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SWLITGGAGYIGSHVARAMLEAGRDVVVIDDLSSGFESFVPDGAAFVEGTLLDAALVDDTLARFDVDGVI HIAGYKYAGESVKRPLHTYEQNVSTTVILLQAMEARGVGQIVFSSSAATFGTPDVDIVDESTPTTPESPY GETKLIGEWLLRDAGRASGLRHTSLRYFNVVGSGAVELFDASPHNLFPLVFDMLFRGETPRINGDDYPTP DGTCVRDYIHVSDLALAHVAAAQRLAAGEPVEPVYNLGSGAGTSVREIMTAMRTVTGVDFEPVVMPRRPG DPARIVAAGDLAARDLGWSNRHSLEEMVASAWRARQHAGDAYPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1401 | - | - | 100% (325) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_3296 | - | 7e-18 | 28.34% (307) | dTDP-glucose 4,6-dehydratase |
| M. gilvum PYR-GCK | Mflv_5007 | - | 1e-14 | 27.69% (325) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-24 | 31.41% (312) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-24 | 31.41% (312) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-25 | 31.09% (312) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-25 | 29.39% (313) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 4e-24 | 29.84% (315) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 2e-27 | 32.59% (313) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 2e-28 | 32.59% (313) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_3729 | - | 1e-148 | 78.46% (325) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 2e-24 | 29.84% (315) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_5389 | - | 1e-132 | 74.29% (315) | UDP-glucose 4-epimerase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAANLEHLA
MAV_0524|M.avium_104 -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFASGRASNLEHLV
Mb3658c|M.bovis_AF2122/97 -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
Rv3634c|M.tuberculosis_H37Rv -----MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLA
MMAR_5133|M.marinum_M -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLV
MUL_4210|M.ulcerans_Agy99 -----MRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGRATNLEHLV
MAB_0503|M.abscessus_ATCC_1997 -----MRAMVTGAAGFIGSTLVDRLLADGHEVTGLDNLATGKVANLEAAE
MSMEG_6142|M.smegmatis_MC2_155 ---MAVRTLVTGAAGFIGSTLVDRLLADGHGVVGLDDLSSGRAENLHSAE
Mflv_1401|M.gilvum_PYR-GCK -----MSWLITGGAGYIGSHVARAMLEAGRDVVVIDDLSSGFESFVPDGA
TH_3729|M.thermoresistible__bu -----MTWLVTGGAGYIGSHVVRALLEADLPVVVIDDLSTGLEKFVPSEV
Mvan_5389|M.vanbaalenii_PYR-1 -----MTWLVTGGAGYIGSHVVRALRGADLDVVVIDDLSTGRAEFVPDGV
: ::**.**:*** :. : . *. :*::::* :
MLBr_00204|M.leprae_Br4923 STPALAFVEADIVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDAS
MAV_0524|M.avium_104 GNPAHVFVEADIVTADLEAILDEHRPEVVFHLAAQIDVRHSVADPQFDAS
Mb3658c|M.bovis_AF2122/97 DNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAA
Rv3634c|M.tuberculosis_H37Rv DNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAA
MMAR_5133|M.marinum_M DNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDAS
MUL_4210|M.ulcerans_Agy99 DNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDVRHSVADPQFDAS
MAB_0503|M.abscessus_ATCC_1997 ANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDVRHSVADPQFDSS
MSMEG_6142|M.smegmatis_MC2_155 NSDKFEFVKADIVDADLTGLLAEFKPEVIFHLAAQISVKRSVDDPPFDAT
Mflv_1401|M.gilvum_PYR-GCK AFVEGTLLDAALVDD----TLARFDVDGVIHIAGYKYAGESVKRPLHTYE
TH_3729|M.thermoresistible__bu PLVRGTLLDADLVAR----ALREHRVSGVIHIAGFKYAGVSVQQPLHTYE
Mvan_5389|M.vanbaalenii_PYR-1 PLVRANLLDADAVRT----TLDAYGVSGVIHIAGYKYAGESVRRPLHTYQ
::. * . . . ::*:*. . ** * .
MLBr_00204|M.leprae_Br4923 VNVIGTVRLAEAARHTGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSP
MAV_0524|M.avium_104 VNVIGTVRLAEAARRTGVRKIVHTSSGGSIYGTPPTYPTPETVPTDPASP
Mb3658c|M.bovis_AF2122/97 VNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASP
Rv3634c|M.tuberculosis_H37Rv VNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASP
MMAR_5133|M.marinum_M VNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSERVPTDPASP
MUL_4210|M.ulcerans_Agy99 VNVIGTLRLAEAARLTGVRKVVHTSSGGSIYGTPPQYPTSERVPTDPASP
MAB_0503|M.abscessus_ATCC_1997 VNVVGTVRLAEAARKAGVRKIVHTSSGGSIYGTPKQIPTSETVPTDPHSP
MSMEG_6142|M.smegmatis_MC2_155 VNVVGTVRLAEAARLAGVRKVVHTSSGGSVYGTPPAYPTSEDMPVNPASP
Mflv_1401|M.gilvum_PYR-GCK QNVSTTVILLQAMEARGVGQIVFSSS-AATFGTPDVDIVDESTPTTPESP
TH_3729|M.thermoresistible__bu QNVSAMVTLLKAMQDTGVDMMVFSSS-AATFGTPDVDLVTETTPTRPESP
Mvan_5389|M.vanbaalenii_PYR-1 QNVSAMVTLLDAMSDAGVDRIVFSSS-AATYGTPDTAVVDETTATRPESP
** : * .* ** :*.:** .: :*** . * .. * **
MLBr_00204|M.leprae_Br4923 YAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAG---VVAI
MAV_0524|M.avium_104 YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
Mb3658c|M.bovis_AF2122/97 YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
Rv3634c|M.tuberculosis_H37Rv YAAGKVAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAG---VVAI
MMAR_5133|M.marinum_M YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MUL_4210|M.ulcerans_Agy99 YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MAB_0503|M.abscessus_ATCC_1997 YAAGKVAGEIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAG---VVAI
MSMEG_6142|M.smegmatis_MC2_155 YAAGKVAGEVYLNMYRNLYDLDCSHIAPANVYGPRQDPHGEAG---VVAI
Mflv_1401|M.gilvum_PYR-GCK YGETKLIGEWLLRDAGRASGLRHTSLRYFNVVGSGAVELFDASPHNLFPL
TH_3729|M.thermoresistible__bu YGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELFDVSPHNLFPL
Mvan_5389|M.vanbaalenii_PYR-1 YGESKLIGEWLLRDIGVATGLRHTSLRYFNVVGSGPDGVFDVSPFNLFPK
*. *: ** * .* : : ** *. :.. :..
MLBr_00204|M.leprae_Br4923 FVQALLSDRPTKVFGD------GTHTRDYVFVDDVVDAFIKASGDAGGGQ
MAV_0524|M.avium_104 FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKASGDAGGGQ
Mb3658c|M.bovis_AF2122/97 FAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL
Rv3634c|M.tuberculosis_H37Rv FAQALLSGKPTRVFGD------GTNTRDYVFVDDVVDAFVRVSADVGGGL
MMAR_5133|M.marinum_M FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVRAGSDVGGGQ
MUL_4210|M.ulcerans_Agy99 FAQALLSGKPTKVFGD------GTNTRDYVFVDDVVDAFVKAGSDVGGGQ
MAB_0503|M.abscessus_ATCC_1997 FAQALLSGRSTKVFGD------GGNTRDYVFVDDVVEAFVRASGPDGGGQ
MSMEG_6142|M.smegmatis_MC2_155 FSEALLAGRTTKIFGD------GSDTRDYVFVDDVVDAFVRAGGPAGGGQ
Mflv_1401|M.gilvum_PYR-GCK VFDMLFRGETPRINGDDYPTPDGTCVRDYIHVSDLALAHVAAAQRLAAGE
TH_3729|M.thermoresistible__bu VFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHVAAARRLQAGE
Mvan_5389|M.vanbaalenii_PYR-1 VFDMLVHGQTPRINGDDYPTPDGTCVRDYIHVEDVAAAHVAAAHRLESGL
. : * ....:: ** * .***:.* *:. *.: .. .*
MLBr_00204|M.leprae_Br4923 ----RFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPPRLGDLKRSCLDI
MAV_0524|M.avium_104 ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
Mb3658c|M.bovis_AF2122/97 ----RFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
Rv3634c|M.tuberculosis_H37Rv ----RFNIGTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MMAR_5133|M.marinum_M ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MUL_4210|M.ulcerans_Agy99 ----RFNIGTGVETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDI
MAB_0503|M.abscessus_ATCC_1997 ----RFNVGTGVETSDRQLHSLVAAAAGAPDDPEFHPPRLGDLRQSCLDV
MSMEG_6142|M.smegmatis_MC2_155 ----RFNVGTGVETSTRELHTAIAGAVGAPDEPEFHPPRLGDLRRSRLDN
Mflv_1401|M.gilvum_PYR-GCK PVEPVYNLGSGAGTSVREIMTAMRTVTGVDFEPVVMPRRPGDPARIVAAG
TH_3729|M.thermoresistible__bu PVEPVYNLGSGSGTSVREIMTAIRKVTGVDFVPEIAPRRPGDPARIVASG
Mvan_5389|M.vanbaalenii_PYR-1 PIEPVYNLGSGSGTSVREIMTTMRAVTGVDFEPDVAARRAGDPARIVAAG
:*:*:* ** *:: : : ..* * . . * ** :
MLBr_00204|M.leprae_Br4923 GLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS----
MAV_0524|M.avium_104 GLAARVLGWQPKVGLQQGVARTVEYFRNQHN-----
Mb3658c|M.bovis_AF2122/97 GLAERVLGWRPQIELADGVRRTVEYFRHKHTD----
Rv3634c|M.tuberculosis_H37Rv GLAERVLGWRPQIELADGVRRTVEYFRHKHTD----
MMAR_5133|M.marinum_M SRAEEVLGWRPQVELADGVRRTVDYFRRTHGS----
MUL_4210|M.ulcerans_Agy99 SRAEEVLGWRPQVELADGVRRTVDYFRRTHGS----
MAB_0503|M.abscessus_ATCC_1997 GLAKRVLGWEPRVPLADGIRRTVDFFRS--------
MSMEG_6142|M.smegmatis_MC2_155 TRAREVLGWQPQVALAEGIAKTVEFFRNKSQ-----
Mflv_1401|M.gilvum_PYR-GCK DLAARDLGWSNRHSLEEMVASAWRAR-QHAGDAYPR
TH_3729|M.thermoresistible__bu ELAARDLGWRMRHTLEDMVKSAWEAR-QRAGDAYPR
Mvan_5389|M.vanbaalenii_PYR-1 DLAARDLDWRMRHSLTDMVASAWSALPSRATDEAAP
* *.* : * : : :