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PITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIG VRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPR PPFHEELPRITSSDTKDPNREHDTSDQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0600c | - | - | 100% (168) | PROBABLE TWO COMPONENT SENSOR KINASE -SECOND PART |
| M. tuberculosis H37Rv | Rv0902c | prrB | 4e-14 | 37.50% (128) | two component sensor histidine kinase PRRB |
| M. tuberculosis H37Rv | Rv0490 | senX3 | 9e-12 | 32.90% (155) | putative two component sensor histidine kinase SENX3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0616c | - | 1e-96 | 100.00% (168) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_3888 | - | 1e-15 | 35.53% (152) | integral membrane sensor signal transduction histidine kinase |
| M. leprae Br4923 | MLBr_02124 | - | 2e-13 | 35.66% (129) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 3e-15 | 35.29% (153) | sensor histidine kinase |
| M. marinum M | MMAR_2299 | - | 3e-14 | 41.23% (114) | two-component regulator - sensor kinase |
| M. avium 104 | MAV_3405 | - | 5e-17 | 40.19% (107) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_2793 | - | 6e-14 | 35.21% (142) | sensor-type histidine kinase PrrB |
| M. thermoresistible (build 8) | TH_0454 | - | 1e-13 | 37.98% (129) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_1502 | - | 3e-14 | 41.23% (114) | two component regulator - sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_3675 | - | 2e-16 | 43.20% (125) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M ------MAEELESPGDPETPTPSLQRRVILLVVALLAVLLVVLGVTIDVS
MUL_1502|M.ulcerans_Agy99 ------MAEELESPGDPETPTPSLQRRVILLVVALLAVLLVVLGVTIDVS
Mflv_3888|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3675|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3340|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02124|M.leprae_Br4923 ----------MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVG
TH_0454|M.thermoresistible__bu ----------MNLVTRLFRRTPSLRTRVAFATAIAAAIVVGIVGVVVWVG
MSMEG_2793|M.smegmatis_MC2_155 MTFEERMIRLLRPVLRPVMRVLSLRT-IVIVAALSVVVLVLTLGTWVWIG
MAV_3405|M.avium_104 ----------MFSGGPRACRIEGVHLGISARSAAVAAIVVFCALTVAGAG
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M LGLQARRNLHD-LLLAATSR--ADALASVGTSPELIAAEINGGSVRALLV
MUL_1502|M.ulcerans_Agy99 LGLQARRNLHD-LLLAATSR--ADALASVGTSPELIAAEINGGSVRALLV
Mflv_3888|M.gilvum_PYR-GCK -----------------------MSVTRRSPAASTRRWRRPGIGLRLLAA
Mvan_3675|M.vanbaalenii_PYR-1 --------------------------MRTDTSIQPRSRRSPGVGARLLLA
MAB_3340|M.abscessus_ATCC_1997 -----------------------------------MTRPRYGIGLRLLVV
MLBr_02124|M.leprae_Br4923 ITNDRKERLDR-KLDEAAGF----AIPFVPRGLDEIPRSPNDQDAIITVR
TH_0454|M.thermoresistible__bu ITNDRKERLDR-RLDEAAGF----ALPFVPRGLEQIPPSPNDQDVVITVR
MSMEG_2793|M.smegmatis_MC2_155 VTNDQYAQLDR-RLDSLSSLGDVSTLLNSTRETDADNAGHDDGGLVRTAY
MAV_3405|M.avium_104 LDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLTTDQRVVAT
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M TADGATYGDPNISPDTTAGPAVPALPGPPPLIPPGGHQGPHGPPPPPPPP
MUL_1502|M.ulcerans_Agy99 TADGATYGDPNISPDTTAGPAVPALPGPPPLIPPGGHQGPHGPPPPPPPP
Mflv_3888|M.gilvum_PYR-GCK QAIVLAVG-------AATTAVVAAVVGPPLFQEHLHRAG---------VP
Mvan_3675|M.vanbaalenii_PYR-1 QALVLLAG-------GATTGVVAVIVGPPLFREHLNRAG---------LP
MAB_3340|M.abscessus_ATCC_1997 NSLVVLAG-------IATTSVVAAIVGPPMFRRLMDQQV---------SP
MLBr_02124|M.leprae_Br4923 RGNLVKSN-FDITLPKLTNDYADTYLRGVRYRVRTVEIPA-------PEP
TH_0454|M.thermoresistible__bu RGDEVRSN-SEVVLPELDADYADTYIDGVRYRVRTVQTPY-------PIR
MSMEG_2793|M.smegmatis_MC2_155 IGGVTVSVPSDIVLPHLENGYANTTIDGVEYRVRTFTAG----------P
MAV_3405|M.avium_104 QLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVSGQ
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M PGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTRQLRQLMIGA
MUL_1502|M.ulcerans_Agy99 PGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTRQLRQLMIGA
Mflv_3888|M.gilvum_PYR-GCK MNSPEEMHAEEAYGYATVMSIG--------------------------GA
Mvan_3675|M.vanbaalenii_PYR-1 HSSNEQFHAEEAYRYATAISIA--------------------------VA
MAB_3340|M.abscessus_ATCC_1997 GAGN-DHPYERAFRDATAMSIG--------------------------FA
MLBr_02124|M.leprae_Br4923 TSIAVGATYDATVAETNNLHRR------------------------VLLI
TH_0454|M.thermoresistible__bu TTLAVGATYDDTIADTANLHRR------------------------VILI
MSMEG_2793|M.smegmatis_MC2_155 ATIALGAPLAETQRRIDELHLR------------------------VVLI
MAV_3405|M.avium_104 KVATRSGVYTVLVGGGSEAVEATAR----------------TLAILLATT
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M GLVTLVVAALLLVLVSRAALAPLDRLAALAKDITTGDRGRRLRPSRADTE
MUL_1502|M.ulcerans_Agy99 GLVTLVVAALLLVLVSRAALAPLDRLAALAKDITTGDRGRRLRPSRGDTE
Mflv_3888|M.gilvum_PYR-GCK LAVSALAALAVSVYVSRRLQRSVTEVACAAALVAEGRYDIRVSPPRLGDD
Mvan_3675|M.vanbaalenii_PYR-1 IGVAALTALVVTWYFSRRLQHSIAEVASAATAVADGRYDIRVSPLRLGED
MAB_3340|M.abscessus_ATCC_1997 VAVSALAALTLSWYLSHRVHRSATALSQAASAVADGNYDIRVPPPRLGKE
MLBr_02124|M.leprae_Br4923 CGFAIAAAAVFAWLLAAFAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEA
TH_0454|M.thermoresistible__bu CTLAIGAATIAGWLLAAFAVRPFKQLAAQARSIDAGDEVPDVEIRGATEA
MSMEG_2793|M.smegmatis_MC2_155 CAGVIAGTVVVGWVISLVMINPFRLLAQQARAINAQSNPEEVKVRGVREA
MAV_3405|M.avium_104 APVIVAVAAGATYWLVRRSLKSVDAIRARVADISASDLAERVPVPDGRDE
Rv0600c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0616c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2299|M.marinum_M LGRAASAFDGMLDALEDSELRAQQAATAAQRAENATRQFLVDAAHELRTP
MUL_1502|M.ulcerans_Agy99 LGRAASAFDGMLDALEDSELRAQQAATAAQRAENATRQFLVDAAHELRTP
Mflv_3888|M.gilvum_PYR-GCK FDALATAFN--------------QMASRLQSVESTRRRLFGDLAHEIRTP
Mvan_3675|M.vanbaalenii_PYR-1 FANLSRAFN--------------RMSERLESVETTRRQLFGDLAHEIRTP
MAB_3340|M.abscessus_ATCC_1997 FDAVAAAFN--------------KMAQRLGAVDEARRQMLADLAHEIRTP
MLBr_02124|M.leprae_Br4923 VEIAEAMRG--------MLQRIWNEQNRTKEALASARDFAAVSSHELRTP
TH_0454|M.thermoresistible__bu VEIADAVKG--------MLQRIWKEQDRTKAALASARDFASAAAHELRTP
MSMEG_2793|M.smegmatis_MC2_155 VEIAEAVEG--------MLARIGSEQERTKAALESARDFAAVASHELRTP
MAV_3405|M.avium_104 IAALAVTMN--------------EMLSRLEAGHRAQQRFVGDASHELRSP
Rv0600c|M.tuberculosis_H37Rv -------------------MPITP-LLHESVARFAATGADITTRAEPD--
Mb0616c|M.bovis_AF2122/97 -------------------MPITP-LLHESVARFAATGADITTRAEPD--
MMAR_2299|M.marinum_M IAGMQVAAEQLASSAGQQQEDPAA-RGQYRRASLLLSDARRAGRLVADML
MUL_1502|M.ulcerans_Agy99 IAGMQVAAEQLASSAGQQQEDPAA-RGQYRRASLLLSDARRAGRLVADML
Mflv_3888|M.gilvum_PYR-GCK VAVLDAYVEALEDGVRTLNPDTVA-VLRDQTGRLVRFSGDVAALAKAEES
Mvan_3675|M.vanbaalenii_PYR-1 VSVLKAYIEAVEDGVKTLDPETVA-VLNDQASRLVRFSDDFAALAQAEEG
MAB_3340|M.abscessus_ATCC_1997 VAVLEAYMEAVEDGVQQLDQQTVA-TLRDQTRRLTRFSIDVNALSVAESR
MLBr_02124|M.leprae_Br4923 LTAMRTNLEVLAT-LDLADDQRKE-VLGDVIRTQSRIEATLSALERLAQG
TH_0454|M.thermoresistible__bu LTAMRTNLEVLST-LDMPEEQRKE-VLADVIRTQSRIEATLSALERLAQG
MSMEG_2793|M.smegmatis_MC2_155 LTAMRTNLEVLST-LDMTPEQRQE-VIGDVMRTQSRIEATLTALERLAQG
MAV_3405|M.avium_104 LTTIISGLEVAEAHPELLDAELAVNTLLPEAHRMRALIDDLLLLARADER
Rv0600c|M.tuberculosis_H37Rv ---------------------------------------------LFVSI
Mb0616c|M.bovis_AF2122/97 ---------------------------------------------LFVSI
MMAR_2299|M.marinum_M DLSRIDAGLPLDRHDTDLAEIVDAESQRTTMLAPQITVTRSGLGTLTVAA
MUL_1502|M.ulcerans_Agy99 DLSRIDAGLPLDRHDTDLAEIVDAESQRTTMLAPQITVTRSGLGTLTVAA
Mflv_3888|M.gilvum_PYR-GCK SVTMTYTEVDLD----GLVRRAVAAARERYETKGVALQVMSARELPLLRA
Mvan_3675|M.vanbaalenii_PYR-1 PGAVTPQWIDPR----AAIVTTVSAAADRYAQKDVALIFDAANPLPEVWV
MAB_3340|M.abscessus_ATCC_1997 TTSIDARSVSPA----DLVTTAVAAFAPRYQTKGVILTSHADDGLPDVWA
MLBr_02124|M.leprae_Br4923 ELSTSDDHVPVD-----ITELLDRAAHDATRSYPELKVSLVPSPTCIIVG
TH_0454|M.thermoresistible__bu ELSTSDDHVPVD-----ITELLDRAAHEAMRIYPDLEVSLVPAPTVIIVG
MSMEG_2793|M.smegmatis_MC2_155 ELTTVEDFVPMD-----VTELLDRAAHDAQHTYPGLKVTLMPSPTVLMLG
MAV_3405|M.avium_104 NLLRRKELVALD---------DLAEAEAARVRRDADCAVHTDIRPARLLA
:
Rv0600c|M.tuberculosis_H37Rv DPDHLRRILTAVLDNAITHG--DGEIAVTAHARDGAVDIGVRDHGPGFAD
Mb0616c|M.bovis_AF2122/97 DPDHLRRILTAVLDNAITHG--DGEIAVTAHARDGAVDIGVRDHGPGFAD
MMAR_2299|M.marinum_M DPTRVAQILSNLLDNARRYTSAGGAIAIDLRAGQGVATVTVTDTGPGIPD
MUL_1502|M.ulcerans_Agy99 DPTRVAQILSNLLDNARRYTPAGGAIAIDLRAGQGVATVTVTDTGPGIPD
Mflv_3888|M.gilvum_PYR-GCK DEQRLSQVLDNLLDNALRHTARGGRVEIHCHTEGARVRIAVTDDGEGIAA
Mvan_3675|M.vanbaalenii_PYR-1 DPLRLAQVIGNLLDNALRHTPARGRVEVDAAAKPGEVIITVGDNGDGIAA
MAB_3340|M.abscessus_ATCC_1997 DPERMGQVLSNLLDNALRHTGPGGQVTVTATATGTGATIAVADTGDGVPA
MLBr_02124|M.leprae_Br4923 LPAGLRLAVDNAVANAVKHGG-ATRVQLSAVSSRAGVEIAVDDNGSGVPE
TH_0454|M.thermoresistible__bu LPAGLRLAVDNAIANAVKHGG-ATRVQLSAVSSREGVEIAIDDNGTGVPE
MSMEG_2793|M.smegmatis_MC2_155 MPAGLRLVIDNAIANAVKHGG-ATEIRLSAVSSADDVEIAVDDNGSGVPE
MAV_3405|M.avium_104 DPAAMTRMIRNLVDNAVRHAV--SCVAIEVGSRDGTAVLTVGDDGPGIPP
: : : ** : : : : . : : * * *..
Rv0600c|M.tuberculosis_H37Rv HFLPVAFDRFTRADTARGG--RGSGLGLAIVAALTTTHGGHANATNHPDG
Mb0616c|M.bovis_AF2122/97 HFLPVAFDRFTRADTARGG--RGSGLGLAIVAALTTTHGGHANATNHPDG
MMAR_2299|M.marinum_M DERNRIFERLVRLDAARTRDHGGAGLGLPIARALARAHGGELVCLPH-QG
MUL_1502|M.ulcerans_Agy99 DERNRIFERLVRLDAARTRDHGGAGLGLPIARALARAHGGELVCLPH-QG
Mflv_3888|M.gilvum_PYR-GCK EHLSSVFERFYRADAARDREHGGAGLGLAIAKALVEAHGGSVTAASD-GA
Mvan_3675|M.vanbaalenii_PYR-1 EHLPHVFERFYRADVARDRSHGGAGIGLAIAKALTEAHGGRITAASR-GP
MAB_3340|M.abscessus_ATCC_1997 EHLDRLFDRFYRADAARDRQHGGAGIGLSIAKALVEAHEGRIEAHSA-GH
MLBr_02124|M.leprae_Br4923 DERQVVFERFSRGSTASHS---GSGLGLALVAQQAQLHGGTASLETSPLG
TH_0454|M.thermoresistible__bu EERERVFDRFTRGSTASHS---GSGLGLALVAQQAEIHGGTASLEASPLG
MSMEG_2793|M.smegmatis_MC2_155 AERAEVFERFARGSTASRS---GSGLGLALVAQQAELHGGKAALEESPLG
MAV_3405|M.avium_104 AQRSRVFERFVRLDTDRARSGGGAGLGLAIVAEVVAAHGGTVTIGDRPGG
*:*: * .. *:*:**.:. . * *
Rv0600c|M.tuberculosis_H37Rv GAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
Mb0616c|M.bovis_AF2122/97 GAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ
MMAR_2299|M.marinum_M GARFRLTLPLAVAGGVE----------------------
MUL_1502|M.ulcerans_Agy99 GARFRLTLPLAVAGGVE----------------------
Mflv_3888|M.gilvum_PYR-GCK GTGATFTVELP--TTRP----------------------
Mvan_3675|M.vanbaalenii_PYR-1 GMGSTFTIELPARTDRP----------------------
MAB_3340|M.abscessus_ATCC_1997 AAGTTFTVSLPRPSDHPEKAPGQRPG-------------
MLBr_02124|M.leprae_Br4923 GARLLLRISAPS---------------------------
TH_0454|M.thermoresistible__bu GARLVLRLPGPR---------------------------
MSMEG_2793|M.smegmatis_MC2_155 GARLLLRLPINRSRGDDASF-------------------
MAV_3405|M.avium_104 GTTLTVALPQHPAQHSSR---------------------
. . :