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MLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVL RLRALMESFWSDELDRLVADAAHYPPSQGDCAMPFEKAVVVPLDPTSTFALITQPDRLRRWMAVAARIEL RTGGAYRWTVTPGHSAAGTVIDVDPGKRVVFTWGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTA QQAARHAKGWNHFLDRLVVAGQRGDAGPDEWAAAPDPLDELSCAEATLAVLQHVLRGIGASDLTRQTPCT EYDVSQLADHLLRSLAIIGAAAGAQLAPRDVDAPLETQVADAAQAVMEAWRRRGLAGTVELNSNQVPATV PVGILCLEFLVHAWDFAIATGSQVIASEPVSEYVLAVAGKVITPATRNSAGFAAPAAVGSFAPVLDRLIA FTGRQPTAGHVSAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0576 | - | - | 100% (434) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY ARSR-FAMILY) |
| M. tuberculosis H37Rv | Rv3773c | - | 7e-44 | 47.40% (192) | hypothetical protein Rv3773c |
| M. tuberculosis H37Rv | Rv0738 | - | 1e-11 | 29.28% (181) | hypothetical protein Rv0738 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0591 | - | 0.0 | 99.77% (434) | ArsR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1118 | - | 4e-09 | 31.79% (173) | hypothetical protein Mflv_1118 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4446 | - | 9e-29 | 38.80% (183) | hypothetical protein MAB_4446 |
| M. marinum M | MMAR_0942 | - | 1e-145 | 74.07% (324) | transcriptional regulator |
| M. avium 104 | MAV_0248 | - | 3e-41 | 46.60% (191) | hypothetical protein MAV_0248 |
| M. smegmatis MC2 155 | MSMEG_6832 | - | 4e-34 | 40.00% (200) | hypothetical protein MSMEG_6832 |
| M. thermoresistible (build 8) | TH_0041 | - | 2e-09 | 36.26% (91) | transcriptional regulator, ArsR family protein |
| M. ulcerans Agy99 | MUL_0693 | - | 1e-145 | 73.48% (328) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5506 | - | 1e-11 | 41.77% (79) | regulatory protein, ArsR |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0576|M.tuberculosis_H37Rv MLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGMLAEAGL
Mb0591|M.bovis_AF2122/97 MLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGMLAEAGL
MMAR_0942|M.marinum_M --------------------------------------------------
MUL_0693|M.ulcerans_Agy99 --------------------------MNSPESLDSGYEPAPPGRPAET--
MAV_0248|M.avium_104 --------------------------------------------------
MSMEG_6832|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4446|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1118|M.gilvum_PYR-GCK --------------------------------------------------
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0576|M.tuberculosis_H37Rv VTARKQGRERYYRLDERGVLRLRALMESFWSDELDRLVADAAHYPPSQGD
Mb0591|M.bovis_AF2122/97 VTARKQGRERYYRLDERGVLRLRALMESFWSDELDRLVADAAHYPPSQGD
MMAR_0942|M.marinum_M --------------------------------------------------
MUL_0693|M.ulcerans_Agy99 ----------------------------------------------VSGE
MAV_0248|M.avium_104 --------------------------------------------------
MSMEG_6832|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4446|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1118|M.gilvum_PYR-GCK --------------------------------------------------
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0576|M.tuberculosis_H37Rv CAMPFEKAVVVPLDPTSTFALITQPDRLRRWMAVAARIELRTGGAYRWTV
Mb0591|M.bovis_AF2122/97 CAMPFEKAVVVPLDPTSTFALITQPDRLRRWMAVAARIELRTGGAYRWTV
MMAR_0942|M.marinum_M --MPLENAVVLPVNPAQSFALFTRPEGLRRWMAITARIEPYDAGVYRWTV
MUL_0693|M.ulcerans_Agy99 RAMPLENAVVLPVDPAQSFALFTRPEGLRRWMAITARIEPYDAGVYRWTV
MAV_0248|M.avium_104 --------------------------------------------------
MSMEG_6832|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4446|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1118|M.gilvum_PYR-GCK --------------------------------------------------
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0576|M.tuberculosis_H37Rv TPGHSAAGTVIDVDPGKRVVFTWGWEDHGDPPPGGSTVTITLTPVDGGTE
Mb0591|M.bovis_AF2122/97 TPGHSAAGTVIDVDPGKRVVFTWGWEDHGDPPPGGSTVTITLTPVDGGTE
MMAR_0942|M.marinum_M TPGHTAVGAVVEADPGRRLVLSWGWEGHGDPAPGESTVTVTLAPAPDGTE
MUL_0693|M.ulcerans_Agy99 TPGHTAVGAVVEADPGQRLVLSWGWEGHGDPAPGESTVTVTLAPAPDGTE
MAV_0248|M.avium_104 --------------------------------------------------
MSMEG_6832|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4446|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1118|M.gilvum_PYR-GCK --------------------------------------------------
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0576|M.tuberculosis_H37Rv VRLVHDGLTAQQAARHAKGWNHFLDRLVVAGQRGDAGPDEWAAAPDPLDE
Mb0591|M.bovis_AF2122/97 VRLVHDGLTAQQAARHAKGWNHFLDRLVVAGQHGDAGPDEWAAAPDPLDE
MMAR_0942|M.marinum_M IRLVHEGLTEQQAARHAEGWSHYLDRLVAAALQGDAGPDEWAAVPDPLDE
MUL_0693|M.ulcerans_Agy99 IRLVHEGLTEQQAARHAEGWSHYLDRLVAAALQGDAGPDEWGAVPGPLDE
MAV_0248|M.avium_104 -------------------------------MANMAPDLRPGPDSPPTDE
MSMEG_6832|M.smegmatis_MC2_155 --------------------------------MTYAGARASTPHWADMDE
MAB_4446|M.abscessus_ATCC_1997 ----------------------------------MTTALNP---------
Mflv_1118|M.gilvum_PYR-GCK --------------------------------------------------
TH_0041|M.thermoresistible__bu --------------------------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv0576|M.tuberculosis_H37Rv LSCAEATLAVLQHVLRGIGASDLTRQTPCTEYDVSQLADHLLRSLAIIGA
Mb0591|M.bovis_AF2122/97 LSCAEATLAVLQHVLRGIGASDLTRQTPCTEYDVSQLADHLLRSLAIIGA
MMAR_0942|M.marinum_M LSCAEATLAVVQHVLRALEPADLARQTPCSQYDVVQLADHLMRSLTIIGS
MUL_0693|M.ulcerans_Agy99 LSCAEATLAVVQHVLRALEPADLARQTPCSQYDVVQLADHLMRSLTIIGG
MAV_0248|M.avium_104 LDGAEAALRVMQQVLHPIAADDMPRPTPCAQFDVTRLTDHLLKSLEALGG
MSMEG_6832|M.smegmatis_MC2_155 LSSAQSALSALRPVLSAITPDDCGLPTPCAGFDVAALGEHLVGTVRMVGA
MAB_4446|M.abscessus_ATCC_1997 LETVANARAALHEVVSRLTEADNDKQTPNAKFTVAQLTDHLQNSIKLLGG
Mflv_1118|M.gilvum_PYR-GCK MIDMTAACAGTAGLLDRVRDDQLSGATPCSGMDLGALVAHIGGLALAFDA
TH_0041|M.thermoresistible__bu -----------VDVFEAIAEPNRR-----------ALLDALTEGERTAG-
Mvan_5506|M.vanbaalenii_PYR-1 -----MTTYQAADPWHAIADGTRR-----------SIMRRLATGPCAVG-
: : : .
Rv0576|M.tuberculosis_H37Rv AAGAQLAPR---------DVDAPLETQVADAAQAVMEAWRR-RGLAGTVE
Mb0591|M.bovis_AF2122/97 AAGAQLAPR---------DVDAPLETQVADAAQAVMEAWRR-RGLAGTVE
MMAR_0942|M.marinum_M AAGAQLPPR---------DLDAPLETQVADAGQAVLEAWRR-RGVDGTVE
MUL_0693|M.ulcerans_Agy99 AAGAQLPPR---------DLDAPLETQVADAGQAVLEAWRR-RGVDGTVE
MAV_0248|M.avium_104 MAGADFP--------DHADSADSVERRVIAVARPALDAWRQ-RGLDGTVS
MSMEG_6832|M.smegmatis_MC2_155 AADAGFVRF------EVVSHDDDIEARVAASTEAVIAVWQR-RGTAGEVV
MAB_4446|M.abscessus_ATCC_1997 AAGVDIA----------LTTEGSVADRLLPQSQAVVDAWQR-RGIDGTVT
Mflv_1118|M.gilvum_PYR-GCK AARKEFGPLTDTPPEMGDGVEDGWRESYPSRLASLASAWREPAAWEGMSR
TH_0041|M.thermoresistible__bu ------------------ELAATLPGLTQPTVSRHLRVLRE-VGLVEVRP
Mvan_5506|M.vanbaalenii_PYR-1 ------------------ELARDLP-ISRPAVSQHLKVLKS-AGLVSDRA
. : .
Rv0576|M.tuberculosis_H37Rv LNSNQVPATVPVGILCLEFLVHAWDFAIATGSQVIASEPVSEYVLAVAGK
Mb0591|M.bovis_AF2122/97 LNSNQVPATVPVGILCLEFLVHAWDFAIATGSQVIASEPVSEYVLAVAGK
MMAR_0942|M.marinum_M LNANQVPAAVPVGILCLELLVHAWDFAFATDRRVVVSDTVTEYVLTVAGK
MUL_0693|M.ulcerans_Agy99 LNANQVPAAVPVGILCLELLVHAWDFAFATDRRVVVSDTVTEYVLTVAGK
MAV_0248|M.avium_104 FGGGEMPARNACAILALELLVHAWDYARAVGRDARAPEPLAEYVLGLAHR
MSMEG_6832|M.smegmatis_MC2_155 FAGRVMPARLALGVLSVELVVHGWDFAQALHRPLGITAAHADFVLAMARH
MAB_4446|M.abscessus_ATCC_1997 LPIGEYPAEVAVRILGSEFLVHAWDYAVATGQEFEPMDALTDGVLESVRM
Mflv_1118|M.gilvum_PYR-GCK AGGVDFPADVGGLIALTEVVVHGWDVAVSAGLPYEVDGETLAAVHGHLAA
TH_0041|M.thermoresistible__bu DAQRRIYALRADGLIAIDTWIDRY-------------RRYWAGRLDALER
Mvan_5506|M.vanbaalenii_PYR-1 HGTRRVYQLNPEGLETLRAELD----------------RFWTQALVDFKD
: :.
Rv0576|M.tuberculosis_H37Rv VITPATRNSAGFAAPAAVGSFAPVLDRLIAFTGRQPT--AGHVSAT----
Mb0591|M.bovis_AF2122/97 VITPATRNSAGFAAPAAVGSFAPVLDRLIAFTGRQPT--AGHVSAT----
MMAR_0942|M.marinum_M VITPAARNSAGFAAPVAVGAFAPVLDRLIAFTGRRPVHPTGLTSPIRADP
MUL_0693|M.ulcerans_Agy99 VITPAARNSAGFAAPVAVGAFAPVLDRLIAFTGRRPVHPTGLTSPIRADP
MAV_0248|M.avium_104 VIRPEVRGQAGFDDPVEVPADADALTKLVAFTGRNPAR------------
MSMEG_6832|M.smegmatis_MC2_155 IITPASRETAGFDDPVSVAADAAALDRLVAYTGRTPRRWPSNMKSR----
MAB_4446|M.abscessus_ATCC_1997 IIQPERRDGDFFADEVPVPDDSPNLVKLIAFTGRNPGWSPAS--------
Mflv_1118|M.gilvum_PYR-GCK FTADGPVEG-LFDAPVPVPDDAPLLDRVIAMTGRDPSWSAA---------
TH_0041|M.thermoresistible__bu HLHETHRDETNREDR-----------------------------------
Mvan_5506|M.vanbaalenii_PYR-1 IVEQPTQEER----------------------------------------
Rv0576|M.tuberculosis_H37Rv --
Mb0591|M.bovis_AF2122/97 --
MMAR_0942|M.marinum_M GS
MUL_0693|M.ulcerans_Agy99 GS
MAV_0248|M.avium_104 --
MSMEG_6832|M.smegmatis_MC2_155 --
MAB_4446|M.abscessus_ATCC_1997 --
Mflv_1118|M.gilvum_PYR-GCK --
TH_0041|M.thermoresistible__bu --
Mvan_5506|M.vanbaalenii_PYR-1 --