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VTFEERMIRLLRPVLRPVMRVLSLRTIVIVAALSVVVLVLTLGTWVWIGVTNDQYAQLDRRLDSLSSLGD VSTLLNSTRETDADNAGHDDGGLVRTAYIGGVTVSVPSDIVLPHLENGYANTTIDGVEYRVRTFTAGPAT IALGAPLAETQRRIDELHLRVVLICAGVIAGTVVVGWVISLVMINPFRLLAQQARAINAQSNPEEVKVRG VREAVEIAEAVEGMLARIGSEQERTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDMTPEQRQEV IGDVMRTQSRIEATLTALERLAQGELTTVEDFVPMDVTELLDRAAHDAQHTYPGLKVTLMPSPTVLMLGM PAGLRLVIDNAIANAVKHGGATEIRLSAVSSADDVEIAVDDNGSGVPEAERAEVFERFARGSTASRSGSG LGLALVAQQAELHGGKAALEESPLGGARLLLRLPINRSRGDDASF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2793 | - | - | 100% (465) | sensor-type histidine kinase PrrB |
| M. smegmatis MC2 155 | MSMEG_5663 | - | e-136 | 59.68% (439) | sensor-type histidine kinase PrrB |
| M. smegmatis MC2 155 | MSMEG_0246 | - | 1e-73 | 40.83% (458) | sensor-type histidine kinase PrrB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0926c | prrB | 1e-134 | 59.00% (439) | two component sensor histidine kinase PRRB |
| M. gilvum PYR-GCK | Mflv_4243 | - | 0.0 | 76.84% (449) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0902c | prrB | 1e-134 | 59.00% (439) | two component sensor histidine kinase PRRB |
| M. leprae Br4923 | MLBr_02124 | - | 1e-135 | 59.59% (438) | sensor histidine kinase |
| M. abscessus ATCC 19977 | MAB_0955c | - | 1e-178 | 70.73% (451) | sensor histidine kinase PrrB |
| M. marinum M | MMAR_4634 | prrB | 1e-133 | 59.45% (439) | two-component sensor histidine kinase PrrB |
| M. avium 104 | MAV_0147 | - | 0.0 | 80.69% (435) | sensor-type histidine kinase PrrB |
| M. thermoresistible (build 8) | TH_0454 | - | 1e-135 | 58.88% (445) | sensor-type histidine kinase PrrB |
| M. ulcerans Agy99 | MUL_0249 | prrB | 1e-133 | 59.23% (439) | two component sensor histidine kinase PrrB |
| M. vanbaalenii PYR-1 | Mvan_2118 | - | 0.0 | 76.27% (451) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4634|M.marinum_M -------------------MTVMNILSRIFA---RTPSLRTRVVVATAIG
MUL_0249|M.ulcerans_Agy99 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
Mb0926c|M.bovis_AF2122/97 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
Rv0902c|M.tuberculosis_H37Rv ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
MLBr_02124|M.leprae_Br4923 ----------------------MNILSRIFA---RTPSLRTRVVVATAIG
TH_0454|M.thermoresistible__bu ----------------------MNLVTRLFR---RTPSLRTRVAFATAIA
MSMEG_2793|M.smegmatis_MC2_155 ---------------MTFEERMIRLLRPVLRPVMRVLSLRT-IVIVAALS
MAV_0147|M.avium_104 ---------------------------------MRVLSLRT-IVIVAAIS
Mflv_4243|M.gilvum_PYR-GCK ------------------MTRIQDLVYRVLDHPLRWLSLRS-IVILSQLG
Mvan_2118|M.vanbaalenii_PYR-1 ------------------MTRIQDLVFRVLQHPLRMLSLRS-IVILSQLG
MAB_0955c|M.abscessus_ATCC_199 MSTSHENPPVMGRPSKHRSQRITDLSYRLLEKPMRIFSLRT-LVAIAALG
* ***: :. : :.
MMAR_4634|M.marinum_M AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGF-AIPFVPRGLDEIPRS
MUL_0249|M.ulcerans_Agy99 AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGF-AIPFVPRGLDEIPRS
Mb0926c|M.bovis_AF2122/97 AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGF-AIPFVPRGLDEIPRS
Rv0902c|M.tuberculosis_H37Rv AAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGF-AIPFVPRGLDEIPRS
MLBr_02124|M.leprae_Br4923 AAIPVLIVGTVVWVGITNDRKERLDRKLDEAAGF-AIPFVPRGLDEIPRS
TH_0454|M.thermoresistible__bu AAIVVGIVGVVVWVGITNDRKERLDRRLDEAAGF-ALPFVPRGLEQIPPS
MSMEG_2793|M.smegmatis_MC2_155 VVVLVLTLGTWVWIGVTNDQYAQLDRRLDSLSSLGDVSTLLNSTRETDAD
MAV_0147|M.avium_104 VMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNPQHNSPD
Mflv_4243|M.gilvum_PYR-GCK VTILVLTLGVWVWVGVTNDQYDQLDRRLDSLSSLGDVNTLLRSAQEGVGP
Mvan_2118|M.vanbaalenii_PYR-1 VIILVLTLGVWVWVGVTNDQYDQLDRRLDSLSSLGDVNTLLRSAQDGVGP
MAB_0955c|M.abscessus_ATCC_199 VMVLVVTLGTWVWLGVEEDQYSQLDRRLDSVSSLGAVSNLLNSVISSDKK
. * :*. **:*: :*: :***:**. :.: : : .
MMAR_4634|M.marinum_M PNDQD---ALITVRRGDLVKSN-SDITLPKLQKDYADTYIRGVRYRVRTV
MUL_0249|M.ulcerans_Agy99 PNDQD---ALITVRRGDLVKSN-SDITLPKLQEDYADTYIRGVRYRVRTV
Mb0926c|M.bovis_AF2122/97 PNDQD---ALITVRRGNVIKSN-SDITLPKLQDDYADTYVRGVRYRVRTV
Rv0902c|M.tuberculosis_H37Rv PNDQD---ALITVRRGNVIKSN-SDITLPKLQDDYADTYVRGVRYRVRTV
MLBr_02124|M.leprae_Br4923 PNDQD---AIITVRRGNLVKSN-FDITLPKLTNDYADTYLRGVRYRVRTV
TH_0454|M.thermoresistible__bu PNDQD---VVITVRRGDEVRSN-SEVVLPELDADYADTYIDGVRYRVRTV
MSMEG_2793|M.smegmatis_MC2_155 NAGHDDGGLVRTAYIGGVTVSVPSDIVLPHLENGYANTTIDGVEYRVRTF
MAV_0147|M.avium_104 RATQD-GNLVRTARIGGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTF
Mflv_4243|M.gilvum_PYR-GCK EPTEG--GLVRTARWAGSTVSIPADIVLPDLDSGYADATIDGVEYRVRTI
Mvan_2118|M.vanbaalenii_PYR-1 EPTEG--GLVRTARIGGITVSTPAEVVLPELPNGYADATIEGVEYRVRTI
MAB_0955c|M.abscessus_ATCC_199 LDTPD--GLVLTARVAGLTKSIPTDTELPLLEPGYANTKINGVEYRVRSF
. : *. .. * : ** * .**:: : **.****:.
MMAR_4634|M.marinum_M EIPGPEPTSVAVGATYDATIAETNNLHRRVLLICTFAIGAATVFAWLLAV
MUL_0249|M.ulcerans_Agy99 EIPGPEPTSVAVGATYDATIAETNNLHRRVLLICTFAIGAATVFAWLLAV
Mb0926c|M.bovis_AF2122/97 EIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAA
Rv0902c|M.tuberculosis_H37Rv EIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAA
MLBr_02124|M.leprae_Br4923 EIPAPEPTSIAVGATYDATVAETNNLHRRVLLICGFAIAAAAVFAWLLAA
TH_0454|M.thermoresistible__bu QTPYPIRTTLAVGATYDDTIADTANLHRRVILICTLAIGAATIAGWLLAA
MSMEG_2793|M.smegmatis_MC2_155 TA---GPATIALGAPLAETQRRIDELHLRVVLICAGVIAGTVVVGWVISL
MAV_0147|M.avium_104 TA---GPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVISL
Mflv_4243|M.gilvum_PYR-GCK KT---GNASIALGAPMAETQARIDSLHWRVFWICSGVILTTMLVGWVIGL
Mvan_2118|M.vanbaalenii_PYR-1 TT---GTASIALGAPLADTQARIDGLHWRVFWICAGVILSTLLIGWVIGL
MAB_0955c|M.abscessus_ATCC_199 IAP--GNIPVAVGAPVAETQRQIDRYHMRILAICGGVLIGTVIVGWVISL
.:*:.*. : * *:. ** .: : : .*::.
MMAR_4634|M.marinum_M FAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNE
MUL_0249|M.ulcerans_Agy99 FAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEGMRGMLQRIWNE
Mb0926c|M.bovis_AF2122/97 FAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNE
Rv0902c|M.tuberculosis_H37Rv FAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNE
MLBr_02124|M.leprae_Br4923 FAVRPFKQLAQQTRSVDAGGEAPRVEVHGATEAVEIAEAMRGMLQRIWNE
TH_0454|M.thermoresistible__bu FAVRPFKQLAAQARSIDAGDEVPDVEIRGATEAVEIADAVKGMLQRIWKE
MSMEG_2793|M.smegmatis_MC2_155 VMINPFRLLAQQARAINAQSNPEEVKVRGVREAVEIAEAVEGMLARIGSE
MAV_0147|M.avium_104 IMVNPFLLLAQQARAINAQSSPDEVQVRGVREAVEIAEAVEGMLARIGKE
Mflv_4243|M.gilvum_PYR-GCK IMVNPFRLLAQQARAINAQSNPDEVQVRGVWEAVEISEAVEGMLARIGDE
Mvan_2118|M.vanbaalenii_PYR-1 IMVNPFRLLARQARAINAQSNPDEVQVRGVWEAVEISEAVEGMLARIGDE
MAB_0955c|M.abscessus_ATCC_199 IVVSPFRLLAQQARLINAQSNPDDVNVRGVREAVEISEAVEGMLERINTE
. : ** ** *:* ::* .. *:::*. **:**::.:.*** ** *
MMAR_4634|M.marinum_M QIRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVL
MUL_0249|M.ulcerans_Agy99 QIRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVL
Mb0926c|M.bovis_AF2122/97 QNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVL
Rv0902c|M.tuberculosis_H37Rv QNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVL
MLBr_02124|M.leprae_Br4923 QNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLATLDLADDQRKEVL
TH_0454|M.thermoresistible__bu QDRTKAALASARDFASAAAHELRTPLTAMRTNLEVLSTLDMPEEQRKEVL
MSMEG_2793|M.smegmatis_MC2_155 QERTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDMTPEQRQEVI
MAV_0147|M.avium_104 QQRTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLDLPHEQRQEVI
Mflv_4243|M.gilvum_PYR-GCK QQRTRAALESARDFAAVASHELRTPLTAMRTNLEVLATLDLGAEQRQEVL
Mvan_2118|M.vanbaalenii_PYR-1 QQRTRAALETARDFASVASHELRTPLTAMRTNLEVLSTLDLAPEQRQEVI
MAB_0955c|M.abscessus_ATCC_199 QEKTKAALESARDFAAVASHELRTPLTAMRTNLEVLSTLNLSDDQREEII
* :*: ** :*****:.::*****************:**:: :**:*::
MMAR_4634|M.marinum_M NDVIRTQSRIEATLGALERLAQGELSTSEDHVPVDITELLDRAAHDAMRI
MUL_0249|M.ulcerans_Agy99 NDVIRTQSRIEATLGALERLAQGELSTSEDHVPVDITELLDRAAHDAMRI
Mb0926c|M.bovis_AF2122/97 NDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARI
Rv0902c|M.tuberculosis_H37Rv NDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARI
MLBr_02124|M.leprae_Br4923 GDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHDATRS
TH_0454|M.thermoresistible__bu ADVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITELLDRAAHEAMRI
MSMEG_2793|M.smegmatis_MC2_155 GDVMRTQSRIEATLTALERLAQGELTTVEDFVPMDVTELLDRAAHDAQHT
MAV_0147|M.avium_104 GDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITELLDRAAHDALRV
Mflv_4243|M.gilvum_PYR-GCK GDVIRTQSRIEATLTALERLAQGELTTVDDFVPVDVAELLDRAAHDAMHN
Mvan_2118|M.vanbaalenii_PYR-1 GDVIRTQSRIEATLTALERLAQGQLTTVEDFVPVDIAELLDRAAHDAMRN
MAB_0955c|M.abscessus_ATCC_199 EETIRTQSRVEATLSALERLAQGQLTTEDDHVPVDITELLDRAAHDADRS
:.:*****:**** ********:*:* :*.**.*:::*******:* :
MMAR_4634|M.marinum_M YPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGSTRVQLSAVSS
MUL_0249|M.ulcerans_Agy99 YPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGSTRVQLSAVSS
Mb0926c|M.bovis_AF2122/97 YPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSS
Rv0902c|M.tuberculosis_H37Rv YPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSS
MLBr_02124|M.leprae_Br4923 YPELKVSLVPSPTCIIVGLPAGLRLAVDNAVANAVKHGGATRVQLSAVSS
TH_0454|M.thermoresistible__bu YPDLEVSLVPAPTVIIVGLPAGLRLAVDNAIANAVKHGGATRVQLSAVSS
MSMEG_2793|M.smegmatis_MC2_155 YPGLKVTLMPSPTVLMLGMPAGLRLVIDNAIANAVKHGGATEIRLSAVSS
MAV_0147|M.avium_104 YPDVEVSLVPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVSSS
Mflv_4243|M.gilvum_PYR-GCK YPGVEVTLASSTTVLMLGMPAGLRLVIDNAIANAVKHGGATQIRLSVVSS
Mvan_2118|M.vanbaalenii_PYR-1 YPGVDVSLASSTTVLMLGMPAGLRLVIDNAIANAVKHGGATQIRLSVVSS
MAB_0955c|M.abscessus_ATCC_199 YPNLEISLVPSSTILMLGLPAGLRLVIDNAIKNAVKHGGASKIQLSATST
** :.::* .:.* :::*:*:****.:***: ******.: ::*:. *:
MMAR_4634|M.marinum_M RAGVEIAVDDNGSGVPEAERQMVFERFSRGSTASHSGSGLGLALVAQQAH
MUL_0249|M.ulcerans_Agy99 RAGVEIAVDDNGSGVPEAERQMVFERFSRGSTASHSGSGLGLALVAQQAH
Mb0926c|M.bovis_AF2122/97 RAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQ
Rv0902c|M.tuberculosis_H37Rv RAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQ
MLBr_02124|M.leprae_Br4923 RAGVEIAVDDNGSGVPEDERQVVFERFSRGSTASHSGSGLGLALVAQQAQ
TH_0454|M.thermoresistible__bu REGVEIAIDDNGTGVPEEERERVFDRFTRGSTASHSGSGLGLALVAQQAE
MSMEG_2793|M.smegmatis_MC2_155 ADDVEIAVDDNGSGVPEAERAEVFERFARGSTASRSGSGLGLALVAQQAE
MAV_0147|M.avium_104 GEGVEIAIDDDGSGIPESERATVFERFARGSTASRSGSGLGLALVAQQAE
Mflv_4243|M.gilvum_PYR-GCK HTGVEIAVDDNGSGVPEEERAEVFARFHRGTTASRSGSGLGLALVAQQAE
Mvan_2118|M.vanbaalenii_PYR-1 QSGVEIAVDDNGSGVPEEERAAVFERFHRGTTASRSGSGLGLALVAQQAE
MAB_0955c|M.abscessus_ATCC_199 VHGVEIAVDDNGSGIPEAERVQVFERFSRGSTASHSGSGLGLALVAQQAE
.****:**:*:*:** ** ** ** **:***:**************.
MMAR_4634|M.marinum_M LHGGTASLQNSPLGGARLLLKLPGPS--------
MUL_0249|M.ulcerans_Agy99 LHGGTASLQNSPLGGARLLLKLPGPS--------
Mb0926c|M.bovis_AF2122/97 LHGGTASLENSPLGGARLVLRLPGPS--------
Rv0902c|M.tuberculosis_H37Rv LHGGTASLENSPLGGARLVLRLPGPS--------
MLBr_02124|M.leprae_Br4923 LHGGTASLETSPLGGARLLLRISAPS--------
TH_0454|M.thermoresistible__bu IHGGTASLEASPLGGARLVLRLPGPR--------
MSMEG_2793|M.smegmatis_MC2_155 LHGGKAALEESPLGGARLLLRLPINRSRGDDASF
MAV_0147|M.avium_104 LHGGTAELQNSPLGGTRLLLRLAGD-GRGPA---
Mflv_4243|M.gilvum_PYR-GCK IHGGTASLEVSPQGGTRLMLRLPGS---GPS---
Mvan_2118|M.vanbaalenii_PYR-1 IHGGTASLEVSPQGGTRLMLRLPGH---GPE---
MAB_0955c|M.abscessus_ATCC_199 LHGGTAALESSPLGGARLVLRLPGH---------
:***.* *: ** **:**:*::.