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MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPH ERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYGQS IVSRESVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAEVFAEVGLPEGVLSVVP GGIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSG VMNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEALHRQGHRGG RSVGVRRRPSRGLGQRLLYPIHERRWRGKWHGQCG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0228c | - | - | 100% (385) | aldehyde dehydrogenase |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 6e-56 | 38.46% (338) | aldehyde dehydrogenase NAD dependant AldA |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 4e-45 | 37.23% (325) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-132 | 65.52% (348) | betaine-aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 0.0 | 95.83% (360) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 7e-36 | 32.27% (313) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-135 | 64.80% (358) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 1e-164 | 80.34% (356) | aldehyde dehydrogenase |
| M. avium 104 | MAV_4946 | - | 1e-162 | 78.89% (360) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 1e-128 | 63.59% (357) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3080 | - | 9e-77 | 45.72% (339) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-162 | 79.21% (356) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-132 | 65.07% (355) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0428|M.gilvum_PYR-GCK ---MTQS----TAFRTEWDKLFIGGKWVEPASSEVIEVRSPATGDVVGKV
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
Mb0228c|M.bovis_AF2122/97 ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MMAR_0472|M.marinum_M -----------MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAV_4946|M.avium_104 ------MSDIQTQAKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKV
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
TH_3080|M.thermoresistible__bu ---------------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAV
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
* . * * : *
Mflv_0428|M.gilvum_PYR-GCK PLASAADVDAACAAAREAFDNGPWPQMSPTERAEVLGRAVKLMEERADEL
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADEL
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGPWPRMTPQEREAVLAKATALIEESADEF
Mb0228c|M.bovis_AF2122/97 PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLF
MMAR_0472|M.marinum_M PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHF
MAV_4946|M.avium_104 PLAAAADVDAAVAAARAAFDNGPWPTTPPKERAAVIANALKVMEERKDLF
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEI
TH_3080|M.thermoresistible__bu AAACPDDVDRAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSEL
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQS
. : :*: * : * ** : :* .
Mflv_0428|M.gilvum_PYR-GCK KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYGQ
Mvan_0240|M.vanbaalenii_PYR-1 KFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVYGQ
MSMEG_0309|M.smegmatis_MC2_155 KTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWKDIRDGIYGQ
Mb0228c|M.bovis_AF2122/97 TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYGQ
Rv0223c|M.tuberculosis_H37Rv TKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYGQ
MMAR_0472|M.marinum_M AKLLADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQ
MUL_1122|M.ulcerans_Agy99 AKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQ
MAV_4946|M.avium_104 TGLLAAETGQPPTSVETMHWMSSIGALNFFAGPAVDQVKWKEVRTGGYGQ
MAB_4484|M.abscessus_ATCC_1997 CKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYGQ
TH_3080|M.thermoresistible__bu AELITAQIGAPISFAQRAQVGLPWTMMSAFCT-LAENHPWQQTRAGMYGA
MLBr_02573|M.leprae_Br4923 AALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGAS
: : * . . . . .
Mflv_0428|M.gilvum_PYR-GCK TLVVR-EPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPLS
Mvan_0240|M.vanbaalenii_PYR-1 TLVVR-EPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPLS
MSMEG_0309|M.smegmatis_MC2_155 TLVLK-EPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAAETPLT
Mb0228c|M.bovis_AF2122/97 SIVSR-ESVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT
Rv0223c|M.tuberculosis_H37Rv SIVSR-EPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT
MMAR_0472|M.marinum_M TIVHR-EPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPLT
MUL_1122|M.ulcerans_Agy99 TIVHR-EPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAETPLT
MAV_4946|M.avium_104 SIVHR-EPIGVVGAIVAWNVPLFLAVNKLGPALLAGCTVVLKPAAETPLS
MAB_4484|M.abscessus_ATCC_1997 TLVTR-EPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLS
TH_3080|M.thermoresistible__bu DVHVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLD
MLBr_02573|M.leprae_Br4923 KALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQC
: :. *** *: .**.* : ** :** . :** *.: *
Mflv_0428|M.gilvum_PYR-GCK VFAMAEMFVEAGLPEGVLSIVPGGPETGQALTANPNLDKYTFTGSSGVGK
Mvan_0240|M.vanbaalenii_PYR-1 VFAMAEMFVEAGLPEGVLSIVPGGPETGQALTANPNLDKYTFTGSSGVGK
MSMEG_0309|M.smegmatis_MC2_155 TNLMAQKFLEAGLPEGVLSVVPGGPETGRALTDNPALDKFTFTGSSAVGK
Mb0228c|M.bovis_AF2122/97 ANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGR
Rv0223c|M.tuberculosis_H37Rv ANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGR
MMAR_0472|M.marinum_M ANALAEVFAEAGLPEGVLSVVPGGVETGQALTSNPGVDLFTFTGSSAVGK
MUL_1122|M.ulcerans_Agy99 ANALAEVFAEAGLPEGVLSVVPGGVETGQALTSNPGVDLFTFTGSSAVGK
MAV_4946|M.avium_104 ANALAEAFAEAGLPEGVLSVVPGGIETGQALTSNTDVDIFSFTGSSAVGR
MAB_4484|M.abscessus_ATCC_1997 SFILAEVFAEAGVPEGVLSVVPGGAETGRALTNNPDVDVFSFTGSTAVGK
TH_3080|M.thermoresistible__bu ALLLAELIADSGIPSGVVNVLPGPAGVGERLVRHPGVDKVSFTGSTAAGR
MLBr_02573|M.leprae_Br4923 ALYLADVIARGGFPEDCFQTLLISANGVEAILRDPRVAAATLTGSEPAGQ
:*: : *.*.. .. : . : .. : ::*** .*:
Mflv_0428|M.gilvum_PYR-GCK EIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQAC
Mvan_0240|M.vanbaalenii_PYR-1 EIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGLMNSGQAC
MSMEG_0309|M.smegmatis_MC2_155 EIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGLMNSGQAC
Mb0228c|M.bovis_AF2122/97 EVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGC
Rv0223c|M.tuberculosis_H37Rv EVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGC
MMAR_0472|M.marinum_M EIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQAC
MUL_1122|M.ulcerans_Agy99 EIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQAC
MAV_4946|M.avium_104 EIGRRAADMLKPCTLELGGKSAAIVLDDVDLPSALPMLVFSGIMNSGQAC
MAB_4484|M.abscessus_ATCC_1997 EIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGC
TH_3080|M.thermoresistible__bu AVAAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLSNSGQIC
MLBr_02573|M.leprae_Br4923 AVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSC
:. *. :* *****... ::: ..* :. . . : * ** *
Mflv_0428|M.gilvum_PYR-GCK VGQTRILAPRSRYDEVIEKLGEAVRNMAPGLPDNPAAMIGPLISEKQRDR
Mvan_0240|M.vanbaalenii_PYR-1 VGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLISEKQRDR
MSMEG_0309|M.smegmatis_MC2_155 VGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLISEKQRER
Mb0228c|M.bovis_AF2122/97 VNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTR
Rv0223c|M.tuberculosis_H37Rv VNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTR
MMAR_0472|M.marinum_M VGQTRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQRAR
MUL_1122|M.ulcerans_Agy99 VGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLISEKQRAR
MAV_4946|M.avium_104 VAQTRILAPRSRYDEIVDAVSTFVQSLPVGLPSDPAAQIGSLISEKQRAR
MAB_4484|M.abscessus_ATCC_1997 VNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTR
TH_3080|M.thermoresistible__bu NALTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQER
MLBr_02573|M.leprae_Br4923 IAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQ
.*.: . *. . : * * :. : :*.* :. : :
Mflv_0428|M.gilvum_PYR-GCK VEGYIKKGIEEGARVITGG-GRPEGLDSGWFVEPTVFADVDNSMTIAQEE
Mvan_0240|M.vanbaalenii_PYR-1 VEGYIKKGIEEGARVVTGG-GRPEGLDSGWYVQPTVFADVDNSMTIAQEE
MSMEG_0309|M.smegmatis_MC2_155 VEGYIKKGIEEGARLVTGG-GRPEGLDSGWFVQPTVFADVDNSMTIAQEE
Mb0228c|M.bovis_AF2122/97 VEALHRQG-HRGGRSVGVR-RRP---------------------------
Rv0223c|M.tuberculosis_H37Rv VEGYIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEE
MMAR_0472|M.marinum_M VEGYIAKGIEEGARLVSGG-GRPEGLDNGFFVQPTVFADVDNKMTIAQEE
MUL_1122|M.ulcerans_Agy99 VEGYIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKMTIAQEE
MAV_4946|M.avium_104 VEGYIAKGIEEGARLVCGG-GRPEGLDSGFFVQPTVFADVDNKMTIAQEE
MAB_4484|M.abscessus_ATCC_1997 VEGYIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEE
TH_3080|M.thermoresistible__bu VRGYIEAGCAEGARLVTGGPGLPAGVDRGWYVQPTLFADADNSMRIAREE
MLBr_02573|M.leprae_Br4923 VEQQVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDE
*. . *. *
Mflv_0428|M.gilvum_PYR-GCK IFGPVLSVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTG
Mvan_0240|M.vanbaalenii_PYR-1 IFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTG
MSMEG_0309|M.smegmatis_MC2_155 IFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGVEIASKVRTG
Mb0228c|M.bovis_AF2122/97 ----------------SRGLGQRLLYPIHERRWR----------------
Rv0223c|M.tuberculosis_H37Rv IFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTG
MMAR_0472|M.marinum_M IFGPVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTG
MUL_1122|M.ulcerans_Agy99 IFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTG
MAV_4946|M.avium_104 IFGPVLSIIPYDTEEDAIKIANDSVYGLAGSVWTADVQRGIAVSEKIRTG
MAB_4484|M.abscessus_ATCC_1997 IFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTG
TH_3080|M.thermoresistible__bu IFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIAARIRTG
MLBr_02573|M.leprae_Br4923 VFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAG
: :.: : : :
Mflv_0428|M.gilvum_PYR-GCK TYAVNM-YAFDPCAPFGGYKNSGIGRENGWEGIEAYCEQKSILLPFGYTP
Mvan_0240|M.vanbaalenii_PYR-1 TYAVNM-YAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSILLPFGYTP
MSMEG_0309|M.smegmatis_MC2_155 TYGINM-YAFDPGAPFGGYKNSGIGRECGPEGIAGYCESKSVLLPFGYTP
Mb0228c|M.bovis_AF2122/97 ------------------------GKWHGQCG------------------
Rv0223c|M.tuberculosis_H37Rv TYGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTV
MMAR_0472|M.marinum_M TYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
MUL_1122|M.ulcerans_Agy99 TYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
MAV_4946|M.avium_104 TYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTL
MAB_4484|M.abscessus_ATCC_1997 TYGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTL
TH_3080|M.thermoresistible__bu TFGVNQGYTMDPFAPFGGVKGSGYGRELGPEGIDAYTDVKSISVAPASTT
MLBr_02573|M.leprae_Br4923 QVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-----
*: . *
Mflv_0428|M.gilvum_PYR-GCK PAS
Mvan_0240|M.vanbaalenii_PYR-1 AT-
MSMEG_0309|M.smegmatis_MC2_155 E--
Mb0228c|M.bovis_AF2122/97 ---
Rv0223c|M.tuberculosis_H37Rv A--
MMAR_0472|M.marinum_M ES-
MUL_1122|M.ulcerans_Agy99 ES-
MAV_4946|M.avium_104 EG-
MAB_4484|M.abscessus_ATCC_1997 ESI
TH_3080|M.thermoresistible__bu ---
MLBr_02573|M.leprae_Br4923 ---