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VWNPETYLNFADHRGRPFFELLARIGARTPRRVVDLGCGPGNLTETLTQRWPGAQVEALDSSPEMVAAAR ERGVDARVGAIEDWQPTPDTDVVISNAALQWVPSHRELIVAWVQSLPAGAWLAFQVPGNFDSPSHRAVRT VARSEAFADALRDMPWRDAHQVDDPLDYAGLLTDAGCTVDAWETTYVHELTGETPVLDWITGTALTQVRS RLDDTAWQRYREAIIPLLAEAYPRRPDGITFFPFRRVFVVAQIR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0629 | - | - | 100% (254) | trans-aconitate 2-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_6572 | - | 8e-05 | 38.03% (71) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 1e-96 | 61.26% (253) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_0316 | - | 1e-103 | 67.32% (254) | trans-aconitate 2-methyltransferase |
| M. tuberculosis H37Rv | Rv0294 | tam | 1e-96 | 61.26% (253) | trans-aconitate methyltransferase tam |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2845 | - | 2e-57 | 49.01% (253) | trans-aconitate methyltransferase |
| M. marinum M | MMAR_0553 | tam | 2e-99 | 62.85% (253) | trans-aconitate methyltransferase Tam |
| M. avium 104 | MAV_4859 | - | 2e-97 | 61.66% (253) | trans-aconitate 2-methyltransferase |
| M. thermoresistible (build 8) | TH_2937 | - | 5e-05 | 27.04% (196) | PUTATIVE Methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_1216 | tam | 3e-97 | 61.66% (253) | trans-aconitate methyltransferase Tam |
| M. vanbaalenii PYR-1 | Mvan_0425 | - | 1e-114 | 75.49% (253) | trans-aconitate 2-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0302|M.bovis_AF2122/97 -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARR---VVDLGCGP
Rv0294|M.tuberculosis_H37Rv -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARR---VVDLGCGP
MMAR_0553|M.marinum_M -------MWDPDVYLAFADHRGRPFYDLVSRIGAKRARR---VVDLGCGP
MUL_1216|M.ulcerans_Agy99 -------MWDPAVYLAFADHRGRPFYDLVSRIGAKRARR---VVDLGCGP
MAV_4859|M.avium_104 -------MWDPDVYLAFADHRARPFYDLLSRVGAERARR---VVDLGCGP
Mflv_0316|M.gilvum_PYR-GCK -------MWNPAVYLTYADHRGRPYYDLLSRVDAREPRR---IVDLGCGP
MSMEG_0629|M.smegmatis_MC2_155 -------MWNPETYLNFADHRGRPFFELLARIGARTPRR---VVDLGCGP
Mvan_0425|M.vanbaalenii_PYR-1 -------MWDPDVYLNFADHRGRPFFDLLARVGADRPHR---VVDLGCGP
MAB_2845|M.abscessus_ATCC_1997 MTRTPKTQWSPQEYSRFGDERSRPFFELLARVQAVDPRT---VVDLGCAS
TH_2937|M.thermoresistible__bu ----VTTNWAAGRYEAVGERIAPIADEVLDAAARRTPLRGATLVDLACGT
* . * . . ::: . :***.*..
Mb0302|M.bovis_AF2122/97 GHLTRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPK
Rv0294|M.tuberculosis_H37Rv GHLTRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPK
MMAR_0553|M.marinum_M GNLTRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPK
MUL_1216|M.ulcerans_Agy99 GNLTRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPK
MAV_4859|M.avium_104 GHLTKYLGRRWPDAVIEAMDSSPEMVAAAKE---RGIDAVTGDLRNWKPK
Mflv_0316|M.gilvum_PYR-GCK GNLTRTLTQRWPGAVVEAWDSSEEMVTAARE---RGVDARVGDVRDWAPL
MSMEG_0629|M.smegmatis_MC2_155 GNLTETLTQRWPGAQVEALDSSPEMVAAARE---RGVDARVGAIEDWQPT
Mvan_0425|M.vanbaalenii_PYR-1 GNLTEVLGRRWPDAQVQGWDSSPEMVAAARG---RGVDARLGDIADWVPE
MAB_2845|M.abscessus_ATCC_1997 GVLTLELARRWPNASVLGLDSSAELLATAPADLPANVRLEQGDIADFRAD
TH_2937|M.thermoresistible__bu G--SAALSATARGAAVTGVDITSELIALAAG-------KPGGSTVTWVTA
* : * * : . * : :::: * * : .
Mb0302|M.bovis_AF2122/97 PDTDVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAA
Rv0294|M.tuberculosis_H37Rv PDTDVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAA
MMAR_0553|M.marinum_M PDTDVVISSAALHWVPEHADLMVQWATELPHGSWIAVQVPGNFETPSHAV
MUL_1216|M.ulcerans_Agy99 PDTDVVISSAALHWVPEHADLMVQWATVLPHGSWIAVQVPGNFETPSHAV
MAV_4859|M.avium_104 PDTDVVVSNAALHWVPEHSDLLLRWAGQLAPGSWIGVQMPGNFESPSYAA
Mflv_0316|M.gilvum_PYR-GCK PDTDVVVSNATLHWVPEHPDLLLRWAGQLRAGSWIAFQVPGNFDAPSHRA
MSMEG_0629|M.smegmatis_MC2_155 PDTDVVISNAALQWVPSHRELIVAWVQSLPAGAWLAFQVPGNFDSPSHRA
Mvan_0425|M.vanbaalenii_PYR-1 PDTDVVIANAALQWVPEHRDLLVRWAGQLEPGSWIAFQVAGNFDAPSHAA
MAB_2845|M.abscessus_ATCC_1997 G-VDVVFTNAALQWLPQHRDLISAWAHQLNPGGWLALQVPGNFGAPSHAL
TH_2937|M.thermoresistible__bu DAADTGLKTASFDVAVSNMGIIFVPPDRQVAELARLLKPGGVLSFSAWIR
.*. . .*::. .: :: .: * : .:
Mb0302|M.bovis_AF2122/97 VRALARREPYAKLMRDIPFRVGA-VVQSPAYYAELLMDTGCKVDVWETTY
Rv0294|M.tuberculosis_H37Rv VRALARREPYAKLMRDIPFRVGA-VVQSPAYYAELLMDTGCKVDVWETTY
MMAR_0553|M.marinum_M VRALARREPYAKLMRDIPFRVGA-VVGSPASYAGLLMDAGCKVDAWETTY
MUL_1216|M.ulcerans_Agy99 VRALARREPYAKLVRDIPFRVGA-VVGSPASYAGLLMDAGCKVDAWDPTY
MAV_4859|M.avium_104 VRALARREPYAKLLRDIPFRVGA-VVQPPTHYANMLLDAGCKVDVWETTY
Mflv_0316|M.gilvum_PYR-GCK VRDLVSSARWAHLLRDFPFEKSE-VVRPAAGYAELLTDAGCTVDAWETTY
MSMEG_0629|M.smegmatis_MC2_155 VRTVARSEAFADALRDMPWRDAH-QVDDPLDYAGLLTDAGCTVDAWETTY
Mvan_0425|M.vanbaalenii_PYR-1 IREVARREPFTAALADMPWRDAD-VVGAPVEYAGLLTDAGCTVDAWETTY
MAB_2845|M.abscessus_ATCC_1997 MRQVAESPRWAARLAGV-LRGTD-STDGAEDYARLAISSGLVPDAWETTY
TH_2937|M.thermoresistible__bu TDENPFSDPVAEVLGPPPAGFSPDQWGDAETLTERLTPHFDAIDLIRGLH
: : . : * :
Mb0302|M.bovis_AF2122/97 LHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRA
Rv0294|M.tuberculosis_H37Rv LHQLTGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRA
MMAR_0553|M.marinum_M LHQLTGKNPVLEWITGTALVPVRERLDDVSWEQFRQELIPLLDDAYPPRS
MUL_1216|M.ulcerans_Agy99 LHQLTGKNPVLEWITGTALVPVRERFDDVSWEQFRQELIPLLDDAYPPRS
MAV_4859|M.avium_104 LHQLTGEHPVLEWITGTALVPVRERLDDDAWEQFREELIPLLRDAYPPRA
Mflv_0316|M.gilvum_PYR-GCK VHELTGEKPVLEWIGGTALRPVRAALPDHDWQEFRAELIPLLDAAYPRRA
MSMEG_0629|M.smegmatis_MC2_155 VHELTGETPVLDWITGTALTQVRSRLDDTAWQRYREAIIPLLAEAYPRRP
Mvan_0425|M.vanbaalenii_PYR-1 VHELVGETPVLDWITGTALTQVRQRLSDDAWERYRQAIIPLLAQAYPVRS
MAB_2845|M.abscessus_ATCC_1997 VHLLGGDDPVLRWVHGTGLRPVISALTADEFAEFESEYGALLRRAYP-RS
TH_2937|M.thermoresistible__bu PWEFDSPATALHFLR--TESPVHVEIFRRAGPARRERLAAAFRSALRPHA
: . ..* :: * : . . : * :.
Mb0302|M.bovis_AF2122/97 DGSTIFPFRRLFMVAEVGGARRSGG--
Rv0294|M.tuberculosis_H37Rv DGSTIFPFRRLFMVAEVGGARRSGG--
MMAR_0553|M.marinum_M DGTTMFPFRRLFIVAEVGGARRSADVS
MUL_1216|M.ulcerans_Agy99 DGTTMFPFRRLFIVAEVGGARRSADVS
MAV_4859|M.avium_104 DGTTIFPFRRVFIVAEVGSGRPAA---
Mflv_0316|M.gilvum_PYR-GCK DGITFFPFRRIFVVARVKN--------
MSMEG_0629|M.smegmatis_MC2_155 DGITFFPFRRVFVVAQIR---------
Mvan_0425|M.vanbaalenii_PYR-1 DGRTFFSFRRVFVVAQVT---------
MAB_2845|M.abscessus_ATCC_1997 GDITPFGFRRIFCVASKPDGAR-----
TH_2937|M.thermoresistible__bu GPAGTVGFTAPYVIVTARRRG------
. . * : :.