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VSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPPG SDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAIL PAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSALA NATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDSP AQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAALA RMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | - | 100% (398) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5159 | - | 5e-77 | 41.22% (393) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3187 | - | 2e-72 | 39.60% (404) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-79 | 42.89% (387) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1598 | - | 8e-75 | 40.46% (393) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 3e-79 | 42.89% (387) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-52 | 35.22% (389) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 6e-75 | 39.49% (395) | cytochrome P450 |
| M. marinum M | MMAR_4833 | cyp123B1 | 1e-163 | 72.52% (393) | cytochrome P450 123B1 Cyp123B1 |
| M. avium 104 | MAV_1404 | - | 1e-72 | 40.94% (403) | putative cytochrome P450 130 |
| M. smegmatis MC2 155 | MSMEG_5861 | - | 7e-76 | 41.34% (387) | cytochrome P450 109 |
| M. thermoresistible (build 8) | TH_2539 | - | 5e-83 | 44.05% (395) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 3e-79 | 43.59% (390) | cytochrome P450 123A3 Cyp123A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0317|M.vanbaalenii_PYR-1 -------------------------------MVSVQIRYDPFDASILNDP
MMAR_4833|M.marinum_M -------------------------MWQETLMSTVQLRYDPFDPEIQDDP
MAV_1404|M.avium_104 ------------------------------MSHNVPVAFELPNADTWADP
TH_2539|M.thermoresistible__bu ------------------------VSVQVDKPVDGPVQFDPFSEDYFNGP
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mflv_1598|M.gilvum_PYR-GCK ------------------------------MTTSA-VRLDPYNYDFHEDP
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHVGGPE-LVLDPYDYDFHEDP
MSMEG_5861|M.smegmatis_MC2_155 ----------------------------MSLPTVE-PVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. .*
Mvan_0317|M.vanbaalenii_PYR-1 YPTYRLLRDVAPVYRAE-----ESHTWVLSRHADVQAAALDHSTYSSVDG
MMAR_4833|M.marinum_M YPVYRQLRDDAPVYHAT-----DTNTWVLSRHADVISALLDHHSYSSVDG
MAV_1404|M.avium_104 WPMYRALRDHDPVHHVVPPKRPEHDYYVLSRHADVWAAARDHETFSSAKG
TH_2539|M.thermoresistible__bu WQTYRRLRDEAPVYYNA-----EWDFWALSRFDDVAAATKDHETFSSAKG
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNE-----ERNFWAVSRHHDVLQGFRDSTALSNAYG
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNE-----ERNFWAVSRHHDVLQGFRDSTALSNAYG
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRND-----DLKFWALSRHHDVLQGFRNSEALSNANG
Mflv_1598|M.gilvum_PYR-GCK YPYYQRLRDEAPLYRND-----ELGFWALSRHADVLKGFRNSTTLSNKFG
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQ-----ELGFWALSRRRDVHQGFRNSTTLSNRDG
MSMEG_5861|M.smegmatis_MC2_155 YPYYKRLRDEAPLYRND-----ERNFWALSRHEDVLKGFRNSTALSNKHG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG------MPLTVFSSFSDCDEALRHPLSASDRLK
: *: * : *: ..* * . . : *.
Mvan_0317|M.vanbaalenii_PYR-1 IFPTPPGSDF---IGS-FLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQ
MMAR_4833|M.marinum_M VFPTPPGSTF---RES-LLPMMILMDPPRHDQLRALVSKAFTPRRIAALT
MAV_1404|M.avium_104 LTVNYDDLEL---IGLQDNPPFVMQDPPVHTEFRKLVSRGFTPRQVEAVE
TH_2539|M.thermoresistible__bu ATLDMVKAPE---QSIPVPKVIISMDPPEHNRMRKLVSSVFTPRAVAALE
Mb0789c|M.bovis_AF2122/97 VSLDPSSRT----SEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
Rv0766c|M.tuberculosis_H37Rv VSLDPSSRT----SEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
MAB_1216c|M.abscessus_ATCC_199 VSMDKASFG----PHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELE
Mflv_1598|M.gilvum_PYR-GCK VSLDPASRG----PHASKTMSFLAMDDPDHLRLRTLVSKGFTPRRIRELE
MUL_0475|M.ulcerans_Agy99 VSLDPVSRG----PHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELE
MSMEG_5861|M.smegmatis_MC2_155 VSLDPVSRN----DEAHRVMSFLALDDPAHLRLRTLVSKGFTPRRIRELE
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
:: * * * .:* *** *:*: : :
Mvan_0317|M.vanbaalenii_PYR-1 GTITQMAAELFERLDEGSGS---ADFVTDFAAILPAAVIADLLGVPATDR
MMAR_4833|M.marinum_M SAIEDLADHLTGGLIQEAGS---ADFVADFAAVLPAMVIADLLGVPREDR
MAV_1404|M.avium_104 PKVRDFVVERIERLRAAGG----GDIVAELFKPLPSMVVAHYLGVPEEDR
TH_2539|M.thermoresistible__bu DMVREKIYRLIERLDPAAG----FDAVADFSAIFPNQVITTMLGVPEEDR
Mb0789c|M.bovis_AF2122/97 PQVLELARIHLDSALQTES----FDFVAEFAGKLPMDVISELIGVPDTDR
Rv0766c|M.tuberculosis_H37Rv PQVLELARIHLDSALQTES----FDFVAEFAGKLPMDVISELIGVPDTDR
MAB_1216c|M.abscessus_ATCC_199 GQVVALARTHLDRALANASD-RSFDFIAEYAGKLPMDVISELMGVPESDR
Mflv_1598|M.gilvum_PYR-GCK PRVTEIANQHLDSMLEAAASGATVDYVDEFAGKLPMDVISELMGVPNADR
MUL_0475|M.ulcerans_Agy99 PRVTELAVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADR
MSMEG_5861|M.smegmatis_MC2_155 ARVTEIAVQHLEIALQSD----SFDFVDDFAGKLPMDVISELMGVPEEDR
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQ----FDVIADLAFPLAVAVICRLLGVPYEDA
: * : : :. *: :*** *
Mvan_0317|M.vanbaalenii_PYR-1 DQFRLWSSQLVQVDVNHGQTT--------DALAAAAAIYAYFTDFLADRR
MMAR_4833|M.marinum_M TQFRQWSNALVQSNPTHGETG--------EALAAAAAIYGYFTDFLADRR
MAV_1404|M.avium_104 AQFDGWTEAIVAANTADGGVAG----ALGSAGDAVTSMMAYFTGLIERRR
TH_2539|M.thermoresistible__bu EQIRRWLDLLIERKPGQIHIT-------DEGYEASVATGMYYYGLVQKRR
Mb0789c|M.bovis_AF2122/97 ARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFR
Rv0766c|M.tuberculosis_H37Rv ARIRALADAVLHREDGVADVP-------PPAMAASIELMRYYADLIAEFR
MAB_1216c|M.abscessus_ATCC_199 ARIRELADGVMHREDGLADVP-------PEAIQASFDLMTYYIEMVRERR
Mflv_1598|M.gilvum_PYR-GCK AQVRAWADAVMHREDGVTDVP-------DSAIEASLNLIVYYQEMVKQRR
MUL_0475|M.ulcerans_Agy99 DQIRAMADGVMHREDGVTDVP-------ASAIEASINLIVYYQQMIAERR
MSMEG_5861|M.smegmatis_MC2_155 VRIRALADGVMHREDGVADVP-------ASAIAASGELLVYYADMVKRRR
MLBr_02088|M.leprae_Br4923 PEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRR
.. :: * * :: *
Mvan_0317|M.vanbaalenii_PYR-1 KNPREDLMSALANATVDG----IGLTDEEVLGFCALLLVAGYETTTNLLG
MMAR_4833|M.marinum_M RQPRDDLMSALVCAEIDG----KHLSDDELLGFCLLLLIAGHETTSNLLA
MAV_1404|M.avium_104 TDPEDDTISHLVSAGVGADGDIAGTLSVLAFTFTMVTGGN--DTTTGMLG
TH_2539|M.thermoresistible__bu AAPQDDMISRLIETEIERDGRIEKLTDVDITGFATMLGGAGAETVTKLIG
Mb0789c|M.bovis_AF2122/97 RRPANNLTSALLAAELDGD----RLSDQEIMAFLFLMVIAGNETTTKLLA
Rv0766c|M.tuberculosis_H37Rv RRPANNLTSALLAAELDGD----RLSDQEIMAFLFLMVIAGNETTTKLLA
MAB_1216c|M.abscessus_ATCC_199 RRPTEDLTSALLQAEIDGD----RLTDEEVLAFLFLMVIAGNETTTKLLA
Mflv_1598|M.gilvum_PYR-GCK TALTDDLTSALLEAEIDGD----RLTDDEIIGFMFLMVIAGNETTTKLLA
MUL_0475|M.ulcerans_Agy99 KKPSDDLTSALLAADVDGD----RLTDEEVLGFMFLMVIAGNETTTKLLA
MSMEG_5861|M.smegmatis_MC2_155 RNVSDDLTSALVEAEIDGD----KLTDDEIMAFLFLMVVAGNETTTKLLA
MLBr_02088|M.leprae_Br4923 GTPGEDLISRLIELDESGD----QLTEEEIIATCGLLLVAGHETTVNLIA
:: * * . : :*. ::.
Mvan_0317|M.vanbaalenii_PYR-1 NSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDSPAQGLSRTLTRDVTL
MMAR_4833|M.marinum_M NAAVVLADYRDTRRQLAGDESLLGAAVEELLRYDSPAQGLSRTLTRDVTV
MAV_1404|M.avium_104 GSMPLLHQRPDQRQRLVDEPELIPDAVEELLRLTSPVQGLARTTTRDVTI
TH_2539|M.thermoresistible__bu NAVVAFADFPDEWQKLRADRSKIPAAIEELLRFEAPSQYQVRVNTRDVTL
Mb0789c|M.bovis_AF2122/97 NAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTL
Rv0766c|M.tuberculosis_H37Rv NAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTL
MAB_1216c|M.abscessus_ATCC_199 NAVYWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITV
Mflv_1598|M.gilvum_PYR-GCK NAAFWGHRNPDQLGPVFDDHERIPLWVEETLRYDTSSQILARTVIGELEL
MUL_0475|M.ulcerans_Agy99 NAAFWGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTL
MSMEG_5861|M.smegmatis_MC2_155 NAAYWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTF
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTI
.: : : :** ** .. : *. :: .
Mvan_0317|M.vanbaalenii_PYR-1 HDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIE--RTSEHQVAFGRGIH
MMAR_4833|M.marinum_M HGVRMSAGESVLLLFGSANRDERVFADPDVFDIG--RKPEHQVAFGRGIH
MAV_1404|M.avium_104 GRTTIPAGRRVLLLYGSANRDERQYG-PDAGELDVARCPRNILTFSHGAH
TH_2539|M.thermoresistible__bu HGTTIPEGSAVLLLTGSALRDERVFRDPDRLDIDRDRVMGFNLAFGYGIH
Mb0789c|M.bovis_AF2122/97 YDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR-EIGCKLVSFGSGAH
Rv0766c|M.tuberculosis_H37Rv YDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR-EIGCKLVSFGSGAH
MAB_1216c|M.abscessus_ATCC_199 YDTKIPAGDILLLLPGSANRDDRVFDDADQYRIGR-EIGAKLVSFGSGAH
Mflv_1598|M.gilvum_PYR-GCK YDTVLPDGDVVLLLPGSAHRDERVFQNPDDFVIGR-EIGSKLMSFGSGAH
MUL_0475|M.ulcerans_Agy99 YDTTIPEGDVVLLLPGSAHRDERAFRDPDEYLIGR-EIGSKLLSFGSGAH
MSMEG_5861|M.smegmatis_MC2_155 YGTTVPAGDVLVLLAGSANRDERAFDDPDEYRIGR-DIGSKLVSFGSGAH
MLBr_02088|M.leprae_Br4923 GQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDR--PSSRHLAFAVGSH
. : * ::** .:* ** : .* ::*. * *
Mvan_0317|M.vanbaalenii_PYR-1 FCLGAALARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPIT
MMAR_4833|M.marinum_M FCLGASLARMEARIALRALLARVPNWEVDLERAQRLRSGPIRGYLSLPIS
MAV_1404|M.avium_104 HCLGAAAARMQSRVALTELLARCPDFEVDESGIVWAGGNYVRRPLSVPIR
TH_2539|M.thermoresistible__bu SCLGAALARMESRIALEALLDLIPEYEVDRAGLRRVQMSNVSGFKNVPVR
Mb0789c|M.bovis_AF2122/97 FCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPIS
Rv0766c|M.tuberculosis_H37Rv FCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPIS
MAB_1216c|M.abscessus_ATCC_199 FCLGAHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMT
Mflv_1598|M.gilvum_PYR-GCK FCLGAHLARMEARVALAELFKRIRGYEVDEDNAVRVHSSNVRGFAHLPIS
MUL_0475|M.ulcerans_Agy99 FCLGAHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPIT
MSMEG_5861|M.smegmatis_MC2_155 FCLGAHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPIT
MLBr_02088|M.leprae_Br4923 FCLGAALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQ
**** **::: ::* : :: : :*:
Mvan_0317|M.vanbaalenii_PYR-1 WTTPV--
MMAR_4833|M.marinum_M WSAN---
MAV_1404|M.avium_104 VKS----
TH_2539|M.thermoresistible__bu AGR----
Mb0789c|M.bovis_AF2122/97 VQAR---
Rv0766c|M.tuberculosis_H37Rv VQAR---
MAB_1216c|M.abscessus_ATCC_199 VQLREGR
Mflv_1598|M.gilvum_PYR-GCK VKVS---
MUL_0475|M.ulcerans_Agy99 VEVA---
MSMEG_5861|M.smegmatis_MC2_155 VEKR---
MLBr_02088|M.leprae_Br4923 V------