For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAIPPEVHSGLLSAGCGPGSLLVAAQQWQELSDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYL AWLEQTAINSAVTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIALNEADYVRM WLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPGGDAADTRLDVLSSIGQLIRDILDFIANPYKYFLEF FEQFGFSPAVTVVLALVALQLYDFLWYPYYASYGLLLLPFFTPTLSALTALSALIHLLNLPPAGLLPIAA ALGPGDQWGANLAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAPPGVSSGPKA GTKSPDTAADTLATAGAARPGLARAHRRKRSESGVGIRGYRDEFLDATATVDAATDVPAPANAAGSQGAG TLGFAGTAPTTSGAAAGMVQLSSHSTSTTVPLLPTTWTTDAEQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0096 | PPE1 | - | 100% (463) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 3e-85 | 42.37% (498) | PPE family protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 7e-81 | 40.41% (537) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0099 | PPE1 | 0.0 | 99.78% (463) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-79 | 39.37% (508) | PPE protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 1e-145 | 57.78% (469) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-124 | 52.75% (472) | PPE-family protein |
| M. marinum M | MMAR_0261 | - | 1e-164 | 64.47% (470) | PPE family protein, PPE1 |
| M. avium 104 | MAV_4867 | - | 2e-88 | 43.62% (486) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-83 | 40.86% (509) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 9e-65 | 44.14% (333) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4853 | - | 1e-163 | 64.26% (470) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-82 | 40.73% (518) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0096|M.tuberculosis_H37Rv -------------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQEL
Mb0099|M.bovis_AF2122/97 -------------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQEL
MMAR_0261|M.marinum_M -------------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQEL
MUL_4853|M.ulcerans_Agy99 -------------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQEL
MLBr_01991|M.leprae_Br4923 -------------------MAIPPEVHSVLLSAGQGAESLLVAATQWQEL
MAB_0669|M.abscessus_ATCC_1997 ----------MTA---PIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEI
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
** ****** :**:* *. .:*.*. * :
Rv0096|M.tuberculosis_H37Rv SDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSA
Mb0099|M.bovis_AF2122/97 SDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSA
MMAR_0261|M.marinum_M SAQYSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSS
MUL_4853|M.ulcerans_Agy99 SAQYSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSS
MLBr_01991|M.leprae_Br4923 SKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNA
MAB_0669|M.abscessus_ATCC_1997 GNNYANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESS
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
. :*: : .** :* .:: :*.* :: .: *** .** ** * : .:
Rv0096|M.tuberculosis_H37Rv VTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIA
Mb0099|M.bovis_AF2122/97 VTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIA
MMAR_0261|M.marinum_M VTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIA
MUL_4853|M.ulcerans_Agy99 VTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIA
MLBr_01991|M.leprae_Br4923 ITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIA
MAB_0669|M.abscessus_ATCC_1997 VIAAQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
* :: :* .* :*:*:*** .**: *: :..*: ***:***::***
Rv0096|M.tuberculosis_H37Rv LNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG------
Mb0099|M.bovis_AF2122/97 LNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG------
MMAR_0261|M.marinum_M LNEADYVRMWIQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG------
MUL_4853|M.ulcerans_Agy99 LNEADYVRMWVQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG------
MLBr_01991|M.leprae_Br4923 LNEADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG------
MAB_0669|M.abscessus_ATCC_1997 LNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG------
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
:.****.***:*** :* :**: : : : .* : **
Rv0096|M.tuberculosis_H37Rv -------------GDAADTRLDVLSSIGQLIR-----------DILDFIA
Mb0099|M.bovis_AF2122/97 -------------GDAADTWLDVLSSIGQLIR-----------DILDFIA
MMAR_0261|M.marinum_M -------------GESQAAASGIGSWIGQLLR-----------DILSFLA
MUL_4853|M.ulcerans_Agy99 -------------GGSQAAASGIGSWIGQLLR-----------DILSFLA
MLBr_01991|M.leprae_Br4923 -------------SATQNVLQSVPDWIVQLLT-----------DILDFIA
MAB_0669|M.abscessus_ATCC_1997 -------------GEARSDQSDVPGSPDQIMK-----------MLQG---
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLK
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
MAV_4867|M.avium_104 LAAN---------AAQNSSGDWWQNFIQQLSQFFQN--------------
. . ::
Rv0096|M.tuberculosis_H37Rv NPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYG----LLL
Mb0099|M.bovis_AF2122/97 NPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWYPYYASYG----LLL
MMAR_0261|M.marinum_M DPYKYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYG----LLL
MUL_4853|M.ulcerans_Agy99 DPYKYFLEFFQRMGFSPAVAVILAIIALQLYDFLWYPYYASYG----LLL
MLBr_01991|M.leprae_Br4923 DPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWYPYYASYG----MLL
MAB_0669|M.abscessus_ATCC_1997 -----FQQWFEKMGFNPATSAVLAVIMLFLYDLLWYPYYASY-------L
Mflv_0325|M.gilvum_PYR-GCK DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFL
Mvan_0415|M.vanbaalenii_PYR-1 DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLL
MSMEG_0619|M.smegmatis_MC2_155 DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFA
TH_3569|M.thermoresistible__bu DPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILA
MAV_4867|M.avium_104 -----IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILT
: : * .
Rv0096|M.tuberculosis_H37Rv LPFFTPTLSALTALSALIHLLN-LPPAGLLPIAAALG-----PGDQWGAN
Mb0099|M.bovis_AF2122/97 LPFFTPTLSALTALSALIHLLN-LPPAGLLPIAAALG-----PGDQWGAN
MMAR_0261|M.marinum_M LPFFTPALSALSALSALAYLANRTPITAPVAAPAERS-----VADLAGPQ
MUL_4853|M.ulcerans_Agy99 LPFFTPALSALSVLSALAYLANRTPITAPVAAPAERS-----VADLAGPQ
MLBr_01991|M.leprae_Br4923 LPFFAPALSVLGTLS---VLWNGQLSAGLPPNPAGSH-----PDNNAGPR
MAB_0669|M.abscessus_ATCC_1997 LPFLIPALSGLSGLAALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPN
Mflv_0325|M.gilvum_PYR-GCK LPLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPA---QSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LPLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAAS---SPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 SPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQ---EVAAAPRTD
TH_3569|M.thermoresistible__bu SPVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPE---EDVAAP---
MAV_4867|M.avium_104 APFLLPLLLGIGLSSLLAAPAEIAP----VAAPAAITP---VLASNKPPT
*.. . : . .
Rv0096|M.tuberculosis_H37Rv LAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAP
Mb0099|M.bovis_AF2122/97 LAVAVTPATAAVPGGSPPTSNPAPAAPSSNSVGSASAAPGISYAVPGLAP
MMAR_0261|M.marinum_M PVVGLTPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAP
MUL_4853|M.ulcerans_Agy99 PVVGLTPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAP
MLBr_01991|M.leprae_Br4923 IHVGVAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSP
MAB_0669|M.abscessus_ATCC_1997 LAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVP
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 QPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRD
TH_3569|M.thermoresistible__bu ----------------VRAEPQNPLPLTXXX-------------------
MAV_4867|M.avium_104 LPAAVALAPSVATPAGAPASTVAAGSGAAAAPGPAAAAGNFAYLVAFGGD
. .
Rv0096|M.tuberculosis_H37Rv PGVSSGPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRG
Mb0099|M.bovis_AF2122/97 PGVSSGPKAGTKSPDTAADTLATAGAARPGL--ARAHRRKRSESGVGIRG
MMAR_0261|M.marinum_M PGVSSGPRATTGAAATATDTTRAAAPAALSS--SRASRRKRSKNRVGVRG
MUL_4853|M.ulcerans_Agy99 PGVSSGPGATTGAAATATDTTRPAAPAALSS--SRAGRRKRSKNRVGVRG
MLBr_01991|M.leprae_Br4923 PEVSSGPKAGTKSPDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARG
MAB_0669|M.abscessus_ATCC_1997 PGVSFGPKSTEKSSESAVDTVAAVAAARGAVA-AQARRRLRGKNKAEAGG
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAAS-AAERRKRRRRQKEEIKG
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAAS-AAERRKRRRRQKDEIAG
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAAS-LASRRKRRRKKGAQIEE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 PDTGVGPTLSGRGGAKAPAATIPAAGAAAPAR-AEARARRRRRAALHDYS
Rv0096|M.tuberculosis_H37Rv YRDEFLDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-A
Mb0099|M.bovis_AF2122/97 YRDEFLDATATVDAATDVP---APANAAGS-QGAGTLGFAGTAPTTSG-A
MMAR_0261|M.marinum_M YRDEFLQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-A
MUL_4853|M.ulcerans_Agy99 YRDEFLQEPATMDSPIDAPGTAEPAPSPSS-QGAGPLGLTGTAASHDG-A
MLBr_01991|M.leprae_Br4923 YRYEFVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTAS-T
MAB_0669|M.abscessus_ATCC_1997 RRHEYLEETAGMGATATAD---VPAYAATG-RGTGPLGFAGTAPAAASTH
Mflv_0325|M.gilvum_PYR-GCK RGYADAYADYEELPDDGPPEQPAPRVTAST-RGAGPMGFAGTVSR-GDEQ
Mvan_0415|M.vanbaalenii_PYR-1 RAYADAYADYEPEPDDEPPVRQEPRIAATE-RGAGPMGFAGTVSR-DAAQ
MSMEG_0619|M.smegmatis_MC2_155 RGYADAYMDYEE-PDEDPAPQPEPRVRASE-RGSDAMGFTGTVTR-HDVT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 DEFLDMDSGFGVPPDYG-AEEELAAAVASG-QGAGTLGFAGTQQRRKAFQ
Rv0096|M.tuberculosis_H37Rv AAGMVQLSSH--STSTTVPLLPTTWTTDAEQ-------------------
Mb0099|M.bovis_AF2122/97 AAGMVQLSSH--STSTTVPLLPTTWTTDAEQ-------------------
MMAR_0261|M.marinum_M AAGMVRLSSH--GTSTAVPLLPATWTNDSEGRPEGE--------------
MUL_4853|M.ulcerans_Agy99 AAGMVRLSSH--GTSTAVPLLPATWTNDSEGRPEGE--------------
MLBr_01991|M.leprae_Br4923 PTGMAAS------TSSSVPLLPTTWITGTSETAVHE--------------
MAB_0669|M.abscessus_ATCC_1997 VAATVRLSSD--EARQVIPMLPSTWDADGGDQN-----------------
Mflv_0325|M.gilvum_PYR-GCK AGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_4867|M.avium_104 AAGLTKLADDDFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-