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MAEELESPGDPETPTPSLQRRVILLVVALLAVLLVVLGVTIDVSLGLQARRNLHDLLLAATSRADALASV GTSPELIAAEINGGSVRALLVTADGATYGDPNISPDTTAGPAVPALPGPPPLIPPGGHQGPHGPPPPPPP PPGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTRQLRQLMIGAGLVTLVVAALLLVLVSRAA LAPLDRLAALAKDITTGDRGRRLRPSRGDTELGRAASAFDGMLDALEDSELRAQQAATAAQRAENATRQF LVDAAHELRTPIAGMQVAAEQLASSAGQQQEDPAARGQYRRASLLLSDARRAGRLVADMLDLSRIDAGLP LDRHDTDLAEIVDAESQRTTMLAPQITVTRSGLGTLTVAADPTRVAQILSNLLDNARRYTPAGGAIAIDL RAGQGVATVTVTDTGPGIPDDERNRIFERLVRLDAARTRDHGGAGLGLPIARALARAHGGELVCLPHQGG ARFRLTLPLAVAGGVE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1502 | - | - | 100% (506) | two component regulator - sensor kinase |
| M. ulcerans Agy99 | MUL_0464 | phoR | 3e-46 | 32.38% (420) | two component system response phosphate sensor kinase, PhoR |
| M. ulcerans Agy99 | MUL_4700 | mprB | 6e-34 | 28.01% (482) | two component sensor kinase MprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 1e-43 | 32.61% (414) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_1582 | - | 1e-43 | 32.25% (338) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 1e-43 | 32.61% (414) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00175 | - | 5e-33 | 28.01% (482) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_0674 | - | 2e-41 | 32.94% (340) | putative sensor histidine kinase PhoR |
| M. marinum M | MMAR_2299 | - | 0.0 | 99.60% (506) | two-component regulator - sensor kinase |
| M. avium 104 | MAV_3282 | - | 0.0 | 74.90% (490) | hypothetical protein MAV_3282 |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 5e-44 | 32.94% (340) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2428 | - | 3e-35 | 30.25% (476) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 3e-46 | 34.30% (344) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1502|M.ulcerans_Agy99 ----------------MAEELESPGDPETPTPSLQRRVILLVVALLAVLL
MMAR_2299|M.marinum_M ----------------MAEELESPGDPETPTPSLQRRVILLVVALLAVLL
MAV_3282|M.avium_104 ---------------------------MTPTPSLQRRVTLVVLALLTVLL
Mflv_1582|M.gilvum_PYR-GCK ----MSSASPDERSNLNNGDVAGRRRYLRRGVPLRVALVAATLLLVACGL
Mvan_5174|M.vanbaalenii_PYR-1 ----MDGG---DGPTLNNGGVPGR---IRRGVPLRVGLVAAMLLLVACGL
MSMEG_5870|M.smegmatis_MC2_155 ----MNRG--------------------RRGIPLRVGLVAAALVLVACGL
Mb0781|M.bovis_AF2122/97 ----MARH-------------------LRGRLPLRVRLVAATLILVATGL
Rv0758|M.tuberculosis_H37Rv ----MARH-------------------LRGRLPLRVRLVAATLILVATGL
MAB_0674|M.abscessus_ATCC_1997 MAWDTYCASRDERLREEQLALLVAVPGVRRGVPLRVSLVVGTLVLVALGL
MLBr_00175|M.leprae_Br4923 -------MVRFAW-------RRRASLRATSSLSLRWRVMLLAMSMVAMVV
TH_2428|M.thermoresistible__bu --------MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLAMSMVAMVV
.*: : : ::: :
MUL_1502|M.ulcerans_Agy99 VVLGVTIDVSLGLQARRNLHDLLLAATSRADALASVGTSPELIAAEINGG
MMAR_2299|M.marinum_M VVLGVTIDVSLGLQARRNLHDLLLAATSRADALASVGTSPELIAAEINGG
MAV_3282|M.avium_104 VVLGVTIDVTMGVLARRNLHDRLLAATSRADALSAAHTAPDLLAAELNGG
Mflv_1582|M.gilvum_PYR-GCK LASGIAVTTIMQHSLMNRVDDTLLDASRGWAQVPRRLPTITVDDPNPARP
Mvan_5174|M.vanbaalenii_PYR-1 LASGIAVTTIMQHSLMNRVDDTLLDASRGWAQVPRRVLTVPMEGPNPARP
MSMEG_5870|M.smegmatis_MC2_155 LASGIAVTSIMRHTEVSRIDQTLLDASRSWAQAPRRAPTTPLEGPNPARP
Mb0781|M.bovis_AF2122/97 VASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPIHNPDRP
Rv0758|M.tuberculosis_H37Rv VASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRP
MAB_0674|M.abscessus_ATCC_1997 VASGIAVTTTMQRTMMNRADRELIDAANGWANRPP--PPPPAFETTRHRP
MLBr_00175|M.leprae_Br4923 VLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYS
TH_2428|M.thermoresistible__bu VLMSIALYAVVSRALYNDIDNQLHSRARLLIESGSLAADPGRAIEGTAYS
: ..:: : . * :
MUL_1502|M.ulcerans_Agy99 SVRALLVTADGATYGDPNISPDTTAGPAVPALPGPPPLIPPGGHQGPHGP
MMAR_2299|M.marinum_M SVRALLVTADGATYGDPNISPDTTAGPAVPALPGPPPLIPPGGHQGPHGP
MAV_3282|M.avium_104 GIRALVVTADGQAYGDRVISPDLAEGPVEPPPPYPPPLPPP--YPPPAYP
Mflv_1582|M.gilvum_PYR-GCK PSDFYVRGIDPDGHVWMLINDRE-AEPELPA-------------------
Mvan_5174|M.vanbaalenii_PYR-1 PSDFYVRAVDPDGHVWMEVNDRE-AEPALPE-------------------
MSMEG_5870|M.smegmatis_MC2_155 PSNFYVRGFDEDGRTWIAVNDRE-AEPALPE-------------------
Mb0781|M.bovis_AF2122/97 PSRFYVRVISPDGQSYTALNDNT-AIPAVPA-------------------
Rv0758|M.tuberculosis_H37Rv PSRFYVRVISPDGQSYTALNDNT-AIPAVPA-------------------
MAB_0674|M.abscessus_ATCC_1997 PSLFFIRTTDDRGRVVIMLNDRARADPDLPF-------------------
MLBr_00175|M.leprae_Br4923 DVNAMLVNP---GHSIYTANQPG---QTLPVG------------------
TH_2428|M.thermoresistible__bu DVNAMLVNP---GRSIYTANQQG---EALPLG------------------
: . *
MUL_1502|M.ulcerans_Agy99 PPPPPPPPGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTRQL
MMAR_2299|M.marinum_M PPPPPPPPGGPPPGPPPDATATAAVHTLPDGSRLILVADTTQTTQVTRQL
MAV_3282|M.avium_104 PPYPPPYP--PPPGPLPDTTATAVVHPLSGGARLILVADTTQTTQVTRQL
Mflv_1582|M.gilvum_PYR-GCK DNNVGPEPRTVGSVDHSDVQWRAMTVRGLRGELTTVAIDLSDVKSTMRSL
Mvan_5174|M.vanbaalenii_PYR-1 DNDVGSEPVTVASVDHSHVQWRAMTVRGLSGELTTVAIDLSDVKSTVRSL
MSMEG_5870|M.smegmatis_MC2_155 NNDVGPVPVTVGSIDKSNVEWRAMTVRGPNGELTTVAIDLSEVQSSVRAL
Mb0781|M.bovis_AF2122/97 NNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSL
Rv0758|M.tuberculosis_H37Rv NNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSL
MAB_0674|M.abscessus_ATCC_1997 DNDVGGRPVTVRSSDGG-TEWRAVSRHDALGGYTTVARDITDVRTTVRDL
MLBr_00175|M.leprae_Br4923 TAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKL
TH_2428|M.thermoresistible__bu EPERQVLSGELVMSLRTADQQRVLAIHLSNGSSLLISKSLAPTMEVLRRL
. : . . *
MUL_1502|M.ulcerans_Agy99 RQLMIGAGLVTLVVAALLLVLVSRAALAPLDRLAALAKDITTGDRGRRLR
MMAR_2299|M.marinum_M RQLMIGAGLVTLVVAALLLVLVSRAALAPLDRLAALAKDITTGDRGRRLR
MAV_3282|M.avium_104 RGLMIAAGIVTLLIAALLLIAVSRAALRPLDRLTALANAITTGDRGRRLR
Mflv_1582|M.gilvum_PYR-GCK VYTQVGIGAAVLLVLGIAGYAVVHRSLRPLSEVEQTAAAIAAGQLDRRVP
Mvan_5174|M.vanbaalenii_PYR-1 VYTQAGFGVAVLVVLGIAGYAVVHRSLRPLSEVEQTAAAIAAGQLDRRVP
MSMEG_5870|M.smegmatis_MC2_155 VWSQVGIGAAVLLVLGVVGYVVVHRSLRPLVEVERTAAAIAAGQLDRRVP
Mb0781|M.bovis_AF2122/97 VLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVP
Rv0758|M.tuberculosis_H37Rv VLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVP
MAB_0674|M.abscessus_ATCC_1997 LWLQVAIGIAVLTVLGVAGYWLVHRSLRPLAEVEATAADIAAGHLDRRVP
MLBr_00175|M.leprae_Br4923 RWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIP
TH_2428|M.thermoresistible__bu GTVLLIVGGIGVAVAAIAGGMVARAGLRPVSRLTEAAERVARTDDLRPIP
* : : .: : : .* *: .. * : . * :
MUL_1502|M.ulcerans_Agy99 PSRGDTELGRAASAFDGMLDALEDSELRAQQAATAAQRAENATRQFLVDA
MMAR_2299|M.marinum_M PSRADTELGRAASAFDGMLDALEDSELRAQQAATAAQRAENATRQFLVDA
MAV_3282|M.avium_104 PHRADTELGRAASAFDTMLDALEMSERRAQQAAEAAQRAETATRRFLVDA
Mflv_1582|M.gilvum_PYR-GCK ERDPRTEVGRLSLALNGMLAQIQHAMALSESSAEKARSSEDRMRRFITDA
Mvan_5174|M.vanbaalenii_PYR-1 ERDPRTEVGRLSLALNGMLAQIQRAMASSEASAEQARTSEDRMRRFITDA
MSMEG_5870|M.smegmatis_MC2_155 ERDPRTEVGRLSSALNGMLAQIQRAVAASEASAEQARSSEDRMRRFITDA
Mb0781|M.bovis_AF2122/97 QWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDA
Rv0758|M.tuberculosis_H37Rv QWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDA
MAB_0674|M.abscessus_ATCC_1997 ERDPRTEVGRLSLALNGMLAQIQRAVADSEKSAKAARTSEERMRRFITDA
MLBr_00175|M.leprae_Br4923 VFGS-DELARLTEAFNLMLRALAE--------------SRERQARLVTDA
TH_2428|M.thermoresistible__bu VVGS-DELARLTEAFNMMLRALAE--------------SRERQARLVADA
*:.* : *:: ** : :. :::.**
MUL_1502|M.ulcerans_Agy99 AHELRTPIAGMQVAAEQLASSAGQQQEDPAARGQYRRASLLLSDARRAGR
MMAR_2299|M.marinum_M AHELRTPIAGMQVAAEQLASSAGQQQEDPAARGQYRRASLLLSDARRAGR
MAV_3282|M.avium_104 AHELRTPIAGMQVAAEQLAHGASEHPDD----GQYRRAGLLLSDARRAGR
Mflv_1582|M.gilvum_PYR-GCK SHELRTPLTTIRGFAELYRQGAAR--------DVEMLMGRIKSESRRMGL
Mvan_5174|M.vanbaalenii_PYR-1 SHELRTPLTTIRGFAELYRQGAAR--------DVEMLMSRIESESRRMGL
MSMEG_5870|M.smegmatis_MC2_155 SHELRTPLTTIRGFAELYRQGAAR--------DIEMLMGRIESESRRMGL
Mb0781|M.bovis_AF2122/97 SHELRTPLTTIRGFAELYRQGAAR--------DVGMLLSRIESEASRMGL
Rv0758|M.tuberculosis_H37Rv SHELRTPLTTIRGFAELYRQGAAR--------DVGMLLSRIESEASRMGL
MAB_0674|M.abscessus_ATCC_1997 SHELRTPLTTIRGYAELYRQGAAT--------DTELVLGRIEGESTRMGQ
MLBr_00175|M.leprae_Br4923 GHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELST
TH_2428|M.thermoresistible__bu GHELRTPLTSLRTNVELLMASQQPGAPGLPEEEMAGLRADVIAQIEELST
.******:: :: .* . . : .: . .
MUL_1502|M.ulcerans_Agy99 LVADMLDLSRIDAGLPLDRHDTDLAEIVDAESQRTTMLAPQITVTRSGLG
MMAR_2299|M.marinum_M LVADMLDLSRIDAGLPLDRHDTDLAEIVDAESQRTTMLAPQITVTRSGLG
MAV_3282|M.avium_104 LVNDMLDLSRIDAGLPLELHDVDVAAVLRDEADRAALLAPQIGVRRTGLT
Mflv_1582|M.gilvum_PYR-GCK LVEDLLLLARLDAQRPLEHRRVDLLALASDTVHDAQSIAPKRRIRMEVFD
Mvan_5174|M.vanbaalenii_PYR-1 LVEDLLLLARLDAQRPLDRHRVDLLTLATDAVHDAQSIAPKRSIKMEVFD
MSMEG_5870|M.smegmatis_MC2_155 LVEDLLLLARLDAQRPLERRRVDLLALATDAVHDAQSIAPKRRVKMEVFD
Mb0781|M.bovis_AF2122/97 LVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLD
Rv0758|M.tuberculosis_H37Rv LVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLD
MAB_0674|M.abscessus_ATCC_1997 LVEDLLLLARLDAHRPMEQRLVDLLVLATDAVHDAKATAPERDVELEVFD
MLBr_00175|M.leprae_Br4923 LVGDLVDLTRDDAGQVVHEP-IDMSEVLYRSLERVRRRRNDIHFDVQAIG
TH_2428|M.thermoresistible__bu LVGDLVDLTRDDAGGVIHEP-VDIADVVDRSLERVRRRRNDIDFDIEVVP
** *:: *:* ** :. *: : . . . . .
MUL_1502|M.ulcerans_Agy99 ---TLTVAADPTRVAQILSNLLDNARRYTPAGGAIAIDLRAGQ-GVATVT
MMAR_2299|M.marinum_M ---TLTVAADPTRVAQILSNLLDNARRYTSAGGAIAIDLRAGQ-GVATVT
MAV_3282|M.avium_104 ---ALNVRADATRLSQIVSNLLDNARRYTPAGGAIEIDLRAGD-GAAEIT
Mflv_1582|M.gilvum_PYR-GCK GPGTPEVLGDEARLRQVLSNLVANALQHTPESAGVTVRVGTAD-DTAIVE
Mvan_5174|M.vanbaalenii_PYR-1 GPGTPEVLGDEPRLRQVLSNLVANALQHTPETAAVTVRVGTDG-NDAVVE
MSMEG_5870|M.smegmatis_MC2_155 GPGTPEVLGDEARLRQVIGNLVANAVQHTPETAGITVRVGTDG-DNAVLE
Mb0781|M.bovis_AF2122/97 GPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEG-DDAILE
Rv0758|M.tuberculosis_H37Rv GPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEG-DDAILE
MAB_0674|M.abscessus_ATCC_1997 GPGTPEVIGDELRLRQVLGNLVSNALGHT--TAAVRVRVGTEG-DDAVLE
MLBr_00175|M.leprae_Br4923 ----WQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELV
TH_2428|M.thermoresistible__bu ----WQVYGDAAGLSRAVMNLLDNAAKWSPSGGRVGVRLTQVDPVHAELV
: .* : : : **: ** : . : : : . :
MUL_1502|M.ulcerans_Agy99 VTDTGPGIPDDERNRIFERLVRLDAARTRDHGGAGLGLPIARALARAHGG
MMAR_2299|M.marinum_M VTDTGPGIPDDERNRIFERLVRLDAARTRDHGGAGLGLPIARALARAHGG
MAV_3282|M.avium_104 VTDTGPGIPDDEREHIFDRLVRLDAGRARDHGGAGLGLAIARALARAHGG
Mflv_1582|M.gilvum_PYR-GCK VCDEGPGMTGEDAQRVFERFYRADSSRARASGGTGLGLSIVDSLVYAHGG
Mvan_5174|M.vanbaalenii_PYR-1 VCDEGPGMRPEDAQRVFERFYRTDTSRARASGGTGLGLSIVDSLVYAHGG
MSMEG_5870|M.smegmatis_MC2_155 VCDEGPGMSQEDARRVFERFYRADTSRTRASGGTGLGLSIVDSLVYAHGG
Mb0781|M.bovis_AF2122/97 VADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGG
Rv0758|M.tuberculosis_H37Rv VADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGG
MAB_0674|M.abscessus_ATCC_1997 VIDRGPGMTKTDAERVFERFYRADSSRTRSSGGTGLGLSIVDALTAAHGG
MLBr_00175|M.leprae_Br4923 VSDYGPGIPPQERRLVFERFYRSTTARSLP--GSGLGLAIVKQVVINHGG
TH_2428|M.thermoresistible__bu VSDHGPGIPPQERRLVFERFYRSTTARSMP--GSGLGLAIVKQVVLKHGG
* * ***: : :*:*: * :.*: *:****.*. :. ***
MUL_1502|M.ulcerans_Agy99 ELVCLPHQG-----GARFRLTLPLAVAGGVE-------------------
MMAR_2299|M.marinum_M ELVCLPHQG-----GARFRLTLPLAVAGGVE-------------------
MAV_3282|M.avium_104 DLVCLPHQG-----GARFRLTLPRATTQ----------------------
Mflv_1582|M.gilvum_PYR-GCK RVSVTTAPGC----GCRFTVRLPRVTDERLREEQATDERLREEQMPAPEH
Mvan_5174|M.vanbaalenii_PYR-1 RVSVTTAPGQ----GSRFRVSLPRIADAGP--------------------
MSMEG_5870|M.smegmatis_MC2_155 TVKVTTALGK----GSRFTVSLPRIADLPARL------------------
Mb0781|M.bovis_AF2122/97 AVTVTTALGE----GCCFRVSLPRVSDVDQ--------------------
Rv0758|M.tuberculosis_H37Rv AVTVTTALGE----GCCFRVSLPRVSDVDQ--------------------
MAB_0674|M.abscessus_ATCC_1997 TVTVHTAPGA----GCRFEVRLPRADMTDDDADVDEPE----------SA
MLBr_00175|M.leprae_Br4923 LLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIG
TH_2428|M.thermoresistible__bu TLRVEDTVPGGQPPGTSIHVVLPGRPLSGVPPASQEPQPP-----QHAPG
: * : : **
MUL_1502|M.ulcerans_Agy99 -----------------------------
MMAR_2299|M.marinum_M -----------------------------
MAV_3282|M.avium_104 -----------------------------
Mflv_1582|M.gilvum_PYR-GCK AGEESRGEQTDVPVSATAPTPP-------
Mvan_5174|M.vanbaalenii_PYR-1 ----DAGPDAEVPVSSAQLG---------
MSMEG_5870|M.smegmatis_MC2_155 -----------------------------
Mb0781|M.bovis_AF2122/97 -----------LSLTPVVPGPP-------
Rv0758|M.tuberculosis_H37Rv -----------LSLTPVVPGPP-------
MAB_0674|M.abscessus_ATCC_1997 TPDAAASEPKIVRASRSESAQP-------
MLBr_00175|M.leprae_Br4923 PAVQVSGKSANFRDSAHVISVDYQSARAR
TH_2428|M.thermoresistible__bu ADPHAPTQTGN-DAVQSVFTAENK-----