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TAHNKTHRVVVIGGGYAGTLAANRLQQNPDIDITLINPRPQFVHRMRLHQMAAGACEAVVDYGTLLGSGV RLLADRVDRIDTANRRIDLASGDSMGYDYVVYAVGSTALVPESVEGAAEFAHTVAEYEAAQRLRATVNAL APDAWITVVGAGFTGIEVAAELATGGRTVSLVAGAQLAPTLGGPARRAVSRWMAENGVGLLEDAMVTEVR PDAVVLDDGTVWRSDLTIWAGGFGVPDLASRSGLRTDTLGRLITDATLTSIDDDRVLAAGDAAAPSGKAL RMACYTAGPMAATAADTILSRIAGTPPEAFSLGYLGSCLGLGRRSAVMQFTRRDDTPLDVHLRGRVAGAV KELVLKGILWSLRREGRKPGATSWLKNGDTVTSPALVDAKGSGHDGPIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6818 | - | - | 100% (400) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5443 | - | 1e-98 | 50.81% (370) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3621 | ndh | 4e-18 | 27.57% (370) | NADH dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1842c | - | 5e-28 | 30.68% (352) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1928 | - | 8e-99 | 48.07% (414) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1812c | - | 5e-28 | 30.68% (352) | dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 7e-15 | 26.46% (325) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4199 | - | 1e-122 | 57.99% (369) | putative oxidoreductase |
| M. marinum M | MMAR_4486 | - | 1e-117 | 55.94% (379) | dehydrogenase |
| M. avium 104 | MAV_1130 | - | 1e-119 | 57.41% (378) | dehydrogenase |
| M. thermoresistible (build 8) | TH_1143 | - | 1e-130 | 59.10% (401) | dehydrogenase |
| M. ulcerans Agy99 | MUL_4658 | - | 1e-118 | 55.94% (379) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5348 | - | 1e-123 | 56.85% (387) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1842c|M.bovis_AF2122/97 -------------------------------------MTRVVVIGSGFAG
Rv1812c|M.tuberculosis_H37Rv -------------------------------------MTRVVVIGSGFAG
MAB_4199|M.abscessus_ATCC_1997 ---------------------MT------------DQHPHVVVLGGGYAG
TH_1143|M.thermoresistible__bu VACVTLKVVLSHLRRDRDLKGMTGHNARTPEIGRDTRGPKVVVIGGGYAG
MSMEG_6818|M.smegmatis_MC2_155 ---------------------MTAH----------NKTHRVVVIGGGYAG
MMAR_4486|M.marinum_M ---------------------MSEM---------TEDRNHVVVIGGGYAG
MUL_4658|M.ulcerans_Agy99 ---------------------MSEM---------TEDRNHVVVIGGGYAG
MAV_1130|M.avium_104 ---------------------MTEV---------TRSKTHVVVVGGGYAG
Mflv_1928|M.gilvum_PYR-GCK ------------------------M---------TAQNIRVIVVGGGYAG
Mvan_5348|M.vanbaalenii_PYR-1 ---------------------MTDH---------KAP-TKVVVIGGGYSG
MLBr_02061|M.leprae_Br4923 ---------------------MNAQP---AATAAQDRRHQVVIIGSGFGG
:*:::*.*:.*
Mb1842c|M.bovis_AF2122/97 LWAALGAARRLDELAVPAGTVDVMVVSNKPFHDIRVRNYEADLS------
Rv1812c|M.tuberculosis_H37Rv LWAALGAARRLDELAVLAGTVDVMVVSNKPFHDIRVRNYEADLS------
MAB_4199|M.abscessus_ATCC_1997 TMAANRLQQHTNIDITLVNPREEFVHR------LRLHQFAAGTG------
TH_1143|M.thermoresistible__bu TLAANRLQRRADVDITLVNARPTMVQR------LQLHRLAAGTADA----
MSMEG_6818|M.smegmatis_MC2_155 TLAANRLQQNPDIDITLINPRPQFVHR------MRLHQMAAGAC------
MMAR_4486|M.marinum_M IMAANHLRSRADLEITVVNPRPVFVER------IRLHQLAAGSG------
MUL_4658|M.ulcerans_Agy99 IMAANHLRSRADLEITVVNPRPVFVER------IRLHQLAAGSG------
MAV_1130|M.avium_104 TLAANHLRQRPDIDITLVNPRPVFVER------IRLHQLVADTG------
Mflv_1928|M.gilvum_PYR-GCK VMAANRLRSRDDLHVTLVNPRPQFVER------IRLHQLAADAGGTAGRA
Mvan_5348|M.vanbaalenii_PYR-1 TLAANHLRLRSDVDITLVNPRPKFVER------IRLHQLAAAGR------
MLBr_02061|M.leprae_Br4923 LNAAKKLKR-ANVDIKLIARTTHHLFQP------LLYQVATGIISE----
** : : : . :
Mb1842c|M.bovis_AF2122/97 ----------------------------ACRIPLGDVLGP-AGVAHVTAE
Rv1812c|M.tuberculosis_H37Rv ----------------------------ACRIPLGDVLGP-AGVAHVTAE
MAB_4199|M.abscessus_ATCC_1997 ----------------------------IATAEYAPMLG--KRVRLVVDS
TH_1143|M.thermoresistible__bu ---------------------------DEVTADYRGLLG--ARVRLVVGE
MSMEG_6818|M.smegmatis_MC2_155 ----------------------------EAVVDYGTLLG--SGVRLLADR
MMAR_4486|M.marinum_M ----------------------------TATVDYDSMLG--DGIHLVVDA
MUL_4658|M.ulcerans_Agy99 ----------------------------TATVDYDSMLG--DGIHLVVDA
MAV_1130|M.avium_104 ----------------------------TATADYATLLG--EGIELIVDT
Mflv_1928|M.gilvum_PYR-GCK KRRGTSTAGRAKRRGTSTAGRAKRRGTSSAVAEFGAVLN--PGVQLVVDN
Mvan_5348|M.vanbaalenii_PYR-1 ----------------------------DATVDYGTLLG--EGVRLVVDS
MLBr_02061|M.leprae_Br4923 ---------------------------GEIAPPTRVVLRKQRNIQVLLGN
:* : :
Mb1842c|M.bovis_AF2122/97 VTAIDADGRRVT---TSTGASYSYDRLVLASG-SHVVKPALPGLAEFGFD
Rv1812c|M.tuberculosis_H37Rv VTAIDADGRRVT---TSTGASYSYDRLVLASG-SHVVKPALPGLAEFGFD
MAB_4199|M.abscessus_ATCC_1997 AVRIDAPARMIR---LESGDVLDYDYLIYAIGSTDSTAAGVPGLSEFAYP
TH_1143|M.thermoresistible__bu ATRIDTAARRVQ---LRSGAPLEYDYLIYAVGSTSAVPESVPGAAEFAYP
MSMEG_6818|M.smegmatis_MC2_155 VDRIDTANRRID---LASGDSMGYDYVVYAVGSTALVPESVEGAAEFAHT
MMAR_4486|M.marinum_M VDRIDADEHRLL---LTSGSELRYDYLIYAVGSTAAMPA-VAGAAEFAFS
MUL_4658|M.ulcerans_Agy99 VDRIDADEHRLL---LTSGSELGYDYLIYAVGSTAAMPA-VAGAAEFAFS
MAV_1130|M.avium_104 VDHIDATARRAV---LTSGAGLDYDYLIYAVGSTGAVAE-VPGCAEFAHS
Mflv_1928|M.gilvum_PYR-GCK VERIDAPVRRLA---LSSGTSLDYDYLVYAVGSTGAVPDGVPGAAEFAYP
Mvan_5348|M.vanbaalenii_PYR-1 ASRIDTAARKVW---LASGRQLDYVYVVYAVGSTGAPPAGVPGAVEFAYP
MLBr_02061|M.leprae_Br4923 VTHIDLANQCVVSELLGHTYETLYDSLIVAAG-AGQSYFGNDQFAEFAPG
. ** : * :: * * : **.
Mb1842c|M.bovis_AF2122/97 VDTYDGAVRLQQHLQGLAGGPLTS-------AAATVVVVGAGLTGIETAC
Rv1812c|M.tuberculosis_H37Rv VDTYDGAVRLQQHLQGLAGGPLTS-------AAATVVVVGAGLTGIETAC
MAB_4199|M.abscessus_ATCC_1997 LSEFESAQRLRVALETSG-------------PDVQITVVGAGLTGIEMAS
TH_1143|M.thermoresistible__bu MADFESAQRLRAVVDELP-------------AQAWITVVGAGLTGIEIAA
MSMEG_6818|M.smegmatis_MC2_155 VAEYEAAQRLRATVNALA-------------PDAWITVVGAGFTGIEVAA
MMAR_4486|M.marinum_M VADLDGATRLRHAMADLP-------------ADAAITVVGGGLTGIEAAA
MUL_4658|M.ulcerans_Agy99 VADLDGATRLRHAMADLP-------------ADAAITVVGGGLTGIEAAA
MAV_1130|M.avium_104 VADLESAQRLHYALADLP-------------LPAPITVVGGGLTGIETAS
Mflv_1928|M.gilvum_PYR-GCK LAELEQAQRLRSRLADVA-------------AIAPVVVIGGGLTGIEAAA
Mvan_5348|M.vanbaalenii_PYR-1 VAELEQADRLRAALDDLH-------------PAAPVTVVGAGLTGTETAA
MLBr_02061|M.leprae_Br4923 MKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGAGPTGVEMAG
: : * .*: : ..*:*.* ** * *
Mb1842c|M.bovis_AF2122/97 ELPGRLHALFA----RGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALL
Rv1812c|M.tuberculosis_H37Rv ELPGRLHALFA----RGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQALL
MAB_4199|M.abscessus_ATCC_1997 ELAD----------------LGRHVRLVCGGQLAPTFGAPARRTIAQWFA
TH_1143|M.thermoresistible__bu ELAE----------------QDRTVSLVCGGRLAPAFGEPARRSIAAWLT
MSMEG_6818|M.smegmatis_MC2_155 ELAT----------------GGRTVSLVAGAQLAPTLGGPARRAVSRWMA
MMAR_4486|M.marinum_M ELAE----------------RGRRVTLVCGGRLGPSLSNRGRRSVARQLG
MUL_4658|M.ulcerans_Agy99 ELAE----------------RGRRVTLVCGGRLGPSLSNRGRRSVARQLG
MAV_1130|M.avium_104 ELAE----------------LGRPVTLICGPVLGPSLSPRGRRSVAKRLR
Mflv_1928|M.gilvum_PYR-GCK EFAE----------------AGRDVTLVS-PVVGPSLSGPGRRSVTRRLR
Mvan_5348|M.vanbaalenii_PYR-1 ELAE----------------AGRNVTLVCGGGLLPTFSAAGRRSAARWLR
MLBr_02061|M.leprae_Br4923 QIAELADHTLKGAFRRIDSTKARVVLLDAAPAVLPPMGEKLGQRAAARLQ
::. * * : : . :. :
Mb1842c|M.bovis_AF2122/97 DNGVETRTGVSVAAVSPGGVTLSSG----ERLAAATVVWCAGMRAS----
Rv1812c|M.tuberculosis_H37Rv DNGVETRTGVSVAAVSPGGVTLSSG----ERLAAATVVWCAGMRAS----
MAB_4199|M.abscessus_ATCC_1997 RRRVDVLENTSVTEVRPDSVVLADG----TALSSAITVWAGGFGVP----
TH_1143|M.thermoresistible__bu AHHVAVLEDDSVVEVRPDAVVFADG----AVRPSAVTVWAGGFGVP----
MSMEG_6818|M.smegmatis_MC2_155 ENGVGLLEDAMVTEVRPDAVVLDDG----TVWRSDLTIWAGGFGVP----
MMAR_4486|M.marinum_M KLGVNVLESAAVSEVRWNAVVLADD----TVLASAATVWTAGFGVP----
MUL_4658|M.ulcerans_Agy99 KLGVNVLESAAVSEVRWNAVVLADD----TVLASAATVWTAGFGVP----
MAV_1130|M.avium_104 RLGVGVLESVTVTEVRWNEVVLSDG----VVLPSAATVWTAGFSVP----
Mflv_1928|M.gilvum_PYR-GCK KLGV-HLVSASVRAVGADHVVLDDA----RSLPSAVTVWTAGFGVP----
Mvan_5348|M.vanbaalenii_PYR-1 RHGVAVLESDTVAEVRAGAVVFADG----AVRPSALTVWTTGFGVP----
MLBr_02061|M.leprae_Br4923 KMGVEIQLSAMVTDVDRNGITVQDSDGTVRRIESACKVWSAGVSASRLGR
* . * * . :.. . : :* *. ..
Mb1842c|M.bovis_AF2122/97 RLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMS
Rv1812c|M.tuberculosis_H37Rv RLTEQLPVARDRLGRLQVDDYLRVIGVPAMFAAGDVAAARMDDEHLSVMS
MAB_4199|M.abscessus_ATCC_1997 ALAAHSGLSVDADGRLLTDDTLTSMDDGRIIGAGDAVTT---TSLPTRMS
TH_1143|M.thermoresistible__bu QLAAASGLSTDALGRLRTDDTLTSVDDDRIVGAGDAVTS---SATPLRMS
MSMEG_6818|M.smegmatis_MC2_155 DLASRSGLRTDTLGRLITDATLTSIDDDRVLAAGDAAAP---SGKALRMA
MMAR_4486|M.marinum_M DLAARSGLRTDDLGRLLTDETLTSVSDDRIVAAGDAVAP---SGQPLRMS
MUL_4658|M.ulcerans_Agy99 DLAARSGLRTDDLGRLLTDETLTSVSDDRIVAAGDAVAP---SGQPLRMS
MAV_1130|M.avium_104 DLAARSGLRTDPLGRLLTDETLTSIDDDRIVAAGDAAAP---SGRPLRMS
Mflv_1928|M.gilvum_PYR-GCK TLAADSGLATDPLGRLLTDETLTSVDDDRIVAAGDSAAP---SGLPYRMS
Mvan_5348|M.vanbaalenii_PYR-1 DLAAVSGLATDDIGRLLTDETLTSVDDPRIVAAGDCAAP---SGAPLRMC
MLBr_02061|M.leprae_Br4923 DLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAID--GVPGVAQG
*: : * **: . * . :. .** .:
Mb1842c|M.bovis_AF2122/97 CQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEG--
Rv1812c|M.tuberculosis_H37Rv CQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYTEG--
MAB_4199|M.abscessus_ATCC_1997 CYTANTTGAAAADTVLSRLADTEPAPFRLAYVGQCLSLGRRNAVLQFTRK
TH_1143|M.thermoresistible__bu CYAAAPTAATAADTVLSRLDGAEPAPFALAYVGSTVGLGRRAAVAQFTRA
MSMEG_6818|M.smegmatis_MC2_155 CYTAGPMAATAADTILSRIAGTPPEAFSLGYLGSCLGLGRRSAVMQFTRR
MMAR_4486|M.marinum_M CQAAGPLGAQAANTVLSRIAGDQPVALNQAFVGQCISVGRSYGTIQLART
MUL_4658|M.ulcerans_Agy99 CQAAGPLGAQAANTVLSRIAGDQPVALNQAFVGQCISVGRSYGTIQLAHT
MAV_1130|M.avium_104 CQAAGPLGAQAANTVLGRIAGTEPAPLNQAFVGQCISLGRAAATFQLART
Mflv_1928|M.gilvum_PYR-GCK CQAGLPLGAQAAETVLARIAGTDAAVATVPMSGQCISLGRDAGTVQLQRK
Mvan_5348|M.vanbaalenii_PYR-1 CASASQLGPQAANTVLSRIAGEQPSDFDYAFAGSCVSLGRRTGILQFARK
MLBr_02061|M.leprae_Br4923 AIQGAKYVANNIKAELGEANPAEREPFQYFDKGSMATVSRFSAVAKIGPL
. . : :. .
Mb1842c|M.bovis_AF2122/97 ------------------------WERKVVSQGAPAKTTKQSINTRRIYP
Rv1812c|M.tuberculosis_H37Rv ------------------------WERKVVSQGAPAKTTKQSINTRRIYP
MAB_4199|M.abscessus_ATCC_1997 DDS---------PVGAHARGRLTAWFKEFVLTGVPWGLRREGRKPGASVW
TH_1143|M.thermoresistible__bu DDS---------PLRAHLRGRIPALIKDAVVKGTLWSIRREARKPGATIW
MSMEG_6818|M.smegmatis_MC2_155 DDT---------PLDVHLRGRVAGAVKELVLKGILWSLRREGRKPGATSW
MMAR_4486|M.marinum_M DDT---------PVNVIIGGRAGAAVKETICKGTLWALRREAAKPGSYFW
MUL_4658|M.ulcerans_Agy99 DDT---------PVNVIIGGRAGAAVKEAICKGTLWALRREAAKPGSYFW
MAV_1130|M.avium_104 DDT---------PINAYLGGRAAAKLKEAICRGTLWAIRREAAKPGSYRW
Mflv_1928|M.gilvum_PYR-GCK DDT---------PLNLYLGGRTGAFVKEQVCRFTITWLAAEARKPGSYRS
Mvan_5348|M.vanbaalenii_PYR-1 DDS---------PVSVYIGGRVGGSLKEAICKGTLWGLRRGARKPGSAIW
MLBr_02061|M.leprae_Br4923 EFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWTVTFLSTRRGQLTITEQQ
: . .
Mb1842c|M.bovis_AF2122/97 PLNGSRADLLAAAAPRVQPRP----------
Rv1812c|M.tuberculosis_H37Rv PLNGSRADLLAAAAPRVQPRP----------
MAB_4199|M.abscessus_ATCC_1997 FKSRPRPAEAAQHRAEVVQS-----------
TH_1143|M.thermoresistible__bu YRGRRSAAPAPVPEPETVR------------
MSMEG_6818|M.smegmatis_MC2_155 LKNGDTVTSPALVDAKGSGHDGPIG------
MMAR_4486|M.marinum_M LKGGSRPVQPSAEQPVVLS------------
MUL_4658|M.ulcerans_Agy99 LKGGSRPVQPSAEQPVVLP------------
MAV_1130|M.avium_104 LKGGQR--VPADERVGV--------------
Mflv_1928|M.gilvum_PYR-GCK LKGPDRSELIASTAVPVR-------------
Mvan_5348|M.vanbaalenii_PYR-1 FKGGPRPGQPAVRPRAVTQS-----------
MLBr_02061|M.leprae_Br4923 AFARTRLEQLAELTAESQSTAAANRATMRAS
.