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VSVTRRSPAASTRRWRRPGIGLRLLAAQAIVLAVGAATTAVVAAVVGPPLFQEHLHRAGVPMNSPEEMHA EEAYGYATVMSIGGALAVSALAALAVSVYVSRRLQRSVTEVACAAALVAEGRYDIRVSPPRLGDDFDALA TAFNQMASRLQSVESTRRRLFGDLAHEIRTPVAVLDAYVEALEDGVRTLNPDTVAVLRDQTGRLVRFSGD VAALAKAEESSVTMTYTEVDLDGLVRRAVAAARERYETKGVALQVMSARELPLLRADEQRLSQVLDNLLD NALRHTARGGRVEIHCHTEGARVRIAVTDDGEGIAAEHLSSVFERFYRADAARDREHGGAGLGLAIAKAL VEAHGGSVTAASDGAGTGATFTVELPTTRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3888 | - | - | 100% (380) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_2837 | - | e-159 | 77.81% (374) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_0892 | - | e-157 | 77.33% (375) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 4e-35 | 33.33% (303) | two component system response sensor kinase membrane |
| M. tuberculosis H37Rv | Rv0758 | phoR | 8e-35 | 33.33% (312) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_02440 | - | 2e-29 | 33.61% (244) | putative two-component system sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 1e-103 | 56.11% (360) | sensor histidine kinase |
| M. marinum M | MMAR_4941 | phoR | 1e-36 | 34.53% (307) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 1e-35 | 32.15% (311) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 2e-34 | 32.17% (314) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2452 | - | 7e-31 | 29.16% (367) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_0464 | phoR | 9e-37 | 34.53% (307) | two component system response phosphate sensor kinase, PhoR |
| M. vanbaalenii PYR-1 | Mvan_1833 | - | 1e-145 | 73.35% (364) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3888|M.gilvum_PYR-GCK ---------------------------------MSVTRRSPAASTRRWRR
Mvan_1833|M.vanbaalenii_PYR-1 ---------------------------------MARTEEELRPRRRMLRR
MAB_3340|M.abscessus_ATCC_1997 ---------------------------------MTRP------------R
MMAR_4941|M.marinum_M ---------------------MAERLPRAVPLRVGLVAATLALVLCGLLA
MUL_0464|M.ulcerans_Agy99 ---------------------MAERLPRAVQLRVGLVAATLALVLCGLLA
MAV_0703|M.avium_104 --------------------MVVTRPRRGLPLRVGLVAATLALVACGLAV
MSMEG_5870|M.smegmatis_MC2_155 ----------------------MNRGRRGIPLRVGLVAAALVLVACGLLA
Mb0781|M.bovis_AF2122/97 ---------------------MARHLRGRLPLRVRLVAATLILVATGLVA
Rv0758|M.tuberculosis_H37Rv ---------------------MARHLRGRLPLRVRLVAATLILVATGLVA
TH_2452|M.thermoresistible__bu MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTTWRLMV
MLBr_02440|M.leprae_Br4923 -----------------------------MFSALLLAGVLSGLAFVVGIV
:
Mflv_3888|M.gilvum_PYR-GCK PGIGLRL-------------LAAQAIVLAVGAATTAVVAAVVGPP-----
Mvan_1833|M.vanbaalenii_PYR-1 PGIGLRL-------------LAAQAIVLVAGAVTTSVVAAIVGPP-----
MAB_3340|M.abscessus_ATCC_1997 YGIGLRL-------------LVVNSLVVLAGIATTSVVAAIVGPP-----
MMAR_4941|M.marinum_M SGVAVTS-------------ILRHSLVSRIDSTLLEASRTWAQASWRHSM
MUL_0464|M.ulcerans_Agy99 SGVAVTS-------------ILRHSLVSRIDSTLLEASRTWAQASWRHSM
MAV_0703|M.avium_104 SGIAVTS-------------ILRHSLVSRIDSTLLDASRGWAQAPRRQSS
MSMEG_5870|M.smegmatis_MC2_155 SGIAVTS-------------IMRHTEVSRIDQTLLDASRSWAQAPRRAPT
Mb0781|M.bovis_AF2122/97 SGIAVTS-------------MLQHRLTSRIDRVLLEEAQIWAQITLPLAP
Rv0758|M.tuberculosis_H37Rv SGIAVTS-------------MLQHRLTSRIDRVLLEEAQIWAQITLPLAP
TH_2452|M.thermoresistible__bu SSIDARMDEALHIEVDEFEELTASGLNPRTGAPFTGVAEVIREAIAYNLA
MLBr_02440|M.leprae_Br4923 AGIRLSPR------------LIERRQRLANEWAGITVLQMLQRIIALMP-
.: :
Mflv_3888|M.gilvum_PYR-GCK --------------LFQEHLHRAGVPMNSPEEMHAEEAYG--------YA
Mvan_1833|M.vanbaalenii_PYR-1 --------------LFHDHLHQAGISAGSPEEMHAEEAYT--------YA
MAB_3340|M.abscessus_ATCC_1997 --------------MFRRLMDQQ-VSPGAGNDHPYERAFR--------DA
MMAR_4941|M.marinum_M PSVEGPDPARPPSKFYVRSISPDGRAMTAINDRNAEPALPADNDVGSDPT
MUL_0464|M.ulcerans_Agy99 PSVEGPDPARPPSKFYVRSISPDGRAMTAINDRNAEPALPADNDVGSDPT
MAV_0703|M.avium_104 SAYEGPDPGRPPSKFYVRGVSTDGTPFTAINDRNAEPALPADNDVGPNPT
MSMEG_5870|M.smegmatis_MC2_155 TPLEGPNPARPPSNFYVRGFDEDGRTWIAVNDREAEPALPENNDVGPVPV
Mb0781|M.bovis_AF2122/97 DPYPIHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPT
Rv0758|M.tuberculosis_H37Rv DPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPT
TH_2452|M.thermoresistible__bu RPNEKFLGYVDGEYHTQSRQEPGFPEVLAGDDAFTERVATVTEPVEGSYD
MLBr_02440|M.leprae_Br4923 ---------------LGAAVVDTYRDVVYLNEQAKELGLVR---------
::
Mflv_3888|M.gilvum_PYR-GCK TVMSIGG---------------------------------------ALAV
Mvan_1833|M.vanbaalenii_PYR-1 TVISIGG---------------------------------------ALAV
MAB_3340|M.abscessus_ATCC_1997 TAMSIGF---------------------------------------AVAV
MMAR_4941|M.marinum_M TLPSVNGSNIEWRAVSVHGPQGGLTTVAIDLSDVQHTVRSLVWLQIGIGA
MUL_0464|M.ulcerans_Agy99 TLPSVNGSNIEWRAVSVHGPQGGLTTVAIDLSDVQHTVRSLVWLQIGIGA
MAV_0703|M.avium_104 TLPSVNGSDIQWRAVSVRGPHG-LTTVAIDLSDVQHTVSSLVWLQIGIGV
MSMEG_5870|M.smegmatis_MC2_155 TVGSIDKSNVEWRAMTVRGPNGELTTVAIDLSEVQSSVRALVWSQVGIGA
Mb0781|M.bovis_AF2122/97 TLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGS
Rv0758|M.tuberculosis_H37Rv TLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGS
TH_2452|M.thermoresistible__bu HPEVGEVRYLAIPVTMAGDPAQGVIVAAYLGDAERAAADDAARLMLLVGA
MLBr_02440|M.leprae_Br4923 ------------------------------------------------DR
Mflv_3888|M.gilvum_PYR-GCK SALAALAVS-VYVSRRLQRSVTEVACAAALVAEGRYDIRVSPPRLGDDFD
Mvan_1833|M.vanbaalenii_PYR-1 SALAALAVS-WYISRRLQRSVTEVAEAASSVAEGHYDVRVSSPQLGDDFD
MAB_3340|M.abscessus_ATCC_1997 SALAALTLS-WYLSHRVHRSATALSQAASAVADGNYDIRVPPPRLGKEFD
MMAR_4941|M.marinum_M GVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVG
MUL_0464|M.ulcerans_Agy99 GVLVVVGLAGFAVVQRSLRPLSEVEQTAAAIASGQLDRRVPERDPRTEVG
MAV_0703|M.avium_104 AVLAVVGIASFAVVQRSLRPLVEVEQTAAAIAAGQLDRRVPERDPRTEVG
MSMEG_5870|M.smegmatis_MC2_155 AVLLVLGVVGYVVVHRSLRPLVEVERTAAAIAAGQLDRRVPERDPRTEVG
Mb0781|M.bovis_AF2122/97 AVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVG
Rv0758|M.tuberculosis_H37Rv AVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVG
TH_2452|M.thermoresistible__bu ATLFGAIGAAWLVAGRILRPLRDVADTARTITDTDLSRRIPSRGEGDEMD
MLBr_02440|M.leprae_Br4923 QLDDQAWRAAQQALGGDDVEFDLLPGKRPAAGRSGLSVHGHARLLSEKDR
. . : .
Mflv_3888|M.gilvum_PYR-GCK ALATAFNQMASRLQSVESTR--------------RRLFGDLAHEIRTPVA
Mvan_1833|M.vanbaalenii_PYR-1 ALADAFNQMASRLQTVESTR--------------QRLFSDLAHEIRTPVA
MAB_3340|M.abscessus_ATCC_1997 AVAAAFNKMAQRLGAVDEAR--------------RQMLADLAHEIRTPVA
MMAR_4941|M.marinum_M QLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLT
MUL_0464|M.ulcerans_Agy99 QLSLAMNGMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLT
MAV_0703|M.avium_104 RLSLALNGMLAQIQQALASSESSAEKARGSEDRMRRFITDASHELRTPLT
MSMEG_5870|M.smegmatis_MC2_155 RLSSALNGMLAQIQRAVAASEASAEQARSSEDRMRRFITDASHELRTPLT
Mb0781|M.bovis_AF2122/97 RLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLT
Rv0758|M.tuberculosis_H37Rv RLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLT
TH_2452|M.thermoresistible__bu SLVRTINGMLDRIEAGVSAQ--------------RRFIDDAGHELRTPIT
MLBr_02440|M.leprae_Br4923 RFAVVFVHDQSDYVRMEAAR--------------RDFVANVSHELKTPVG
. .: : : :. : .**::**:
Mflv_3888|M.gilvum_PYR-GCK VLDAYVEALED--GVRTLNPDTVAVLRDQTGRLVRFSGDVAALAKAEESS
Mvan_1833|M.vanbaalenii_PYR-1 VLEAYIEALED--GVRTLTPQTAAMLRDQTRRLVRFSDDVAALAKAEESS
MAB_3340|M.abscessus_ATCC_1997 VLEAYMEAVED--GVQQLDQQTVATLRDQTRRLTRFSIDVNALSVAESRT
MMAR_4941|M.marinum_M TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLTLARLDVQR
MUL_0464|M.ulcerans_Agy99 TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLTLARLDVQR
MAV_0703|M.avium_104 TIRGFAELYRQ--GAARDVAMLLSRIESEASRMGLLVDDLLLLARLDVQR
MSMEG_5870|M.smegmatis_MC2_155 TIRGFAELYRQ--GAARDIEMLMGRIESESRRMGLLVEDLLLLARLDAQR
Mb0781|M.bovis_AF2122/97 TIRGFAELYRQ--GAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHR
Rv0758|M.tuberculosis_H37Rv TIRGFAELYRQ--GAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHR
TH_2452|M.thermoresistible__bu IVRGHLEVLDP--DDPDDVRSTVALVDDELVRMNRMVTDLLLLARSE-QP
MLBr_02440|M.leprae_Br4923 AMALLAEALLASADDAETVSRFAEKVLIEANRLGYMVAELIELSRLQGAE
: * . : : *: : :: *: :
Mflv_3888|M.gilvum_PYR-GCK VTMTYTEVDLDGLVRRAVAAARERYETKGVALQVMSARELPLLRADEQRL
Mvan_1833|M.vanbaalenii_PYR-1 ASMACSFVDVPRLAHHCAAAAQERFDSKNVTLAVRVAEGLPPLWADEQRL
MAB_3340|M.abscessus_ATCC_1997 TSIDARSVSPADLVTTAVAAFAPRYQTKGVILTSHADDGLPDVWADPERM
MMAR_4941|M.marinum_M P-LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRL
MUL_0464|M.ulcerans_Agy99 P-LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRL
MAV_0703|M.avium_104 P-LEHHRVDLLALASDAVHDAQAMDPKRTITLEVLDGPGTPEVFGDEPRI
MSMEG_5870|M.smegmatis_MC2_155 P-LERRRVDLLALATDAVHDAQSIAPKRRVKMEVFDGPGTPEVLGDEARL
Mb0781|M.bovis_AF2122/97 P-LELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRL
Rv0758|M.tuberculosis_H37Rv P-LELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRL
TH_2452|M.thermoresistible__bu TFLTPEPTDIGALTRAIFDKVVQLGDRDYQLQSVAEVT----AVLDAQRI
MLBr_02440|M.leprae_Br4923 RLPNVTDIDVDIIVSEAIARHKVAADTAAIEVRTDPPSGLR-VLGDQTLL
. :. * :
Mflv_3888|M.gilvum_PYR-GCK SQVLDNLLDNALRHTARGGRVEIHCHTEGARVRIAVTDDGEGIAAEHLSS
Mvan_1833|M.vanbaalenii_PYR-1 AQVVGNLVDNALRHTPAGGRVEVSWEREGAELALRVADNGAGIAAEHLPR
MAB_3340|M.abscessus_ATCC_1997 GQVLSNLLDNALRHTGPGGQVTVTATATGTGATIAVADTGDGVPAEHLDR
MMAR_4941|M.marinum_M RQVLSNLVGNALQHTPDSADVTVRVGTAGQNAVLEVADKGPGMPAEDAAR
MUL_0464|M.ulcerans_Agy99 RQVLSNLVGNALQHTPDSADVTVRVGTAGENAVLEVADKGPGMPAEDAAR
MAV_0703|M.avium_104 RQVLGNLIANALQHTPESADVTVRVGTDGDDAVLEVADRGPGMNEQDASR
MSMEG_5870|M.smegmatis_MC2_155 RQVIGNLVANAVQHTPETAGITVRVGTDGDNAVLEVCDEGPGMSQEDARR
Mb0781|M.bovis_AF2122/97 RQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALR
Rv0758|M.tuberculosis_H37Rv RQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALR
TH_2452|M.thermoresistible__bu TQALIALADNACRYTRDGDWIAVGSGLYDGWLRFWVSDSGPGVSDADRDR
MLBr_02440|M.leprae_Br4923 VTALANLVSNAIAYSPGGSLVSISRRRRGDNIEIAVTDRGIGIALEDQER
.: * ** :: : : . : * * * *: .
Mflv_3888|M.gilvum_PYR-GCK VFERFYRADAARDREHGGAGLGLAIAKALVEAHGGSVTAASDGAGTGATF
Mvan_1833|M.vanbaalenii_PYR-1 LFERFYRADTARDREHGGAGIGLAITRALVEAHGGTISVASAGPGTGATF
MAB_3340|M.abscessus_ATCC_1997 LFDRFYRADAARDRQHGGAGIGLSIAKALVEAHEGRIEAHSAGHAAGTTF
MMAR_4941|M.marinum_M VFERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTA-PGEGCCF
MUL_0464|M.ulcerans_Agy99 VFERFYRTDSSRARASGGTGLGLSIVHSLVKAHGGDVTLTTA-PGEGCCF
MAV_0703|M.avium_104 VFERFYRTDSSRARASGGTGLGLSIVESLVRAHGGTVGVTTA-PGQGCCF
MSMEG_5870|M.smegmatis_MC2_155 VFERFYRADTSRTRASGGTGLGLSIVDSLVYAHGGTVKVTTA-LGKGSRF
Mb0781|M.bovis_AF2122/97 VFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTA-LGEGCCF
Rv0758|M.tuberculosis_H37Rv VFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTA-LGEGCCF
TH_2452|M.thermoresistible__bu IFERFARGSAGGQRSDG-AGLGLSIVRAIAGAHGGHVDLDTV-VGRGSTF
MLBr_02440|M.leprae_Br4923 VFERFFRGDKARSRATGGSGLGLAIVKHVAANHNGSIGVWSK-PGTGSTF
:*:** * . . * * :*:**:*. :. * * : : . * *
Mflv_3888|M.gilvum_PYR-GCK TVELPTT------------RP-----------------------------
Mvan_1833|M.vanbaalenii_PYR-1 TVTLPLAPARDELVALGVARPAAQ--------------------------
MAB_3340|M.abscessus_ATCC_1997 TVSLPRPSDHPEKAP--GQRPG----------------------------
MMAR_4941|M.marinum_M RVTLPRVSEAAVELTEPVS-------------------------------
MUL_0464|M.ulcerans_Agy99 RVTLPRVSEAAVELTEPVS-------------------------------
MAV_0703|M.avium_104 RVTLPRISDVPAVQAS----------------------------------
MSMEG_5870|M.smegmatis_MC2_155 TVSLPRIADLPARL------------------------------------
Mb0781|M.bovis_AF2122/97 RVSLPRVSDVDQLSLTPVVPGPP---------------------------
Rv0758|M.tuberculosis_H37Rv RVSLPRVSDVDQLSLTPVVPGPP---------------------------
TH_2452|M.thermoresistible__bu TITIPAVLEAPWPAS-----------------------------------
MLBr_02440|M.leprae_Br4923 TLSIPAAMPLYQDNDEQSGQPRGCDMWLNRPQREEEEFKSMTPAQAMMQS
: :*
Mflv_3888|M.gilvum_PYR-GCK ---------------------
Mvan_1833|M.vanbaalenii_PYR-1 ---------------------
MAB_3340|M.abscessus_ATCC_1997 ---------------------
MMAR_4941|M.marinum_M ---------------------
MUL_0464|M.ulcerans_Agy99 ---------------------
MAV_0703|M.avium_104 ---------------------
MSMEG_5870|M.smegmatis_MC2_155 ---------------------
Mb0781|M.bovis_AF2122/97 ---------------------
Rv0758|M.tuberculosis_H37Rv ---------------------
TH_2452|M.thermoresistible__bu ---------------------
MLBr_02440|M.leprae_Br4923 EVTRGNVNDKCPDCGGRGIAG