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VRTDTSIQPRSRRSPGVGARLLLAQALVLLAGGATTGVVAVIVGPPLFREHLNRAGLPHSSNEQFHAEEA YRYATAISIAVAIGVAALTALVVTWYFSRRLQHSIAEVASAATAVADGRYDIRVSPLRLGEDFANLSRAF NRMSERLESVETTRRQLFGDLAHEIRTPVSVLKAYIEAVEDGVKTLDPETVAVLNDQASRLVRFSDDFAA LAQAEEGPGAVTPQWIDPRAAIVTTVSAAADRYAQKDVALIFDAANPLPEVWVDPLRLAQVIGNLLDNAL RHTPARGRVEVDAAAKPGEVIITVGDNGDGIAAEHLPHVFERFYRADVARDRSHGGAGIGLAIAKALTEA HGGRITAASRGPGMGSTFTIELPARTDRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3675 | - | - | 100% (379) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_1833 | - | e-125 | 60.43% (374) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 8e-33 | 30.32% (310) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0781 | phoR | 3e-33 | 31.66% (319) | two component system response sensor kinase membrane |
| M. gilvum PYR-GCK | Mflv_3888 | - | 1e-124 | 61.90% (378) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0758 | phoR | 2e-32 | 31.35% (319) | two component system response sensor kinase membrane |
| M. leprae Br4923 | MLBr_00774 | mtrB | 5e-26 | 28.12% (313) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3340 | - | 1e-104 | 53.85% (364) | sensor histidine kinase |
| M. marinum M | MMAR_4941 | phoR | 9e-33 | 30.18% (338) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_0703 | - | 5e-34 | 29.28% (321) | sensor histidine kinase PhoR |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 8e-34 | 31.75% (315) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_2452 | - | 2e-31 | 29.60% (321) | PUTATIVE putative sensor histidine kinase PhoR |
| M. ulcerans Agy99 | MUL_0464 | phoR | 6e-33 | 30.18% (338) | two component system response phosphate sensor kinase, PhoR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4941|M.marinum_M ---------------------------MAERLPRAVPLRVGLVAATLALV
MUL_0464|M.ulcerans_Agy99 ---------------------------MAERLPRAVQLRVGLVAATLALV
MAV_0703|M.avium_104 --------------------------MVVTRPRRGLPLRVGLVAATLALV
MSMEG_5870|M.smegmatis_MC2_155 ----------------------------MNRGRRGIPLRVGLVAAALVLV
Mb0781|M.bovis_AF2122/97 ---------------------------MARHLRGRLPLRVRLVAATLILV
Rv0758|M.tuberculosis_H37Rv ---------------------------MARHLRGRLPLRVRLVAATLILV
Mvan_3675|M.vanbaalenii_PYR-1 --------------------------MRTDTSIQPRSRRSPGVGARLLLA
Mflv_3888|M.gilvum_PYR-GCK -----------------------MSVTRRSPAASTRRWRRPGIGLRLLAA
MAB_3340|M.abscessus_ATCC_1997 -----------------------------------MTRPRYGIGLRLLVV
MLBr_00774|M.leprae_Br4923 MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLS
TH_2452|M.thermoresistible__bu ----------------MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLV
:. :
MMAR_4941|M.marinum_M LCGLLASGVAVTSILR----------------------HSLVSRIDSTLL
MUL_0464|M.ulcerans_Agy99 LCGLLASGVAVTSILR----------------------HSLVSRIDSTLL
MAV_0703|M.avium_104 ACGLAVSGIAVTSILR----------------------HSLVSRIDSTLL
MSMEG_5870|M.smegmatis_MC2_155 ACGLLASGIAVTSIMR----------------------HTEVSRIDQTLL
Mb0781|M.bovis_AF2122/97 ATGLVASGIAVTSMLQ----------------------HRLTSRIDRVLL
Rv0758|M.tuberculosis_H37Rv ATGLVASGIAVTSMLQ----------------------HRLTSRIDRVLL
Mvan_3675|M.vanbaalenii_PYR-1 QALVLLAGGATTGVVA----------------------VIVG--------
Mflv_3888|M.gilvum_PYR-GCK QAIVLAVGAATTAVVA----------------------AVVG--------
MAB_3340|M.abscessus_ATCC_1997 NSLVVLAGIATTSVVA----------------------AIVG--------
MLBr_00774|M.leprae_Br4923 LAVILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSL
TH_2452|M.thermoresistible__bu MVALGVVTLTTWRLMVSSIDARMDEALHIEVDEFEELTASGLNPRTGAPF
: . :
MMAR_4941|M.marinum_M EASRTWAQASWRHSMPSVEGPDPARPPSKFYVRSISPDGRAMTAINDRNA
MUL_0464|M.ulcerans_Agy99 EASRTWAQASWRHSMPSVEGPDPARPPSKFYVRSISPDGRAMTAINDRNA
MAV_0703|M.avium_104 DASRGWAQAPRRQSSSAYEGPDPGRPPSKFYVRGVSTDGTPFTAINDRNA
MSMEG_5870|M.smegmatis_MC2_155 DASRSWAQAPRRAPTTPLEGPNPARPPSNFYVRGFDEDGRTWIAVNDREA
Mb0781|M.bovis_AF2122/97 EEAQIWAQITLPLAPDPYPIHNPDRPPSRFYVRVISPDGQSYTALNDNTA
Rv0758|M.tuberculosis_H37Rv EEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTA
Mvan_3675|M.vanbaalenii_PYR-1 ---------------------------PPLFREHLNRAGLPHSSNEQFHA
Mflv_3888|M.gilvum_PYR-GCK ---------------------------PPLFQEHLHRAGVPMNSPEEMHA
MAB_3340|M.abscessus_ATCC_1997 ---------------------------PPMFRRLMDQQVSPGAGN-DHPY
MLBr_00774|M.leprae_Br4923 DSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQV
TH_2452|M.thermoresistible__bu TGVAEVIREAIAYNLARPNEKFLGYVDGEYHTQSRQEPGFPEVLAGDDAF
.
MMAR_4941|M.marinum_M EPALPADNDVGSDPTTLPSVNGSNIEWRAVSVHGPQGGLTT-----VAID
MUL_0464|M.ulcerans_Agy99 EPALPADNDVGSDPTTLPSVNGSNIEWRAVSVHGPQGGLTT-----VAID
MAV_0703|M.avium_104 EPALPADNDVGPNPTTLPSVNGSDIQWRAVSVRGPHG-LTT-----VAID
MSMEG_5870|M.smegmatis_MC2_155 EPALPENNDVGPVPVTVGSIDKSNVEWRAMTVRGPNGELTT-----VAID
Mb0781|M.bovis_AF2122/97 IPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTT-----VAID
Rv0758|M.tuberculosis_H37Rv IPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTT-----VAID
Mvan_3675|M.vanbaalenii_PYR-1 EEAYR---------------------------------------------
Mflv_3888|M.gilvum_PYR-GCK EEAYG---------------------------------------------
MAB_3340|M.abscessus_ATCC_1997 ERAFR---------------------------------------------
MLBr_00774|M.leprae_Br4923 PNSLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFP
TH_2452|M.thermoresistible__bu TERVATVTEPVEGSYDHPEVGEVRYLAIPVTMAGDPAQGVIV----AAYL
MMAR_4941|M.marinum_M LSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVEQTAAA
MUL_0464|M.ulcerans_Agy99 LSDVQHTVRSLVWLQIGIGAGVLVVVGLAGFAVVQRSLRPLSEVEQTAAA
MAV_0703|M.avium_104 LSDVQHTVSSLVWLQIGIGVAVLAVVGIASFAVVQRSLRPLVEVEQTAAA
MSMEG_5870|M.smegmatis_MC2_155 LSEVQSSVRALVWSQVGIGAAVLLVLGVVGYVVVHRSLRPLVEVERTAAA
Mb0781|M.bovis_AF2122/97 LADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAA
Rv0758|M.tuberculosis_H37Rv LADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAA
Mvan_3675|M.vanbaalenii_PYR-1 -------YATAISIAVAIGVAALTALVVT-WYFSRRLQHSIAEVASAATA
Mflv_3888|M.gilvum_PYR-GCK -------YATVMSIGGALAVSALAALAVS-VYVSRRLQRSVTEVACAAAL
MAB_3340|M.abscessus_ATCC_1997 -------DATAMSIGFAVAVSALAALTLS-WYLSHRVHRSATALSQAASA
MLBr_00774|M.leprae_Br4923 LKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAER
TH_2452|M.thermoresistible__bu GDAERAAADDAARLMLLVGAATLFGAIGAAWLVAGRILRPLRDVADTART
. * . : . *
MMAR_4941|M.marinum_M IASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAEKARSS
MUL_0464|M.ulcerans_Agy99 IASGQLDRRVPERDPRTEVGQLSLAMNGMLSQIQVALAASEDSAEKARSS
MAV_0703|M.avium_104 IAAGQLDRRVPERDPRTEVGRLSLALNGMLAQIQQALASSESSAEKARGS
MSMEG_5870|M.smegmatis_MC2_155 IAAGQLDRRVPERDPRTEVGRLSSALNGMLAQIQRAVAASEASAEQARSS
Mb0781|M.bovis_AF2122/97 IGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDS
Rv0758|M.tuberculosis_H37Rv IGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDS
Mvan_3675|M.vanbaalenii_PYR-1 VADGRYDIRVSPLRLGEDFANLSRAFN--------------RMSERLESV
Mflv_3888|M.gilvum_PYR-GCK VAEGRYDIRVSPPRLGDDFDALATAFN--------------QMASRLQSV
MAB_3340|M.abscessus_ATCC_1997 VADGNYDIRVPPPRLGKEFDAVAAAFN--------------KMAQRLGAV
MLBr_00774|M.leprae_Br4923 FAEGHLSERMPVRG-EDDMARLAVSFNDMAESLS-------RQITQLEEF
TH_2452|M.thermoresistible__bu ITDTDLSRRIPSRGEGDEMDSLVRTIN--------------GMLDRIEAG
. . *:. :. : ::* :
MMAR_4941|M.marinum_M EERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS---RIESE
MUL_0464|M.ulcerans_Agy99 EERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS---RIESE
MAV_0703|M.avium_104 EDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDVAMLLS---RIESE
MSMEG_5870|M.smegmatis_MC2_155 EDRMRRFITDASHELRTPLTTIRGFAELYRQGAARDIEMLMG---RIESE
Mb0781|M.bovis_AF2122/97 EDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLS---RIESE
Rv0758|M.tuberculosis_H37Rv EDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLS---RIESE
Mvan_3675|M.vanbaalenii_PYR-1 ETTRRQLFGDLAHEIRTPVSVLKAYIEAVEDGVKTLDPETVA---VLNDQ
Mflv_3888|M.gilvum_PYR-GCK ESTRRRLFGDLAHEIRTPVAVLDAYVEALEDGVRTLNPDTVA---VLRDQ
MAB_3340|M.abscessus_ATCC_1997 DEARRQMLADLAHEIRTPVAVLEAYMEAVEDGVQQLDQQTVA---TLRDQ
MLBr_00774|M.leprae_Br4923 GNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMVSE
TH_2452|M.thermoresistible__bu VSAQRRFIDDAGHELRTPITIVRGHLEVLDPDDPDDVRSTVA---LVDDE
*:: * .**:***:: : : : .:
MMAR_4941|M.marinum_M ASRMGLLVDDLLTLARLDVQR-PLERNRVDLLVLAADAVHDARAIDRKRA
MUL_0464|M.ulcerans_Agy99 ASRMGLLVDDLLTLARLDVQR-PLERNRVDLLVLAADAVHDARAIDRKRA
MAV_0703|M.avium_104 ASRMGLLVDDLLLLARLDVQR-PLEHHRVDLLALASDAVHDAQAMDPKRT
MSMEG_5870|M.smegmatis_MC2_155 SRRMGLLVEDLLLLARLDAQR-PLERRRVDLLALATDAVHDAQSIAPKRR
Mb0781|M.bovis_AF2122/97 ASRMGLLVDDLLLLARLDAHR-PLELCRVDLLALASDAAHDARAMDPKRR
Rv0758|M.tuberculosis_H37Rv ASRMGLLVDDLLLLARLDAHR-PLELCRVDLLALASDAAHDARAMDPKRR
Mvan_3675|M.vanbaalenii_PYR-1 ASRLVRFSDDFAALAQAEEGPGAVTPQWIDPRAAIVTTVSAAADRYAQKD
Mflv_3888|M.gilvum_PYR-GCK TGRLVRFSGDVAALAKAEESSVTMTYTEVDLDGLVRRAVAAARERYETKG
MAB_3340|M.abscessus_ATCC_1997 TRRLTRFSIDVNALSVAESRTTSIDARSVSPADLVTTAVAAFAPRYQTKG
MLBr_00774|M.leprae_Br4923 LDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAG
TH_2452|M.thermoresistible__bu LVRMNRMVTDLLLLARSEQPT-FLTPEPTDIGALTRAIFDKVVQLGDRD-
*: : *. :: : : .
MMAR_4941|M.marinum_M ITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVRVGTAG
MUL_0464|M.ulcerans_Agy99 ITVEVLEGPGTPEVLGDEPRLRQVLSNLVGNALQHTPDSADVTVRVGTAG
MAV_0703|M.avium_104 ITLEVLDGPGTPEVFGDEPRIRQVLGNLIANALQHTPESADVTVRVGTDG
MSMEG_5870|M.smegmatis_MC2_155 VKMEVFDGPGTPEVLGDEARLRQVIGNLVANAVQHTPETAGITVRVGTDG
Mb0781|M.bovis_AF2122/97 ITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEG
Rv0758|M.tuberculosis_H37Rv ITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEG
Mvan_3675|M.vanbaalenii_PYR-1 VALIFDAANPLPEVWVDPLRLAQVIGNLLDNALRHTPARGRVEVDAAAKP
Mflv_3888|M.gilvum_PYR-GCK VALQVMSARELPLLRADEQRLSQVLDNLLDNALRHTARGGRVEIHCHTEG
MAB_3340|M.abscessus_ATCC_1997 VILTSHADDGLPDVWADPERMGQVLSNLLDNALRHTGPGGQVTVTATATG
MLBr_00774|M.leprae_Br4923 IELLVDMPVDEVIAEVDARRVERILRNLIANAIDHS-EHKPVRIRMAADE
TH_2452|M.thermoresistible__bu ---YQLQSVAEVTAVLDAQRITQALIALADNACRYTRDGDWIAVGSGLYD
* *: : : * ** :: : :
MMAR_4941|M.marinum_M QNAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLSIVHSL
MUL_0464|M.ulcerans_Agy99 ENAVLEVADKGPGMPAEDAARVFERFYRTDSSRARASGGTGLGLSIVHSL
MAV_0703|M.avium_104 DDAVLEVADRGPGMNEQDASRVFERFYRTDSSRARASGGTGLGLSIVESL
MSMEG_5870|M.smegmatis_MC2_155 DNAVLEVCDEGPGMSQEDARRVFERFYRADTSRTRASGGTGLGLSIVDSL
Mb0781|M.bovis_AF2122/97 DDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSL
Rv0758|M.tuberculosis_H37Rv DDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSL
Mvan_3675|M.vanbaalenii_PYR-1 GEVIITVGDNGDGIAAEHLPHVFERFYRADVARDRSHGGAGIGLAIAKAL
Mflv_3888|M.gilvum_PYR-GCK ARVRIAVTDDGEGIAAEHLSSVFERFYRADAARDREHGGAGLGLAIAKAL
MAB_3340|M.abscessus_ATCC_1997 TGATIAVADTGDGVPAEHLDRLFDRFYRADAARDRQHGGAGIGLSIAKAL
MLBr_00774|M.leprae_Br4923 DTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIED
TH_2452|M.thermoresistible__bu GWLRFWVSDSGPGVSDADRDRIFERFARGSAGGQR-SDGAGLGLSIVRAI
. * * * *: . :*.** * . . * .*:*:**:*
MMAR_4941|M.marinum_M VKAHGGDVTLTT-APGEGCCFRVTLPRVSEAAVELTEPVS----------
MUL_0464|M.ulcerans_Agy99 VKAHGGDVTLTT-APGEGCCFRVTLPRVSEAAVELTEPVS----------
MAV_0703|M.avium_104 VRAHGGTVGVTT-APGQGCCFRVTLPRISDVPAVQAS-------------
MSMEG_5870|M.smegmatis_MC2_155 VYAHGGTVKVTT-ALGKGSRFTVSLPRIADLPARL---------------
Mb0781|M.bovis_AF2122/97 VAAHGGAVTVTT-ALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP------
Rv0758|M.tuberculosis_H37Rv VAAHGGAVTVTT-ALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP------
Mvan_3675|M.vanbaalenii_PYR-1 TEAHGGRITAASRGPGMGSTFTIELPARTDRP------------------
Mflv_3888|M.gilvum_PYR-GCK VEAHGGSVTAASDGAGTGATFTVELP--TTRP------------------
MAB_3340|M.abscessus_ATCC_1997 VEAHEGRIEAHSAGHAAGTTFTVSLPRPSDHPEKAPGQRPG---------
MLBr_00774|M.leprae_Br4923 ARLHQGRLEAWG-EPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQA
TH_2452|M.thermoresistible__bu AGAHGGHVDLDT-VVGRGSTFTITIPAVLEAPWPAS--------------
. * * : . * * : :*
MMAR_4941|M.marinum_M ----------------------
MUL_0464|M.ulcerans_Agy99 ----------------------
MAV_0703|M.avium_104 ----------------------
MSMEG_5870|M.smegmatis_MC2_155 ----------------------
Mb0781|M.bovis_AF2122/97 ----------------------
Rv0758|M.tuberculosis_H37Rv ----------------------
Mvan_3675|M.vanbaalenii_PYR-1 ----------------------
Mflv_3888|M.gilvum_PYR-GCK ----------------------
MAB_3340|M.abscessus_ATCC_1997 ----------------------
MLBr_00774|M.leprae_Br4923 STAGQQHGTQRQRLREHAERSR
TH_2452|M.thermoresistible__bu ----------------------