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MSHPGATPSDRHKVVIIGSGFGGLTAAKTLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPATR VILRNQKNAQVLLGDVTGIDLQTKTVRSELLGHTYVTPFDSLIVAAGAGQSYFGNDHFAEWAPGMKSIDD ALELRGRILGAFEQAERSSDPARREKLLTFVVVGAGPTGVEMAGQIAELADHTLKGAFRHIDSTKARVIL LDAAPAVLPPMGEKLGKKAQARLEKLGVEIQLNAMVTDVDRNGITVKDPDGTIRRIEAACKVWSAGVSAS PLGRDLAEGSGVELDRAGRVKVLPDLSLPGHPNVFVVGDMAAVEGVPGMAQGAIQGGKYAAKAIAAGLKG ADPTEREPFKYFDKGSMATVSRFSAVAKIGPLEFEGFVAWLAWLVLHLVYLVGFKTKIVTLLSWTVTFLS TKRGQLTITEQQAYARTRIEELEEIAASVQETERAAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3078 | - | - | 100% (457) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2953 | - | 1e-97 | 45.30% (415) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4805 | - | 1e-18 | 25.79% (380) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1885c | ndh | 0.0 | 83.66% (453) | NADH dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3348 | - | 0.0 | 94.09% (457) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1854c | ndh | 0.0 | 83.66% (453) | NADH dehydrogenase |
| M. leprae Br4923 | MLBr_02061 | - | 0.0 | 81.58% (456) | putative dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2429c | - | 0.0 | 79.63% (437) | NADH dehydrogenase (NDH) |
| M. marinum M | MMAR_2728 | ndh | 0.0 | 83.52% (443) | NADH dehydrogenase Ndh |
| M. avium 104 | MAV_2867 | - | 0.0 | 81.84% (457) | DoxD family protein/pyridine nucleotide-disulfide |
| M. smegmatis MC2 155 | MSMEG_3621 | ndh | 0.0 | 88.40% (457) | NADH dehydrogenase |
| M. thermoresistible (build 8) | TH_1173 | ndh | 0.0 | 85.11% (450) | PROBABLE NADH DEHYDROGENASE NDH |
| M. ulcerans Agy99 | MUL_3025 | ndh | 0.0 | 83.52% (443) | NADH dehydrogenase Ndh |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3078|M.vanbaalenii_PYR-1 ------------------MSHPGATPSDRHKVVIIGSGFGGLTAAKTLKR
Mflv_3348|M.gilvum_PYR-GCK ------------------MSHPGATPSDRHKVVIIGSGFGGLTAAKALKK
MSMEG_3621|M.smegmatis_MC2_155 ------------------MSHPGATASDRHKVVIIGSGFGGLTAAKTLKR
TH_1173|M.thermoresistible__bu -------------------------MSDRHKVVIIGSGFGGLNAAKALRR
MMAR_2728|M.marinum_M ---------------MSPQPETTAQARPRHRVVIIGSGFGGLNAAKKLKR
MUL_3025|M.ulcerans_Agy99 ---------------MSPQPETTAQARPRHRVVIIGSGFGGLNAAKKLKR
MAV_2867|M.avium_104 ---------------MSPHSGSTAGPERRHQVVIIGSGFGGLNAAKKLKH
Mb1885c|M.bovis_AF2122/97 ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
Rv1854c|M.tuberculosis_H37Rv ---------------MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKR
MLBr_02061|M.leprae_Br4923 ---------------MNAQPAATAAQDRRHQVVIIGSGFGGLNAAKKLKR
MAB_2429c|M.abscessus_ATCC_199 MSTTPDAAGAAAPVAANPQPKIQDALTPKHRVVIIGSGFGGLTAAKTLKR
:*:***********.*** *::
Mvan_3078|M.vanbaalenii_PYR-1 ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPATRVILRNQKNAQVL
Mflv_3348|M.gilvum_PYR-GCK ADVDIKMIARTTHHLFQPLLYQVATGIISEGEIAPATRVILRNQKNAQVL
MSMEG_3621|M.smegmatis_MC2_155 ADVDVKLIARTTHHLFQPLLYQVATGIISEGEIAPATRVILRKQKNAQVL
TH_1173|M.thermoresistible__bu ADVDVKLIARTTHHLFQPLLYQVATGIISEGEIAPATRVVLRRQRNVQVL
MMAR_2728|M.marinum_M ADVDIKLIARTTHHLFQPLLYQVATGIISEGDIAPPTRVVLRRQRNAQVL
MUL_3025|M.ulcerans_Agy99 ADVDIKLIARTTHHLFQPLLYQVATGIISEGDIAPPTRVVLRRQRNAQVL
MAV_2867|M.avium_104 ANVDIKLIARTTHHLFQPLLYQVATGIVSEGDIAPPTRVVLRRQRNVQVL
Mb1885c|M.bovis_AF2122/97 ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVL
Rv1854c|M.tuberculosis_H37Rv ADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVL
MLBr_02061|M.leprae_Br4923 ANVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNIQVL
MAB_2429c|M.abscessus_ATCC_199 ANADVTLIARTTHHLFQPLLYQVATGIISEGEIAPPTRQILKDQDNAQVV
*:.*:.:********************:***:***.** :*: * * **:
Mvan_3078|M.vanbaalenii_PYR-1 LGDVTGIDLQTKTVRSELLGHTYVTPFDSLIVAAGAGQSYFGNDHFAEWA
Mflv_3348|M.gilvum_PYR-GCK LGDVTRIDLKTNTVRSELLGHTYITPFDSLIVAAGAGQSYFGNDHFAEWA
MSMEG_3621|M.smegmatis_MC2_155 LGDVTHIDLENKTVDSVLLGHTYSTPYDSLIIAAGAGQSYFGNDHFAEFA
TH_1173|M.thermoresistible__bu LGDVTRIDLTNRRVESVLLGHTYSTPYDSLIVAAGAGQSYFGNDHFAEFA
MMAR_2728|M.marinum_M LGNVTHIDLAKQSVVSDLLGHTYETPYDTLIVAAGAGQSYFGNDHFAEFA
MUL_3025|M.ulcerans_Agy99 LGNVTHIDLAKQSVVSDLLGHTYETPYDTLIVAAGAGQSYFGNDHFAEFA
MAV_2867|M.avium_104 LGDVTHIDLAGKFVVSDLLGHTYETPYDTLIVAAGAGQSYFGNDHFAEFA
Mb1885c|M.bovis_AF2122/97 LGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFA
Rv1854c|M.tuberculosis_H37Rv LGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFA
MLBr_02061|M.leprae_Br4923 LGNVTHIDLANQCVVSELLGHTYETLYDSLIVAAGAGQSYFGNDQFAEFA
MAB_2429c|M.abscessus_ATCC_199 LGDVTSIDLEKQVVHSSLLGHDYSTPYDSLIVAAGAGQSYFGNDHFAEWA
**:** *** . * * **** * * :*:**:************:***:*
Mvan_3078|M.vanbaalenii_PYR-1 PGMKSIDDALELRGRILGAFEQAERSSDPARREKLLTFVVVGAGPTGVEM
Mflv_3348|M.gilvum_PYR-GCK PGMKSIDDALELRGRILGSFEQAERSSDPARREKLLTFVVVGAGPTGVEM
MSMEG_3621|M.smegmatis_MC2_155 PGMKSIDDALELRGRILGAFEQAERSSDPVRRAKLLTFTVVGAGPTGVEM
TH_1173|M.thermoresistible__bu PGMKTIDDALELRARILGAFEQAERSSDAKRREKLLTFTVVGAGPTGVEM
MMAR_2728|M.marinum_M PGMKSIDDALELRGRILSAFEQAERSRDAERRAKLLTFTVVGAGPTGVEM
MUL_3025|M.ulcerans_Agy99 PGMKSIDDALELRGRILSAFEQAERSRDAERRAKLLTFTVVGAGPTGVEM
MAV_2867|M.avium_104 PGMKSIDDALEVRGRILSAFEQAERSRDPERRAKLLTFTVIGAGPTGVEM
Mb1885c|M.bovis_AF2122/97 PGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEM
Rv1854c|M.tuberculosis_H37Rv PGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEM
MLBr_02061|M.leprae_Br4923 PGMKSIDDALELRGRILSAFEQAERSNDPERREKLLTFTVVGAGPTGVEM
MAB_2429c|M.abscessus_ATCC_199 PGMKSIDDALELRGRILGAFEQAERSSDPVRRRKLMTFTVVGAGPTGVEM
****:******:*.***.:******* *. ** **:**.*:*********
Mvan_3078|M.vanbaalenii_PYR-1 AGQIAELADHTLKGAFRHIDS-TKARVILLDAAPAVLPPMGEKLGKKAQA
Mflv_3348|M.gilvum_PYR-GCK AGQIAELADHTLKGAFRHIDS-TKARVILLDAAPAVLPPMGEKLGKQAQK
MSMEG_3621|M.smegmatis_MC2_155 AGQIAELADQTLRGSFRHIDP-TEARVILLDAAPAVLPPMGEKLGKKARA
TH_1173|M.thermoresistible__bu AGQIAELAKYTLKGTFRSIDPATEARVILLDAAPAVLPTMGEKLGKKAQA
MMAR_2728|M.marinum_M AGQIAELAEHTLKGAFRHIDS-TRARVILLDAAPAVLPPFGDKLGERAAA
MUL_3025|M.ulcerans_Agy99 AGQIAELAEHTLKGAFRHIDS-TRARVILLDAAPAVLPPFGDKLGERAAA
MAV_2867|M.avium_104 AGQIAELATYTLKGSFRHIDP-TKARVILLDAAPAVLPPFGDKLGKRAAD
Mb1885c|M.bovis_AF2122/97 AGQIAELAEHTLKGAFRHIDS-TKARVILLDAAPAVLPPMGAKLGQRAAA
Rv1854c|M.tuberculosis_H37Rv AGQIAELAEHTLKGAFRHIDS-TKARVILLDAAPAVLPPMGAKLGQRAAA
MLBr_02061|M.leprae_Br4923 AGQIAELADHTLKGAFRRIDS-TKARVVLLDAAPAVLPPMGEKLGQRAAA
MAB_2429c|M.abscessus_ATCC_199 AGQIAELANETLKGTFRHIDP-TDARVILLDAAPAVLPPFGPKLGDKARK
******** **:*:** **. * ***:**********.:* ***.:*
Mvan_3078|M.vanbaalenii_PYR-1 RLEKLGVEIQLNAMVTDVDRNGITVKDPDGTIRRIEAACKVWSAGVSASP
Mflv_3348|M.gilvum_PYR-GCK RLEKMGVEIQLNAMVTDVDRNGITVKDPDGTMRRIEAACKVWSAGVSASP
MSMEG_3621|M.smegmatis_MC2_155 RLEKMGVEVQLGAMVTDVDRNGITVKDSDGTIRRIESACKVWSAGVSASP
TH_1173|M.thermoresistible__bu RLEKMGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASP
MMAR_2728|M.marinum_M RLQKLGVEIQLGAMVTDVDRNGITVKDSDGTIRRIESACKVWSAGVQASR
MUL_3025|M.ulcerans_Agy99 RLQKLGVEIQLGAMVTDVDRNGITVKDSDGTIRRIESACKVWSAGVQASR
MAV_2867|M.avium_104 RLEKMGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASP
Mb1885c|M.bovis_AF2122/97 RLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASW
Rv1854c|M.tuberculosis_H37Rv RLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASR
MLBr_02061|M.leprae_Br4923 RLQKMGVEIQLSAMVTDVDRNGITVQDSDGTVRRIESACKVWSAGVSASR
MAB_2429c|M.abscessus_ATCC_199 RLEKLGVEIQLSAMVTDVDRNGLTVKHADGSIERIESWCKVWSAGVSASP
**:*:***:**.**********:**:..**::.***: ********.**
Mvan_3078|M.vanbaalenii_PYR-1 LGRDLAEGSGVELDRAGRVKVLPDLSLPGHPNVFVVGDMAAVEGVPGMAQ
Mflv_3348|M.gilvum_PYR-GCK LGRDLADQSGVELDRAGRVKVLPDLSIPGHPNVFVVGDMAAVEDVPGMAQ
MSMEG_3621|M.smegmatis_MC2_155 LGKDLAEQSGVELDRAGRVKVQPDLTLPGHPNVFVVGDMAAVEGVPGVAQ
TH_1173|M.thermoresistible__bu LGKDLAEQSGAELDRAGRVKVLPDLSLPGHPNVFVVGDMAAVEGVPGMAQ
MMAR_2728|M.marinum_M LGRDLAEQSEVELDRAGRVQVLPDLSVPGHPNVFVIGDMAAVEGVPGVAQ
MUL_3025|M.ulcerans_Agy99 LGRDLAEQSEVELDRAGRVQVLPDLSVPGHPNVFVIGDMAAVEGVPGVAQ
MAV_2867|M.avium_104 LGRDLAEQSTVELDRAGRVKVLPDLSIPGHPNVFVIGDLAAVEGVPGVAQ
Mb1885c|M.bovis_AF2122/97 LGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQ
Rv1854c|M.tuberculosis_H37Rv LGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQ
MLBr_02061|M.leprae_Br4923 LGRDLAEQSLVELDWAGRVKVLPDLSIPGYRNVFVVGDMAAIDGVPGVAQ
MAB_2429c|M.abscessus_ATCC_199 LGKNLAEQSGVELDRAGRVKVGPDLSIPGHPNVFVVGDMMAVDGVPGVAQ
**::**: * .*** ****:* ***::**: ****:**: *::.***:**
Mvan_3078|M.vanbaalenii_PYR-1 GAIQGGKYAAKAIAAGLKGADPTEREPFKYFDKGSMATVSRFSAVAKIGP
Mflv_3348|M.gilvum_PYR-GCK GAIQGGRYAAKAIAAGLKGAEVSEREPFKYFDKGSMATVSRFSAVAKIGP
MSMEG_3621|M.smegmatis_MC2_155 GAIQGGRYAAKIIKREVSGTSPKIRTPFEYFDKGSMATVSRFSAVAKVGP
TH_1173|M.thermoresistible__bu GAIQGARHAAKLIKNELKGADPADREPFQYFDKGSMATVSRFSAVAKIGP
MMAR_2728|M.marinum_M GAIQGAKYVATTIKSELAGANAAEREPFQYFDKGSMATVSRFSAVAKIGP
MUL_3025|M.ulcerans_Agy99 GAIQGAKYVATTIKSELAGANAAEREPFQYFDKGSMATVSRFSAVAKIGP
MAV_2867|M.avium_104 GAIQGAKYVANTIKAELGGADPAEREPFQYFDKGSMATVSRFSAVAKIGP
Mb1885c|M.bovis_AF2122/97 GAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGP
Rv1854c|M.tuberculosis_H37Rv GAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGP
MLBr_02061|M.leprae_Br4923 GAIQGAKYVANNIKAELGEANPAEREPFQYFDKGSMATVSRFSAVAKIGP
MAB_2429c|M.abscessus_ATCC_199 GAIQGGRYAAKQIKAELKGRSPAERAPFKFFDKGSMATVSRYSAVVKIGK
*****.::.*. * : . * **::***********:***.*:*
Mvan_3078|M.vanbaalenii_PYR-1 LEFEGFVAWLAWLVLHLVYLVGFKTKIVTLLSWTVTFLSTKRGQLTITEQ
Mflv_3348|M.gilvum_PYR-GCK LEFGGFIAWLSWLVLHLVYLVGFKTKIVTLLSWTVTFLSTKRGQLTITEQ
MSMEG_3621|M.smegmatis_MC2_155 VEFAGFFAWLCWLVLHLVYLVGFKTKIVTLLSWGVTFLSTKRGQLTITEQ
TH_1173|M.thermoresistible__bu LEFGGFIAWLAWLFLHLVYIVGFKARLTTALSWIVTFLGSHRGQLTITEQ
MMAR_2728|M.marinum_M VEISGFIAWLAWLVLHLVYLVGFKTKVSTLLSWTVTFLSTRRGQLTITEQ
MUL_3025|M.ulcerans_Agy99 VEISGFIAWLAWLVLHLVYLVGFKTKVSTLLSWTVTFLSTRRGQLTITEQ
MAV_2867|M.avium_104 LEFSGLFAWFAWLVLHLVYLVGFKTKVSTLLSWTVTFLSTRRGQLTITEQ
Mb1885c|M.bovis_AF2122/97 VEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQ
Rv1854c|M.tuberculosis_H37Rv VEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQ
MLBr_02061|M.leprae_Br4923 LEFSGFIAWLMWLVLHLMYLIGFKTKITTLLSWTVTFLSTRRGQLTITEQ
MAB_2429c|M.abscessus_ATCC_199 IEFSGFIAWLSWLALHLVYLVGFKNRLVTLILWSIAFVTRSRGQMAITEQ
:*: *:.**: ** *** *::*** :: * : * ::*: ***::**:*
Mvan_3078|M.vanbaalenii_PYR-1 QAYARTRIEELEEIAASVQETERAAS---------
Mflv_3348|M.gilvum_PYR-GCK QAYARIRLEELEEIAASVQDTEKAAS---------
MSMEG_3621|M.smegmatis_MC2_155 QAYARTRIEELEEIAAAVQDTEKAAS---------
TH_1173|M.thermoresistible__bu QAFARTRIEELQEIAASVQDTQKAAS---------
MMAR_2728|M.marinum_M QAFARTRLEQLAELASEAQSTEARQAS--------
MUL_3025|M.ulcerans_Agy99 QAFARTRLEQLAELASEAQSTEARQAS--------
MAV_2867|M.avium_104 QAFARTRLEQLAVLAAETKRPAARRAS--------
Mb1885c|M.bovis_AF2122/97 QAFARTRLEQLAELAAEAQGSAASAKVAS------
Rv1854c|M.tuberculosis_H37Rv QAFARTRLEQLAELAAEAQGSAASAKVAS------
MLBr_02061|M.leprae_Br4923 QAFARTRLEQLAELTAESQSTAAANRATMRAS---
MAB_2429c|M.abscessus_ATCC_199 QAWARTRLDQLEELVAEKNGDEEPTTQPDKEKAAS
**:** *:::* :.: :