For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TDHKAPTKVVVIGGGYSGTLAANHLRLRSDVDITLVNPRPKFVERIRLHQLAAAGRDATVDYGTLLGEGV RLVVDSASRIDTAARKVWLASGRQLDYVYVVYAVGSTGAPPAGVPGAVEFAYPVAELEQADRLRAALDDL HPAAPVTVVGAGLTGTETAAELAEAGRNVTLVCGGGLLPTFSAAGRRSAARWLRRHGVAVLESDTVAEVR AGAVVFADGAVRPSALTVWTTGFGVPDLAAVSGLATDDIGRLLTDETLTSVDDPRIVAAGDCAAPSGAPL RMCCASASQLGPQAANTVLSRIAGEQPSDFDYAFAGSCVSLGRRTGILQFARKDDSPVSVYIGGRVGGSL KEAICKGTLWGLRRGARKPGSAIWFKGGPRPGQPAVRPRAVTQS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5348 | - | - | 100% (395) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
M. vanbaalenii PYR-1 | Mvan_4805 | - | e-122 | 59.90% (384) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
M. vanbaalenii PYR-1 | Mvan_3078 | - | 6e-13 | 24.86% (370) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1842c | - | 3e-23 | 32.66% (297) | dehydrogenase |
M. gilvum PYR-GCK | Mflv_1928 | - | 1e-110 | 54.55% (407) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
M. tuberculosis H37Rv | Rv1812c | - | 3e-23 | 32.66% (297) | dehydrogenase |
M. leprae Br4923 | MLBr_02061 | - | 1e-12 | 26.56% (369) | putative dehydrogenase |
M. abscessus ATCC 19977 | MAB_4199 | - | 1e-119 | 55.96% (386) | putative oxidoreductase |
M. marinum M | MMAR_4486 | - | 1e-133 | 64.49% (383) | dehydrogenase |
M. avium 104 | MAV_1130 | - | 1e-134 | 64.99% (377) | dehydrogenase |
M. smegmatis MC2 155 | MSMEG_6818 | - | 1e-123 | 56.85% (387) | dehydrogenase |
M. thermoresistible (build 8) | TH_1143 | - | 1e-126 | 59.11% (406) | dehydrogenase |
M. ulcerans Agy99 | MUL_4658 | - | 1e-133 | 64.49% (383) | dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment Mb1842c|M.bovis_AF2122/97 -------------------------------------MTRVVVIGSGFAG Rv1812c|M.tuberculosis_H37Rv -------------------------------------MTRVVVIGSGFAG MMAR_4486|M.marinum_M ---------------------MSEM---------TEDRNHVVVIGGGYAG MUL_4658|M.ulcerans_Agy99 ---------------------MSEM---------TEDRNHVVVIGGGYAG MAV_1130|M.avium_104 ---------------------MTEV---------TRSKTHVVVVGGGYAG Mflv_1928|M.gilvum_PYR-GCK ------------------------M---------TAQNIRVIVVGGGYAG Mvan_5348|M.vanbaalenii_PYR-1 ---------------------MTDH---------KAP-TKVVVIGGGYSG MAB_4199|M.abscessus_ATCC_1997 ---------------------MT------------DQHPHVVVLGGGYAG TH_1143|M.thermoresistible__bu VACVTLKVVLSHLRRDRDLKGMTGHNARTPEIGRDTRGPKVVVIGGGYAG MSMEG_6818|M.smegmatis_MC2_155 ---------------------MTAH----------NKTHRVVVIGGGYAG MLBr_02061|M.leprae_Br4923 ---------------------MNAQP---AATAAQDRRHQVVIIGSGFGG :*:::*.*:.* Mb1842c|M.bovis_AF2122/97 LWAALGAARRLDELAVPAGTVDVMVVSNKPFHDIRVRNYEADLS------ Rv1812c|M.tuberculosis_H37Rv LWAALGAARRLDELAVLAGTVDVMVVSNKPFHDIRVRNYEADLS------ MMAR_4486|M.marinum_M IMAANHLRSRADLEITVVNPRPVFVER------IRLHQLAAGSG------ MUL_4658|M.ulcerans_Agy99 IMAANHLRSRADLEITVVNPRPVFVER------IRLHQLAAGSG------ MAV_1130|M.avium_104 TLAANHLRQRPDIDITLVNPRPVFVER------IRLHQLVADTG------ Mflv_1928|M.gilvum_PYR-GCK VMAANRLRSRDDLHVTLVNPRPQFVER------IRLHQLAADAGGTAGRA Mvan_5348|M.vanbaalenii_PYR-1 TLAANHLRLRSDVDITLVNPRPKFVER------IRLHQLAAAGR------ MAB_4199|M.abscessus_ATCC_1997 TMAANRLQQHTNIDITLVNPREEFVHR------LRLHQFAAGTG------ TH_1143|M.thermoresistible__bu TLAANRLQRRADVDITLVNARPTMVQR------LQLHRLAAGTADA---- MSMEG_6818|M.smegmatis_MC2_155 TLAANRLQQNPDIDITLINPRPQFVHR------MRLHQMAAGAC------ MLBr_02061|M.leprae_Br4923 LNAAKKLKR-ANVDIKLIARTTHHLFQP------LLYQVATGIISE---- ** : : : . : Mb1842c|M.bovis_AF2122/97 ----------------------------ACRIPLGDVLGP-AGVAHVTAE Rv1812c|M.tuberculosis_H37Rv ----------------------------ACRIPLGDVLGP-AGVAHVTAE MMAR_4486|M.marinum_M ----------------------------TATVDYDSMLG--DGIHLVVDA MUL_4658|M.ulcerans_Agy99 ----------------------------TATVDYDSMLG--DGIHLVVDA MAV_1130|M.avium_104 ----------------------------TATADYATLLG--EGIELIVDT Mflv_1928|M.gilvum_PYR-GCK KRRGTSTAGRAKRRGTSTAGRAKRRGTSSAVAEFGAVLN--PGVQLVVDN Mvan_5348|M.vanbaalenii_PYR-1 ----------------------------DATVDYGTLLG--EGVRLVVDS MAB_4199|M.abscessus_ATCC_1997 ----------------------------IATAEYAPMLG--KRVRLVVDS TH_1143|M.thermoresistible__bu ---------------------------DEVTADYRGLLG--ARVRLVVGE MSMEG_6818|M.smegmatis_MC2_155 ----------------------------EAVVDYGTLLG--SGVRLLADR MLBr_02061|M.leprae_Br4923 ---------------------------GEIAPPTRVVLRKQRNIQVLLGN :* : : Mb1842c|M.bovis_AF2122/97 VTAIDADGRRVT---TSTGASYSYDRLVLASG-SHVVKPALPGLAEFGFD Rv1812c|M.tuberculosis_H37Rv VTAIDADGRRVT---TSTGASYSYDRLVLASG-SHVVKPALPGLAEFGFD MMAR_4486|M.marinum_M VDRIDADEHRLL---LTSGSELRYDYLIYAVGSTAAMPA-VAGAAEFAFS MUL_4658|M.ulcerans_Agy99 VDRIDADEHRLL---LTSGSELGYDYLIYAVGSTAAMPA-VAGAAEFAFS MAV_1130|M.avium_104 VDHIDATARRAV---LTSGAGLDYDYLIYAVGSTGAVAE-VPGCAEFAHS Mflv_1928|M.gilvum_PYR-GCK VERIDAPVRRLA---LSSGTSLDYDYLVYAVGSTGAVPDGVPGAAEFAYP Mvan_5348|M.vanbaalenii_PYR-1 ASRIDTAARKVW---LASGRQLDYVYVVYAVGSTGAPPAGVPGAVEFAYP MAB_4199|M.abscessus_ATCC_1997 AVRIDAPARMIR---LESGDVLDYDYLIYAIGSTDSTAAGVPGLSEFAYP TH_1143|M.thermoresistible__bu ATRIDTAARRVQ---LRSGAPLEYDYLIYAVGSTSAVPESVPGAAEFAYP MSMEG_6818|M.smegmatis_MC2_155 VDRIDTANRRID---LASGDSMGYDYVVYAVGSTALVPESVEGAAEFAHT MLBr_02061|M.leprae_Br4923 VTHIDLANQCVVSELLGHTYETLYDSLIVAAG-AGQSYFGNDQFAEFAPG . ** : * :: * * : **. Mb1842c|M.bovis_AF2122/97 VDTYDGAVRLQQHLQGLAGGPLTS-------AAATVVVVGAGLTGIETAC Rv1812c|M.tuberculosis_H37Rv VDTYDGAVRLQQHLQGLAGGPLTS-------AAATVVVVGAGLTGIETAC MMAR_4486|M.marinum_M VADLDGATRLRHAMADLP-------------ADAAITVVGGGLTGIEAAA MUL_4658|M.ulcerans_Agy99 VADLDGATRLRHAMADLP-------------ADAAITVVGGGLTGIEAAA MAV_1130|M.avium_104 VADLESAQRLHYALADLP-------------LPAPITVVGGGLTGIETAS Mflv_1928|M.gilvum_PYR-GCK LAELEQAQRLRSRLADVA-------------AIAPVVVIGGGLTGIEAAA Mvan_5348|M.vanbaalenii_PYR-1 VAELEQADRLRAALDDLH-------------PAAPVTVVGAGLTGTETAA MAB_4199|M.abscessus_ATCC_1997 LSEFESAQRLRVALETSG-------------PDVQITVVGAGLTGIEMAS TH_1143|M.thermoresistible__bu MADFESAQRLRAVVDELP-------------AQAWITVVGAGLTGIEIAA MSMEG_6818|M.smegmatis_MC2_155 VAEYEAAQRLRATVNALA-------------PDAWITVVGAGFTGIEVAA MLBr_02061|M.leprae_Br4923 MKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGAGPTGVEMAG : : * .*: : ..*:*.* ** * * Mb1842c|M.bovis_AF2122/97 ELPGRLHALFA----RGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALL Rv1812c|M.tuberculosis_H37Rv ELPGRLHALFA----RGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALL MMAR_4486|M.marinum_M ELAE----------------RGRRVTLVCGGRLGPSLSNRGRRSVARQLG MUL_4658|M.ulcerans_Agy99 ELAE----------------RGRRVTLVCGGRLGPSLSNRGRRSVARQLG MAV_1130|M.avium_104 ELAE----------------LGRPVTLICGPVLGPSLSPRGRRSVAKRLR Mflv_1928|M.gilvum_PYR-GCK EFAE----------------AGRDVTLVS-PVVGPSLSGPGRRSVTRRLR Mvan_5348|M.vanbaalenii_PYR-1 ELAE----------------AGRNVTLVCGGGLLPTFSAAGRRSAARWLR MAB_4199|M.abscessus_ATCC_1997 ELAD----------------LGRHVRLVCGGQLAPTFGAPARRTIAQWFA TH_1143|M.thermoresistible__bu ELAE----------------QDRTVSLVCGGRLAPAFGEPARRSIAAWLT MSMEG_6818|M.smegmatis_MC2_155 ELAT----------------GGRTVSLVAGAQLAPTLGGPARRAVSRWMA MLBr_02061|M.leprae_Br4923 QIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMGEKLGQRAAARLQ ::. * * : : . :. : Mb1842c|M.bovis_AF2122/97 DNGVETRTGVSVAAVSPGGVTLSSG----ERLAAATVVWCAGMRAS---- Rv1812c|M.tuberculosis_H37Rv DNGVETRTGVSVAAVSPGGVTLSSG----ERLAAATVVWCAGMRAS---- MMAR_4486|M.marinum_M KLGVNVLESAAVSEVRWNAVVLADD----TVLASAATVWTAGFGVP---- MUL_4658|M.ulcerans_Agy99 KLGVNVLESAAVSEVRWNAVVLADD----TVLASAATVWTAGFGVP---- MAV_1130|M.avium_104 RLGVGVLESVTVTEVRWNEVVLSDG----VVLPSAATVWTAGFSVP---- Mflv_1928|M.gilvum_PYR-GCK KLGV-HLVSASVRAVGADHVVLDDA----RSLPSAVTVWTAGFGVP---- Mvan_5348|M.vanbaalenii_PYR-1 RHGVAVLESDTVAEVRAGAVVFADG----AVRPSALTVWTTGFGVP---- MAB_4199|M.abscessus_ATCC_1997 RRRVDVLENTSVTEVRPDSVVLADG----TALSSAITVWAGGFGVP---- TH_1143|M.thermoresistible__bu AHHVAVLEDDSVVEVRPDAVVFADG----AVRPSAVTVWAGGFGVP---- MSMEG_6818|M.smegmatis_MC2_155 ENGVGLLEDAMVTEVRPDAVVLDDG----TVWRSDLTIWAGGFGVP---- MLBr_02061|M.leprae_Br4923 KMGVEIQLSAMVTDVDRNGITVQDSDGTVRRIESACKVWSAGVSASRLGR * . * * . :.. . : :* *. .. Mb1842c|M.bovis_AF2122/97 RLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMS Rv1812c|M.tuberculosis_H37Rv RLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMS MMAR_4486|M.marinum_M DLAARSGLRTDDLGRLLTDETLTSVSDDRIVAAGDAVAP---SGQPLRMS MUL_4658|M.ulcerans_Agy99 DLAARSGLRTDDLGRLLTDETLTSVSDDRIVAAGDAVAP---SGQPLRMS MAV_1130|M.avium_104 DLAARSGLRTDPLGRLLTDETLTSIDDDRIVAAGDAAAP---SGRPLRMS Mflv_1928|M.gilvum_PYR-GCK TLAADSGLATDPLGRLLTDETLTSVDDDRIVAAGDSAAP---SGLPYRMS Mvan_5348|M.vanbaalenii_PYR-1 DLAAVSGLATDDIGRLLTDETLTSVDDPRIVAAGDCAAP---SGAPLRMC MAB_4199|M.abscessus_ATCC_1997 ALAAHSGLSVDADGRLLTDDTLTSMDDGRIIGAGDAVTT---TSLPTRMS TH_1143|M.thermoresistible__bu QLAAASGLSTDALGRLRTDDTLTSVDDDRIVGAGDAVTS---SATPLRMS MSMEG_6818|M.smegmatis_MC2_155 DLASRSGLRTDTLGRLITDATLTSIDDDRVLAAGDAAAP---SGKALRMA MLBr_02061|M.leprae_Br4923 DLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAID--GVPGVAQG *: : * **: . * . :. .** .: Mb1842c|M.bovis_AF2122/97 CQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEG-- Rv1812c|M.tuberculosis_H37Rv CQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEG-- MMAR_4486|M.marinum_M CQAAGPLGAQAANTVLSRIAGDQPVALNQAFVGQCISVGRSYGTIQLART MUL_4658|M.ulcerans_Agy99 CQAAGPLGAQAANTVLSRIAGDQPVALNQAFVGQCISVGRSYGTIQLAHT MAV_1130|M.avium_104 CQAAGPLGAQAANTVLGRIAGTEPAPLNQAFVGQCISLGRAAATFQLART Mflv_1928|M.gilvum_PYR-GCK CQAGLPLGAQAAETVLARIAGTDAAVATVPMSGQCISLGRDAGTVQLQRK Mvan_5348|M.vanbaalenii_PYR-1 CASASQLGPQAANTVLSRIAGEQPSDFDYAFAGSCVSLGRRTGILQFARK MAB_4199|M.abscessus_ATCC_1997 CYTANTTGAAAADTVLSRLADTEPAPFRLAYVGQCLSLGRRNAVLQFTRK TH_1143|M.thermoresistible__bu CYAAAPTAATAADTVLSRLDGAEPAPFALAYVGSTVGLGRRAAVAQFTRA MSMEG_6818|M.smegmatis_MC2_155 CYTAGPMAATAADTILSRIAGTPPEAFSLGYLGSCLGLGRRSAVMQFTRR MLBr_02061|M.leprae_Br4923 AIQGAKYVANNIKAELGEANPAEREPFQYFDKGSMATVSRFSAVAKIGPL . . : :. . Mb1842c|M.bovis_AF2122/97 ------------------------WERKVVSQGAPAKTTKQSINTRRIYP Rv1812c|M.tuberculosis_H37Rv ------------------------WERKVVSQGAPAKTTKQSINTRRIYP MMAR_4486|M.marinum_M DDT---------PVNVIIGGRAGAAVKETICKGTLWALRREAAKPGSYFW MUL_4658|M.ulcerans_Agy99 DDT---------PVNVIIGGRAGAAVKEAICKGTLWALRREAAKPGSYFW MAV_1130|M.avium_104 DDT---------PINAYLGGRAAAKLKEAICRGTLWAIRREAAKPGSYRW Mflv_1928|M.gilvum_PYR-GCK DDT---------PLNLYLGGRTGAFVKEQVCRFTITWLAAEARKPGSYRS Mvan_5348|M.vanbaalenii_PYR-1 DDS---------PVSVYIGGRVGGSLKEAICKGTLWGLRRGARKPGSAIW MAB_4199|M.abscessus_ATCC_1997 DDS---------PVGAHARGRLTAWFKEFVLTGVPWGLRREGRKPGASVW TH_1143|M.thermoresistible__bu DDS---------PLRAHLRGRIPALIKDAVVKGTLWSIRREARKPGATIW MSMEG_6818|M.smegmatis_MC2_155 DDT---------PLDVHLRGRVAGAVKELVLKGILWSLRREGRKPGATSW MLBr_02061|M.leprae_Br4923 EFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWTVTFLSTRRGQLTITEQQ : . . Mb1842c|M.bovis_AF2122/97 PLNGSRADLLAAAAPRVQPRP---------- Rv1812c|M.tuberculosis_H37Rv PLNGSRADLLAAAAPRVQPRP---------- MMAR_4486|M.marinum_M LKGGSRPVQPSAEQPVVLS------------ MUL_4658|M.ulcerans_Agy99 LKGGSRPVQPSAEQPVVLP------------ MAV_1130|M.avium_104 LKGGQR--VPADERVGV-------------- Mflv_1928|M.gilvum_PYR-GCK LKGPDRSELIASTAVPVR------------- Mvan_5348|M.vanbaalenii_PYR-1 FKGGPRPGQPAVRPRAVTQS----------- MAB_4199|M.abscessus_ATCC_1997 FKSRPRPAEAAQHRAEVVQS----------- TH_1143|M.thermoresistible__bu YRGRRSAAPAPVPEPETVR------------ MSMEG_6818|M.smegmatis_MC2_155 LKNGDTVTSPALVDAKGSGHDGPIG------ MLBr_02061|M.leprae_Br4923 AFARTRLEQLAELTAESQSTAAANRATMRAS .