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MWDPDVYLNFADHRGRPFFDLLARVGADRPHRVVDLGCGPGNLTEVLGRRWPDAQVQGWDSSPEMVAAAR GRGVDARLGDIADWVPEPDTDVVIANAALQWVPEHRDLLVRWAGQLEPGSWIAFQVAGNFDAPSHAAIRE VARREPFTAALADMPWRDADVVGAPVEYAGLLTDAGCTVDAWETTYVHELVGETPVLDWITGTALTQVRQ RLSDDAWERYRQAIIPLLAQAYPVRSDGRTFFSFRRVFVVAQVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0425 | - | - | 100% (254) | trans-aconitate 2-methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4027 | - | 5e-07 | 29.63% (108) | methyltransferase type 12 |
| M. vanbaalenii PYR-1 | Mvan_1774 | - | 8e-07 | 32.89% (149) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 1e-100 | 63.64% (253) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_0316 | - | 2e-98 | 65.22% (253) | trans-aconitate 2-methyltransferase |
| M. tuberculosis H37Rv | Rv0294 | tam | 1e-100 | 63.64% (253) | trans-aconitate methyltransferase tam |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2845 | - | 2e-59 | 49.80% (253) | trans-aconitate methyltransferase |
| M. marinum M | MMAR_0553 | tam | 1e-104 | 66.40% (253) | trans-aconitate methyltransferase Tam |
| M. avium 104 | MAV_4859 | - | 1e-105 | 67.19% (253) | trans-aconitate 2-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0629 | - | 1e-114 | 75.49% (253) | trans-aconitate 2-methyltransferase |
| M. thermoresistible (build 8) | TH_3050 | - | 2e-05 | 25.27% (186) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_1216 | tam | 1e-101 | 64.82% (253) | trans-aconitate methyltransferase Tam |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0425|M.vanbaalenii_PYR-1 -------MWDPDVYLNFADHRGRPFFDLLARVGADRPHRVVDLGCGPGNL
MSMEG_0629|M.smegmatis_MC2_155 -------MWNPETYLNFADHRGRPFFELLARIGARTPRRVVDLGCGPGNL
Mb0302|M.bovis_AF2122/97 -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHL
Rv0294|M.tuberculosis_H37Rv -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHL
MMAR_0553|M.marinum_M -------MWDPDVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNL
MUL_1216|M.ulcerans_Agy99 -------MWDPAVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNL
MAV_4859|M.avium_104 -------MWDPDVYLAFADHRARPFYDLLSRVGAERARRVVDLGCGPGHL
Mflv_0316|M.gilvum_PYR-GCK -------MWNPAVYLTYADHRGRPYYDLLSRVDAREPRRIVDLGCGPGNL
MAB_2845|M.abscessus_ATCC_1997 MTRTPKTQWSPQEYSRFGDERSRPFFELLARVQAVDPRTVVDLGCASGVL
TH_3050|M.thermoresistible__bu -------------VTGRRRHLDRAAVPAAFDAGAASYDRLVAANPGYHEH
. *. :* . .
Mvan_0425|M.vanbaalenii_PYR-1 TEVLGRRWPDAQVQGWDSSPEMVAAARG---RGVDARLGDIADWVPEPDT
MSMEG_0629|M.smegmatis_MC2_155 TETLTQRWPGAQVEALDSSPEMVAAARE---RGVDARVGAIEDWQPTPDT
Mb0302|M.bovis_AF2122/97 TRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPKPDT
Rv0294|M.tuberculosis_H37Rv TRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPKPDT
MMAR_0553|M.marinum_M TRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPKPDT
MUL_1216|M.ulcerans_Agy99 TRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPKPDT
MAV_4859|M.avium_104 TKYLGRRWPDAVIEAMDSSPEMVAAAKE---RGIDAVTGDLRNWKPKPDT
Mflv_0316|M.gilvum_PYR-GCK TRTLTQRWPGAVVEAWDSSEEMVTAARE---RGVDARVGDVRDWAPLPDT
MAB_2845|M.abscessus_ATCC_1997 TLELARRWPNASVLGLDSSAELLATAPADLPANVRLEQGDIADFRADG-V
TH_3050|M.thermoresistible__bu LRLSAHRMGLPGCAARXRGLRILDAGCG-----TGASTAALLTYAPDAEI
:* . . . .:: :. . : : .
Mvan_0425|M.vanbaalenii_PYR-1 DVVIANAALQWVPEHR--DLLVRWAGQLEPGSWIAFQVAGNFDAP-SHAA
MSMEG_0629|M.smegmatis_MC2_155 DVVISNAALQWVPSHR--ELIVAWVQSLPAGAWLAFQVPGNFDSP-SHRA
Mb0302|M.bovis_AF2122/97 DVVVSNAALHWVPEHS--DLLVRWVDELAPGSWIAVQIPGNFETP-SHAA
Rv0294|M.tuberculosis_H37Rv DVVVSNAALHWVPEHS--DLLVRWVDELAPGSWIAVQIPGNFETP-SHAA
MMAR_0553|M.marinum_M DVVISSAALHWVPEHA--DLMVQWATELPHGSWIAVQVPGNFETP-SHAV
MUL_1216|M.ulcerans_Agy99 DVVISSAALHWVPEHA--DLMVQWATVLPHGSWIAVQVPGNFETP-SHAV
MAV_4859|M.avium_104 DVVVSNAALHWVPEHS--DLLLRWAGQLAPGSWIGVQMPGNFESP-SYAA
Mflv_0316|M.gilvum_PYR-GCK DVVVSNATLHWVPEHP--DLLLRWAGQLRAGSWIAFQVPGNFDAP-SHRA
MAB_2845|M.abscessus_ATCC_1997 DVVFTNAALQWLPQHR--DLISAWAHQLNPGGWLALQVPGNFGAP-SHAL
TH_3050|M.thermoresistible__bu VAVDASAGMLAAAAAKPWPATVRFVHSR-VEDLAGAGVGGPFDAVFAAYL
.* :.* : . :. . : * * : :
Mvan_0425|M.vanbaalenii_PYR-1 IREVARREPFTAALADMPWRDADVVGAPVEYAGLLTDAGCTVDAWETTYV
MSMEG_0629|M.smegmatis_MC2_155 VRTVARSEAFADALRDMPWRDAHQVDDPLDYAGLLTDAGCTVDAWETTYV
Mb0302|M.bovis_AF2122/97 VRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYL
Rv0294|M.tuberculosis_H37Rv VRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYL
MMAR_0553|M.marinum_M VRALARREPYAKLMRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWETTYL
MUL_1216|M.ulcerans_Agy99 VRALARREPYAKLVRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWDPTYL
MAV_4859|M.avium_104 VRALARREPYAKLLRDIPFRVGAVVQPPTHYANMLLDAGCKVDVWETTYL
Mflv_0316|M.gilvum_PYR-GCK VRDLVSSARWAHLLRDFPFEKSEVVRPAAGYAELLTDAGCTVDAWETTYV
MAB_2845|M.abscessus_ATCC_1997 MRQVAESPRWAARLAGV-LRGTDSTDGAEDYARLAISSGLVPDAWETTYV
TH_3050|M.thermoresistible__bu LRNLPDPDTQLTAFRDLLRPGG--ILAVHEYS--VRDSAVATAVWNVVCG
:* : . .. *: .:. .*: .
Mvan_0425|M.vanbaalenii_PYR-1 HELVGETPVLDWITGTALTQVRQRLSDDAWERYRQAIIPLLAQAYPVRSD
MSMEG_0629|M.smegmatis_MC2_155 HELTGETPVLDWITGTALTQVRSRLDDTAWQRYREAIIPLLAEAYPRRPD
Mb0302|M.bovis_AF2122/97 HQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRAD
Rv0294|M.tuberculosis_H37Rv HQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRAD
MMAR_0553|M.marinum_M HQLTGKNPVLEWITGTALVPVRERLDDVSWEQFRQELIPLLDDAYPPRSD
MUL_1216|M.ulcerans_Agy99 HQLTGKNPVLEWITGTALVPVRERFDDVSWEQFRQELIPLLDDAYPPRSD
MAV_4859|M.avium_104 HQLTGEHPVLEWITGTALVPVRERLDDDAWEQFREELIPLLRDAYPPRAD
Mflv_0316|M.gilvum_PYR-GCK HELTGEKPVLEWIGGTALRPVRAALPDHDWQEFRAELIPLLDAAYPRRAD
MAB_2845|M.abscessus_ATCC_1997 HLLGGDDPVLRWVHGTGLRPVISALTADEFAEFESEYGALLRRAYP-RSG
TH_3050|M.thermoresistible__bu AVVI---PLGRLRTGDAALYRYLRRSVNTFDG-AERFRNRLRACGFTDVR
: *: * . : * .
Mvan_0425|M.vanbaalenii_PYR-1 GRTFFSFRRVFVVAQVT---------
MSMEG_0629|M.smegmatis_MC2_155 GITFFPFRRVFVVAQIR---------
Mb0302|M.bovis_AF2122/97 GSTIFPFRRLFMVAEVGGARRSGG--
Rv0294|M.tuberculosis_H37Rv GSTIFPFRRLFMVAEVGGARRSGG--
MMAR_0553|M.marinum_M GTTMFPFRRLFIVAEVGGARRSADVS
MUL_1216|M.ulcerans_Agy99 GTTMFPFRRLFIVAEVGGARRSADVS
MAV_4859|M.avium_104 GTTIFPFRRVFIVAEVGSGRPAA---
Mflv_0316|M.gilvum_PYR-GCK GITFFPFRRIFVVARVKN--------
MAB_2845|M.abscessus_ATCC_1997 DITPFGFRRIFCVASKPDGAR-----
TH_3050|M.thermoresistible__bu SATMPGWQRDIVHTFLARRPG-----
. * ::* : :