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TRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVMVVSNKPFHDIRVRNYEADLSACRIPLGDVLGPAG VAHVTAEVTAIDADGRRVTTSTGASYSYDRLVLASGSHVVKPALPGLAEFGFDVDTYDGAVRLQQHLQGL AGGPLTSAAATVVVVGAGLTGIETACELPGRLHALFARGDGVTPRVVLIDHNPFVGSDMGLSARPVIEQA LLDNGVETRTGVSVAAVSPGGVTLSSGERLAAATVVWCAGMRASRLTEQLPVARDRLGRLQVDDYLRVIG VPAMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALRIPWYVTVLDLGSAGAVYT EGWERKVVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1812c | - | - | 100% (400) | PROBABLE DEHYDROGENASE |
| M. tuberculosis H37Rv | Rv1854c | ndh | 1e-21 | 30.22% (321) | NADH dehydrogenase |
| M. tuberculosis H37Rv | Rv0392c | ndhA | 2e-17 | 29.38% (320) | membrane NADH dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1842c | - | 0.0 | 99.75% (400) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1928 | - | 2e-25 | 31.22% (378) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. leprae Br4923 | MLBr_02061 | - | 9e-18 | 29.28% (321) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1127c | - | 6e-27 | 32.29% (319) | putative oxidoreductase |
| M. marinum M | MMAR_2688 | - | 1e-170 | 76.00% (400) | NADH dehydrogenase |
| M. avium 104 | MAV_1130 | - | 1e-29 | 31.91% (351) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6818 | - | 7e-28 | 30.68% (352) | dehydrogenase |
| M. thermoresistible (build 8) | TH_1141 | - | 2e-27 | 31.48% (324) | dehydrogenase |
| M. ulcerans Agy99 | MUL_3068 | - | 1e-171 | 75.75% (400) | NADH dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4805 | - | 9e-30 | 32.72% (327) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1812c|M.tuberculosis_H37Rv -------------MTRVVVIGSGFAGLWAALGAARRLDELAVLAGTVDVM
Mb1842c|M.bovis_AF2122/97 -------------MTRVVVIGSGFAGLWAALGAARRLDELAVPAGTVDVM
MMAR_2688|M.marinum_M -------------MSRVLVIGSGFAGLWAALGAARRVEELAVPPGSVDIT
MUL_3068|M.ulcerans_Agy99 -------------MSRVLVIGSGFAGLWAALGAARRVEELAVPPGSVDIT
TH_1141|M.thermoresistible__bu -----MTSNTGTSVSRVVVIGGGYAGVMAAN-RLRLDPSVDVTLINPRPD
Mvan_4805|M.vanbaalenii_PYR-1 -----MTAQR----THVVVIGGGYAGVMAAN-RLMSRDGLRVTLVNPRPE
Mflv_1928|M.gilvum_PYR-GCK -----MTAQN----IRVIVVGGGYAGVMAAN-RLRSRDDLHVTLVNPRPQ
MAV_1130|M.avium_104 -----MTEVTR-SKTHVVVVGGGYAGTLAAN-HLRQRPDIDITLVNPRPV
MSMEG_6818|M.smegmatis_MC2_155 -----MTAHN--KTHRVVVIGGGYAGTLAAN-RLQQNPDIDITLINPRPQ
MAB_1127c|M.abscessus_ATCC_199 -----MTENT-----TVIVIGGGYAGTLAAN-QLLANKNLTVTLVNPRPH
MLBr_02061|M.leprae_Br4923 MNAQPAATAAQDRRHQVVIIGSGFGGLNAAK--KLKRANVDIKLIARTTH
*:::*.*:.* ** : :
Rv1812c|M.tuberculosis_H37Rv VVSNKPFHDIRVRN-----------------------------YEADLSA
Mb1842c|M.bovis_AF2122/97 VVSNKPFHDIRVRN-----------------------------YEADLSA
MMAR_2688|M.marinum_M VLSAKPFHDIRVRN-----------------------------YETDLST
MUL_3068|M.ulcerans_Agy99 VLSAKPFHDIRVRN-----------------------------YETDLST
TH_1141|M.thermoresistible__bu FVERIRLHQLVT----------------------------------GSDD
Mvan_4805|M.vanbaalenii_PYR-1 FVERIRLHQFVT----------------------------------GSDD
Mflv_1928|M.gilvum_PYR-GCK FVERIRLHQLAADAGGTAGRAKRRGTSTAGRAKRRGTSTAGRAKRRGTSS
MAV_1130|M.avium_104 FVERIRLHQLVA----------------------------------DTGT
MSMEG_6818|M.smegmatis_MC2_155 FVHRMRLHQMAA----------------------------------GACE
MAB_1127c|M.abscessus_ATCC_199 FVERIRLHQLVA----------------------------------GNAT
MLBr_02061|M.leprae_Br4923 HLFQPLLYQVATGIIS------------------------------EGEI
: :::. .
Rv1812c|M.tuberculosis_H37Rv CRIPLGDVLGPAGVAHVTAEVTAIDADGRRVT---TSTGASYSYDRLVLA
Mb1842c|M.bovis_AF2122/97 CRIPLGDVLGPAGVAHVTAEVTAIDADGRRVT---TSTGASYSYDRLVLA
MMAR_2688|M.marinum_M CRIPLADLLDPAGVSHIPAVVVGIDAAARRVR---TADGQTYEYDRLVLA
MUL_3068|M.ulcerans_Agy99 CRIPLADLLDPAGVSHIPAVVVGIDAAARRVR---TADGQTYEYDRLVLA
TH_1141|M.thermoresistible__bu AVVDFATVLHPD-VRLVVDTAERIDAADRSVA---LASGGTVSYDHLIYA
Mvan_4805|M.vanbaalenii_PYR-1 AVVDYADVVGEG-IALIVDSVTRIDAPTRRVE---LASGGSIDYDYLIYA
Mflv_1928|M.gilvum_PYR-GCK AVAEFGAVLNPG-VQLVVDNVERIDAPVRRLA---LSSGTSLDYDYLVYA
MAV_1130|M.avium_104 ATADYATLLGEG-IELIVDTVDHIDATARRAV---LTSGAGLDYDYLIYA
MSMEG_6818|M.smegmatis_MC2_155 AVVDYGTLLGSG-VRLLADRVDRIDTANRRID---LASGDSMGYDYVVYA
MAB_1127c|M.abscessus_ATCC_199 ATAGYDKLLNPA-VSLVVDKVTYIDAGAQKLE---LASGAVLPYDYLVYA
MLBr_02061|M.leprae_Br4923 APPTRVVLRKQRNIQVLLGNVTHIDLANQCVVSELLGHTYETLYDSLIVA
. : : : . ** : ** :: *
Rv1812c|M.tuberculosis_H37Rv SGSHVVKPA-LPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTS------
Mb1842c|M.bovis_AF2122/97 SGSHVVKPA-LPGLAEFGFDVDTYDGAVRLQQHLQGLAGGPLTS------
MMAR_2688|M.marinum_M SGSQVAKPD-LPGLQEFGFDVDTYEGAVRLQCHLQQLADRPPAA------
MUL_3068|M.ulcerans_Agy99 SGSQVAKPD-LPGLQEFGFDVDTYEGAVRLQCHLQQLADRPPAA------
TH_1141|M.thermoresistible__bu VGSNAGPST-VPGVGEFAYSVTEFEDAQRLRRAVDARP------------
Mvan_4805|M.vanbaalenii_PYR-1 VGSTGAAPT-VPGAAEFAHPISEYEHGAPLRTAVTAAA------------
Mflv_1928|M.gilvum_PYR-GCK VGSTGAVPDGVPGAAEFAYPLAELEQAQRLRSRLADVA------------
MAV_1130|M.avium_104 VGSTGAVAE-VPGCAEFAHSVADLESAQRLHYALADLP------------
MSMEG_6818|M.smegmatis_MC2_155 VGSTALVPESVEGAAEFAHTVAEYEAAQRLRATVNALA------------
MAB_1127c|M.abscessus_ATCC_199 VGSTTSTPD-VPGVAEYALSINEFEHAQQVRTRYERLA------------
MLBr_02061|M.leprae_Br4923 AGAGQSYFG-NDQFAEFAPGMKSIDDALELRGRILSAFEQAERSNDPERR
*: *:. : : . ::
Rv1812c|M.tuberculosis_H37Rv -AAATVVVVGAGLTGIETACELPGRLHALFARGD----GVTPRVVLIDHN
Mb1842c|M.bovis_AF2122/97 -AAATVVVVGAGLTGIETACELPGRLHALFARGD----GVTPRVVLIDHN
MMAR_2688|M.marinum_M -AAATVVVVGAGLTGIETACELPARLAKLFAHS-----AVVPRVVLVDHN
MUL_3068|M.ulcerans_Agy99 -ATATVVVVGAGLTGIETACELPARLAKLFAHS-----AVVPRVVLVDHN
TH_1141|M.thermoresistible__bu -CDAPITVVGAGPTGLEMAAELAE----------------QGRTVTLVG-
Mvan_4805|M.vanbaalenii_PYR-1 -ADAPIVVVGAGPTGLETAAELAE----------------EGRRVTLVCG
Mflv_1928|M.gilvum_PYR-GCK -AIAPVVVIGGGLTGIEAAAEFAE----------------AGRDVTLVS-
MAV_1130|M.avium_104 -LPAPITVVGGGLTGIETASELAE----------------LGRPVTLICG
MSMEG_6818|M.smegmatis_MC2_155 -PDAWITVVGAGFTGIEVAAELAT----------------GGRTVSLVAG
MAB_1127c|M.abscessus_ATCC_199 -PDAPIVVVGAGLTGVELAGELAE----------------AGRRVTLICG
MLBr_02061|M.leprae_Br4923 EKLLTFTVVGAGPTGVEMAGQIAELADHTLKGAFRRIDSTKARVVLLDAA
..*:*.* **:* * ::. * * :
Rv1812c|M.tuberculosis_H37Rv PFVGSDMGLSARPVIEQALLDNGVETRTG--VSVAAVSPGGVTLSSG---
Mb1842c|M.bovis_AF2122/97 PFVGSDMGLSARPVIEQALLDNGVETRTG--VSVAAVSPGGVTLSSG---
MMAR_2688|M.marinum_M PVVGSDMGASARPVIEEALSEVGVETRTA--VGVTAVTEAGVALSSG---
MUL_3068|M.ulcerans_Agy99 PVVGSDMGASARPVIEEALSEVGVETRTA--VGVTAVTEAGVALSSG---
TH_1141|M.thermoresistible__bu DAIGPYLSEPGWRAVAKRFRRLGVRTVE---ARVAEVRADAVLLADG---
Mvan_4805|M.vanbaalenii_PYR-1 SVLGPYLSTRGRRAAAKRMTKLGVDVIDGPGATVTEVLADAVVLADG---
Mflv_1928|M.gilvum_PYR-GCK PVVGPSLSGPGRRSVTRRLRKLGVHLVS---ASVRAVGADHVVLDDA---
MAV_1130|M.avium_104 PVLGPSLSPRGRRSVAKRLRRLGVGVLES--VTVTEVRWNEVVLSDG---
MSMEG_6818|M.smegmatis_MC2_155 AQLAPTLGGPARRAVSRWMAENGVGLLED--AMVTEVRPDAVVLDDG---
MAB_1127c|M.abscessus_ATCC_199 TQLLPSVGEPARRAAAKRLRKLGVDVQAP--ATAIRVDENSVTLSDG---
MLBr_02061|M.leprae_Br4923 PAVLPPMGEKLGQRAAARLQKMGVEIQLS--AMVTDVDRNGITVQDSDGT
: . :. : ** . . * : : ..
Rv1812c|M.tuberculosis_H37Rv -ERLAAATVVWCAGMRAS----RLTEQLPVARDRLGRLQVDDYLRVIGVP
Mb1842c|M.bovis_AF2122/97 -ERLAAATVVWCAGMRAS----RLTEQLPVARDRLGRLQVDDYLRVIGVP
MMAR_2688|M.marinum_M -ELLEAATVVWCAGMRAN----SLAEQLPVHRDRLGRVEVDDYLRVAGVP
MUL_3068|M.ulcerans_Agy99 -ELLEAATVVWCAGMRAN----SLAEQLPVHRDRLGRVEVDDYLRVVGVP
TH_1141|M.thermoresistible__bu -RRLDSAVTVWTAGFAVP----DLAARSGLSTDAIGRLRTDETLTSVDDD
Mvan_4805|M.vanbaalenii_PYR-1 -RRVASAVTIWTAGFGVP----DLAVRSGLSTDAIGRLLTDETLASVDDP
Mflv_1928|M.gilvum_PYR-GCK -RSLPSAVTVWTAGFGVP----TLAADSGLATDPLGRLLTDETLTSVDDD
MAV_1130|M.avium_104 -VVLPSAATVWTAGFSVP----DLAARSGLRTDPLGRLLTDETLTSIDDD
MSMEG_6818|M.smegmatis_MC2_155 -TVWRSDLTIWAGGFGVP----DLASRSGLRTDTLGRLITDATLTSIDDD
MAB_1127c|M.abscessus_ATCC_199 -RVLPSALTVWTAGFGVP----RLAIDSGLRTDALGRLLTDETLVSLDNP
MLBr_02061|M.leprae_Br4923 VRRIESACKVWSAGVSASRLGRDLAEQSLVELDWAGRVKVLPDLSIPGYR
: :* .*. . *: : * **: . * .
Rv1812c|M.tuberculosis_H37Rv AMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALR
Mb1842c|M.bovis_AF2122/97 AMFAAGDVAAARMDDEHLSVMSCQHGRPMGRYAGCNVINDLFDQPLLALR
MMAR_2688|M.marinum_M EIFAAGDVAAAQMDDDHVSVMSCQHGRPMGRYAGYNVISDLFGEPLLALR
MUL_3068|M.ulcerans_Agy99 EIFAAGDVAAAQMDDDHVSVMSCQHGRPMGRYAGYNVISDLFGEPLLALR
TH_1141|M.thermoresistible__bu RIVAAGDAAAP---SGQPLRMSCQAAGPLGAQAADTVLSRIAGDRPAPLD
Mvan_4805|M.vanbaalenii_PYR-1 RIVAAGDAAAP---SDLPLRMSCQAAIPLGAQAANTVLSRIAGTTPKPIN
Mflv_1928|M.gilvum_PYR-GCK RIVAAGDSAAP---SGLPYRMSCQAGLPLGAQAAETVLARIAGTDAAVAT
MAV_1130|M.avium_104 RIVAAGDAAAP---SGRPLRMSCQAAGPLGAQAANTVLGRIAGTEPAPLN
MSMEG_6818|M.smegmatis_MC2_155 RVLAAGDAAAP---SGKALRMACYTAGPMAATAADTILSRIAGTPPEAFS
MAB_1127c|M.abscessus_ATCC_199 RIIAAGDAASP---SGVPLRMSCQAAGPLAARAVKTVLALVDGLRPEART
MLBr_02061|M.leprae_Br4923 NVFVVGDMAAID--GVPGVAQGAIQGAKYVANNIKAELGEANPAEREPFQ
:...** *: . .. . :
Rv1812c|M.tuberculosis_H37Rv IPWYVTVLDLGSAGAVYTEG--------------------------WERK
Mb1842c|M.bovis_AF2122/97 IPWYVTVLDLGSAGAVYTEG--------------------------WERK
MMAR_2688|M.marinum_M IPWYVTVLDLGPAGAVYTEG--------------------------WDRM
MUL_3068|M.ulcerans_Agy99 IPWYVTVLDLGPAGAVYTEG--------------------------WDRM
TH_1141|M.thermoresistible__bu QAFAGQCISLGRDAGIIQLARRDDT---------AIPVFLSGRAAAWVKE
Mvan_4805|M.vanbaalenii_PYR-1 QAFTGQCISLGRSAGLIQIAHLDDR---------VMPLYIGGRTAASVKE
Mflv_1928|M.gilvum_PYR-GCK VPMSGQCISLGRDAGTVQLQRKDDT---------PLNLYLGGRTGAFVKE
MAV_1130|M.avium_104 QAFVGQCISLGRAAATFQLARTDDT---------PINAYLGGRAAAKLKE
MSMEG_6818|M.smegmatis_MC2_155 LGYLGSCLGLGRRSAVMQFTRRDDT---------PLDVHLRGRVAGAVKE
MAB_1127c|M.abscessus_ATCC_199 QIFTGQNVSIGRRAAVIQVGHTDDT---------PRTLYIGGRTGAAIKE
MLBr_02061|M.leprae_Br4923 YFDKGSMATVSRFSAVAKIGPLEFSGFIAWLMWLVLHLMYLIGFKTKITT
:. ..
Rv1812c|M.tuberculosis_H37Rv VVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP-------
Mb1842c|M.bovis_AF2122/97 VVSQGAPAKTTKQSINTRRIYPPLNGSRADLLAAAAPRVQPRP-------
MMAR_2688|M.marinum_M VVSRGAKAKATKQTINTERIYPPLTRDRADLLAAAAPDLQDRP-------
MUL_3068|M.ulcerans_Agy99 VVSRGAKAKATKQTINTERIYPPLTRDRADLLAAAAPDLQDRP-------
TH_1141|M.thermoresistible__bu RVCRGTIWALAREARRPGSYLWLKGGRRPAQPALDEMAVS----------
Mvan_4805|M.vanbaalenii_PYR-1 AVCKGTISFLSREARKPGSYFWLKGGKR--QQKLAAQPVSS---------
Mflv_1928|M.gilvum_PYR-GCK QVCRFTITWLAAEARKPGSYRSLKGPDRSELIASTAVPVR----------
MAV_1130|M.avium_104 AICRGTLWAIRREAAKPGSYRWLKGGQR--VPADERVGV-----------
MSMEG_6818|M.smegmatis_MC2_155 LVLKGILWSLRREGRKPGATSWLKNGDTVTSPALVDAKGSGHDGPIG---
MAB_1127c|M.abscessus_ATCC_199 MVCKGTLSILATAAKHPTWYYWPQGGKR--AEALRAQV------------
MLBr_02061|M.leprae_Br4923 LLSWTVTFLSTRRGQLTITEQQAFARTRLEQLAELTAESQSTAAANRATM
: .
Rv1812c|M.tuberculosis_H37Rv ---
Mb1842c|M.bovis_AF2122/97 ---
MMAR_2688|M.marinum_M ---
MUL_3068|M.ulcerans_Agy99 ---
TH_1141|M.thermoresistible__bu ---
Mvan_4805|M.vanbaalenii_PYR-1 ---
Mflv_1928|M.gilvum_PYR-GCK ---
MAV_1130|M.avium_104 ---
MSMEG_6818|M.smegmatis_MC2_155 ---
MAB_1127c|M.abscessus_ATCC_199 ---
MLBr_02061|M.leprae_Br4923 RAS