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VATVSSLLAELTEVDDRGVRWVDPETGSVSFVSWRNHIRDGAALAAALRDRLDPDRPAHVGVLLGNTPFF GTVLVAAALSGIVPVGLNPTRRGAALQRDVDHADCQLVLADRSAPHDGIAAVDVESSLFADELATHRGAA VDFPDPDPDDLFMLIFTSGTSGHPKAVRCTHEKVAFPGVMLAQRFGLGAADTCYLSMPLFHSNAIMAGWA PGVAAGASIALRRKFSASQFIPDVRRFGATYANYVGKPLSYILATPEKPDDADNPLRVAYGNEGAPRDLR RFAERFGVTVVDGFGSSEGGVSIARTPDTPEGALGPLVGGVTIVDVDTGAECPPGVVGELVNTEGPGQFR GYYRDPDAEAERMRGGVYHSGDLAYRDERGFAYFAGRLGDWMRVDGENLGTAPIERILMRFPGVTEAAVY PIPDPAVGDQVMAALVLPDIAAFDPDSFTQFLCEQSDLGPKQWPRFVRTATALPRTETFKILKRELSAEG TDCPDPVHPIRRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5208 | - | - | 100% (503) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4341 | - | e-136 | 51.08% (509) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5209 | - | e-112 | 45.92% (490) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3536 | fadD17 | 0.0 | 68.39% (503) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1549 | - | 0.0 | 81.62% (506) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3506 | fadD17 | 0.0 | 68.39% (503) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 3e-29 | 29.41% (357) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4160 | - | 1e-174 | 59.14% (509) | acyl-CoA synthetase |
| M. marinum M | MMAR_4994 | fadD17 | 0.0 | 66.67% (501) | fatty-acid-CoA synthetase FadD17 |
| M. avium 104 | MAV_0650 | - | 0.0 | 69.32% (502) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5908 | - | 0.0 | 71.43% (504) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_1138 | fadD17 | 0.0 | 73.16% (503) | POSSIBLE FATTY-ACID-CoA SYNTHETASE FADD17 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 0.0 | 66.87% (501) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3536|M.bovis_AF2122/97 --MTPTHPTVTELLLPLSEIDDRGVYFED------SFTSWRDHIRHGAAI
Rv3506|M.tuberculosis_H37Rv --MTPTHPTVTELLLPLSEIDDRGVYFED------SFTSWRDHIRHGAAI
MMAR_4994|M.marinum_M ---MSADPTVPQLLVPLAEIGDRGIYFED------SFTSWADHIGHGAAI
MUL_4069|M.ulcerans_Agy99 ---MSADPTVPQLLVPLAEIGDRGIYFED------SFTSWADHIGHGAAI
MAV_0650|M.avium_104 -MELSDDLTVTELLVPLTEIDDRGVYFED------SFTSWRDHLQHGAAI
Mvan_5208|M.vanbaalenii_PYR-1 ------MATVSSLLAELTEVDDRGVRWVDPETGSVSFVSWRNHIRDGAAL
Mflv_1549|M.gilvum_PYR-GCK --MTAPAPTVSALLSALSDVDDRGVHSIDPGSAVTSFISWRNHIRDGATL
MSMEG_5908|M.smegmatis_MC2_155 MTETIDPQTVTALLAPLADVTDRGVHEGD------SFVSWSEHITAGAQV
TH_1138|M.thermoresistible__bu -----MAETVTALLEPLIDVEDRGVWFED------EFTPWRAHLEQASAL
MAB_4160|M.abscessus_ATCC_1997 -MSTSEDATVTRLLVNLADVEDRGLHFEG------SFTSWRDHIAESRRL
MLBr_01051|M.leprae_Br4923 ----MLLASLNPSVVTATDIADAVCVDG--------------VVLSRSGL
:: : :: * : :
Mb3536|M.bovis_AF2122/97 AAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGA
Rv3506|M.tuberculosis_H37Rv AAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGA
MMAR_4994|M.marinum_M AAALRERLDPTRPPHVGVLLQNTPFFSAMLAAAGMSGIIPVGLNPVRRGA
MUL_4069|M.ulcerans_Agy99 AAALRERLDPTRPPHVGVLLRNTPFFSAMLTAAGMSGIIPVGLNPVRRGA
MAV_0650|M.avium_104 AAALRARLDPARPPHVGVLLENTPFFSAVLVAAGMSGIVPVGLNPVRRGD
Mvan_5208|M.vanbaalenii_PYR-1 AAALRDRLDPDRPAHVGVLLGNTPFFGTVLVAAALSGIVPVGLNPTRRGA
Mflv_1549|M.gilvum_PYR-GCK ASALRSRLDPDRPGHVGVLLGNTPFFGTVLAAAALSGIVPVGLNPTRRGD
MSMEG_5908|M.smegmatis_MC2_155 GAALRARLDPQRPGHVGVLLGNTTFFSSLLVAAGLTGLVPVGLNPTRRGE
TH_1138|M.thermoresistible__bu AAALTARLDPNRPPHVGVLSGNTPMFSALLVAAAMTGLVPVGLNPTRRGA
MAB_4160|M.abscessus_ATCC_1997 ASVLRARLDPSKPPHIGVILENTPGFARLLTAAALAGLVLVGLNSTRRGS
MLBr_01051|M.leprae_Br4923 VGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVPVPADIGV
.. : :: .: ... :. : . : * .. *
Mb3536|M.bovis_AF2122/97 ALAGDIAKADCQLVLTGSGS---AEVPADVEHINVDSPEWTDEVAAHRDT
Rv3506|M.tuberculosis_H37Rv ALAGDIAKADCQLVLTGSGS---AEVPADVEHINVDSPEWTDEVAAHRDT
MMAR_4994|M.marinum_M ALARDIEHADCQMVLADTAS---ASTLDGIEHVNVDSAEWAEVIDAHRNS
MUL_4069|M.ulcerans_Agy99 ALARDIEHADCQMVLADTAS---ASTLDGIEHVNVDSAEWAEVIDAHRNS
MAV_0650|M.avium_104 ALRRDIARADCQLVLADANS---AGTLGDIEHLNVDSAAWADEVAAHRGA
Mvan_5208|M.vanbaalenii_PYR-1 ALQRDVDHADCQLVLADRS-----APHDGIAAVDVESSLFADELATHRGA
Mflv_1549|M.gilvum_PYR-GCK ALRRDADHADCQFVLADAENVAQCGGLSGLDVIDVESEAFAEELSAHRGA
MSMEG_5908|M.smegmatis_MC2_155 ALRRDIVRADCQVVLTDTPD-LVPAGMNEVPVIDVESADWAAELDAHRGA
TH_1138|M.thermoresistible__bu ALVRDIERADCRLVLADDPE-SVPAG---VDFIDVTAPRFADELAAHRGA
MAB_4160|M.abscessus_ATCC_1997 ALRRDIELADCQFVVADESD----------------------TVAGLQHP
MLBr_01051|M.leprae_Br4923 VERRHMLTDSGAQAWLGPGP--------SADSAPDGLPHIPVQLDARSWN
. . . . . :
Mb3536|M.bovis_AF2122/97 EVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGR
Rv3506|M.tuberculosis_H37Rv EVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGR
MMAR_4994|M.marinum_M EISFQNAAPADLFMLIYTSGTSGDPKAVKCSHSKVAIAGVTMTQRFGLGR
MUL_4069|M.ulcerans_Agy99 EISFQNAAPADLFMLIYTSGTSGDPKAVKCGHSKVAIAGVTMTQRFGLGR
MAV_0650|M.avium_104 PIVFRSASPADLFMLIFTSGTSGEPKAVKCSHGKAAIAGVTMTQRFGLGR
Mvan_5208|M.vanbaalenii_PYR-1 AVDFPDPDPDDLFMLIFTSGTSGHPKAVRCTHEKVAFPGVMLAQRFGLGA
Mflv_1549|M.gilvum_PYR-GCK DAGFIEPDPEDLFMLIFTSGTSGDPKAVRCTHEKVALPGLMLAERFGLGP
MSMEG_5908|M.smegmatis_MC2_155 PVRFAATRADDLFMLIFTSGTSGEPKAVRVTHDKVAFPGRMLAERFGLAP
TH_1138|M.thermoresistible__bu PVRFRRAAPDDLFMLIFTSGTSGDPKAVRVTHDKVAHPGTMLATRFGLGP
MAB_4160|M.abscessus_ATCC_1997 QIEIADVRPDDLYMLIFTSGTSGDPKAVQITHAKVASAGIMLSSRFGLGS
MLBr_01051|M.leprae_Br4923 --RYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTA
*:*:****:* **.* : * :: :
Mb3536|M.bovis_AF2122/97 DDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGA
Rv3506|M.tuberculosis_H37Rv DDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGA
MMAR_4994|M.marinum_M DDVCYVSMPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGA
MUL_4069|M.ulcerans_Agy99 DDVCYVSMPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGA
MAV_0650|M.avium_104 DDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASGFLPDVRRYGA
Mvan_5208|M.vanbaalenii_PYR-1 ADTCYLSMPLFHSNAIMAGWAPGVAAGASIALRRKFSASQFIPDVRRFGA
Mflv_1549|M.gilvum_PYR-GCK ADTCYLSMPLFHSNAIMAGWAPAVAAGASIALRRKFSASQFIPDIRRFGA
MSMEG_5908|M.smegmatis_MC2_155 SDTAYLSMPLFHSNAIMAGWSVAVAAGASIALRRKFSASGFIEDVRRYGA
TH_1138|M.thermoresistible__bu ADTCYLSMPLFHSNAIMAGWAVAVAAGASVALRRRFSASQFIPDVRRYRA
MAB_4160|M.abscessus_ATCC_1997 TDVCYLSMPMFHSNAVMAGWSVAVAAGASIALRRKFSASGFLDDVREYGA
MLBr_01051|M.leprae_Br4923 DDVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGG
*. .:*:** :.:: * . .. : :.: : . .
Mb3536|M.bovis_AF2122/97 TYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPG-DIDRFGRRFGC
Rv3506|M.tuberculosis_H37Rv TYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPG-DIDRFGRRFGC
MMAR_4994|M.marinum_M TYANYVGKPLSYVLATPERPDDADNPLRAVYGNEGVPG-DSERFGCRFGC
MUL_4069|M.ulcerans_Agy99 TYANYVGKPLSYVLATPERPDDADNPLRAVYGNEGVPG-DIERFGCRFGC
MAV_0650|M.avium_104 TYANYVGKPLSYVLATPERPDDAQNPLRAVYGNEGVPA-DIERFARRFGC
Mvan_5208|M.vanbaalenii_PYR-1 TYANYVGKPLSYILATPEKPDDADNPLRVAYGNEGAPR-DLRRFAERFGV
Mflv_1549|M.gilvum_PYR-GCK TYANYVGKPLSYILATPQLPDDADNPLRIAYGNEGAPR-DLSRFAERFAV
MSMEG_5908|M.smegmatis_MC2_155 TYANYVGKPLSYILATDPRPDDADNPLKILYGNEGAAR-DLQRFAERFGV
TH_1138|M.thermoresistible__bu SYANYVGKPLSYILATPPRADDADNPLRILYGNEGAPR-DIARFARRFDV
MAB_4160|M.abscessus_ATCC_1997 TYANYVGKPMSYVLATPQRPDDAENPLRIMYGNEAAAG-DTDRFATRFGA
MLBr_01051|M.leprae_Br4923 SLYFGVPTVWSRLVADEAVARALRPARLLVSGSASLPVPVFDRLAHLTGH
: * . * ::* . . *. . . *:.
Mb3536|M.bovis_AF2122/97 VVMDGFGSTEGGVAITRTLDTP--AGALG-PLPGGIQIVDPDTGEPCPTG
Rv3506|M.tuberculosis_H37Rv VVMDGFGSTEGGVAITRTLDTP--AGALG-PLPGGIQIVDPDTGEPCPTG
MMAR_4994|M.marinum_M VVQDGFGSTEGGVAIARTPDTP--AGSLG-PLPENIEILDPETGQQCPVG
MUL_4069|M.ulcerans_Agy99 VVQDGFGSTEGGVAIARTPDTP--AGSLG-PLPENIEIVDPETGQQCPVG
MAV_0650|M.avium_104 VVQDGFGSTEGGVAIARTPDTP--PGSLG-PLPAGIDIVDPDTGASCPPG
Mvan_5208|M.vanbaalenii_PYR-1 TVVDGFGSSEGGVSIARTPDTP--EGALG-PLVGGVTIVDVDTGAECPPG
Mflv_1549|M.gilvum_PYR-GCK RVVDGFGSSEGGVSIARTPDTP--EGALG-PLTGGVTILDVDTGAECPPG
MSMEG_5908|M.smegmatis_MC2_155 HVVDGFGSTEGGVAVARTPDTP--DGALG-PLTDQVAIIDVDTGEPCPPG
TH_1138|M.thermoresistible__bu LVVDGFGSTEGGVAIARTPDTP--DGALG-PLTDEVAIIDVDTGEPCPPG
MAB_4160|M.abscessus_ATCC_1997 VVVDGFGSTEGGVALGWAPGTP--PGAIG-PLTPDIQILDIQTGRPCPPA
MLBr_01051|M.leprae_Br4923 RPIERYGSTESLITLSTLADGERRAGWVGLPLAGVQTRLVDESGGPVPYD
: :**:*. ::: . * :* ** : ::* *
Mb3536|M.bovis_AF2122/97 V-------------VGELVNTAGPGGFEGYYNDEAAEAERMAG-GVYHSG
Rv3506|M.tuberculosis_H37Rv V-------------VGELVNTAGPGGFEGYYNDEAAEAERMAG-GVYHSG
MMAR_4994|M.marinum_M A-------------VGELVNTAGPGRFEGYYNDEAASAQRMSG-GVYHSG
MUL_4069|M.ulcerans_Agy99 A-------------VGELVNTAGPGRFEGYYNDEAASAQRMSG-GVYHSG
MAV_0650|M.avium_104 V-------------VGELVNTAGPGRFEGYYNDEAAEAERMAG-GVYHSG
Mvan_5208|M.vanbaalenii_PYR-1 V-------------VGELVNTEGPGQFRGYYRDPDAEAERMRG-GVYHSG
Mflv_1549|M.gilvum_PYR-GCK V-------------IGELVNTDGPGQFRGYYKDPEAEADRMRG-GIYHSG
MSMEG_5908|M.smegmatis_MC2_155 R-------------VGELVNPTGPGWFRGYYNDPQAEAERMAG-GVYHTG
TH_1138|M.thermoresistible__bu K-------------IGEIVNPTGPGWFRGYYNDPDAEAERMAG-GVYHTG
MAB_4160|M.abscessus_ATCC_1997 IFDQSGKVINAAEATGELVNVTGPGRFTGYYKNPEADAERMVG-GRYHSG
MLBr_01051|M.leprae_Br4923 G------------ETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTG
:: .* * ** . * *: : * *::*
Mb3536|M.bovis_AF2122/97 DLAYRDDAGYAYFAGR-LGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
Rv3506|M.tuberculosis_H37Rv DLAYRDDAGYAYFAGR-LGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
MMAR_4994|M.marinum_M DLAYRDAAGYAYFAGR-LGDWMRVDGENLGTAPIERVLLRYPDAIEVAVY
MUL_4069|M.ulcerans_Agy99 DLAYRDAAGYAYFAGR-LGDWMRVDGENLGTAPIERVLLRYPDAIEVAVY
MAV_0650|M.avium_104 DLAYRDEAGYAYFAGR-LGDWMRVDGENLGAAPIERVLLRHPDVTEVAVY
Mvan_5208|M.vanbaalenii_PYR-1 DLAYRDERGFAYFAGR-LGDWMRVDGENLGTAPIERILMRFPGVTEAAVY
Mflv_1549|M.gilvum_PYR-GCK DLAYRDEDGYAYFAGR-LGDWMRVDGENIGTAPIERILMRFPGVAEAAVY
MSMEG_5908|M.smegmatis_MC2_155 DLAYRDENGYVYFAGR-LGDWMRVDGENLGTAPIERILLRHPGIVEVAVY
TH_1138|M.thermoresistible__bu DLGYCDENGYIYFAGR-LGDWMRVDGENLGTAPIERILLRHPDVVEAAVY
MAB_4160|M.abscessus_ATCC_1997 DLAYADENGYVYFAGR-LGDWLRVDGENLGTAPIERVLLRHPDITEVAVY
MLBr_01051|M.leprae_Br4923 DVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVV
*:. * * :.** * :::.* .:*:. ** *: .*. *.**
Mb3536|M.bovis_AF2122/97 PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVS
Rv3506|M.tuberculosis_H37Rv PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVS
MMAR_4994|M.marinum_M AIPDPVVGDQVMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRIC
MUL_4069|M.ulcerans_Agy99 AIPDPVVGDQVMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRIC
MAV_0650|M.avium_104 PVPDPTVGDQVMAALVLAPGAEFDDEKFRAFLAEQPDLGPKQWPSYVRIS
Mvan_5208|M.vanbaalenii_PYR-1 PIPDPAVGDQVMAALVLPDIAAFDPDSFTQFLCEQSDLGPKQWPRFVRTA
Mflv_1549|M.gilvum_PYR-GCK PIPDPAVGDQVMAALVMCEGAPFEAAAFTEFLSAQADLGPKQWPRFVRVA
MSMEG_5908|M.smegmatis_MC2_155 PIPDPAVGDQVMAAVVPAPGSVLDPGQLGEFLAAQDDLGPKQWPSYVRVS
TH_1138|M.thermoresistible__bu PIPDPAVGDRVMAALVLTDGAEFDPGRFRDFLADQPDLGPKQWPSFVRVA
MAB_4160|M.abscessus_ATCC_1997 GVPDPTVGDRVMAALV---GADFDPVTLSEFLSAQEDLGPKQWPSFIRVS
MLBr_01051|M.leprae_Br4923 GLPDEDLGQRIVAFVVG--AEALDADELINYVAQQLSIHKR--PREVRFV
:** :*::::* :* :: : :: * .: : * :*
Mb3536|M.bovis_AF2122/97 AGLPRTMTFKVIKRQLSAEGVACADPVWPIRR----------
Rv3506|M.tuberculosis_H37Rv AGLPRTMTFKVIKRQLSAEGVACADPVWPIRR----------
MMAR_4994|M.marinum_M SALPRTETFKVLKRQLAADGVDCGDPVWPIRDQS--------
MUL_4069|M.ulcerans_Agy99 SALPRTETFKVLKRQLAADGVDCGDPVWPIRDQS--------
MAV_0650|M.avium_104 TELPRTVTFKVLKRQLAAQGVDCGDPVWKIGR----------
Mvan_5208|M.vanbaalenii_PYR-1 TALPRTETFKILKRELSAEGTDCPDPVHPIRRP---------
Mflv_1549|M.gilvum_PYR-GCK PALPRTETFKVLKRRLSAEGVDCPDPVHPIVRP---------
MSMEG_5908|M.smegmatis_MC2_155 TELPRTETFKVLKRQLSAEGIDCTDPVWPIVR--GARTNTTA
TH_1138|M.thermoresistible__bu EVLPRTETFKVLKRQLSAEATDCADPVWPIERPRGDRCASP-
MAB_4160|M.abscessus_ATCC_1997 GELPRTATFKVIKRQLSAEALETADPVWALTNGTYTRT----
MLBr_01051|M.leprae_Br4923 DALPRNAMGKVLKKQLLFEG----------------------
***. *::*:.* :.