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HTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPEVVDGRTVSGDVLLAIGATTTAEA VRWARAARAVVVLTRGGGDPEPDTAGVAVLVVDSAMPWSEFAAIVYGLVMEGRETESGRGPTDLFALADN LSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPSLRAVFDAHGVFAHLAVSDEPLFVPGD DAVGLTGRMVVAARAGRELLGSVWVAVPKPLAGQQRQALADGARTVALHLLRSRASADLERQVESEMVIR LLESPADAETVASRLGLPPSALRVIALRALDTTGRHSALLQMFERATAGFGWSRPSRSALADATVYTVLA AEPAAVARDWVSALISTLPDQVTVKAGISAPAAATDLAVARTEADECLALQESTDAGEPPAYDESWDDLL LRRLKTAARSGRTPTRGAVAELREHDSAHGTAYVPTLRAWLQERGDPVRTAAHLGVHENTVRYRMRRMAE LTELHLDDARKRFAMTIELAVLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1946 | - | - | 100% (514) | putative DNA-binding protein |
| M. gilvum PYR-GCK | Mflv_0801 | - | 1e-08 | 33.33% (126) | transcriptional regulator, CdaR |
| M. gilvum PYR-GCK | Mflv_2780 | - | 7e-05 | 30.05% (183) | hypothetical protein Mflv_2780 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 9e-30 | 26.94% (490) | hypothetical protein Mb1218c |
| M. tuberculosis H37Rv | Rv1186c | - | 1e-29 | 26.94% (490) | hypothetical protein Rv1186c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0825 | - | 5e-08 | 24.66% (296) | peptidase |
| M. marinum M | MMAR_4254 | - | 2e-32 | 27.12% (483) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 1e-169 | 63.10% (504) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_6290 | - | 1e-175 | 66.07% (501) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 1e-166 | 60.81% (518) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 1e-32 | 27.12% (483) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_4779 | - | 0.0 | 84.31% (510) | putative DNA-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
Rv1186c|M.tuberculosis_H37Rv --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
MMAR_4254|M.marinum_M --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MUL_0931|M.ulcerans_Agy99 --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
Mflv_1946|M.gilvum_PYR-GCK MHTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPEVV
Mvan_4779|M.vanbaalenii_PYR-1 ------------MITLDRLINVLGGYGARWHSGSADRQTELRSVVLPEVV
MSMEG_6290|M.smegmatis_MC2_155 ------------MVTLDRLINVLGGYGIHLKLCSTPRSTELRSVVMHEPG
MAV_1987|M.avium_104 ------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETP
TH_2137|M.thermoresistible__bu ------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENA
MAB_0825|M.abscessus_ATCC_1997 -----MAEYRLTVPITVRDLTQRADLGLVLSAGEAGAARAIKWAHAIELN
: : : . :
Mb1218c|M.bovis_AF2122/97 DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
Rv1186c|M.tuberculosis_H37Rv DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
MMAR_4254|M.marinum_M DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MUL_0931|M.ulcerans_Agy99 DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
Mflv_1946|M.gilvum_PYR-GCK DGRT------VSGDVLLAIGATTTAEAVRWARAARA----VVVLTRGG-G
Mvan_4779|M.vanbaalenii_PYR-1 DGRT------VSGDVLLAVGAASPAEALQWARAARA----VVVLTRGEHA
MSMEG_6290|M.smegmatis_MC2_155 P---------VVGDVLLAVGAASLADALEWAEAAHA----VVVLVRATDE
MAV_1987|M.avium_104 EDRP------VVGDVLLAVGAGSLDEAVRWAASARA----AVVVLRDDET
TH_2137|M.thermoresistible__bu GGLR------VTGDVLLAVGAESVAEAVRWAETAQA----VVVLTRAG-P
MAB_0825|M.abscessus_ATCC_1997 DPTPYLFGGELVMTTGLTVGLS-HAEQYEYAARLSG----KNVAALAFDT
: :* : .: :
Mb1218c|M.bovis_AF2122/97 SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
Rv1186c|M.tuberculosis_H37Rv SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
MMAR_4254|M.marinum_M AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MUL_0931|M.ulcerans_Agy99 AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
Mflv_1946|M.gilvum_PYR-GCK DPEPD--TAGVAVLVVDSAMPWSEFAAIVYGLVMEGRETE--SGRGPTDL
Mvan_4779|M.vanbaalenii_PYR-1 DPELD--GAGVAVVVIDSAMPWSDFAAIVYGLVMEGRETE--SGRGPTDL
MSMEG_6290|M.smegmatis_MC2_155 DLTTA--PDGIAVMLVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
MAV_1987|M.avium_104 PMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETE--SGRGPTDL
TH_2137|M.thermoresistible__bu DASRSCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
MAB_0825|M.abscessus_ATCC_1997 GTTFSEVPPGILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAV
. : . . : : :
Mb1218c|M.bovis_AF2122/97 FGLAQSLADRIHGMISIEDA-QSHVLAYSASNDEADELRRLSILGRAGPP
Rv1186c|M.tuberculosis_H37Rv FGLAQSLADRIHGMISIEDA-QSHVLAYSASNDEADELRRLSILGRAGPP
MMAR_4254|M.marinum_M FGLAQSLADRIHGMVSIEDA-QSHVLAYSASSDEADELRRLSILGRAGPP
MUL_0931|M.ulcerans_Agy99 FGLAQSLADRIHGMVSIEDA-QSHVLAYSASSDEADELRRLSILGRAGPP
Mflv_1946|M.gilvum_PYR-GCK FALADNLSNAVGGAVVIEDR-ASQVLAFSRGQLDADPARAKTILARQAPP
Mvan_4779|M.vanbaalenii_PYR-1 FALADSLAGAVGGAVVIEDR-SSQVLAFSRGQQDADPGRIATILARQAPP
MSMEG_6290|M.smegmatis_MC2_155 FALADSLAETVGGSVTIEDR-RSSVLAYSRLQHDADPARAETILSRQAPE
MAV_1987|M.avium_104 FALADSLADGIGNPVVIQDR-HLGVLAYSR-LAQADPALVETVLQRQTPE
TH_2137|M.thermoresistible__bu FALADNLADAVGGPVTIEDR-MSRVLAYSQRQQHADPARAQTILARQAPE
MAB_0825|M.abscessus_ATCC_1997 QRVVDQQDVLVRATLRDGAPGVVSALSRSLAATVIVTATDGTLLAEAGHD
:.:. : : .*: * ::* .
Mb1218c|M.bovis_AF2122/97 EHLQWIGQWGIFDALRAGREVVRVAE-------RPELGLRPRLAIGIHQP
Rv1186c|M.tuberculosis_H37Rv EHLQWIGQWGIFDALRPGREVVRVAE-------RPELGLRPRLAIGIHQP
MMAR_4254|M.marinum_M EHLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQP
MUL_0931|M.ulcerans_Agy99 EHLKWIGQWGIFDALRSGSEVVRVAE-------RPELGLRPRLAIGIHQP
Mflv_1946|M.gilvum_PYR-GCK SLRAVFDAHGVFAHLAVSDEPLFVPG-------DDAVGLTGRMVVAARAG
Mvan_4779|M.vanbaalenii_PYR-1 ELRAVYEAHGVFAHLAVSDDPVFVPGDAPDGMLDDAAGRTGRMVVAARAG
MSMEG_6290|M.smegmatis_MC2_155 RLRTLFAERGVFRHLAESDEPLFVAG-------DPEQGLTGRMVVAARAG
MAV_1987|M.avium_104 PLRALLEARGVFAHLQVADEPLFVAE-------DAERGLSGRMVVAVRAG
TH_2137|M.thermoresistible__bu PLRRLFEQLGVSEHLAAGDDPLFIAA-------RPGHDLTGRTVIAVRAG
MAB_0825|M.abscessus_ATCC_1997 AEHLAEITRGAFPNHSRKHASRVVAD---------RDGYCTIQTVRAG--
* :. . .:
Mb1218c|M.bovis_AF2122/97 GVGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPN
Rv1186c|M.tuberculosis_H37Rv GVGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPN
MMAR_4254|M.marinum_M PVAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPS
MUL_0931|M.ulcerans_Agy99 PVAARRPPVFAGSIWVQQGSQPLAEDADEVLRGAAVLGARIMTRLASRPS
Mflv_1946|M.gilvum_PYR-GCK -------RELLGSVWVAVPKPLAGQQRQALADGARTVALHLLRSRASADL
Mvan_4779|M.vanbaalenii_PYR-1 -------RELLGSVWVACASPLVGDRRRALADGAHTVALHLLRSRASADL
MSMEG_6290|M.smegmatis_MC2_155 -------RELLGSVWVTCAQPLPEANRAALADGARMVAVHLLRSRASADL
MAV_1987|M.avium_104 -------AELIGSVWVACEAPLQPAALRALADGARTVALHLLRSRASADL
TH_2137|M.thermoresistible__bu -------RELLGSVWVVTPEPLDDGRRRALADGARTVALHLLRSRASADL
MAB_0825|M.abscessus_ATCC_1997 -------KAERGYLAVRSEDALTAAQRLLVSHAMALIAIELEKPARVADA
* : * : . :. .:
Mb1218c|M.bovis_AF2122/97 THALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENR
Rv1186c|M.tuberculosis_H37Rv THALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENR
MMAR_4254|M.marinum_M THARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEAD
MUL_0931|M.ulcerans_Agy99 THARRVQQLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEAD
Mflv_1946|M.gilvum_PYR-GCK ERQVESEMVIRLLES-----PADAETVASRLGLPPSA-LRVIALRALDTT
Mvan_4779|M.vanbaalenii_PYR-1 ERQVESELVIRLLES-----PADAATVASRLGLPPAT-LRVIALRASDEG
MSMEG_6290|M.smegmatis_MC2_155 ERQVESDLVIRLLEG-----AADAATVASRLALPQTP-LRVIALRAHTAD
MAV_1987|M.avium_104 ERQVESELVIRLLEG-----TADAATVASRLDLAHNG-LRVVAVQAFVGA
TH_2137|M.thermoresistible__bu ERQVESDLVLRLLEG-----TSDAAGAAARLGLPQEA-LRIIAVRARSGV
MAB_0825|M.abscessus_ATCC_1997 EQRLRGAVTRALLADP----AAADRSVLRYFGFDPDTEVVVVLLCN----
: . * . : . :: .
Mb1218c|M.bovis_AF2122/97 DTAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTS
Rv1186c|M.tuberculosis_H37Rv DTAVRHVRLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTS
MMAR_4254|M.marinum_M D---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTS
MUL_0931|M.ulcerans_Agy99 D---KQSRLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTS
Mflv_1946|M.gilvum_PYR-GCK G---RHSALLQMFERATAGFGWSRPSRSALADATVYTVLAAEPAA-VARD
Mvan_4779|M.vanbaalenii_PYR-1 G---RHAALLQMFERATAGFGWSRPSRSALADTTVYTVLAAEAAA-VARD
MSMEG_6290|M.smegmatis_MC2_155 E---GHSALLLAFERATAGFGWSRPGRSALADNTVYTVLPSPDPD-TATT
MAV_1987|M.avium_104 D---RDAPLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEAS-TARR
TH_2137|M.thermoresistible__bu D---RQGPLLLAFEHATTGFGWSRAGRSALAGDTVYTVLPADHAA-TARR
MAB_0825|M.abscessus_ATCC_1997 -----VGSVLPGELHIDRQLARGGPYLMASVSGEIVVVLAAKNVG-----
: . . . : .:*.
Mb1218c|M.bovis_AF2122/97 WVRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI
Rv1186c|M.tuberculosis_H37Rv WVRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPI
MMAR_4254|M.marinum_M WVRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPI
MUL_0931|M.ulcerans_Agy99 WVRGTISALRSELGVELRATIAAPVAGLDGLASARVEVDRVLDSAERHPI
Mflv_1946|M.gilvum_PYR-GCK WVSALISTLPDQVTVKAGISAPAAAT---DLAVARTEADECLALQESTDA
Mvan_4779|M.vanbaalenii_PYR-1 WVSALVAALPEQLTVQAGISAPAAAT---ELAVARTEADECLALQEGTGA
MSMEG_6290|M.smegmatis_MC2_155 WVAGLRAALPDPVSVVAGVSGPAVAA---ELVLARREADECLALHEVRHG
MAV_1987|M.avium_104 WVGALRAALPERLTMIAGISGVAEVG---DLAAARQEADECLALHEMSPA
TH_2137|M.thermoresistible__bu WVEGLQAALPSEVTVSAGISGIADHT---ELPDARREADECLALHDALHD
MAB_0825|M.abscessus_ATCC_1997 ----RASELHRSLGTALGRTICAGISRRVRLDEVPLGLHQARSVARAHPD
: * : : . : . ..
Mb1218c|M.bovis_AF2122/97 -LGQVT------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDL
Rv1186c|M.tuberculosis_H37Rv -LGQVT------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDL
MMAR_4254|M.marinum_M SIGRVT------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDL
MUL_0931|M.ulcerans_Agy99 SIGRVT------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDL
Mflv_1946|M.gilvum_PYR-GCK GEPP--------------AYDESWDDLLLRRLKTAARSGRTPTRGAVAEL
Mvan_4779|M.vanbaalenii_PYR-1 DAPP--------------AYDESWDDLLLRRLRAAARSGRTPPRGAVAEL
MSMEG_6290|M.smegmatis_MC2_155 GAVP--------------VYDEAWDDILLQRLRVAAQSGRAPQRGPVAEL
MAV_1987|M.avium_104 APPP--------------AYDESWDDILLQRLRAAARSGRAPTRGPVADL
TH_2137|M.thermoresistible__bu ARPDTGSPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAAL
MAB_0825|M.abscessus_ATCC_1997 ------------------GRIAEFDELDIYGVLLGGRDRGELAVLAQSVA
: : :
Mb1218c|M.bovis_AF2122/97 GAQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLL
Rv1186c|M.tuberculosis_H37Rv GAQDP----VLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLL
MMAR_4254|M.marinum_M RAKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLL
MUL_0931|M.ulcerans_Agy99 RAKDP----VLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLL
Mflv_1946|M.gilvum_PYR-GCK REHDSAHGTAYVPTLRAWLQERGDPVRTAAHLGVHENTVRYRMRRMAELT
Mvan_4779|M.vanbaalenii_PYR-1 RAHDSTHGTAYVPTLRAWLQERGDPGRTGTRLGVHENTVRYRMRRMAELT
MSMEG_6290|M.smegmatis_MC2_155 RRHDQAHGTHYAPTLQAWLQAQGDLAEAGRMLGVHENTVRYRLRRMAEVT
MAV_1987|M.avium_104 GRHDRANGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEIT
TH_2137|M.thermoresistible__bu HEHDLRHATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVT
MAB_0825|M.abscessus_ATCC_1997 PLLGTGADTTLLDTLESFLACNGQMETAALNLGVHRHTMRNRIARIAALL
. **. :* *: :. * ** :*:* *: :: :
Mb1218c|M.bovis_AF2122/97 STSLGDPDVRLLFSLGLRAMERTA----
Rv1186c|M.tuberculosis_H37Rv STSLGDPDVRLLFSLGLRAMERTA----
MMAR_4254|M.marinum_M STSFADPDVRLVFSLGLRATDRSS----
MUL_0931|M.ulcerans_Agy99 STSFADPDVRLVFSLGLRATDHSS----
Mflv_1946|M.gilvum_PYR-GCK ELHLDDARKRFAMTIELAVLD-------
Mvan_4779|M.vanbaalenii_PYR-1 DLRLDDADKRFAMMIELAVLD-------
MSMEG_6290|M.smegmatis_MC2_155 NLELTDPRKRLAMMIQLAASEHLS----
MAV_1987|M.avium_104 NLSLDDSKKRLAMMIELAAIHTD-----
TH_2137|M.thermoresistible__bu QLDLQDPDKRLAMMIELAAIEGPPILSG
MAB_0825|M.abscessus_ATCC_1997 DCDLHSADTRAALWIAIRARALLG----
. : .. * : : : .