGGNGGAGGV
Mvan_3865|M.vanbaalenii_PYR-1 --GHGGDGGKAGLFRGDGGAGGAGGAAVRTGNGPDGQVYAGRGGDGGDAV
MLBr_01183|M.leprae_Br4923 ---------HDSL-------------------------------------
MAV_1346|M.avium_104 -------AGTTSLGTSIGWAQNVGAAASDFITLGEGQFAPVPGAAGIPNF
MAB_0664|M.abscessus_ATCC_1997 ---------AATYLPGIA--------------------------------
Rv0742|M.tuberculosis_H37Rv FGNGGAGGPGASG----------------GALG-----------------
Mb0763|M.bovis_AF2122/97 FGNGGAGGPGASG----------------GALG-----------------
MMAR_0608|M.marinum_M FGRGGAGGAGGFGNNT---------TGGIGGLGGAGGLFGAGGDGGVGGF
MUL_0570|M.ulcerans_Agy99 FGRGGAGGAGGFGNNT---------TGGIGGLGGAGGLFGAGGDGGVGGF
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGTGGTGGQG-----GTGGTGGTGGTGGTGGAGGDGGLGGLGGF
TH_3810|M.thermoresistible__bu GGSGGWGGHGGNGGD-------TDADGGNGGDGGNGGSAGRGGTGGLRGV
MSMEG_3202|M.smegmatis_MC2_155 FGNGGRGGDGGDANNGTVGTRNGNAAAGKGGNGGSTG-IGTGGAGGNGGK
Mvan_3865|M.vanbaalenii_PYR-1 VGSGGQGGVGGDATS-----QGGPATSGGGGHGGSVAVFGDAGDGGFGGY
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 NPGLTAATTAGPPAPA-----------APAAAAGAPVLASMGRGPSIGGL
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M GTFAGNGGDGGTGLFAAGGDGGAGGSGLTQGGDGGIGGAALGLFGAGGAG
MUL_0570|M.ulcerans_Agy99 GTFAGNGGDGGTGLFAAGGDSGAGG-------------------------
Mflv_5091|M.gilvum_PYR-GCK GG--SGGTGGQGGLGGPGGSTGGAGGAGGQAGTAGKGGLFGGSGSAGKAG
TH_3810|M.thermoresistible__bu FG--INGGNGRAGLGGRGXXXX--GGGVGAAVRSGNGVFSGGGGTP----
MSMEG_3202|M.smegmatis_MC2_155 ATGTNAAYGGNGGNGGSGLAGGGNGGDGGD-AQSSSNRARPGQGGQ----
Mvan_3865|M.vanbaalenii_PYR-1 AGSQNQATGRSGGDGGRGGVLSGNGGDGGIGGYATSIGTGPAEGGA----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 SVPPSWAPGGVAPAANATPAQLVGAGFTSAAPDTAPVTAVPGGVPS----
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M GTGGEGGLFGGAGGMGGSAGMLFGNGGDGGAGAAATIGNAAGNGGAGGNA
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATGAAGA-------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M GMLIGAGGAGGNGGFGFSASDGGAGGAGGNAGFLYGAGGAGGAGGDSVGG
MUL_0570|M.ulcerans_Agy99 ---------------------------------------------DSVGG
Mflv_5091|M.gilvum_PYR-GCK -----------------------------------SGGKGAQGATGAQGA
TH_3810|M.thermoresistible__bu -----------------------------------SAGFGVP--TTIQFP
MSMEG_3202|M.smegmatis_MC2_155 ------------------------------------AGRGGFGRDGKTGN
Mvan_3865|M.vanbaalenii_PYR-1 ------------------------------------GGYGGSGGAFSRGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ------------------------------------------MATAGRGG
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M ADGGDGGNGGKAGLVGQGGDGGAGGNNNSGFGTGGSGGKGGDAVLIGNGG
MUL_0570|M.ulcerans_Agy99 ADGGDGGNGGKAGLVGQGGDGGAGGNNNSGFGTGGSGGKGGDAVLIGNGG
Mflv_5091|M.gilvum_PYR-GCK TGAQGATGATGAAGKAGATGAAGAAGAAGSAGTTGAQGSAGTNGANGANG
TH_3810|M.thermoresistible__bu AGSCTSRAVSREGIMPSSRAASARAGAACASSTSRSRRSFCCSRA-----
MSMEG_3202|M.smegmatis_MC2_155 PGNATDRSATRENVSNRVTGRSTPTRSADKAGSRTSSSSESNSESNSESS
Mvan_3865|M.vanbaalenii_PYR-1 DGGAGGN-----------------GLSATAPGNGGSGGRGGDGGPGGDGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 YGLGAPRYGVKPTVMPKPAI------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M NGGNAGSGGVGPGIAGAAGIGGLLIGEDGMAGLTP---------------
MUL_0570|M.ulcerans_Agy99 NGGNAGSGGVGPGIAGAAGIGGLLIGEDGMAGLTP---------------
Mflv_5091|M.gilvum_PYR-GCK SQGAAGKAGATGTTGATGAAGEDGDAGSGGSGINGGAGGAGGAGGEGGEG
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 SKTSSKAGGTKSSDTKSGGGAAGTGSDSKDSE------------------
Mvan_3865|M.vanbaalenii_PYR-1 LGGKGGVGSTNNGADGPDGGPAD---------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv --------------------------------------------------
Mb0763|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0608|M.marinum_M --------------------------------------------------
MUL_0570|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GDGGKGGAGAEGGAGGGGGAGGSGAGGAGGAGGSGGSGGSGGSGGSGGAA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MSMEG_3202|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3865|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_0664|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0742|M.tuberculosis_H37Rv -----
Mb0763|M.bovis_AF2122/97 -----
MMAR_0608|M.marinum_M -----
MUL_0570|M.ulcerans_Agy99 -----
Mflv_5091|M.gilvum_PYR-GCK GDSDD
TH_3810|M.thermoresistible__bu -----
MSMEG_3202|M.smegmatis_MC2_155 -----
Mvan_3865|M.vanbaalenii_PYR-1 -----
MLBr_01183|M.leprae_Br4923 -----
MAV_1346|M.avium_104 -----
MAB_0664|M.abscessus_ATCC_1997 -----