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TAVSVPRAGVPRVDIAAMLLDRVGDSHLGLRTRDRDWTWDQVVDESAARGALARKLRADGPFHIGVLLDN VPDFVFWLGGAALAGATIVGINPTRGPAEMAAEIRHTDCQLIVTDTAHLGRLQSLELGLSADRLLVIDSP EYLQRIAESRCTAQASEGVGADSLLLLLFTSGTTGASKAVKCSQGRLAQIAHLATEKFGHVRSDVDYCCM PLFHGNALMALWAPALANGATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLLATPERADDADNQLA RGFGTEASPEDQAQFRRRFGAELFEGYGSSEGGGAVVLDPAAPPGALGRPAHEGVVVVDPETLQDCAAAV FDQHGRVLNADAAVGEIVDKQGRRGFEGYYNNDDADADRIRNGWYWTGDLGYLDAAGFIYFAGRRGDWIR VDGENMSALTVERVLRRHPLVIAAGVYAVPDPRSGDQVMASIEVAEPDSFDVDGFTQYLSAQEELGSKGI PRFLRISANLPVTGSNKVLKRELQEQRWHTDEPVFRWVGRGGPVFLRMSSDDKTALDAQFAVYGRQRLL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3628c | - | - | 100% (560) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4160 | - | e-106 | 41.21% (512) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2609 | - | e-104 | 42.12% (501) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1779c | fadD1 | 1e-119 | 43.88% (515) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1548 | - | 0.0 | 72.53% (546) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1750c | fadD1 | 1e-119 | 43.88% (515) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 4e-23 | 25.00% (504) | acyl-CoA synthetase |
| M. marinum M | MMAR_2625 | fadD1 | 1e-111 | 40.94% (530) | fatty-acid-CoA ligase FadD1 |
| M. avium 104 | MAV_5257 | - | 1e-112 | 42.15% (503) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4952 | - | 1e-108 | 42.05% (497) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4470 | - | 1e-103 | 40.34% (528) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 1e-107 | 42.64% (516) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5209 | - | 0.0 | 72.84% (545) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1548|M.gilvum_PYR-GCK -------MTDLRRTDVATMLLDRAGDQHLGVLTRERDWTWDQVVRESAAR
Mvan_5209|M.vanbaalenii_PYR-1 --------MTARRDDVAAMLLDRTGDRRPGLRTRERDWTWDEVVHESAVR
MAB_3628c|M.abscessus_ATCC_199 MTAVSVPRAGVPRVDIAAMLLDRVGDSHLGLRTRDRDWTWDQVVDESAAR
Mb1779c|M.bovis_AF2122/97 -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
Rv1750c|M.tuberculosis_H37Rv -----------MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAAR
MMAR_2625|M.marinum_M -----------MTETIQALLQQRMSDSSIAVKYHDLQWTWREYLAEAAAR
MAV_5257|M.avium_104 ----------MAEDTIQALLRKRWSDPGVAVKYGDTQWSWAQYLRDAAAR
MSMEG_4952|M.smegmatis_MC2_155 -----------MADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQ
TH_4470|M.thermoresistible__bu -----------MADTLQQLLRERAAQDTIAIKYDDRRITWREHVADAARQ
MUL_4069|M.ulcerans_Agy99 ---------MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAI
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
: * . . .
Mflv_1548|M.gilvum_PYR-GCK ASLATRLLDGV------PGPFHVGILLAN---------VPDFVFWLGGAA
Mvan_5209|M.vanbaalenii_PYR-1 ASIASTLSD--------LDPPHIGVLLDN---------VPDFVFWLGGAA
MAB_3628c|M.abscessus_ATCC_199 GALARKLRAD--------GPFHIGVLLDN---------VPDFVFWLGGAA
Mb1779c|M.bovis_AF2122/97 AAALITIADP-------QRPTHIGSLLGN---------TPEMLAQLAAAG
Rv1750c|M.tuberculosis_H37Rv AAALITIADP-------QRPTHIGSLLGN---------TPEMLAQLAAAG
MMAR_2625|M.marinum_M AAGLIAAADP-------DRPLHIGSLLGN---------TPEMLAQMAAAG
MAV_5257|M.avium_104 AAALLGAADP-------GRPMHVGTLLGN---------TPEMLSQMAAAG
MSMEG_4952|M.smegmatis_MC2_155 ARFLISRADH-------GRPLHVGVLLGN---------TPQMLTALAAAA
TH_4470|M.thermoresistible__bu AAALLAAADP-------NRPPHIAVLLGN---------TPDMLTALAGAA
MUL_4069|M.ulcerans_Agy99 AAALRERLDP-------TRPPHVGVLLRN---------TPFFSAMLTAAG
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
:. ** . : : .*.
Mflv_1548|M.gilvum_PYR-GCK LAGATVVGLNPTRGTADLAADIRHADCRLIVTDSVGAQ--------RLRG
Mvan_5209|M.vanbaalenii_PYR-1 LAGATIVGLNPTRGAADLAADIRHADCRLIVTDAAGAD--------RLRG
MAB_3628c|M.abscessus_ATCC_199 LAGATIVGINPTRGPAEMAAEIRHTDCQLIVTDTAHLG--------RLQS
Mb1779c|M.bovis_AF2122/97 LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRA--------LLDG
Rv1750c|M.tuberculosis_H37Rv LGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRA--------LLDG
MMAR_2625|M.marinum_M LGGYVLCGLNTTRRGEALAADIRRAECQIIVTDAENRS--------LLDG
MAV_5257|M.avium_104 LGGYVLCGLNTTRRGKALAADVRRADCQFVVTDAEHRP--------LLDG
MSMEG_4952|M.smegmatis_MC2_155 LGGYVLCGINTTRRGEGLARDIARVDCQLLITDAEHRG--------LIDG
TH_4470|M.thermoresistible__bu LGGYVLCGINTTRRGAALARDVERVDAQILITDAEHRH--------LLDG
MUL_4069|M.ulcerans_Agy99 MSGIIPVGLNPVRRGAALARDIEHADCQMVLADTASAS--------TLDG
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
.* ::.. . . :. :.*: :
Mflv_1548|M.gilvum_PYR-GCK IGHGVPDDRVLVVDDPEYRRALEACATEPAVAAGVG--ASSLFLLLFTSG
Mvan_5209|M.vanbaalenii_PYR-1 LDHGVPPDHLLRVDSPDHAQLLDAHRVEPVAAPGVG--AKSLFLLLFTSG
MAB_3628c|M.abscessus_ATCC_199 LELGLSADRLLVIDSPEYLQRIAESRCTAQASEGVG--ADSLLLLLFTSG
Mb1779c|M.bovis_AF2122/97 LDLAGA--RILDTSTPRWAELVAGDG-AFVPYREVD--TMDPFMMIFTSG
Rv1750c|M.tuberculosis_H37Rv LDLAGA--RILDTSTPRWAELVAGDG-AFVPYREVD--TMDPFMMIFTSG
MMAR_2625|M.marinum_M LDLADV--EIFDTSTPRWAELVGGAG-SLVPHRKVE--MMDPFMMIFTSG
MAV_5257|M.avium_104 LDLAGT--QILDTSTPDWAGFVDAAG-ELTPHREVA--AMDPFMMIFTSG
MSMEG_4952|M.smegmatis_MC2_155 LELPGV--TVLDAS-----DICPEAG-ELTPYREAG--PDDTFMMIFTSG
TH_4470|M.thermoresistible__bu LELPGV--TVFDTSTTEWARLLAAAP-ELTPHREVT--PDDTFMMIFTSG
MUL_4069|M.ulcerans_Agy99 IEH-------VNVDSAEWAEVIDAHRNSEISFQNAA--PADLFMLIYTSG
MLBr_02661|M.leprae_Br4923 WPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGLRHDDAMIMFTGG
. . ::::*.*
Mflv_1548|M.gilvum_PYR-GCK TTGASKAVKCSQGRLARIAYVATEKFGHHRGDVDYCCMPLFHGNALMALW
Mvan_5209|M.vanbaalenii_PYR-1 TTGTSKAVRCSQGRLARIAYAATDKFGHHRDDVDYCCMPLFHGNAIMALW
MAB_3628c|M.abscessus_ATCC_199 TTGASKAVKCSQGRLAQIAHLATEKFGHVRSDVDYCCMPLFHGNALMALW
Mb1779c|M.bovis_AF2122/97 TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
Rv1750c|M.tuberculosis_H37Rv TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGW
MMAR_2625|M.marinum_M TSGNPKAVQVSHLMPTFAGRSLTERFGLSAHDTCYVSMPLFHSNAVVAGW
MAV_5257|M.avium_104 TSGNPKAVQVSHLMAVFAGSNLVQRFGLTEHDTCYVSMPLFHSNAVVAGW
MSMEG_4952|M.smegmatis_MC2_155 TSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLAMPLFHSNAVYAGW
TH_4470|M.thermoresistible__bu TSGEPKAVQVPHSTVLFSGTALVDRYQLGSADTCYLAMPLFHSNAVYAGW
MUL_4069|M.ulcerans_Agy99 TSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDDVCYVSMPLFHSNAVLVGW
MLBr_02661|M.leprae_Br4923 TTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVVVMPLYHGHGLIAAL
*:* .* * . : *. ***:*.:.: .
Mflv_1548|M.gilvum_PYR-GCK APALANG--ATVCLTPSFSASRFLSDIRYFGATFFTYVGKALAYLMATPE
Mvan_5209|M.vanbaalenii_PYR-1 APALANG--ATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLMATPE
MAB_3628c|M.abscessus_ATCC_199 APALANG--ATVCLTPTFSASRFLPDVRYFGATFFTYVGKALGYLLATPE
Mb1779c|M.bovis_AF2122/97 APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
Rv1750c|M.tuberculosis_H37Rv APAVVSG--AAIAP-ATFSATGFLDDVRRYHATYMNYVGKPLAYILATPE
MMAR_2625|M.marinum_M APAVVSG--AAIAP-AKFSATGFLDDIRRYQATYMNYVGKPLAYILATPE
MAV_5257|M.avium_104 APAVCSG--AAIVP-AKFSARNFLDDIRRYGATYMNYVGKPLAYVLATPE
MSMEG_4952|M.smegmatis_MC2_155 SVAVGAG--AAMAP-ATFSASGFLPDIRRYGATYMNYVGKPLAYILATPE
TH_4470|M.thermoresistible__bu SVAVGAG--AAMAP-ATFSASRFLHDIRRYGATYMNYVGKPLAYILATPE
MUL_4069|M.ulcerans_Agy99 AVAVACQ--GSMALRRKFSASQFLSDVRRYGATYANYVGKPLSYVLATPE
MLBr_02661|M.leprae_Br4923 LSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRILLELAS
:: : *** * *: **: . . :: ..
Mflv_1548|M.gilvum_PYR-GCK ----QADDSDNTLTRGFGTEASPEDQAEFRRRFGAELHEGYGSSEGGAVA
Mvan_5209|M.vanbaalenii_PYR-1 ----APDDADNTLQRGFGTEASPEDQKEFRRRFAAELFEGYGSSEGGAVA
MAB_3628c|M.abscessus_ATCC_199 ----RADDADNQLARGFGTEASPEDQAQFRRRFGAELFEGYGSSEGGGAV
Mb1779c|M.bovis_AF2122/97 ----RDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIV
Rv1750c|M.tuberculosis_H37Rv ----RDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIV
MMAR_2625|M.marinum_M ----RDDDDENPLRVAFGNEANEKDIEEFSRRFAVQVEDGFGSTENAVIV
MAV_5257|M.avium_104 ----RADDADNPLRVAFGNEANDKDIEEFGRRFGVQVEDGFGSTENAVIV
MSMEG_4952|M.smegmatis_MC2_155 ----KPDDHDNPLRIAFGNEAADRDIAAFSRRFGCTVWDGFGSTETAVII
TH_4470|M.thermoresistible__bu ----KPDDHDNPLRIAFGNEATDRDIEAFSRRFGCTVWDGFGSTEIAVII
MUL_4069|M.ulcerans_Agy99 ----RPDDADNPLRAVYGNEGVPGDIERFGCRFGCVVQDGFGSTEGGVAI
MLBr_02661|M.leprae_Br4923 TQSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQV
. . : . : .* : .:* :*
Mflv_1548|M.gilvum_PYR-GCK TPDPAAPATALGRPAHEDVVVVDPATLKPCAPAVLDPRGRVTNADDAIGE
Mvan_5209|M.vanbaalenii_PYR-1 TPDPAAPPAALGRPAHDDVVVVHPETLCLCPTAVLDASGRVLNPDEAVGE
MAB_3628c|M.abscessus_ATCC_199 VLDPAAPPGALGRPAHEGVVVVDPETLQDCAAAVFDQHGRVLNADAAVGE
Mb1779c|M.bovis_AF2122/97 IREPGTPPGSIG-RGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGE
Rv1750c|M.tuberculosis_H37Rv IREPGTPPGSIG-RGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGE
MMAR_2625|M.marinum_M IREPGTPPGSIG-KGVDGVAVYNSDSVTECAVARFDEHGALANADEAVGE
MAV_5257|M.avium_104 IREPGTPRGSIG-RGIDGVAIYNSDTVTECPVARFDADGALINADEAVGE
MSMEG_4952|M.smegmatis_MC2_155 TRPDDCPPGSIG-KGFPGVAIYDPQTVTECAVAEFDATGALANPDAAIGE
TH_4470|M.thermoresistible__bu TRPDDCPPGSVG-KGFPGVAIYNPETLQECSVARFDANGALINPDEAIGE
MUL_4069|M.ulcerans_Agy99 ARTPDTPAGSLG-PLPENIEIVDPETGQQCPVG-------------AVGE
MLBr_02661|M.leprae_Br4923 TTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVG----SDGQPLPPDTVGE
. : . . ::**
Mflv_1548|M.gilvum_PYR-GCK IVDRRGARDFEGYYRNDAADADRVRNGWYWSGDLGYVDRDGFLYFAGRRG
Mvan_5209|M.vanbaalenii_PYR-1 IVDRRGAADFEGYYRNDAADAERVRNGWYWSGDLGYLDGAGFLYFAGRRG
MAB_3628c|M.abscessus_ATCC_199 IVDKQGRRGFEGYYNNDDADADRIRNGWYWTGDLGYLDAAGFIYFAGRRG
Mb1779c|M.bovis_AF2122/97 LVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTA
Rv1750c|M.tuberculosis_H37Rv LVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTA
MMAR_2625|M.marinum_M LVNTMGSGFFTGYYNDPGANAERMRHGMYWSGDLAYRDSQGWIYLAGRTA
MAV_5257|M.avium_104 LVNTAGSGFFTGYYNDPDANAERMRHGMYWSGDLAYRDADGWIYLAGRTA
MSMEG_4952|M.smegmatis_MC2_155 LVNTAGGGLFRGYYNDQGATDQRMRHGMYWSGDLAYRDADGWIYLAGRTA
TH_4470|M.thermoresistible__bu LVNTAGAGLFRGYYNDPQATDERMRHGMYWSGDLAYRDADGWIYLAGRTA
MUL_4069|M.ulcerans_Agy99 LVNTAGPGRFEGYYNDEAASAQRMSGGVYHSGDLAYRDAAGYAYFAGRLG
MLBr_02661|M.leprae_Br4923 VWLR-GSTVVRGYLGDPAITAANFTHGWLRTGDLGSLSVTGDLRIRGRIK
: * . ** : .. * :***. . * : **
Mflv_1548|M.gilvum_PYR-GCK DWIRVDGENTSALTIERVLRRHPEVIAAAVYGVPDPRSGDQVMAAVEVAE
Mvan_5209|M.vanbaalenii_PYR-1 DWLRVDGENISTLTIERVLRRHAGVIAAAVYGVPDPRSGDQMMAAVEVAD
MAB_3628c|M.abscessus_ATCC_199 DWIRVDGENMSALTVERVLRRHPLVIAAGVYAVPDPRSGDQVMASIEVAE
Mb1779c|M.bovis_AF2122/97 DWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRA
Rv1750c|M.tuberculosis_H37Rv DWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRA
MMAR_2625|M.marinum_M DWMRVDGENLAAAPIERILLRDNSVNRVAVYAVPDARVGDQVMAAVVPHR
MAV_5257|M.avium_104 DWMRVDGENLAAAPIERILLRHTAINRVAVYAVPDGHVGDQVMAAVVLND
MSMEG_4952|M.smegmatis_MC2_155 DWMRVDGENLTAAPIERILLRLDAVNRVAVYPVPDEYVGDQVMAAIVLQD
TH_4470|M.thermoresistible__bu DWMRVDGENLTAAPIERILLRLPAINRAAVYPVPDELVGDQVMAAVVLQD
MUL_4069|M.ulcerans_Agy99 DWMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVGDQVMAAMVLTP
MLBr_02661|M.leprae_Br4923 ELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVIVPRE
: :. .**: . :* :* ..*: ** *: : * :
Mflv_1548|M.gilvum_PYR-GCK PGSFDINAFVDFLVGQDDLGAKGFPRLLRVSARLPATGSNKVLKRELQTQ
Mvan_5209|M.vanbaalenii_PYR-1 PGSFDVDAFASFLVAQDDLGRKGFPRLLRISAKLPATGSNKVLKRDLQAQ
MAB_3628c|M.abscessus_ATCC_199 PDSFDVDGFTQYLSAQEELGSKGIPRFLRISANLPVTGSNKVLKRELQEQ
Mb1779c|M.bovis_AF2122/97 GDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDE
Rv1750c|M.tuberculosis_H37Rv GDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHKVLKRQLIDE
MMAR_2625|M.marinum_M DQRFTPESLEAFLRAQPDLSAKAWPRYVRIAADLPSTATHKVLKRQLVAE
MAV_5257|M.avium_104 GETLTPAAFEVFLDAQPDLSPKARPRYVRIAADLPSTATHKVLKRQLISQ
MSMEG_4952|M.smegmatis_MC2_155 GATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTATNKILKRELVAT
TH_4470|M.thermoresistible__bu --ELTPRQFADFLAAQTDLSPKAWPRYVWVADDLPVTATNKVLKRELIAR
MUL_4069|M.ulcerans_Agy99 GAKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTETFKVLKRQLAAD
MLBr_02661|M.leprae_Br4923 VIAPTPSELAVFCRDR--LAAFEVPTRFQEASALPHTAKGSLDRRAVAEQ
: : : *. * . . ** * . .: :* :
Mflv_1548|M.gilvum_PYR-GCK RWHTDEAVYRWSGRGRPRYRLMTADDRAALDEEFVTHGRAHHGTT
Mvan_5209|M.vanbaalenii_PYR-1 RWHTDDAVHRWVGRGHPRYRLMTDADRGALDAEFTVHGREHHVAE
MAB_3628c|M.abscessus_ATCC_199 RWHTDEPVFRWVGRGGPVFLRMSSDDKTALDAQFAVYGRQRLL--
Mb1779c|M.bovis_AF2122/97 GTAVGKADTLWVREPRGSAYHHASGPAKAI---------------
Rv1750c|M.tuberculosis_H37Rv GTAVGKADTLWVREPRGSAYHHASGPAKAI---------------
MMAR_2625|M.marinum_M GTAIGPDEALWVREQRGTRYRIASDESR-----------------
MAV_5257|M.avium_104 GTAVAAGEVLWEREPRGTAYTVVASPDCGVPGDGSAPSTVAPV--
MSMEG_4952|M.smegmatis_MC2_155 GTDPA-GRVLWHRD--GTRFTDLSAASAPGAAPGISPA-------
TH_4470|M.thermoresistible__bu GTAPD-GRVLWRRD--GAQYHVYAESDE-----------------
MUL_4069|M.ulcerans_Agy99 GVDCG--DPVWPIRDQS----------------------------
MLBr_02661|M.leprae_Br4923 FAHRG----------------------------------------