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MTARRDDVAAMLLDRTGDRRPGLRTRERDWTWDEVVHESAVRASIASTLSDLDPPHIGVLLDNVPDFVFW LGGAALAGATIVGLNPTRGAADLAADIRHADCRLIVTDAAGADRLRGLDHGVPPDHLLRVDSPDHAQLLD AHRVEPVAAPGVGAKSLFLLLFTSGTTGTSKAVRCSQGRLARIAYAATDKFGHHRDDVDYCCMPLFHGNA IMALWAPALANGATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLMATPEAPDDADNTLQRGFGTEA SPEDQKEFRRRFAAELFEGYGSSEGGAVATPDPAAPPAALGRPAHDDVVVVHPETLCLCPTAVLDASGRV LNPDEAVGEIVDRRGAADFEGYYRNDAADAERVRNGWYWSGDLGYLDGAGFLYFAGRRGDWLRVDGENIS TLTIERVLRRHAGVIAAAVYGVPDPRSGDQMMAAVEVADPGSFDVDAFASFLVAQDDLGRKGFPRLLRIS AKLPATGSNKVLKRDLQAQRWHTDDAVHRWVGRGHPRYRLMTDADRGALDAEFTVHGREHHVAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5209 | - | - | 100% (554) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5208 | - | e-112 | 45.92% (490) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4341 | - | e-106 | 41.17% (532) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1779c | fadD1 | 1e-114 | 43.33% (517) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1548 | - | 0.0 | 79.45% (550) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1750c | fadD1 | 1e-114 | 43.33% (517) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 4e-23 | 25.54% (466) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3628c | - | 0.0 | 72.84% (545) | acyl-CoA synthetase |
| M. marinum M | MMAR_4994 | fadD17 | 1e-117 | 44.47% (506) | fatty-acid-CoA synthetase FadD17 |
| M. avium 104 | MAV_0650 | - | 1e-114 | 46.03% (491) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4952 | - | 1e-104 | 40.35% (518) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4470 | - | 1e-105 | 41.28% (533) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 1e-116 | 44.47% (506) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1779c|M.bovis_AF2122/97 -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
Rv1750c|M.tuberculosis_H37Rv -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
MSMEG_4952|M.smegmatis_MC2_155 -----------MADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQ
TH_4470|M.thermoresistible__bu -----------MADTLQQLLRERAAQDTIAIKYDDRRITWREHVADAARQ
MMAR_4994|M.marinum_M ---------MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAI
MUL_4069|M.ulcerans_Agy99 ---------MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAI
MAV_0650|M.avium_104 -------MELSDDLTVTELLVPLTEIDDRGVYFEDSFTSWRDHLQHGAAI
Mvan_5209|M.vanbaalenii_PYR-1 --------MTARRDDVAAMLLDRTGDRRPGLRTRERDWTWDEVVHESAVR
Mflv_1548|M.gilvum_PYR-GCK -------MTDLRRTDVATMLLDRAGDQHLGVLTRERDWTWDQVVRESAAR
MAB_3628c|M.abscessus_ATCC_199 MTAVSVPRAGVPRVDIAAMLLDRVGDSHLGLRTRDRDWTWDQVVDESAAR
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
: * . . .
Mb1779c|M.bovis_AF2122/97 AAALITIADP----------------QRPTHIGSLLGNTPEMLAQLAAAG
Rv1750c|M.tuberculosis_H37Rv AAALITIADP----------------QRPTHIGSLLGNTPEMLAQLAAAG
MSMEG_4952|M.smegmatis_MC2_155 ARFLISRADH----------------GRPLHVGVLLGNTPQMLTALAAAA
TH_4470|M.thermoresistible__bu AAALLAAADP----------------NRPPHIAVLLGNTPDMLTALAGAA
MMAR_4994|M.marinum_M AAALRERLDP----------------TRPPHVGVLLQNTPFFSAMLAAAG
MUL_4069|M.ulcerans_Agy99 AAALRERLDP----------------TRPPHVGVLLRNTPFFSAMLTAAG
MAV_0650|M.avium_104 AAALRARLDP----------------ARPPHVGVLLENTPFFSAVLVAAG
Mvan_5209|M.vanbaalenii_PYR-1 ASIASTLSD-----------------LDPPHIGVLLDNVPDFVFWLGGAA
Mflv_1548|M.gilvum_PYR-GCK ASLATRLLDGV---------------PGPFHVGILLANVPDFVFWLGGAA
MAB_3628c|M.abscessus_ATCC_199 GALARKLRAD-----------------GPFHIGVLLDNVPDFVFWLGGAA
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
::. . : * .*.
Mb1779c|M.bovis_AF2122/97 LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDG--------
Rv1750c|M.tuberculosis_H37Rv LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDG--------
MSMEG_4952|M.smegmatis_MC2_155 LGGYVLCGINTTRRGEGLARDIARVDCQLLITDAEHRGLIDG--------
TH_4470|M.thermoresistible__bu LGGYVLCGINTTRRGAALARDVERVDAQILITDAEHRHLLDG--------
MMAR_4994|M.marinum_M MSGIIPVGLNPVRRGAALARDIEHADCQMVLADTASASTLDG--------
MUL_4069|M.ulcerans_Agy99 MSGIIPVGLNPVRRGAALARDIEHADCQMVLADTASASTLDG--------
MAV_0650|M.avium_104 MSGIVPVGLNPVRRGDALRRDIARADCQLVLADANSAGTLGD--------
Mvan_5209|M.vanbaalenii_PYR-1 LAGATIVGLNPTRGAADLAADIRHADCRLIVTDAAGADRLRG--------
Mflv_1548|M.gilvum_PYR-GCK LAGATVVGLNPTRGTADLAADIRHADCRLIVTDSVGAQRLRG--------
MAB_3628c|M.abscessus_ATCC_199 LAGATIVGINPTRGPAEMAAEIRHTDCQLIVTDTAHLGRLQS--------
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
.* ::.. .. :: :.*: : .
Mb1779c|M.bovis_AF2122/97 --LDL---AGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSG
Rv1750c|M.tuberculosis_H37Rv --LDL---AGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSG
MSMEG_4952|M.smegmatis_MC2_155 --LEL---PGVTVLDAS-----DICPEAGELTPYREAGPDDTFMMIFTSG
TH_4470|M.thermoresistible__bu --LEL---PGVTVFDTSTTEWARLLAAAPELTPHREVTPDDTFMMIFTSG
MMAR_4994|M.marinum_M --IEH---VNVDSAEWA----EVIDAHRNSEISFQNAAPADLFMLIYTSG
MUL_4069|M.ulcerans_Agy99 --IEH---VNVDSAEWA----EVIDAHRNSEISFQNAAPADLFMLIYTSG
MAV_0650|M.avium_104 --IEH---LNVDSAAWA----DEVAAHRGAPIVFRSASPADLFMLIFTSG
Mvan_5209|M.vanbaalenii_PYR-1 --LDHGVPPDHLLRVDSPDHAQLLDAHRVEPVAAPGVGAKSLFLLLFTSG
Mflv_1548|M.gilvum_PYR-GCK --IGHGVPDDRVLVVDDPEYRRALEACATEPAVAAGVGASSLFLLLFTSG
MAB_3628c|M.abscessus_ATCC_199 --LELGLSADRLLVIDSPEYLQRIAESRCTAQASEGVGADSLLLLLFTSG
MLBr_02661|M.leprae_Br4923 WPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGG
: . ::::*.*
Mb1779c|M.bovis_AF2122/97 TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
Rv1750c|M.tuberculosis_H37Rv TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
MSMEG_4952|M.smegmatis_MC2_155 TSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLAMPLFHSNAVYAGW
TH_4470|M.thermoresistible__bu TSGEPKAVQVPHSTVLFSGTALVDRYQLGSADTCYLAMPLFHSNAVYAGW
MMAR_4994|M.marinum_M TSGDPKAVKCSHSKVAIAGVTMTQRFGLGRDDVCYVSMPLFHSNAVLVGW
MUL_4069|M.ulcerans_Agy99 TSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDDVCYVSMPLFHSNAVLVGW
MAV_0650|M.avium_104 TSGEPKAVKCSHGKAAIAGVTMTQRFGLGRDDVCYVSMPLFHSNAVLVGW
Mvan_5209|M.vanbaalenii_PYR-1 TTGTSKAVRCSQGRLARIAYAATDKFGHHRDDVDYCCMPLFHGNAIMALW
Mflv_1548|M.gilvum_PYR-GCK TTGASKAVKCSQGRLARIAYVATEKFGHHRGDVDYCCMPLFHGNALMALW
MAB_3628c|M.abscessus_ATCC_199 TTGASKAVKCSQGRLAQIAHLATEKFGHVRSDVDYCCMPLFHGNALMALW
MLBr_02661|M.leprae_Br4923 TTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHGLIAAL
*:* .* * . : *. ***:*.:.: .
Mb1779c|M.bovis_AF2122/97 APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
Rv1750c|M.tuberculosis_H37Rv APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
MSMEG_4952|M.smegmatis_MC2_155 SVAVGAG--AAMAP-ATFSASGFLPDIRRYGATYMNYVGKPLAYILATPE
TH_4470|M.thermoresistible__bu SVAVGAG--AAMAP-ATFSASRFLHDIRRYGATYMNYVGKPLAYILATPE
MMAR_4994|M.marinum_M AVAVACQ--GSMALRRKFSASQFLSDVRRYGATYANYVGKPLSYVLATPE
MUL_4069|M.ulcerans_Agy99 AVAVACQ--GSMALRRKFSASQFLSDVRRYGATYANYVGKPLSYVLATPE
MAV_0650|M.avium_104 AVAAACQ--GSMALRRKFSASGFLPDVRRYGATYANYVGKPLSYVLATPE
Mvan_5209|M.vanbaalenii_PYR-1 APALANG--ATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLMATPE
Mflv_1548|M.gilvum_PYR-GCK APALANG--ATVCLTPSFSASRFLSDIRYFGATFFTYVGKALAYLMATPE
MAB_3628c|M.abscessus_ATCC_199 APALANG--ATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLLATPE
MLBr_02661|M.leprae_Br4923 LSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRILLELAS
: : *** * *: **: . . :: ..
Mb1779c|M.bovis_AF2122/97 ----RDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIV
Rv1750c|M.tuberculosis_H37Rv ----RDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIV
MSMEG_4952|M.smegmatis_MC2_155 ----KPDDHDNPLRIAFGNEAADRDIAAFSRRFGCTVWDGFGSTETAVII
TH_4470|M.thermoresistible__bu ----KPDDHDNPLRIAFGNEATDRDIEAFSRRFGCTVWDGFGSTEIAVII
MMAR_4994|M.marinum_M ----RPDDADNPLRAVYGNEGVPGDSERFGCRFGCVVQDGFGSTEGGVAI
MUL_4069|M.ulcerans_Agy99 ----RPDDADNPLRAVYGNEGVPGDIERFGCRFGCVVQDGFGSTEGGVAI
MAV_0650|M.avium_104 ----RPDDAQNPLRAVYGNEGVPADIERFARRFGCVVQDGFGSTEGGVAI
Mvan_5209|M.vanbaalenii_PYR-1 ----APDDADNTLQRGFGTEASPEDQKEFRRRFAAELFEGYGSSEGGAVA
Mflv_1548|M.gilvum_PYR-GCK ----QADDSDNTLTRGFGTEASPEDQAEFRRRFGAELHEGYGSSEGGAVA
MAB_3628c|M.abscessus_ATCC_199 ----RADDADNQLARGFGTEASPEDQAQFRRRFGAELFEGYGSSEGGGAV
MLBr_02661|M.leprae_Br4923 TQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQV
. . : . : .* : .:* :*
Mb1779c|M.bovis_AF2122/97 IREPGTPPGSIG-RGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGE
Rv1750c|M.tuberculosis_H37Rv IREPGTPPGSIG-RGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGE
MSMEG_4952|M.smegmatis_MC2_155 TRPDDCPPGSIG-KGFPGVAIYDPQTVTECAVAEFDATGALANPDAAIGE
TH_4470|M.thermoresistible__bu TRPDDCPPGSVG-KGFPGVAIYNPETLQECSVARFDANGALINPDEAIGE
MMAR_4994|M.marinum_M ARTPDTPAGSLG-PLPENIEILDPETGQQCPVG-------------AVGE
MUL_4069|M.ulcerans_Agy99 ARTPDTPAGSLG-PLPENIEIVDPETGQQCPVG-------------AVGE
MAV_0650|M.avium_104 ARTPDTPPGSLG-PLPAGIDIVDPDTGASCPPG-------------VVGE
Mvan_5209|M.vanbaalenii_PYR-1 TPDPAAPPAALGRPAHDDVVVVHPETLCLCPTAVLDASGRVLNPDEAVGE
Mflv_1548|M.gilvum_PYR-GCK TPDPAAPATALGRPAHEDVVVVDPATLKPCAPAVLDPRGRVTNADDAIGE
MAB_3628c|M.abscessus_ATCC_199 VLDPAAPPGALGRPAHEGVVVVDPETLQDCAAAVFDQHGRVLNADAAVGE
MLBr_02661|M.leprae_Br4923 TTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVG----SDGQPLPPDTVGE
. : . . .:**
Mb1779c|M.bovis_AF2122/97 LVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTA
Rv1750c|M.tuberculosis_H37Rv LVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTA
MSMEG_4952|M.smegmatis_MC2_155 LVNTAGGGLFRGYYNDQGATDQRMRHGMYWSGDLAYRDADGWIYLAGRTA
TH_4470|M.thermoresistible__bu LVNTAGAGLFRGYYNDPQATDERMRHGMYWSGDLAYRDADGWIYLAGRTA
MMAR_4994|M.marinum_M LVNTAGPGRFEGYYNDEAASAQRMSGGVYHSGDLAYRDAAGYAYFAGRLG
MUL_4069|M.ulcerans_Agy99 LVNTAGPGRFEGYYNDEAASAQRMSGGVYHSGDLAYRDAAGYAYFAGRLG
MAV_0650|M.avium_104 LVNTAGPGRFEGYYNDEAAEAERMAGGVYHSGDLAYRDEAGYAYFAGRLG
Mvan_5209|M.vanbaalenii_PYR-1 IVDRRGAADFEGYYRNDAADAERVRNGWYWSGDLGYLDGAGFLYFAGRRG
Mflv_1548|M.gilvum_PYR-GCK IVDRRGARDFEGYYRNDAADADRVRNGWYWSGDLGYVDRDGFLYFAGRRG
MAB_3628c|M.abscessus_ATCC_199 IVDKQGRRGFEGYYNNDDADADRIRNGWYWTGDLGYLDAAGFIYFAGRRG
MLBr_02661|M.leprae_Br4923 VWLR-GSTVVRGYLGDPAITAANFTHGWLRTGDLGSLSVTGDLRIRGRIK
: * . ** : .. * :***. . * : **
Mb1779c|M.bovis_AF2122/97 DWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRA
Rv1750c|M.tuberculosis_H37Rv DWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRA
MSMEG_4952|M.smegmatis_MC2_155 DWMRVDGENLTAAPIERILLRLDAVNRVAVYPVPDEYVGDQVMAAIVLQD
TH_4470|M.thermoresistible__bu DWMRVDGENLTAAPIERILLRLPAINRAAVYPVPDELVGDQVMAAVVLQD
MMAR_4994|M.marinum_M DWMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVGDQVMAAMVLTP
MUL_4069|M.ulcerans_Agy99 DWMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVGDQVMAAMVLTP
MAV_0650|M.avium_104 DWMRVDGENLGAAPIERVLLRHPDVTEVAVYPVPDPTVGDQVMAALVLAP
Mvan_5209|M.vanbaalenii_PYR-1 DWLRVDGENISTLTIERVLRRHAGVIAAAVYGVPDPRSGDQMMAAVEVAD
Mflv_1548|M.gilvum_PYR-GCK DWIRVDGENTSALTIERVLRRHPEVIAAAVYGVPDPRSGDQVMAAVEVAE
MAB_3628c|M.abscessus_ATCC_199 DWIRVDGENMSALTVERVLRRHPLVIAAGVYAVPDPRSGDQVMASIEVAE
MLBr_02661|M.leprae_Br4923 ELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVIVPRE
: :. .**: . :* :* ..*: ** *: : * :
Mb1779c|M.bovis_AF2122/97 GDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDE
Rv1750c|M.tuberculosis_H37Rv GDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDE
MSMEG_4952|M.smegmatis_MC2_155 GATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTATNKILKRELVAT
TH_4470|M.thermoresistible__bu --ELTPRQFADFLAAQTDLSPKAWPRYVWVADDLPVTATNKVLKRELIAR
MMAR_4994|M.marinum_M GAKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTETFKVLKRQLAAD
MUL_4069|M.ulcerans_Agy99 GAKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTETFKVLKRQLAAD
MAV_0650|M.avium_104 GAEFDDEKFRAFLAEQPDLGPKQWPSYVRISTELPRTVTFKVLKRQLAAQ
Mvan_5209|M.vanbaalenii_PYR-1 PGSFDVDAFASFLVAQDDLGRKGFPRLLRISAKLPATGSNKVLKRDLQAQ
Mflv_1548|M.gilvum_PYR-GCK PGSFDINAFVDFLVGQDDLGAKGFPRLLRVSARLPATGSNKVLKRELQTQ
MAB_3628c|M.abscessus_ATCC_199 PDSFDVDGFTQYLSAQEELGSKGIPRFLRISANLPVTGSNKVLKRELQEQ
MLBr_02661|M.leprae_Br4923 VIAPTPSELAVFCRDR--LAAFEVPTRFQEASALPHTAKGSLDRRAVAEQ
: : : *. * . . ** * . .: :* :
Mb1779c|M.bovis_AF2122/97 GTAVGKADTLWVRE-PRGSAYHHASGPAKAI--------------
Rv1750c|M.tuberculosis_H37Rv GTAVGKADTLWVRE-PRGSAYHHASGPAKAI--------------
MSMEG_4952|M.smegmatis_MC2_155 GTDP-AGRVLWHRDGTRFTDLSAASAPGAAPGISPA---------
TH_4470|M.thermoresistible__bu GTAP-DGRVLWRRDGAQYHVYAESDE-------------------
MMAR_4994|M.marinum_M GVDC--GDPVWPIRDQS----------------------------
MUL_4069|M.ulcerans_Agy99 GVDC--GDPVWPIRDQS----------------------------
MAV_0650|M.avium_104 GVDC--GDPVWKIGR------------------------------
Mvan_5209|M.vanbaalenii_PYR-1 RWHTDDAVHRWVGRGHPRYRLMTDADRGALDAEFTVHGREHHVAE
Mflv_1548|M.gilvum_PYR-GCK RWHTDEAVYRWSGRGRPRYRLMTADDRAALDEEFVTHGRAHHGTT
MAB_3628c|M.abscessus_ATCC_199 RWHTDEPVFRWVGRGGPVFLRMSSDDKTALDAQFAVYGRQRLL--
MLBr_02661|M.leprae_Br4923 FAHRG----------------------------------------