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MWDPAVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNLTRYLARRWPEAIIEAWDSSPQMVAAAR ERGIDATTGDLRTWKPKPDTDVVISSAALHWVPEHADLMVQWATVLPHGSWIAVQVPGNFETPSHAVVRA LARREPYAKLVRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWDPTYLHQLTGKNPVLEWITGTALVPVRE RFDDVSWEQFRQELIPLLDDAYPPRSDGTTMFPFRRLFIVAEVGGARRSADVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1216 | tam | - | 100% (263) | trans-aconitate methyltransferase Tam |
| M. ulcerans Agy99 | MUL_2739 | - | 5e-06 | 31.25% (96) | methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 1e-128 | 81.47% (259) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_0316 | - | 1e-100 | 64.82% (253) | trans-aconitate 2-methyltransferase |
| M. tuberculosis H37Rv | Rv0294 | tam | 1e-128 | 81.47% (259) | trans-aconitate methyltransferase tam |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2845 | - | 2e-48 | 41.54% (260) | trans-aconitate methyltransferase |
| M. marinum M | MMAR_0553 | tam | 1e-153 | 97.72% (263) | trans-aconitate methyltransferase Tam |
| M. avium 104 | MAV_4859 | - | 1e-126 | 78.85% (260) | trans-aconitate 2-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0629 | - | 4e-97 | 61.66% (253) | trans-aconitate 2-methyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0425 | - | 1e-101 | 64.82% (253) | trans-aconitate 2-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1216|M.ulcerans_Agy99 -------MWDPAVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNL
MMAR_0553|M.marinum_M -------MWDPDVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNL
Mb0302|M.bovis_AF2122/97 -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHL
Rv0294|M.tuberculosis_H37Rv -------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHL
MAV_4859|M.avium_104 -------MWDPDVYLAFADHRARPFYDLLSRVGAERARRVVDLGCGPGHL
Mflv_0316|M.gilvum_PYR-GCK -------MWNPAVYLTYADHRGRPYYDLLSRVDAREPRRIVDLGCGPGNL
MSMEG_0629|M.smegmatis_MC2_155 -------MWNPETYLNFADHRGRPFFELLARIGARTPRRVVDLGCGPGNL
Mvan_0425|M.vanbaalenii_PYR-1 -------MWDPDVYLNFADHRGRPFFDLLARVGADRPHRVVDLGCGPGNL
MAB_2845|M.abscessus_ATCC_1997 MTRTPKTQWSPQEYSRFGDERSRPFFELLARVQAVDPRTVVDLGCASGVL
*.* * :...* **:::*::*: .: :*****..* *
MUL_1216|M.ulcerans_Agy99 TRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPKPDT
MMAR_0553|M.marinum_M TRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKPKPDT
Mb0302|M.bovis_AF2122/97 TRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPKPDT
Rv0294|M.tuberculosis_H37Rv TRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKPKPDT
MAV_4859|M.avium_104 TKYLGRRWPDAVIEAMDSSPEMVAAAKE---RGIDAVTGDLRNWKPKPDT
Mflv_0316|M.gilvum_PYR-GCK TRTLTQRWPGAVVEAWDSSEEMVTAARE---RGVDARVGDVRDWAPLPDT
MSMEG_0629|M.smegmatis_MC2_155 TETLTQRWPGAQVEALDSSPEMVAAARE---RGVDARVGAIEDWQPTPDT
Mvan_0425|M.vanbaalenii_PYR-1 TEVLGRRWPDAQVQGWDSSPEMVAAARG---RGVDARLGDIADWVPEPDT
MAB_2845|M.abscessus_ATCC_1997 TLELARRWPNASVLGLDSSAELLATAPADLPANVRLEQGDIADFRADG-V
* * :*** * : . *** :::::* .: * : : . .
MUL_1216|M.ulcerans_Agy99 DVVISSAALHWVPEHADLMVQWATVLPHGSWIAVQVPGNFETPSHAVVRA
MMAR_0553|M.marinum_M DVVISSAALHWVPEHADLMVQWATELPHGSWIAVQVPGNFETPSHAVVRA
Mb0302|M.bovis_AF2122/97 DVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRA
Rv0294|M.tuberculosis_H37Rv DVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRA
MAV_4859|M.avium_104 DVVVSNAALHWVPEHSDLLLRWAGQLAPGSWIGVQMPGNFESPSYAAVRA
Mflv_0316|M.gilvum_PYR-GCK DVVVSNATLHWVPEHPDLLLRWAGQLRAGSWIAFQVPGNFDAPSHRAVRD
MSMEG_0629|M.smegmatis_MC2_155 DVVISNAALQWVPSHRELIVAWVQSLPAGAWLAFQVPGNFDSPSHRAVRT
Mvan_0425|M.vanbaalenii_PYR-1 DVVIANAALQWVPEHRDLLVRWAGQLEPGSWIAFQVAGNFDAPSHAAIRE
MAB_2845|M.abscessus_ATCC_1997 DVVFTNAALQWLPQHRDLISAWAHQLNPGGWLALQVPGNFGAPSHALMRQ
***.:.*:*:*:*.* :*: *. * *.*:..*:.*** :**: :*
MUL_1216|M.ulcerans_Agy99 LARREPYAKLVRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWDPTYLHQL
MMAR_0553|M.marinum_M LARREPYAKLMRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWETTYLHQL
Mb0302|M.bovis_AF2122/97 LARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYLHQL
Rv0294|M.tuberculosis_H37Rv LARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYLHQL
MAV_4859|M.avium_104 LARREPYAKLLRDIPFRVGAVVQPPTHYANMLLDAGCKVDVWETTYLHQL
Mflv_0316|M.gilvum_PYR-GCK LVSSARWAHLLRDFPFEKSEVVRPAAGYAELLTDAGCTVDAWETTYVHEL
MSMEG_0629|M.smegmatis_MC2_155 VARSEAFADALRDMPWRDAHQVDDPLDYAGLLTDAGCTVDAWETTYVHEL
Mvan_0425|M.vanbaalenii_PYR-1 VARREPFTAALADMPWRDADVVGAPVEYAGLLTDAGCTVDAWETTYVHEL
MAB_2845|M.abscessus_ATCC_1997 VAESPRWAARLAGV-LRGTDSTDGAEDYARLAISSGLVPDAWETTYVHLL
:. :: : .. . . . ** : .:* *.*:.**:* *
MUL_1216|M.ulcerans_Agy99 TGKNPVLEWITGTALVPVRERFDDVSWEQFRQELIPLLDDAYPPRSDGTT
MMAR_0553|M.marinum_M TGKNPVLEWITGTALVPVRERLDDVSWEQFRQELIPLLDDAYPPRSDGTT
Mb0302|M.bovis_AF2122/97 TGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRADGST
Rv0294|M.tuberculosis_H37Rv TGEHPVLDWITGSALVPVRERLSDESWQQFRQELIPLLNDAYPPRADGST
MAV_4859|M.avium_104 TGEHPVLEWITGTALVPVRERLDDDAWEQFREELIPLLRDAYPPRADGTT
Mflv_0316|M.gilvum_PYR-GCK TGEKPVLEWIGGTALRPVRAALPDHDWQEFRAELIPLLDAAYPRRADGIT
MSMEG_0629|M.smegmatis_MC2_155 TGETPVLDWITGTALTQVRSRLDDTAWQRYREAIIPLLAEAYPRRPDGIT
Mvan_0425|M.vanbaalenii_PYR-1 VGETPVLDWITGTALTQVRQRLSDDAWERYRQAIIPLLAQAYPVRSDGRT
MAB_2845|M.abscessus_ATCC_1997 GGDDPVLRWVHGTGLRPVISALTADEFAEFESEYGALLRRAYP-RSGDIT
*. *** *: *:.* * : : .:. .** *** *... *
MUL_1216|M.ulcerans_Agy99 MFPFRRLFIVAEVGGARRSADVS
MMAR_0553|M.marinum_M MFPFRRLFIVAEVGGARRSADVS
Mb0302|M.bovis_AF2122/97 IFPFRRLFMVAEVGGARRSGG--
Rv0294|M.tuberculosis_H37Rv IFPFRRLFMVAEVGGARRSGG--
MAV_4859|M.avium_104 IFPFRRVFIVAEVGSGRPAA---
Mflv_0316|M.gilvum_PYR-GCK FFPFRRIFVVARVKN--------
MSMEG_0629|M.smegmatis_MC2_155 FFPFRRVFVVAQIR---------
Mvan_0425|M.vanbaalenii_PYR-1 FFSFRRVFVVAQVT---------
MAB_2845|M.abscessus_ATCC_1997 PFGFRRIFCVASKPDGAR-----
* ***:* **