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ADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQARFLISRADHGRPLHVGVLLGNTPQMLTALAA AALGGYVLCGINTTRRGEGLARDIARVDCQLLITDAEHRGLIDGLELPGVTVLDASDICPEAGELTPYRE AGPDDTFMMIFTSGTSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLAMPLFHSNAVYAGWSVAVGA GAAMAPATFSASGFLPDIRRYGATYMNYVGKPLAYILATPEKPDDHDNPLRIAFGNEAADRDIAAFSRRF GCTVWDGFGSTETAVIITRPDDCPPGSIGKGFPGVAIYDPQTVTECAVAEFDATGALANPDAAIGELVNT AGGGLFRGYYNDQGATDQRMRHGMYWSGDLAYRDADGWIYLAGRTADWMRVDGENLTAAPIERILLRLDA VNRVAVYPVPDEYVGDQVMAAIVLQDGATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTATNKILK RELVATGTDPAGRVLWHRDGTRFTDLSAASAPGAAPGISPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4952 | - | - | 100% (532) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5908 | - | e-136 | 52.50% (501) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4036 | - | 6e-36 | 30.24% (496) | crotonobetaine/carnitine-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1779c | fadD1 | 0.0 | 65.60% (532) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2305 | - | 0.0 | 76.69% (519) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1750c | fadD1 | 0.0 | 65.60% (532) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 9e-24 | 26.81% (455) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2609 | - | 0.0 | 65.18% (514) | acyl-CoA synthetase |
| M. marinum M | MMAR_2625 | fadD1 | 0.0 | 65.52% (522) | fatty-acid-CoA ligase FadD1 |
| M. avium 104 | MAV_5257 | - | 0.0 | 66.17% (538) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4470 | - | 0.0 | 80.35% (519) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 1e-138 | 51.38% (506) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4341 | - | 0.0 | 74.24% (524) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4952|M.smegmatis_MC2_155 --MADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQARFLISRAD
TH_4470|M.thermoresistible__bu --MADTLQQLLRERAAQDTIAIKYDDRRITWREHVADAARQAAALLAAAD
Mflv_2305|M.gilvum_PYR-GCK --MAETVQQLLRERVTDDGIAMKHEDRTWTWREHLGEAAAQASALIGLAD
Mvan_4341|M.vanbaalenii_PYR-1 --MAETVQQLLRERLDSDGIALKYEGSTWTWREHLGEAAMQAAALIGAAD
Mb1779c|M.bovis_AF2122/97 --MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIAD
Rv1750c|M.tuberculosis_H37Rv --MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIAD
MMAR_2625|M.marinum_M --MTETIQALLQQRMSDSSIAVKYHDLQWTWREYLAEAAARAAGLIAAAD
MAV_5257|M.avium_104 -MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAARAAALLGAAD
MAB_2609|M.abscessus_ATCC_1997 --MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIAD
MUL_4069|M.ulcerans_Agy99 MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAIAAALRERLD
MLBr_01051|M.leprae_Br4923 --------MLLASLNPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAER
*: . . : .. .
MSMEG_4952|M.smegmatis_MC2_155 HGRPLHVGVLLGNTPQMLTALAAAALGGYVLCGINTTRRGEGLARDIARV
TH_4470|M.thermoresistible__bu PNRPPHIAVLLGNTPDMLTALAGAALGGYVLCGINTTRRGAALARDVERV
Mflv_2305|M.gilvum_PYR-GCK PSRPLHVGVLLGNTPDMLTAMAAAGLGGYVLCGINTTRRGSALGRDVLRG
Mvan_4341|M.vanbaalenii_PYR-1 PERPLHVGVLLGNNPDMLTAMAAAGLGGYVLCGINNTRRGDALARDIRRA
Mb1779c|M.bovis_AF2122/97 PQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRA
Rv1750c|M.tuberculosis_H37Rv PQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRA
MMAR_2625|M.marinum_M PDRPLHIGSLLGNTPEMLAQMAAAGLGGYVLCGLNTTRRGEALAADIRRA
MAV_5257|M.avium_104 PGRPMHVGTLLGNTPEMLSQMAAAGLGGYVLCGLNTTRRGKALAADVRRA
MAB_2609|M.abscessus_ATCC_1997 PTRPLHVGTLLGNTPAMTTAMAAAAQGGYILCAINNTRRGEGLLRDIRKS
MUL_4069|M.ulcerans_Agy99 PTRPPHVGVLLRNTPFFSAMLTAAGMSGIIPVGLNPVRRGAALARDIEHA
MLBr_01051|M.leprae_Br4923 VGGARLVAVLATPTASTVLAITGCLIAGVPVVPVP---------ADIGVV
. :. * .. ::.. .* : *:
MSMEG_4952|M.smegmatis_MC2_155 DCQLLITDAEHRGLIDGLELPGVTVLDAS-----DICPEAG-ELTPYREA
TH_4470|M.thermoresistible__bu DAQILITDAEHRHLLDGLELPGVTVFDTSTTEWARLLAAAP-ELTPHREV
Mflv_2305|M.gilvum_PYR-GCK DCQILITDDAHRGLLDGVDLPGVRVLVVGTPEWSELIGRAG-ELTPHREV
Mvan_4341|M.vanbaalenii_PYR-1 DCQFLITDDAHRHLLDGLDLSGVRVLVVGTPEWKELTGRAG-TLTPHREV
Mb1779c|M.bovis_AF2122/97 DCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDG-AFVPYREV
Rv1750c|M.tuberculosis_H37Rv DCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDG-AFVPYREV
MMAR_2625|M.marinum_M ECQIIVTDAENRSLLDGLDLADVEIFDTSTPRWAELVGGAG-SLVPHRKV
MAV_5257|M.avium_104 DCQFVVTDAEHRPLLDGLDLAGTQILDTSTPDWAGFVDAAG-ELTPHREV
MAB_2609|M.abscessus_ATCC_1997 DVQVLLVDAEHRPLLDAVDLPDVTVIDVDSAEWIERMKTPG-ELHPYRTA
MUL_4069|M.ulcerans_Agy99 DCQMVLADTASASTLDGIEH-----VNVDSAEWAEVIDAHRNSEISFQNA
MLBr_01051|M.leprae_Br4923 ERRHMLTDSGAQAWLG--PGPSADSAPDGLPHIPVQLDARS--WNRYPEP
: : ::.* :. . .
MSMEG_4952|M.smegmatis_MC2_155 GPDDTFMMIFTSGTSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLA
TH_4470|M.thermoresistible__bu TPDDTFMMIFTSGTSGEPKAVQVPHSTVLFSGTALVDRYQLGSADTCYLA
Mflv_2305|M.gilvum_PYR-GCK TVTDTYMLIFTSGTSGDPKAVKMMHAMVLLAGAALAGRYELTPRDVCYLS
Mvan_4341|M.vanbaalenii_PYR-1 TATDTYMLIFTSGTSGDPKAVKMMHAMVLLAGAALMGRYELTSDDVCYLS
Mb1779c|M.bovis_AF2122/97 DTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVS
Rv1750c|M.tuberculosis_H37Rv DTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVS
MMAR_2625|M.marinum_M EMMDPFMMIFTSGTSGNPKAVQVSHLMPTFAGRSLTERFGLSAHDTCYVS
MAV_5257|M.avium_104 AAMDPFMMIFTSGTSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVS
MAB_2609|M.abscessus_ATCC_1997 APLDPFMMIFTSGTSGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVS
MUL_4069|M.ulcerans_Agy99 APADLFMLIYTSGTSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDDVCYVS
MLBr_01051|M.leprae_Br4923 SPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHG
*:*:****:* **.* : . : : *. .
MSMEG_4952|M.smegmatis_MC2_155 MPLFHSNAVYAGWSVAVGAGAAMAP-ATFSASGFLPDIRRYGATYMNYVG
TH_4470|M.thermoresistible__bu MPLFHSNAVYAGWSVAVGAGAAMAP-ATFSASRFLHDIRRYGATYMNYVG
Mflv_2305|M.gilvum_PYR-GCK MPLFHSNAVLAGWSVALNAGAAMAP-AHFSASGFLGDIRRYGATYMNYVG
Mvan_4341|M.vanbaalenii_PYR-1 MPLFHSNAVLAGWSVAVNSGAAMAP-AQFSASRFVDDIRRYGATYMNYVG
Mb1779c|M.bovis_AF2122/97 MPLFHSNAVVAGWAPAVVSGAAIAP-ATFSATGFLDDVRRYHATYMNYVG
Rv1750c|M.tuberculosis_H37Rv MPLFHSNAVVAGWAPAVVSGAAIAP-ATFSATGFLDDVRRYHATYMNYVG
MMAR_2625|M.marinum_M MPLFHSNAVVAGWAPAVVSGAAIAP-AKFSATGFLDDIRRYQATYMNYVG
MAV_5257|M.avium_104 MPLFHSNAVVAGWAPAVCSGAAIVP-AKFSARNFLDDIRRYGATYMNYVG
MAB_2609|M.abscessus_ATCC_1997 MPLFHSNAVLAGWAVAVAAGAALAP-AKFSASRFLADIREVGATYMNYVG
MUL_4069|M.ulcerans_Agy99 MPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGATYANYVG
MLBr_01051|M.leprae_Br4923 LPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVP
:**** :.: * :: :. :. : . .: *
MSMEG_4952|M.smegmatis_MC2_155 KPLAYILATPEKPDDHDNPLRIAFGNEAADR-DIAAFSRRFGCTVWDGFG
TH_4470|M.thermoresistible__bu KPLAYILATPEKPDDHDNPLRIAFGNEATDR-DIEAFSRRFGCTVWDGFG
Mflv_2305|M.gilvum_PYR-GCK KPLAYILASPEKPDDIDNPLRVAFGNEAGDR-DIAEFSRRFGCEVWDGFG
Mvan_4341|M.vanbaalenii_PYR-1 KPLAYILAGPERPDDADNPLRVAFGNEASDR-DIAEFARRFGCQVWDGFG
Mb1779c|M.bovis_AF2122/97 KPLAYILATPERDDDADNPLRVAFGNEANDK-DIEEFSRRFGVQVEDGFG
Rv1750c|M.tuberculosis_H37Rv KPLAYILATPERDDDADNPLRVAFGNEANDK-DIEEFSRRFGVQVEDGFG
MMAR_2625|M.marinum_M KPLAYILATPERDDDDENPLRVAFGNEANEK-DIEEFSRRFAVQVEDGFG
MAV_5257|M.avium_104 KPLAYVLATPERADDADNPLRVAFGNEANDK-DIEEFGRRFGVQVEDGFG
MAB_2609|M.abscessus_ATCC_1997 KPLAYVLATAEHADDAANPLRVAFGNEASES-DIAEFARRFDVTVYDGFG
MUL_4069|M.ulcerans_Agy99 KPLSYVLATPERPDDADNPLRAVYGNEGVPG-DIERFGCRFGCVVQDGFG
MLBr_01051|M.leprae_Br4923 TVWSRLVADEAVARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYG
. : ::* . . *. . : :. : :*
MSMEG_4952|M.smegmatis_MC2_155 STETAVIITRPDD--CPPGSIGKGFPGVAIYDPQTVTECAVAEFDATGAL
TH_4470|M.thermoresistible__bu STEIAVIITRPDD--CPPGSVGKGFPGVAIYNPETLQECSVARFDANGAL
Mflv_2305|M.gilvum_PYR-GCK STENAVTITREDG--CPPGSIGKGFPGVAIYDPDTLTECAVAEFDAHGAL
Mvan_4341|M.vanbaalenii_PYR-1 STENAVTVTREDG--CPPGSIGKGFPGVAIYDAETLTECAVAEFDEHGAL
Mb1779c|M.bovis_AF2122/97 STENAVIVIREPG--TPPGSIGRGAHGVAVYNGETVTECAVARFDAHGAL
Rv1750c|M.tuberculosis_H37Rv STENAVIVIREPG--TPPGSIGRGAHGVAVYNGETVTECAVARFDAHGAL
MMAR_2625|M.marinum_M STENAVIVIREPG--TPPGSIGKGVDGVAVYNSDSVTECAVARFDEHGAL
MAV_5257|M.avium_104 STENAVIVIREPG--TPRGSIGRGIDGVAIYNSDTVTECPVARFDADGAL
MAB_2609|M.abscessus_ATCC_1997 STENAVIITREEG--TPTGSIGKGFPGIAVYNPDTLRECAVARFDAHGIL
MUL_4069|M.ulcerans_Agy99 STEGGVAIARTPD--TPAGSLGPLPENIEIVDPETGQQCPVG--------
MLBr_01051|M.leprae_Br4923 STESLITLSTLADGERRAGWVGLPLAGVQTRLVD----------ESGGPV
*** : : . * :* .: :
MSMEG_4952|M.smegmatis_MC2_155 ANPDAAIGELVNTAGGGLFRGYYNDQGATDQRMR-HGMYWSGDLAYRDAD
TH_4470|M.thermoresistible__bu INPDEAIGELVNTAGAGLFRGYYNDPQATDERMR-HGMYWSGDLAYRDAD
Mflv_2305|M.gilvum_PYR-GCK VNGDDAIGELVNTQGAGMFAGYYNDQDATDDRMR-HGMFWSGDLAYRDAD
Mvan_4341|M.vanbaalenii_PYR-1 ANADDAIGELVNTQGAGMFAGYYNDQGATDERMR-HGMFWSGDLAYRDAD
Mb1779c|M.bovis_AF2122/97 TNADEAIGELVNTTGSGFFTGYYNDPEANAERMR-HGMYWSGDLAYRDSE
Rv1750c|M.tuberculosis_H37Rv TNADEAIGELVNTTGSGFFTGYYNDPEANAERMR-HGMYWSGDLAYRDSE
MMAR_2625|M.marinum_M ANADEAVGELVNTMGSGFFTGYYNDPGANAERMR-HGMYWSGDLAYRDSQ
MAV_5257|M.avium_104 INADEAVGELVNTAGSGFFTGYYNDPDANAERMR-HGMYWSGDLAYRDAD
MAB_2609|M.abscessus_ATCC_1997 ANPADAVGELVNTQGAGFFSGYYNDDDATGERMR-HGMYWSGDLAYRDAD
MUL_4069|M.ulcerans_Agy99 -----AVGELVNTAGPGRFEGYYNDEAASAQRMS-GGVYHSGDLAYRDAA
MLBr_01051|M.leprae_Br4923 PYDGETVGRLQVRS-PTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSG
::*.* * ** * *. : : * : :**:* *:
MSMEG_4952|M.smegmatis_MC2_155 GWIYLAGR-TADWMRVDGENLTAAPIERILLRLDAVNRVAVYPVPDEYVG
TH_4470|M.thermoresistible__bu GWIYLAGR-TADWMRVDGENLTAAPIERILLRLPAINRAAVYPVPDELVG
Mflv_2305|M.gilvum_PYR-GCK GWIYLAGR-TADWMRVDGENMTAAPIERILIRLPAISMAAVYPVPDEFVG
Mvan_4341|M.vanbaalenii_PYR-1 GWIYLAGR-TADWMRVDGENMTSAPIERILIRLPAISMAAVYPVPDEFVG
Mb1779c|M.bovis_AF2122/97 GWIYLAGR-TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVG
Rv1750c|M.tuberculosis_H37Rv GWIYLAGR-TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVG
MMAR_2625|M.marinum_M GWIYLAGR-TADWMRVDGENLAAAPIERILLRDNSVNRVAVYAVPDARVG
MAV_5257|M.avium_104 GWIYLAGR-TADWMRVDGENLAAAPIERILLRHTAINRVAVYAVPDGHVG
MAB_2609|M.abscessus_ATCC_1997 GWIYLAGR-TPDWMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGG
MUL_4069|M.ulcerans_Agy99 GYAYFAGR-LGDWMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVG
MLBr_01051|M.leprae_Br4923 GMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLG
* :.** * :::.* .: :. ** * .** : * *
MSMEG_4952|M.smegmatis_MC2_155 DQVMAAIVLQDGATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTAT
TH_4470|M.thermoresistible__bu DQVMAAVVLQD--ELTPRQFADFLAAQTDLSPKAWPRYVWVADDLPVTAT
Mflv_2305|M.gilvum_PYR-GCK DQVMAAIVVQDEATLTPQEFGTFLSEQPDLSPKAWPRYVWIADELPSTAT
Mvan_4341|M.vanbaalenii_PYR-1 DQVMAALVLQDEATLTPDEFARFLAAQPDLSPKAWPRHVWIADALPSTAT
Mb1779c|M.bovis_AF2122/97 DQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTAT
Rv1750c|M.tuberculosis_H37Rv DQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTAT
MMAR_2625|M.marinum_M DQVMAAVVPHRDQRFTPESLEAFLRAQPDLSAKAWPRYVRIAADLPSTAT
MAV_5257|M.avium_104 DQVMAAVVLNDGETLTPAAFEVFLDAQPDLSPKARPRYVRIAADLPSTAT
MAB_2609|M.abscessus_ATCC_1997 DAVMAALVLRAP--LTYLGLAEFLSAQQDLPRIGWPRYIRLSENLPTTAT
MUL_4069|M.ulcerans_Agy99 DQVMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTET
MLBr_01051|M.leprae_Br4923 QRIVAFVVGAEA--LDADELINYVAQQLSIHKR--PREVRFVDALPRNAM
: ::* :* : : :: * .: * : . ** .
MSMEG_4952|M.smegmatis_MC2_155 NKILKRELVATGTDPA-GRVLWHRD--GTRFTDLSAASAPGAAPGISPA-
TH_4470|M.thermoresistible__bu NKVLKRELIARGTAPD-GRVLWRRD--GAQYHVYAESDE-----------
Mflv_2305|M.gilvum_PYR-GCK NKVLKRELVAMGTTPA-GRTLWTRD--GSGYRTVAEE-------------
Mvan_4341|M.vanbaalenii_PYR-1 NKVLKRELVAMGVEPA-GRTLWRRD--GGTYRTVSAQE------------
Mb1779c|M.bovis_AF2122/97 HKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI---------
Rv1750c|M.tuberculosis_H37Rv HKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI---------
MMAR_2625|M.marinum_M HKVLKRQLVAEGTAIGPDEALWVREQRGTRYRIASDESR-----------
MAV_5257|M.avium_104 HKVLKRQLISQGTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPST
MAB_2609|M.abscessus_ATCC_1997 NKILKRVLISEGLDIA-DETLWYRAERGAEYIDFDPVGHSPHLIAPRLRS
MUL_4069|M.ulcerans_Agy99 FKVLKRQLAADGVDCG--DPVWPIRDQS----------------------
MLBr_01051|M.leprae_Br4923 GKVLKKQLLFEG--------------------------------------
*:**: * *
MSMEG_4952|M.smegmatis_MC2_155 ------------
TH_4470|M.thermoresistible__bu ------------
Mflv_2305|M.gilvum_PYR-GCK ------------
Mvan_4341|M.vanbaalenii_PYR-1 ------------
Mb1779c|M.bovis_AF2122/97 ------------
Rv1750c|M.tuberculosis_H37Rv ------------
MMAR_2625|M.marinum_M ------------
MAV_5257|M.avium_104 VAPV--------
MAB_2609|M.abscessus_ATCC_1997 IGAAAPPSEPTR
MUL_4069|M.ulcerans_Agy99 ------------
MLBr_01051|M.leprae_Br4923 ------------