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MSNLLVTPELVAAAAADLAGIGSAIGAANAAAGAPTMALLAAGADEVSAAVAAVFSSYAQQYQALSAAAA AFHDQFVRALAAGAGAYAGAEAANVEQQLLNAINAPTLALLGRPLIGNGADGAAGTGQAGGAGGLLYGNG GNGGSGAAGQAGGAGGAAGLIGHGGTGGAVTGVSTTGGPGGHGGDAGLYGFGGAGGAGGFGQSGAAGGAG GAGGWLYGDGGDGGAGDNGGNESGTGVSAVGGVGGAGGAGGLLFGNGGDGGVGGDGGDGSSTQDSGGDGG AGGAGGAGGWLLGNGGAGGAGGAASIKVATGGLGGDGGDAGLFGFGGDGGWGGRGVDARFGAAGGAAGAG GAGGWLYGDGGAGGVGGVGGAVFSLSSGDGGAGGAGGGGGWLFGNGGDGGAGGGGGGRFGSGSGAGGDGA VGGAGGAGAWFGNGGAGGVGGGGGRGTTAIGGDGGAGGAGGAGGWLYGDGGAGGAGGGGGRGGTGNDGGD GGDGGRGGDAQLLGNGGDGGAGGAGGPAGLALPPGPARPAGAAVPAVRCSAAPARPARTADPWLAPIFAR STLRHSHHLGGIAQTGAVADQQGQIAGLGRAGRQ
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0532 | PE_PGRS6 | - | 100% (594) | PE-PGRS FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv1396c | PE_PGRS25 | e-166 | 57.07% (594) | PE-PGRS family protein |
M. tuberculosis H37Rv | Rv2162c | PE_PGRS38 | e-160 | 59.93% (534) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0545 | PE_PGRS6a | 0.0 | 92.53% (562) | hypothetical protein Mb0545 |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-102 | 44.93% (552) | triple helix repeat-containing collagen |
M. leprae Br4923 | MLBr_01183 | - | 5e-12 | 39.08% (87) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 1e-40 | 37.14% (385) | hypothetical protein MAB_4284c |
M. marinum M | MMAR_2645 | - | 1e-155 | 53.81% (617) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 2e-22 | 43.37% (166) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 5e-73 | 37.90% (591) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-40 | 39.03% (351) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3292 | - | 1e-153 | 53.38% (607) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 5e-95 | 41.64% (634) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv0532|M.tuberculosis_H37Rv -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2645|M.marinum_M -------------------------------------------------- MUL_3292|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv0532|M.tuberculosis_H37Rv -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2645|M.marinum_M -------------------------------------------------- MUL_3292|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv0532|M.tuberculosis_H37Rv ---------------------------------------MSNLLVTP--- Mb0545|M.bovis_AF2122/97 ---------------------------------------MSNLLVTP--- MMAR_2645|M.marinum_M ---------------------------------------MSYLIAAP--- MUL_3292|M.ulcerans_Agy99 ---------------------------------------MSYVIAAP--- Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MLBr_01183|M.leprae_Br4923 ---------------------------------------MPLFLNAEP-- MAV_4827|M.avium_104 ---------------------------------------MNIVLGVSMAP Rv0532|M.tuberculosis_H37Rv ----------------------------------------ELVAAAAADL Mb0545|M.bovis_AF2122/97 ----------------------------------------ELVAAAAADL MMAR_2645|M.marinum_M ----------------------------------------EMVAAAATDL MUL_3292|M.ulcerans_Agy99 ----------------------------------------EMLAGAATDL Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------VEAASYVADP MLBr_01183|M.leprae_Br4923 ----------------------------------------QALTAAANTL MAV_4827|M.avium_104 ----------------------------------------SSIQMVVLEG Rv0532|M.tuberculosis_H37Rv AG---------------------------------------IGSAIGAAN Mb0545|M.bovis_AF2122/97 AG---------------------------------------IGSAIGAAN MMAR_2645|M.marinum_M AS---------------------------------------VGSSISAAN MUL_3292|M.ulcerans_Agy99 AG---------------------------------------IGAALQSAN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 EAA-------------------------------------LANAGLSAVS MLBr_01183|M.leprae_Br4923 EG---------------------------------------LSAATVASN MAV_4827|M.avium_104 EYAD--------------------------------------GATVEEDA Rv0532|M.tuberculosis_H37Rv AAAGAPTMALLAAGADEVSAAVAAVFSSYAQQYQALSAAAAAFHDQFVRA Mb0545|M.bovis_AF2122/97 AAAGAPTMALLAAGADEVSAAVAAVFSSYAQQYQALSAAAAAFHDQFVRA MMAR_2645|M.marinum_M AAAAAPTMSVLAAGADEVSAVVAALFDAHAQAYQSLSAQAALFHEQFVQA MUL_3292|M.ulcerans_Agy99 GAAAAPITGVLAAGADEISAAVAALFSGHALDYQALSTQMAGFHQQFVTA Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MAB_4284c|M.abscessus_ATCC_199 AAQVGAVMPVVAESVASNYGYQSQWVNTGN----PIHDLSGNLQNYYAAQ MLBr_01183|M.leprae_Br4923 AAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQS MAV_4827|M.avium_104 IDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAA Rv0532|M.tuberculosis_H37Rv LAAGAGAYAGAEAANVE------QQLLNAINAPTLALLGRPLIGN--GAD Mb0545|M.bovis_AF2122/97 LAAGAGAYAGAEAANVE------QQLLNAINAPTLALLGRPLIGN--GAD MMAR_2645|M.marinum_M LNAGAGSYALAEAASVSPL----QDALNLINAPTQALFGRPLIGN--GAD MUL_3292|M.ulcerans_Agy99 LNSAGASYAAAEAASANPLQAVEQQLLGVINAPTQALLGRPLIGD--GTA Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGA--TGA Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGA--TGA MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGT--GGG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGH--GGG MAB_4284c|M.abscessus_ATCC_199 PDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGN--VDS MLBr_01183|M.leprae_Br4923 LLTSSSAYAGTETANHDSL------------------------------- MAV_4827|M.avium_104 ALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTAT Rv0532|M.tuberculosis_H37Rv GAAGTGQAGGAGGLLYGNGGNGGSG-AAGQAGGAGGA------------- Mb0545|M.bovis_AF2122/97 GAAGTGQAGGAGGLLYGNGGNGGSG-AAGQAGGAGGA------------- MMAR_2645|M.marinum_M GAPGTGQSGGNGGFLYGNGGNGGSG-ANNQGGGNGGS------------- MUL_3292|M.ulcerans_Agy99 GAP--GQNGGDGGLLWGNGGAGGVGTAAHPTGGSGGS------------- Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------------- Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------------- MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN TH_3810|M.thermoresistible__bu TGIIS--------------------LLSLAGNGGNGG------------- MAB_4284c|M.abscessus_ATCC_199 FNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSG------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAG------------- Rv0532|M.tuberculosis_H37Rv -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2645|M.marinum_M -------------------------------------------------- MUL_3292|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG---- Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG---- MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv0532|M.tuberculosis_H37Rv ----------AGLIGHGGTG----------------------------GA Mb0545|M.bovis_AF2122/97 ----------AGLIGHGGTGGVGGTGAAGGAGGTGGWLFGNGGAGGTGGA MMAR_2645|M.marinum_M ----------AGLWGNGGAGG-------------------------AGGD MUL_3292|M.ulcerans_Agy99 ----------AGLIGTGGAGG------------------------AGYGP Mflv_5091|M.gilvum_PYR-GCK ---AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGG Mvan_1264|M.vanbaalenii_PYR-1 ---VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGT MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG TH_3810|M.thermoresistible__bu ----------NGYRTTDNNALDGGHGGNG-----------------GNVG MAB_4284c|M.abscessus_ATCC_199 ----------PIASGQGSTAVNGDVRDSN-----IINADHGSNVGVDQSQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------LEKLESLPGGLLLVGSG-------------------VDVAP Rv0532|M.tuberculosis_H37Rv VTGVSTTGGPGGHGGDAG----------------LYGFGGAGGAGG---- Mb0545|M.bovis_AF2122/97 VTGVSTTGGPGGHGGDAG----------------LYGFGGAGGAGG---- MMAR_2645|M.marinum_M STVAGVNGFNGGAGGSGGL---------------LWGNGGAGGAGGNGGG MUL_3292|M.ulcerans_Agy99 AAQTGATGGSGGVGGTGG--------------------SGLDGPDS---- Mflv_5091|M.gilvum_PYR-GCK LGETGTTG---GAGGVG--------------------GQGTAGGTGGVGG Mvan_1264|M.vanbaalenii_PYR-1 AGETGVTG---GVGGIG--------------------GQGTEGGTGGVGG MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIG---GNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGG TH_3810|M.thermoresistible__bu FFSLFNLG---GAGGWG--------------------GSGVDG------- MAB_4284c|M.abscessus_ATCC_199 TRVGGDYTNVSGHG-----------------------SADIDKSVTVVDD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 LKQVLQTTTFLDVSVAEEP-----------------ETALARGAALAAAN Rv0532|M.tuberculosis_H37Rv ----------------FGQSGAA--------------------------- Mb0545|M.bovis_AF2122/97 ----------------FGQSGAA--------------------------- MMAR_2645|M.marinum_M AP-------------LAGFVGTS--------------------------- MUL_3292|M.ulcerans_Agy99 -----------------GAAGGA--------------------------- Mflv_5091|M.gilvum_PYR-GCK IGGAG----------STGAVGG-------VGGKG----IQGGQG------ Mvan_1264|M.vanbaalenii_PYR-1 VGGVG----------ATGGAGG-------VGGKG----IQGGQG------ MSMEG_0868|M.smegmatis_MC2_155 MGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGK TH_3810|M.thermoresistible__bu ----------------VDVVGG---------------------------- MAB_4284c|M.abscessus_ATCC_199 HSQRN----------TTNINDS---------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AP-------------LFASSTAALAY------------------------ Rv0532|M.tuberculosis_H37Rv ------------GGAGGAG---GWLYG---------------------DG Mb0545|M.bovis_AF2122/97 ------------GGAGGAGGAGGWLYG---------------------DG MMAR_2645|M.marinum_M ------------GGNGGNGGGAGLLYG---------------------YG MUL_3292|M.ulcerans_Agy99 ------------GGSGGSGG-AARLFG---------------------NG Mflv_5091|M.gilvum_PYR-GCK -------LQGGKGGDGGAGGKGGDADSMGS------------------AG Mvan_1264|M.vanbaalenii_PYR-1 -------LQGGQGGDGGTGGTGGDATSMGE------------------AG MSMEG_0868|M.smegmatis_MC2_155 ASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAAS TH_3810|M.thermoresistible__bu ------------NPDGGTPG------------------------------ MAB_4284c|M.abscessus_ATCC_199 -------FNTDRSTNIGSGNTTNTEIGSHN------------------QA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------AQDPGTGAVDQYSLPDYLYVPVDPE-------PGDDEL Rv0532|M.tuberculosis_H37Rv GDGGAGDNGGNESGTGVS-------------------------------- Mb0545|M.bovis_AF2122/97 GDGGAGGNGGNESGTGVS-------------------------------- MMAR_2645|M.marinum_M GAGGAGGTGGVAPPTGVGQTIL---------------------------- MUL_3292|M.ulcerans_Agy99 GAGGSGGKGGNGGSAIET-------------------------------- Mflv_5091|M.gilvum_PYR-GCK ATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD------ Mvan_1264|M.vanbaalenii_PYR-1 ATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN------ MSMEG_0868|M.smegmatis_MC2_155 ANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAY TH_3810|M.thermoresistible__bu AHGESHTPGVYTDRQ----------------------------------- MAB_4284c|M.abscessus_ATCC_199 NIGTSTSAGGSAAVGGNAG------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AYSAVGEEDAESPTVVIEK------------------------------- Rv0532|M.tuberculosis_H37Rv -----------------AVGGVGGAGGAGGLLFGNGGDGG---------- Mb0545|M.bovis_AF2122/97 -----------------GVGGVGGAGGAGGLLFGNGGDGG---------- MMAR_2645|M.marinum_M --------------SAGGVGGTGGAGGGGAALIGFGGAGG---------- MUL_3292|M.ulcerans_Agy99 -----------------GNDGAAGAGGHGGWLVGNGGIGG---------- Mflv_5091|M.gilvum_PYR-GCK ----------------GGTGGAGGAGGTGG-TGGAGGTGG---------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------GGTGGNGGNGGTGG-TGGNGGTGG---------- MSMEG_0868|M.smegmatis_MC2_155 DPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQ TH_3810|M.thermoresistible__bu --------------------GEDGEDGTGTGIGGRGGNGG---------- MAB_4284c|M.abscessus_ATCC_199 ------------------LAGNAGLAGNAGLAGNAGLAGN---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------LFLPEDSEPRRRPVLLVGSGLAVV---------- Rv0532|M.tuberculosis_H37Rv -------VGGDGG-DGSSTQD-------SGGDGGAGGAG-----GAGGWL Mb0545|M.bovis_AF2122/97 -------VGGDGG-DGSSTQD-------SGGDGGAGGAG-----GAGGWL MMAR_2645|M.marinum_M -------TGGTGGLSDTTTET-------IGGYGGMGGLG-----GQSGVL MUL_3292|M.ulcerans_Agy99 -------DGGSGGVGGDAGAYGPPANGGAGGHGGMGGVG-----GDAGLL Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG---GTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG---GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 HSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSE--GEGGTGGH TH_3810|M.thermoresistible__bu ------SSSGTHPMAEDG--------EHVKALDGRPGLD-----GGNGSH MAB_4284c|M.abscessus_ATCC_199 -----AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------GISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPTEQAPAP Rv0532|M.tuberculosis_H37Rv LGNGGAGGAGGAASIK-VAT--------GGLGGDGGDAG---LFG---FG Mb0545|M.bovis_AF2122/97 LGNGGAGGAGGAASIK-VAT--------GGLGGDGGDAG---LFG---FG MMAR_2645|M.marinum_M FGTPGAGGAGGAGGAG-VGTF----ASPGGHGGSGGDAGAIGLFGNGAAG MUL_3292|M.ulcerans_Agy99 FGSGGAGGVGGNGAIGGTGVM----SGAGGAGGDGGNGGYAQLIG---DG Mflv_5091|M.gilvum_PYR-GCK GGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTG MSMEG_0868|M.smegmatis_MC2_155 GGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAG TH_3810|M.thermoresistible__bu GGNGGHGGRGGFLGIGGSG-------GWGGHGGNGGD-----------TD MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAG----NAGLAGNAGLAGNAG--------LAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPPPAAPPLPEAPPIP Rv0532|M.tuberculosis_H37Rv GDGGWGG------------RGVDARFGAAGG------------------- Mb0545|M.bovis_AF2122/97 GDGGWGG------------RGVDARFGAAGG------------------- MMAR_2645|M.marinum_M GDGGIGGD--------GASGGNDGGNGGVGG------------------- MUL_3292|M.ulcerans_Agy99 GGGGAGGAGY------SASGLPPAGIGAPGG------------------- Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEAL TH_3810|M.thermoresistible__bu ADGGNGGDG---------------GNGGSAG------------------- MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAG-------------LAGNAGLAG------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AAPPVVPVP---------VVVPPVPVPVPVR------------------- Rv0532|M.tuberculosis_H37Rv --------------AAGAGGAGGWLYGDGGAG------------------ Mb0545|M.bovis_AF2122/97 --------------AAGAGGAGGWLYGDGGAG------------------ MMAR_2645|M.marinum_M --------------LGGVGGPGGWIFGTGGAG------------------ MUL_3292|M.ulcerans_Agy99 --------------AGGAGGSGGWLVGNGGAG------------------ Mflv_5091|M.gilvum_PYR-GCK --------------TGGTGGQGG-LGGGGGTG------------------ Mvan_1264|M.vanbaalenii_PYR-1 --------------TGGTGGQGG-LGGVGGTG------------------ MSMEG_0868|M.smegmatis_MC2_155 IRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQAS TH_3810|M.thermoresistible__bu --------------RGGTGGLRGVFGINGGNG------------------ MAB_4284c|M.abscessus_ATCC_199 --------------NAAVAGNAAVAGNAAVAG------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------IPVPDPVSPPQLLAPPRLSVP----------------- Rv0532|M.tuberculosis_H37Rv -----GVGGVGGAVFS--LSSGDGGAGGAG--------GGGG--WLFGNG Mb0545|M.bovis_AF2122/97 -----GVGGVGGAVFS--LSSGDGGAGGAG--------GGGG--WLFGNG MMAR_2645|M.marinum_M -----GNGGLGGSGGTGVVTNGFAGSGGFG--------GAGGDAQFLGFG MUL_3292|M.ulcerans_Agy99 -----GIGGIGASGSFG-APSGQGGNGGIG--------GAAG---LFGQG Mflv_5091|M.gilvum_PYR-GCK -----GQGGTGGTGGQG-GTGGTGGTGGTG--------GTGGAGGDGGLG Mvan_1264|M.vanbaalenii_PYR-1 -----GTGGTGGTGGQG-GTGGTGGTGGTG--------GTGGAGGDGGLG MSMEG_0868|M.smegmatis_MC2_155 GTATDGHGGSGINGGHG-GNGGQGTIEANGPSAVASGIGAGGNGGDGIDG TH_3810|M.thermoresistible__bu ------RAGLGGRGXXX-XGGGVGAAVRSG---------------NGVFS MAB_4284c|M.abscessus_ATCC_199 ------NAAVGGVLNTG-VSGAIGGSSHVG---------GAINESLGGSG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----QPVQPPVRVPQPPSPPQVGGTVPQS------------PPQHQTPP Rv0532|M.tuberculosis_H37Rv GDGGAGG--GGGGRFGSGSGAGGDGAVGGAGG------------------ Mb0545|M.bovis_AF2122/97 GDGGAGG--GGGGRFGSGSGAGGDGAVGGAGG------------------ MMAR_2645|M.marinum_M GTGGSGGGIGAGETAAVPLTTQPVGGTGGNGGR----------------- MUL_3292|M.ulcerans_Agy99 GAGGNGGQ-GGGDDFALSGGAGGAGGAGGHGG------------------ Mflv_5091|M.gilvum_PYR-GCK GLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG---- Mvan_1264|M.vanbaalenii_PYR-1 GLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG---- MSMEG_0868|M.smegmatis_MC2_155 GLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWV TH_3810|M.thermoresistible__bu GGGGTPSAGFGVPTTIQFPAGSCTSRAVSREG------------------ MAB_4284c|M.abscessus_ATCC_199 SVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGG------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GEGTPPKPDGPGNYGGGHVPTPGAGGSGGSGGG----------------- Rv0532|M.tuberculosis_H37Rv ---AGAWFGNGGAGGVG------------GGGGR--------------GT Mb0545|M.bovis_AF2122/97 ---AGAWFGNGGAGGVG------------GGGGR--------------GT MMAR_2645|M.marinum_M ---AGLFFGVGGTGGNGGATSTNGALYATGGNGG--------------DG MUL_3292|M.ulcerans_Agy99 -----QLYGDGGGGGAG------------GMGGSV----------DIAES Mflv_5091|M.gilvum_PYR-GCK GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGA Mvan_1264|M.vanbaalenii_PYR-1 GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGA MSMEG_0868|M.smegmatis_MC2_155 QSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGN TH_3810|M.thermoresistible__bu ------IMPSSRAASARAG---------------------------AACA MAB_4284c|M.abscessus_ATCC_199 --GISESLGGSGSVGGSTAVGGGAHTGVGGGVS----------TGVGVGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---HVPTPGAGGSGGSGG------------------------------GH Rv0532|M.tuberculosis_H37Rv TAIGGDGGAGGAGGAGG-------------WLYGDGGAGGAG-----GGG Mb0545|M.bovis_AF2122/97 TAIGGDGGAGGAGGAGG-------------WLYGDGGAGGAG-----GGG MMAR_2645|M.marinum_M GLIFGNGGTGGNGGAGGG------------TSVGAGGQGGAAS-AFFGNG MUL_3292|M.ulcerans_Agy99 GVTGGRGGSGSVGGGAG--------------LWGAGGQGGDGAQGGDGGA Mflv_5091|M.gilvum_PYR-GCK AGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANG Mvan_1264|M.vanbaalenii_PYR-1 SGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANG MSMEG_0868|M.smegmatis_MC2_155 TATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNG TH_3810|M.thermoresistible__bu SSTSRSRRSFCCSRA----------------------------------- MAB_4284c|M.abscessus_ATCC_199 HVGGGISESLGGSGSVGGSTAVG---------GGAHTGVGGGVNTGVGVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPTPGTGGPGGTGGSGG----------------GHVPTPGAGTPGGSGGG Rv0532|M.tuberculosis_H37Rv GRGGTGNDGGDGGDGGRGGD-AQLLGNGGDGGAG-------GAGGPAGLA Mb0545|M.bovis_AF2122/97 GRGGTGNDGGDGGDGGRGGD-AQLLGNGGDGGAG-------GAGGPAGFG MMAR_2645|M.marinum_M GAGGDGGAGGQGAGGAGGSG-ALFFGNGGAGGNG-------APGG-TGVG MUL_3292|M.ulcerans_Agy99 GVDTTTGAGGDGGAGAGGGTSGFLYGNGGAGGAGGHGGGGPGMGGDGGDG Mflv_5091|M.gilvum_PYR-GCK SQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAG Mvan_1264|M.vanbaalenii_PYR-1 SQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 GKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SHVGGGISESLGGSGSVG-------GSTAVGGGAHTSAINDALGGSGSVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 HLPFPGAGSTPGGSGGGHLP------TPGAGTPG---------GGLGGFG Rv0532|M.tuberculosis_H37Rv L-----------PPGPARPAGAAVPAVRCSAAPARPARTADPWLAPIFAR Mb0545|M.bovis_AF2122/97 A-----------SPG----AGAAG-------------------------- MMAR_2645|M.marinum_M G-----------TGGSAVLIGNGGD------------------------- MUL_3292|M.ulcerans_Agy99 G-----------DGGRAQLIGTGGNG------------------------ Mflv_5091|M.gilvum_PYR-GCK G-----------AGGEGGEGGDGGKGGAGAE--------GGAGG------ Mvan_1264|M.vanbaalenii_PYR-1 G-----------AGGEGGEGGAGGAGGDGSE--------GGAGG------ MSMEG_0868|M.smegmatis_MC2_155 GNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGG------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G----------STAVGGGAHTSAINESMNSSINASHSSSMNESF------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 G-----------GHAPAPGGGLGGGG------------------------ Rv0532|M.tuberculosis_H37Rv STLRHSHHLGGIAQTG---AVADQQGQ----IAGLGRAGRQ----- Mb0545|M.bovis_AF2122/97 ---------GGGGAGG---SLFGSPGT----TGPHG---------- MMAR_2645|M.marinum_M ---------GGDGTGG---AAGGAGGSGGFIFGQNGSNGLP----- MUL_3292|M.ulcerans_Agy99 -------GAGGTAAPGGTDGTAGAAGKGGVLFGTDGATG------- Mflv_5091|M.gilvum_PYR-GCK -----GGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 -----SGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 -----NGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ---------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----GSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH--- MLBr_01183|M.leprae_Br4923 ---------------------------------------------- MAV_4827|M.avium_104 ---------GHAPAPGGGLGGFGGGHSGGGLGGLGGGHK-------