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AIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQYSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLI WLEQAAIDSSVTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNEADYVRMW IQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPGGESQAAASGIGSWIGQLLRDILSFLADPYKYFLEFF QRMGFSPAVAVILAIIALQLYDFLWYPYYASYGLLLLPFFTPALSALSALSALAYLANRTPITAPVAAPA ERSVADLAGPQPVVGLTPAASAFAPPSPQATSPAPSAPSPAPTGSPPSSPAISYAVLGPAPPGVSSGPRA TTGAAATATDTTRAAAPAALSSSRASRRKRSKNRVGVRGYRDEFLQEPATMDSPIDAPGTAEPAPSPSSQ GAGPLGLTGTAASHDGAAAGMVRLSSHGTSTAVPLLPATWTNDSEGRPEGE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0261 | - | - | 100% (472) | PPE family protein, PPE1 |
| M. marinum M | MMAR_0545 | - | 5e-86 | 41.09% (516) | PPE family protein, PPE4 |
| M. marinum M | MMAR_1418 | - | 2e-79 | 39.19% (518) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0099 | PPE1 | 1e-164 | 64.47% (470) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-84 | 41.22% (507) | PPE protein |
| M. tuberculosis H37Rv | Rv0096 | PPE1 | 1e-165 | 64.47% (470) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 1e-140 | 56.57% (472) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-117 | 50.00% (472) | PPE-family protein |
| M. avium 104 | MAV_4867 | - | 7e-91 | 43.48% (483) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-88 | 39.07% (517) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-64 | 35.55% (512) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4853 | - | 0.0 | 98.73% (472) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-89 | 42.23% (521) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MMAR_0261|M.marinum_M -------------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQEL
MUL_4853|M.ulcerans_Agy99 -------------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQEL
Mb0099|M.bovis_AF2122/97 -------------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQEL
Rv0096|M.tuberculosis_H37Rv -------------------MAIPPEVHSGLLSAGCGPGSLLVAAQQWQEL
MLBr_01991|M.leprae_Br4923 -------------------MAIPPEVHSVLLSAGQGAESLLVAATQWQEL
MAB_0669|M.abscessus_ATCC_1997 ----------MTA---PIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEI
TH_3113|M.thermoresistible__bu -------------------MALPPEVHSTLLRTGPGPGALSAAADAWRML
** ****** :* :* *. .: .*. * :
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MMAR_0261|M.marinum_M SAQYSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSS
MUL_4853|M.ulcerans_Agy99 SAQYSAAVVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSS
Mb0099|M.bovis_AF2122/97 SDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSA
Rv0096|M.tuberculosis_H37Rv SDQYALACAELGQLLGEVQASSWQGTAATQYVAAHGPYLAWLEQTAINSA
MLBr_01991|M.leprae_Br4923 SKQYTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNA
MAB_0669|M.abscessus_ATCC_1997 GNNYANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESS
TH_3113|M.thermoresistible__bu SDEYRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAA
. :* : .** :: . : :*.* .: : *** .** ** : : :
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MMAR_0261|M.marinum_M VTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIA
MUL_4853|M.ulcerans_Agy99 VTAAQHRIAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIA
Mb0099|M.bovis_AF2122/97 VTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIA
Rv0096|M.tuberculosis_H37Rv VTAAQHVAAAAAYCSALAAMPTPAELAANHAIHGVLIATNFFGINTVPIA
MLBr_01991|M.leprae_Br4923 ITAKQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIA
MAB_0669|M.abscessus_ATCC_1997 VIAAQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIA
TH_3113|M.thermoresistible__bu AAGAQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIA
. * :* .: :*:*:*** .**: *: :. *: ***:*:*::***
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKP-----GG
MMAR_0261|M.marinum_M LNEADYVRMWIQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG-GESQA
MUL_4853|M.ulcerans_Agy99 LNEADYVRMWVQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPG-GGSQA
Mb0099|M.bovis_AF2122/97 LNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG-GDAAD
Rv0096|M.tuberculosis_H37Rv LNEADYVRMWLQAADTMAAYQAVADAATVAVPSTQPAPPIRAPG-GDAAD
MLBr_01991|M.leprae_Br4923 LNEADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPG-SATQN
MAB_0669|M.abscessus_ATCC_1997 LNEADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARS
TH_3113|M.thermoresistible__bu VNEADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESAT
:.****.***:*** ** :*:: : : : .* : .
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK
MAV_4867|M.avium_104 EANNLAANAAQNSSGD------------------------WWQNFIQQLS
MMAR_0261|M.marinum_M AASGIGSWIGQ-----------------------------LLRDILSFLA
MUL_4853|M.ulcerans_Agy99 AASGIGSWIGQ-----------------------------LLRDILSFLA
Mb0099|M.bovis_AF2122/97 TWLDVLSSIGQ-----------------------------LIRDILDFIA
Rv0096|M.tuberculosis_H37Rv TRLDVLSSIGQ-----------------------------LIRDILDFIA
MLBr_01991|M.leprae_Br4923 VLQSVPDWIVQ-----------------------------LLTDILDFIA
MAB_0669|M.abscessus_ATCC_1997 DQSDVPGSPDQ-----------------------------IMKMLQG---
TH_3113|M.thermoresistible__bu AAITGAHVTAELRAAES-------------------------RTLLDEIN
: :
Mflv_0325|M.gilvum_PYR-GCK DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA---------VSWVGA
Mvan_0415|M.vanbaalenii_PYR-1 DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA---------VSWVGA
MSMEG_0619|M.smegmatis_MC2_155 DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFN-----LVGWPTW
MAV_4867|M.avium_104 QFFQNIQKMLQDFWANLPAFLAANGPLLFFVAYQVFFN-----AVGWPTW
MMAR_0261|M.marinum_M DPYKYFLEFFQRMGFSPAVAVILAIIALQLYDFLWY---------PYYAS
MUL_4853|M.ulcerans_Agy99 DPYKYFLEFFQRMGFSPAVAVILAIIALQLYDFLWY---------PYYAS
Mb0099|M.bovis_AF2122/97 NPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWY---------PYYAS
Rv0096|M.tuberculosis_H37Rv NPYKYFLEFFEQFGFSPAVTVVLALVALQLYDFLWY---------PYYAS
MLBr_01991|M.leprae_Br4923 DPYKYFLRFFQRLGFRPAIAVVLAIIALQLYDFLWY---------PYYAS
MAB_0669|M.abscessus_ATCC_1997 -----FQQWFEKMGFNPATSAVLAVIMLFLYDLLWY---------PYYAS
TH_3113|M.thermoresistible__bu ELIDRLFAPLFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLL
: *
Mflv_0325|M.gilvum_PYR-GCK SILYPSLFLLPLLATT--L---AIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 SILYPSLLLLPLVATT--L---AIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 GMIFASPFLIPALAALGIT---GLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAV_4867|M.avium_104 GAILTAPFLLPLLLGIG--------------LSSLLAAPAEIAPVAAPAA
MMAR_0261|M.marinum_M YGLLLLPFFTPALSALS-------ALSALAYLANRTPITAPVAAPAERS-
MUL_4853|M.ulcerans_Agy99 YGLLLLPFFTPALSALS-------VLSALAYLANRTPITAPVAAPAERS-
Mb0099|M.bovis_AF2122/97 YGLLLLPFFTPTLSALT-------ALSALIHLLN-LPPAGLLPIAAALG-
Rv0096|M.tuberculosis_H37Rv YGLLLLPFFTPTLSALT-------ALSALIHLLN-LPPAGLLPIAAALG-
MLBr_01991|M.leprae_Br4923 YGMLLLPFFAPALSVLG-------TLS---VLWNGQLSAGLPPNPAGSH-
MAB_0669|M.abscessus_ATCC_1997 Y---LLPFLIPALSGLS-------GLAALMHLRPAAPGPVPAAALSPGDR
TH_3113|M.thermoresistible__bu MGLSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAAL
: * : *
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPP-PPSGAPIAANTVSAGSPPAPG-APAAAA
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPP-PPSSAAATVGTVATGTAPAPG-APAAAT
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAG-VPGSAATAAAPAPAPAGTTVA-APAPAA
MAV_4867|M.avium_104 ITPVLASNKPPTLPAAVALAPSVATPAGAPASTVAAGSGAAAAPGPAAAA
MMAR_0261|M.marinum_M ----VADLAGPQPVVGLTPAA-SAFAPPSPQATSPAPSAPSPAPTGSPPS
MUL_4853|M.ulcerans_Agy99 ----VADLAGPQPVVGLTPAA-SAFAPPSPQATSPAPSAPSPAPTGSPPS
Mb0099|M.bovis_AF2122/97 ----PGDQWGANLAVAVTPAT-AAVPGGSPPTSNPAPAAPSSNSVGSASA
Rv0096|M.tuberculosis_H37Rv ----PGDQWGANLAVAVTPAT-AAVPGGSPPTSNPAPAAPSSNSVGSASA
MLBr_01991|M.leprae_Br4923 ----PDNNAGPRIHVGVAPPA-SATSSGNSYTSNSAPSTSASATTDNPLS
MAB_0669|M.abscessus_ATCC_1997 PIRRPTQHVEPNLAALPLPTS-SVVPSGGSSVPVSTPTAPAHTVSSVPAP
TH_3113|M.thermoresistible__bu GGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPSGSSAPPA
. . . .: . . .
Mflv_0325|M.gilvum_PYR-GCK ATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRK
Mvan_0415|M.vanbaalenii_PYR-1 ASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRK
MSMEG_0619|M.smegmatis_MC2_155 ATFVPYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRK
MAV_4867|M.avium_104 GNFAYLVAFGGDPDTGVGPTLSGRGGAKAPAATIPAAGAAAPARAEARAR
MMAR_0261|M.marinum_M SPAISYAVLGPAPPGVSSGPRATTGAAATATDTTRAAAPAALSS--SRAS
MUL_4853|M.ulcerans_Agy99 SPAISYAVLGPAPPGVSSGPGATTGAAATATDTTRPAAPAALSS--SRAG
Mb0099|M.bovis_AF2122/97 APGISYAVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGL--ARAH
Rv0096|M.tuberculosis_H37Rv APGISYAVPGLAPPGVSSGPKAGTKSPDTAADTLATAGAARPGL--ARAH
MLBr_01991|M.leprae_Br4923 SPSIRYAIPGLSPPEVSSGPKAGTKSPDTATNTIGITAAARTNSPSARAH
MAB_0669|M.abscessus_ATCC_1997 SAAISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVA-AQAR
TH_3113|M.thermoresistible__bu PTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPA
. * . :. .. :
Mflv_0325|M.gilvum_PYR-GCK R--RRRQKEEIKGRGYADAYADYEELPDDGPPEQP--APRVTAST-RGAG
Mvan_0415|M.vanbaalenii_PYR-1 R--RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQ--EPRIAATE-RGAG
MSMEG_0619|M.smegmatis_MC2_155 R--RRKKGAQIEERGYADAYMDYEE-PDEDPAPQP--EPRVRASE-RGSD
MAV_4867|M.avium_104 R--RRRAALHDYSDEFLDMDSGFGVPPDYG-AEEE--LAAAVASG-QGAG
MMAR_0261|M.marinum_M R--RKRSKNRVGVRGYRDEFLQEPATMDSPIDAPGTAEPAPSPSS-QGAG
MUL_4853|M.ulcerans_Agy99 R--RKRSKNRVGVRGYRDEFLQEPATMDSPIDAPGTAEPAPSPSS-QGAG
Mb0099|M.bovis_AF2122/97 R--RKRSESGVGIRGYRDEFLDATATVDAATDVP---APANAAGS-QGAG
Rv0096|M.tuberculosis_H37Rv R--RKRSESGVGIRGYRDEFLDATATVDAATDVP---APANAAGS-QGAG
MLBr_01991|M.leprae_Br4923 R--KRGNKTRGGARGYRYEFVEGTATMADTVDAPDHSEPTSHTISNHSAG
MAB_0669|M.abscessus_ATCC_1997 R--RLRGKNKAEAGGRRHEYLEETAGMGATATAD---VPAYAATG-RGTG
TH_3113|M.thermoresistible__bu PGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRH
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSR-GDEQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSR-DAAQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTR-HDVTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP--
MAV_4867|M.avium_104 TLGFAGTQQRRKAFQAAGLTKLADDDFGGSPRMPMVPGTWEQDTQNG---
MMAR_0261|M.marinum_M PLGLTGTAASHDG-AAAGMVRLSSH--GTSTAVPLLPATWTNDSEGRPEG
MUL_4853|M.ulcerans_Agy99 PLGLTGTAASHDG-AAAGMVRLSSH--GTSTAVPLLPATWTNDSEGRPEG
Mb0099|M.bovis_AF2122/97 TLGFAGTAPTTSG-AAAGMVQLSSH--STSTTVPLLPTTWTTDAEQ----
Rv0096|M.tuberculosis_H37Rv TLGFAGTAPTTSG-AAAGMVQLSSH--STSTTVPLLPTTWTTDAEQ----
MLBr_01991|M.leprae_Br4923 PIGFAGTVPTTAS-TPTGMAAS------TSSSVPLLPTTWITGTSETAVH
MAB_0669|M.abscessus_ATCC_1997 PLGFAGTAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDADGGDQN--
TH_3113|M.thermoresistible__bu EHQQPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSS
..: . .: .
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAV_4867|M.avium_104 ----AHPTEPGKGG-
MMAR_0261|M.marinum_M E--------------
MUL_4853|M.ulcerans_Agy99 E--------------
Mb0099|M.bovis_AF2122/97 ---------------
Rv0096|M.tuberculosis_H37Rv ---------------
MLBr_01991|M.leprae_Br4923 E--------------
MAB_0669|M.abscessus_ATCC_1997 ---------------
TH_3113|M.thermoresistible__bu PTDRAHRPAEPN---