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LTRVVVIGSGFAGLWAALGAARRLDELAVPAGTVDVMVVSNKPFHDIRVRNYEADLSACRIPLGDVLGPA GVAHVTAEVTAIDADGRRVTTSTGASYSYDRLVLASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQG LAGGPLTSAAATVVVVGAGLTGIETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQ ALLDNGVETRTGVSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDYLRVI GVPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVY TEGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1842c | - | - | 100% (400) | dehydrogenase |
| M. bovis AF2122 / 97 | Mb1885c | ndh | 7e-21 | 29.91% (321) | NADH dehydrogenase |
| M. bovis AF2122 / 97 | Mb0398c | ndhA | 6e-17 | 29.06% (320) | membrane NADH dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1928 | - | 2e-25 | 31.22% (378) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1812c | - | 0.0 | 99.75% (400) | dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 9e-18 | 29.28% (321) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1127c | - | 6e-27 | 32.29% (319) | putative oxidoreductase |
| M. marinum M | MMAR_2688 | - | 1e-172 | 76.25% (400) | NADH dehydrogenase |
| M. avium 104 | MAV_1130 | - | 1e-29 | 31.91% (351) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6818 | - | 7e-28 | 30.68% (352) | dehydrogenase |
| M. thermoresistible (build 8) | TH_2218 | - | 2e-27 | 30.67% (388) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3068 | - | 1e-172 | 76.00% (400) | NADH dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4805 | - | 9e-30 | 32.72% (327) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1842c|M.bovis_AF2122/97 -------------MTRVVVIGSGFAGLWAALGAARRLDELAVPAGTVDVM
Rv1812c|M.tuberculosis_H37Rv -------------MTRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVM
MMAR_2688|M.marinum_M -------------MSRVLVIGSGFAGLWAALGAARRVEELAVPPGSVDIT
MUL_3068|M.ulcerans_Agy99 -------------MSRVLVIGSGFAGLWAALGAARRVEELAVPPGSVDIT
Mflv_1928|M.gilvum_PYR-GCK ---------MTAQNIRVIVVGGGYAGVMAAN--------RLRSRDDLHVT
MAV_1130|M.avium_104 ------MTEVTRSKTHVVVVGGGYAGTLAAN--------HLRQRPDIDIT
Mvan_4805|M.vanbaalenii_PYR-1 ---------MTAQRTHVVVIGGGYAGVMAAN--------RLMSRDGLRVT
MAB_1127c|M.abscessus_ATCC_199 ----------MTENTTVIVIGGGYAGTLAAN--------QLLANKNLTVT
MSMEG_6818|M.smegmatis_MC2_155 -------MTAHNKTHRVVVIGGGYAGTLAAN--------RLQQNPDIDIT
TH_2218|M.thermoresistible__bu -------------MTSVVIVGSGFAGFECAR---HLSDKLRRQQAPVDIT
MLBr_02061|M.leprae_Br4923 MNAQPAATAAQDRRHQVVIIGSGFGGLNAAK---------KLKRANVDIK
*:::*.*:.* .* : :
Mb1842c|M.bovis_AF2122/97 VVSNKP--FHDIRVRNYEADLS----------------------------
Rv1812c|M.tuberculosis_H37Rv VVSNKP--FHDIRVRNYEADLS----------------------------
MMAR_2688|M.marinum_M VLSAKP--FHDIRVRNYETDLS----------------------------
MUL_3068|M.ulcerans_Agy99 VLSAKP--FHDIRVRNYETDLS----------------------------
Mflv_1928|M.gilvum_PYR-GCK LVNPRPQFVERIRLHQLAADAGGTAGRAKRRGTSTAGRAKRRGTSTAGRA
MAV_1130|M.avium_104 LVNPRPVFVERIRLHQLVADTG----------------------------
Mvan_4805|M.vanbaalenii_PYR-1 LVNPRPEFVERIRLHQFVTGSD----------------------------
MAB_1127c|M.abscessus_ATCC_199 LVNPRPHFVERIRLHQLVAGNA----------------------------
MSMEG_6818|M.smegmatis_MC2_155 LINPRPQFVHRMRLHQMAAGAC----------------------------
TH_2218|M.thermoresistible__bu MISPVDYMLYTPLLPDVAGGVVDAR-------------------------
MLBr_02061|M.leprae_Br4923 LIARTTHHLFQPLLYQVATGIISEG-------------------------
:: . : : .
Mb1842c|M.bovis_AF2122/97 ------ACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGA----SY
Rv1812c|M.tuberculosis_H37Rv ------ACRIPLGDVLGPAGVAHVTAEVTAIDADGRRVTTSTGA----SY
MMAR_2688|M.marinum_M ------TCRIPLADLLDPAGVSHIPAVVVGIDAAARRVRTADGQ----TY
MUL_3068|M.ulcerans_Agy99 ------TCRIPLADLLDPAGVSHIPAVVVGIDAAARRVRTADGQ----TY
Mflv_1928|M.gilvum_PYR-GCK KRRGTSSAVAEFGAVLN-PGVQLVVDNVERIDAPVRRLALSSGT----SL
MAV_1130|M.avium_104 ------TATADYATLLG-EGIELIVDTVDHIDATARRAVLTSGA----GL
Mvan_4805|M.vanbaalenii_PYR-1 ------DAVVDYADVVG-EGIALIVDSVTRIDAPTRRVELASGG----SI
MAB_1127c|M.abscessus_ATCC_199 ------TATAGYDKLLN-PAVSLVVDKVTYIDAGAQKLELASGA----VL
MSMEG_6818|M.smegmatis_MC2_155 ------EAVVDYGTLLG-SGVRLLADRVDRIDTANRRIDLASGD----SM
TH_2218|M.thermoresistible__bu ------FVTVPLANTLR--GVRTARGWVDSVDFDARTVSFTDPEDRTHTV
MLBr_02061|M.leprae_Br4923 -----EIAPPTRVVLRKQRNIQVLLGNVTHIDLANQCVVSELLG-HTYET
: * :* :
Mb1842c|M.bovis_AF2122/97 SYDRLVLASGSHVVKPA-LPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPL
Rv1812c|M.tuberculosis_H37Rv SYDRLVLASGSHVVKPA-LPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPL
MMAR_2688|M.marinum_M EYDRLVLASGSQVAKPD-LPGLQEFGFDVDTYEGAVRLQCHLQQLADRPP
MUL_3068|M.ulcerans_Agy99 EYDRLVLASGSQVAKPD-LPGLQEFGFDVDTYEGAVRLQCHLQQLADRPP
Mflv_1928|M.gilvum_PYR-GCK DYDYLVYAVGSTGAVPDGVPGAAEFAYPLAELEQAQRLRSRLADVA----
MAV_1130|M.avium_104 DYDYLIYAVGSTGAVAE-VPGCAEFAHSVADLESAQRLHYALADLP----
Mvan_4805|M.vanbaalenii_PYR-1 DYDYLIYAVGSTGAAPT-VPGAAEFAHPISEYEHGAPLRTAVTAAA----
MAB_1127c|M.abscessus_ATCC_199 PYDYLVYAVGSTTSTPD-VPGVAEYALSINEFEHAQQVRTRYERLA----
MSMEG_6818|M.smegmatis_MC2_155 GYDYVVYAVGSTALVPESVEGAAEFAHTVAEYEAAQRLRATVNALA----
TH_2218|M.thermoresistible__bu AWDRLVLTPGSVTRLFD-IPGLAEHARGLKSTAEALYLRDHFLQQLQLSC
MLBr_02061|M.leprae_Br4923 LYDSLIVAAGAGQSYFG-NDQFAEFAPGMKSIDDALELRGRILSAFEQAE
:* :: : *: *.. : . ::
Mb1842c|M.bovis_AF2122/97 T-------SAAATVVVVGAGLTGIETACELPGRLHALFARG----DGVTP
Rv1812c|M.tuberculosis_H37Rv T-------SAAATVVVVGAGLTGIETACELPGRLHALFARG----DGVTP
MMAR_2688|M.marinum_M A-------AAAATVVVVGAGLTGIETACELPARLAKLFAHS-----AVVP
MUL_3068|M.ulcerans_Agy99 A-------AATATVVVVGAGLTGIETACELPARLAKLFAHS-----AVVP
Mflv_1928|M.gilvum_PYR-GCK ---------AIAPVVVIGGGLTGIEAAAEFAE----------------AG
MAV_1130|M.avium_104 ---------LPAPITVVGGGLTGIETASELAE----------------LG
Mvan_4805|M.vanbaalenii_PYR-1 ---------ADAPIVVVGAGPTGLETAAELAE----------------EG
MAB_1127c|M.abscessus_ATCC_199 ---------PDAPIVVVGAGLTGVELAGELAE----------------AG
MSMEG_6818|M.smegmatis_MC2_155 ---------PDAWITVVGAGFTGIEVAAELAT----------------GG
TH_2218|M.thermoresistible__bu IDDDPDEIAARRTVVVVGASYSGTELVAQLRALADTAAEQMG--FDPAEV
MLBr_02061|M.leprae_Br4923 RSNDPERREKLLTFTVVGAGPTGVEMAGQIAELADHTLKGAFRRIDSTKA
..*:*.. :* * . ::
Mb1842c|M.bovis_AF2122/97 RVVLIDHNPFVGSDMGLSARPVIEQALLDNGVETRTG--VSVAAVSPGGV
Rv1812c|M.tuberculosis_H37Rv RVVLIDHNPFVGSDMGLSARPVIEQALLDNGVETRTG--VSVAAVSPGGV
MMAR_2688|M.marinum_M RVVLVDHNPVVGSDMGASARPVIEEALSEVGVETRTA--VGVTAVTEAGV
MUL_3068|M.ulcerans_Agy99 RVVLVDHNPVVGSDMGASARPVIEEALSEVGVETRTA--VGVTAVTEAGV
Mflv_1928|M.gilvum_PYR-GCK RDVTLVS-PVVGPSLSGPGRRSVTRRLRKLGV-HLVS--ASVRAVGADHV
MAV_1130|M.avium_104 RPVTLICGPVLGPSLSPRGRRSVAKRLRRLGVGVLES--VTVTEVRWNEV
Mvan_4805|M.vanbaalenii_PYR-1 RRVTLVCGSVLGPYLSTRGRRAAAKRMTKLGVDVIDGPGATVTEVLADAV
MAB_1127c|M.abscessus_ATCC_199 RRVTLICGTQLLPSVGEPARRAAAKRLRKLGVDVQAP--ATAIRVDENSV
MSMEG_6818|M.smegmatis_MC2_155 RTVSLVAGAQLAPTLGGPARRAVSRWMAENGVGLLED--AMVTEVRPDAV
TH_2218|M.thermoresistible__bu RFVLLDLAEQVMPEVGEKLGTAAMQVLRHRGIDVRLG--LTLSEVHADHV
MLBr_02061|M.leprae_Br4923 RVVLLDAAPAVLPPMGEKLGQRAAARLQKMGVEIQLS--AMVTDVDRNGI
* * : : . :. : *: * :
Mb1842c|M.bovis_AF2122/97 TLSSG----ERLAAATVVWCAGMRAS----RLTEQLPVARDRLGRLQVDD
Rv1812c|M.tuberculosis_H37Rv TLSSG----ERLAAATVVWCAGMRAS----RLTEQLPVARDRLGRLQVDD
MMAR_2688|M.marinum_M ALSSG----ELLEAATVVWCAGMRAN----SLAEQLPVHRDRLGRVEVDD
MUL_3068|M.ulcerans_Agy99 ALSSG----ELLEAATVVWCAGMRAN----SLAEQLPVHRDRLGRVEVDD
Mflv_1928|M.gilvum_PYR-GCK VLDDA----RSLPSAVTVWTAGFGVP----TLAADSGLATDPLGRLLTDE
MAV_1130|M.avium_104 VLSDG----VVLPSAATVWTAGFSVP----DLAARSGLRTDPLGRLLTDE
Mvan_4805|M.vanbaalenii_PYR-1 VLADG----RRVASAVTIWTAGFGVP----DLAVRSGLSTDAIGRLLTDE
MAB_1127c|M.abscessus_ATCC_199 TLSDG----RVLPSALTVWTAGFGVP----RLAIDSGLRTDALGRLLTDE
MSMEG_6818|M.smegmatis_MC2_155 VLDDG----TVWRSDLTIWAGGFGVP----DLASRSGLRTDTLGRLITDA
TH_2218|M.thermoresistible__bu VLSDG----SRVGTRTVAWLTGVTAA----PLIETLGLP-TTKGRLEVDA
MLBr_02061|M.leprae_Br4923 TVQDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSLVELDWAGRVKVLP
.: .. : * *. . * : **: .
Mb1842c|M.bovis_AF2122/97 YLRVIGVPAMFAAGDVAAAR----MDDEHLSVMSCQHGRPMGRYAGCNVI
Rv1812c|M.tuberculosis_H37Rv YLRVIGVPAMFAAGDVAAAR----MDDEHLSVMSCQHGRPMGRYAGCNVI
MMAR_2688|M.marinum_M YLRVAGVPEIFAAGDVAAAQ----MDDDHVSVMSCQHGRPMGRYAGYNVI
MUL_3068|M.ulcerans_Agy99 YLRVVGVPEIFAAGDVAAAQ----MDDDHVSVMSCQHGRPMGRYAGYNVI
Mflv_1928|M.gilvum_PYR-GCK TLTSVDDDRIVAAGDSAAP-------SGLPYRMSCQAGLPLGAQAAETVL
MAV_1130|M.avium_104 TLTSIDDDRIVAAGDAAAP-------SGRPLRMSCQAAGPLGAQAANTVL
Mvan_4805|M.vanbaalenii_PYR-1 TLASVDDPRIVAAGDAAAP-------SDLPLRMSCQAAIPLGAQAANTVL
MAB_1127c|M.abscessus_ATCC_199 TLVSLDNPRIIAAGDAASP-------SGVPLRMSCQAAGPLAARAVKTVL
MSMEG_6818|M.smegmatis_MC2_155 TLTSIDDDRVLAAGDAAAP-------SGKALRMACYTAGPMAATAADTIL
TH_2218|M.thermoresistible__bu ELRVPDRPDVFAAGDAAAVPDLAQPDPERITPPTAQHATRQGKVLANNVA
MLBr_02061|M.leprae_Br4923 DLSIPGYRNVFVVGDMAAID------GVPGVAQGAIQGAKYVANNIKAEL
* . :...** *: . .
Mb1842c|M.bovis_AF2122/97 NDLFDQPLLALRIPWYVTVLDLGSAGAVYTEGWER---KVVSQGAP----
Rv1812c|M.tuberculosis_H37Rv NDLFDQPLLALRIPWYVTVLDLGSAGAVYTEGWER---KVVSQGAP----
MMAR_2688|M.marinum_M SDLFGEPLLALRIPWYVTVLDLGPAGAVYTEGWDR---MVVSRGAK----
MUL_3068|M.ulcerans_Agy99 SDLFGEPLLALRIPWYVTVLDLGPAGAVYTEGWDR---MVVSRGAK----
Mflv_1928|M.gilvum_PYR-GCK ARIAGTDAAVATVPMSGQCISLGRDAGTVQLQRKDDTPLNLYLGGR----
MAV_1130|M.avium_104 GRIAGTEPAPLNQAFVGQCISLGRAAATFQLARTDDTPINAYLGGR----
Mvan_4805|M.vanbaalenii_PYR-1 SRIAGTTPKPINQAFTGQCISLGRSAGLIQIAHLDDRVMPLYIGGR----
MAB_1127c|M.abscessus_ATCC_199 ALVDGLRPEARTQIFTGQNVSIGRRAAVIQVGHTDDTPRTLYIGGR----
MSMEG_6818|M.smegmatis_MC2_155 SRIAGTPPEAFSLGYLGSCLGLGRRSAVMQFTRRDDTPLDVHLRGR----
TH_2218|M.thermoresistible__bu ASLGYGRMKQYRHRNMGLVVDLGPRYAVANPLNVHLSGFPAKAVARGYHL
MLBr_02061|M.leprae_Br4923 GEANPAEREPFQYFDKGSMATVSRFSAVAKIGPLEFSGFIAWLMWLVLHL
:. .
Mb1842c|M.bovis_AF2122/97 ------------AKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP--
Rv1812c|M.tuberculosis_H37Rv ------------AKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP--
MMAR_2688|M.marinum_M ------------AKATKQTINTERIYPPLTRDRADLLAAAAPDLQDRP--
MUL_3068|M.ulcerans_Agy99 ------------AKATKQTINTERIYPPLTRDRADLLAAAAPDLQDRP--
Mflv_1928|M.gilvum_PYR-GCK ------------TGAFVKEQVCRFTITWLAAEARKPGSYRSLKGPDRSEL
MAV_1130|M.avium_104 ------------AAAKLKEAICRGTLWAIRREAAKPGSYRWLKGGQR--V
Mvan_4805|M.vanbaalenii_PYR-1 ------------TAASVKEAVCKGTISFLSREARKPGSYFWLKGGKRQQK
MAB_1127c|M.abscessus_ATCC_199 ------------TGAAIKEMVCKGTLSILATAAKHPTWYYWPQGGKRAEA
MSMEG_6818|M.smegmatis_MC2_155 ------------VAGAVKELVLKGILWSLRREGRKPGATSWLKNGDTVTS
TH_2218|M.thermoresistible__bu YAIPRFVNRWAVALAYLTDALFDRSVVSIGLSSKEDASFAVSQRIPPPKQ
MLBr_02061|M.leprae_Br4923 MYLIGFKTKITTLLSWTVTFLSTRRGQLTITEQQAFARTRLEQLAELTAE
Mb1842c|M.bovis_AF2122/97 ----------------
Rv1812c|M.tuberculosis_H37Rv ----------------
MMAR_2688|M.marinum_M ----------------
MUL_3068|M.ulcerans_Agy99 ----------------
Mflv_1928|M.gilvum_PYR-GCK IASTAVPVR-------
MAV_1130|M.avium_104 PADERVGV--------
Mvan_4805|M.vanbaalenii_PYR-1 LAAQPVSS--------
MAB_1127c|M.abscessus_ATCC_199 LRAQV-----------
MSMEG_6818|M.smegmatis_MC2_155 PALVDAKGSGHDGPIG
TH_2218|M.thermoresistible__bu PTPGD-----------
MLBr_02061|M.leprae_Br4923 SQSTAAANRATMRAS-