For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AETVQQLLRERLDSDGIALKYEGSTWTWREHLGEAAMQAAALIGAADPERPLHVGVLLGNNPDMLTAMAA AGLGGYVLCGINNTRRGDALARDIRRADCQFLITDDAHRHLLDGLDLSGVRVLVVGTPEWKELTGRAGTL TPHREVTATDTYMLIFTSGTSGDPKAVKMMHAMVLLAGAALMGRYELTSDDVCYLSMPLFHSNAVLAGWS VAVNSGAAMAPAQFSASRFVDDIRRYGATYMNYVGKPLAYILAGPERPDDADNPLRVAFGNEASDRDIAE FARRFGCQVWDGFGSTENAVTVTREDGCPPGSIGKGFPGVAIYDAETLTECAVAEFDEHGALANADDAIG ELVNTQGAGMFAGYYNDQGATDERMRHGMFWSGDLAYRDADGWIYLAGRTADWMRVDGENMTSAPIERIL IRLPAISMAAVYPVPDEFVGDQVMAALVLQDEATLTPDEFARFLAAQPDLSPKAWPRHVWIADALPSTAT NKVLKRELVAMGVEPAGRTLWRRDGGTYRTVSAQE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4341 | - | - | 100% (526) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5208 | - | e-136 | 51.08% (509) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5209 | - | e-106 | 41.17% (532) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1779c | fadD1 | 0.0 | 66.35% (526) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2305 | - | 0.0 | 87.05% (525) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1750c | fadD1 | 0.0 | 66.35% (526) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 2e-24 | 28.18% (362) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2609 | - | 0.0 | 65.76% (514) | acyl-CoA synthetase |
| M. marinum M | MMAR_2625 | fadD1 | 0.0 | 65.78% (526) | fatty-acid-CoA ligase FadD1 |
| M. avium 104 | MAV_3000 | - | 0.0 | 69.46% (514) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4952 | - | 0.0 | 74.24% (524) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4470 | - | 0.0 | 73.38% (526) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4069 | fadD17 | 1e-137 | 51.08% (511) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1779c|M.bovis_AF2122/97 --MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIAD
Rv1750c|M.tuberculosis_H37Rv --MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIAD
MMAR_2625|M.marinum_M --MTETIQALLQQRMSDSSIAVKYHDLQWTWREYLAEAAARAAGLIAAAD
Mvan_4341|M.vanbaalenii_PYR-1 --MAETVQQLLRERLDSDGIALKYEGSTWTWREHLGEAAMQAAALIGAAD
Mflv_2305|M.gilvum_PYR-GCK --MAETVQQLLRERVTDDGIAMKHEDRTWTWREHLGEAAAQASALIGLAD
MSMEG_4952|M.smegmatis_MC2_155 --MADTLQQLLRSRAEQDTVAVKYGDRTWTWREHIAEAAAQARFLISRAD
TH_4470|M.thermoresistible__bu --MADTLQQLLRERAAQDTIAIKYDDRRITWREHVADAARQAAALLAAAD
MAV_3000|M.avium_104 --MIETVQQLLRQRRHDDTPAVAYGDKTWTWREHLAEAEAEASALIARAD
MAB_2609|M.abscessus_ATCC_1997 --MAETIQQLVLARATDDSIGLIYRGQTWTWRAHLAAAARHAAALIGIAD
MUL_4069|M.ulcerans_Agy99 MSADPTVPQLLVPLAEIGDRGIYFEDSFTSWADHIGHGAAIAAALRERLD
MLBr_01051|M.leprae_Br4923 --------MLLASLNPSVVTATDIAD-----AVCVDGVVLSRSGLVGAAT
*: . . : *
Mb1779c|M.bovis_AF2122/97 PQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRA
Rv1750c|M.tuberculosis_H37Rv PQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRA
MMAR_2625|M.marinum_M PDRPLHIGSLLGNTPEMLAQMAAAGLGGYVLCGLNTTRRGEALAADIRRA
Mvan_4341|M.vanbaalenii_PYR-1 PERPLHVGVLLGNNPDMLTAMAAAGLGGYVLCGINNTRRGDALARDIRRA
Mflv_2305|M.gilvum_PYR-GCK PSRPLHVGVLLGNTPDMLTAMAAAGLGGYVLCGINTTRRGSALGRDVLRG
MSMEG_4952|M.smegmatis_MC2_155 HGRPLHVGVLLGNTPQMLTALAAAALGGYVLCGINTTRRGEGLARDIARV
TH_4470|M.thermoresistible__bu PNRPPHIAVLLGNTPDMLTALAGAALGGYVLCGINTTRRGAALARDVERV
MAV_3000|M.avium_104 PARPLHVGAALGNSPAMLRAMAAAGLGGYVLCGLNTTRRGSALLSDIHRS
MAB_2609|M.abscessus_ATCC_1997 PTRPLHVGTLLGNTPAMTTAMAAAAQGGYILCAINNTRRGEGLLRDIRKS
MUL_4069|M.ulcerans_Agy99 PTRPPHVGVLLRNTPFFSAMLTAAGMSGIIPVGLNPVRRGAALARDIEHA
MLBr_01051|M.leprae_Br4923 SVAERVGGARLVAVLATPTASTVLAITGCLIAGVPVVP----VPADIGVV
. * : . * : .: . : *:
Mb1779c|M.bovis_AF2122/97 DCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDG-AFVPYREV
Rv1750c|M.tuberculosis_H37Rv DCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDG-AFVPYREV
MMAR_2625|M.marinum_M ECQIIVTDAENRSLLDGLDLADVEIFDTSTPRWAELVGGAG-SLVPHRKV
Mvan_4341|M.vanbaalenii_PYR-1 DCQFLITDDAHRHLLDGLDLSGVRVLVVGTPEWKELTGRAG-TLTPHREV
Mflv_2305|M.gilvum_PYR-GCK DCQILITDDAHRGLLDGVDLPGVRVLVVGTPEWSELIGRAG-ELTPHREV
MSMEG_4952|M.smegmatis_MC2_155 DCQLLITDAEHRGLIDGLELPGVTVLDAS-----DICPEAG-ELTPYREA
TH_4470|M.thermoresistible__bu DAQILITDAEHRHLLDGLELPGVTVFDTSTTEWARLLAAAP-ELTPHREV
MAV_3000|M.avium_104 DCQILLVDDEHLPLLDGLDFNGIQVLEVGSPAYADAVAAAP-PLIPHREV
MAB_2609|M.abscessus_ATCC_1997 DVQVLLVDAEHRPLLDAVDLPDVTVIDVDSAEWIERMKTPG-ELHPYRTA
MUL_4069|M.ulcerans_Agy99 DCQMVLADTASASTLDGIEH-----VNVDSAEWAEVIDAHRNSEISFQNA
MLBr_01051|M.leprae_Br4923 ERRHMLTDSGAQAWLG--PGPSADSAPDGLPHIPVQLDARS--WNRYPEP
: : ::.* :. . .
Mb1779c|M.bovis_AF2122/97 DTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVS
Rv1750c|M.tuberculosis_H37Rv DTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVS
MMAR_2625|M.marinum_M EMMDPFMMIFTSGTSGNPKAVQVSHLMPTFAGRSLTERFGLSAHDTCYVS
Mvan_4341|M.vanbaalenii_PYR-1 TATDTYMLIFTSGTSGDPKAVKMMHAMVLLAGAALMGRYELTSDDVCYLS
Mflv_2305|M.gilvum_PYR-GCK TVTDTYMLIFTSGTSGDPKAVKMMHAMVLLAGAALAGRYELTPRDVCYLS
MSMEG_4952|M.smegmatis_MC2_155 GPDDTFMMIFTSGTSGDPKAVEVPHAMVLFAGSALVERYGLTCEDVCYLA
TH_4470|M.thermoresistible__bu TPDDTFMMIFTSGTSGEPKAVQVPHSTVLFSGTALVDRYQLGSADTCYLA
MAV_3000|M.avium_104 TAADPFMMIFTSGTSGNPKAVRFAHGMAIMCGASLIFQYDVTADDVCYLA
MAB_2609|M.abscessus_ATCC_1997 APLDPFMMIFTSGTSGDPKAVLVTHATVLVAAESLVERFSLSAADVCYVS
MUL_4069|M.ulcerans_Agy99 APADLFMLIYTSGTSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDDVCYVS
MLBr_01051|M.leprae_Br4923 SPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHG
*:*:****:* **.* : . :: : *. .
Mb1779c|M.bovis_AF2122/97 MPLFHSNAVVAGWAPAVVSGAAIAP-ATFSATGFLDDVRRYHATYMNYVG
Rv1750c|M.tuberculosis_H37Rv MPLFHSNAVVAGWAPAVVSGAAIAP-ATFSATGFLDDVRRYHATYMNYVG
MMAR_2625|M.marinum_M MPLFHSNAVVAGWAPAVVSGAAIAP-AKFSATGFLDDIRRYQATYMNYVG
Mvan_4341|M.vanbaalenii_PYR-1 MPLFHSNAVLAGWSVAVNSGAAMAP-AQFSASRFVDDIRRYGATYMNYVG
Mflv_2305|M.gilvum_PYR-GCK MPLFHSNAVLAGWSVALNAGAAMAP-AHFSASGFLGDIRRYGATYMNYVG
MSMEG_4952|M.smegmatis_MC2_155 MPLFHSNAVYAGWSVAVGAGAAMAP-ATFSASGFLPDIRRYGATYMNYVG
TH_4470|M.thermoresistible__bu MPLFHSNAVYAGWSVAVGAGAAMAP-ATFSASRFLHDIRRYGATYMNYVG
MAV_3000|M.avium_104 MPLFHSNGVAAGWAVAVGSGALMVP-AKFSPSRFLDDVRRYRVTYLNYVG
MAB_2609|M.abscessus_ATCC_1997 MPLFHSNAVLAGWAVAVAAGAALAP-AKFSASRFLADIREVGATYMNYVG
MUL_4069|M.ulcerans_Agy99 MPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGATYANYVG
MLBr_01051|M.leprae_Br4923 LPLFHVHGLVLGLLGSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVP
:**** :.: * :: :. :.: : . : *
Mb1779c|M.bovis_AF2122/97 KPLAYILATPERDDDADNPLRVAFGNEANDK-DIEEFSRRFGVQVEDGFG
Rv1750c|M.tuberculosis_H37Rv KPLAYILATPERDDDADNPLRVAFGNEANDK-DIEEFSRRFGVQVEDGFG
MMAR_2625|M.marinum_M KPLAYILATPERDDDDENPLRVAFGNEANEK-DIEEFSRRFAVQVEDGFG
Mvan_4341|M.vanbaalenii_PYR-1 KPLAYILAGPERPDDADNPLRVAFGNEASDR-DIAEFARRFGCQVWDGFG
Mflv_2305|M.gilvum_PYR-GCK KPLAYILASPEKPDDIDNPLRVAFGNEAGDR-DIAEFSRRFGCEVWDGFG
MSMEG_4952|M.smegmatis_MC2_155 KPLAYILATPEKPDDHDNPLRIAFGNEAADR-DIAAFSRRFGCTVWDGFG
TH_4470|M.thermoresistible__bu KPLAYILATPEKPDDHDNPLRIAFGNEATDR-DIEAFSRRFGCTVWDGFG
MAV_3000|M.avium_104 KPLALILSTPERPDDADNTLRVAFGNEATDR-DIAEFARRFGCRVVDSFG
MAB_2609|M.abscessus_ATCC_1997 KPLAYVLATAEHADDAANPLRVAFGNEASES-DIAEFARRFDVTVYDGFG
MUL_4069|M.ulcerans_Agy99 KPLSYVLATPERPDDADNPLRAVYGNEGVPG-DIERFGCRFGCVVQDGFG
MLBr_01051|M.leprae_Br4923 TVWSRLVADEAVARALRPARLLVSGSASLPVPVFDRLAHLTGHRPIERYG
. : ::: . . *. . : :. : :*
Mb1779c|M.bovis_AF2122/97 STENAVIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTN
Rv1750c|M.tuberculosis_H37Rv STENAVIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTN
MMAR_2625|M.marinum_M STENAVIVIREPGTPPGSIGKGVDGVAVYNSDSVTECAVARFDEHGALAN
Mvan_4341|M.vanbaalenii_PYR-1 STENAVTVTREDGCPPGSIGKGFPGVAIYDAETLTECAVAEFDEHGALAN
Mflv_2305|M.gilvum_PYR-GCK STENAVTITREDGCPPGSIGKGFPGVAIYDPDTLTECAVAEFDAHGALVN
MSMEG_4952|M.smegmatis_MC2_155 STETAVIITRPDDCPPGSIGKGFPGVAIYDPQTVTECAVAEFDATGALAN
TH_4470|M.thermoresistible__bu STEIAVIITRPDDCPPGSVGKGFPGVAIYNPETLQECSVARFDANGALIN
MAV_3000|M.avium_104 SSEFAVIVVREDGTPPGSIGRPYPGVSIYNPTTLKECAVAQFDEHGALTN
MAB_2609|M.abscessus_ATCC_1997 STENAVIITREEGTPTGSIGKGFPGIAVYNPDTLRECAVARFDAHGILAN
MUL_4069|M.ulcerans_Agy99 STEGGVAIARTPDTPAGSLGPLPENIEIVDPETGQQCPVG----------
MLBr_01051|M.leprae_Br4923 STESLITLS---TLADGERRAGWVGLPLAG------VQTRLVDESGGPVP
*:* : : . *. .: : . .
Mb1779c|M.bovis_AF2122/97 ADEAIGELVNTTGSGFFTGYYNDPEANAERMR-HGMYWSGDLAYRDSEGW
Rv1750c|M.tuberculosis_H37Rv ADEAIGELVNTTGSGFFTGYYNDPEANAERMR-HGMYWSGDLAYRDSEGW
MMAR_2625|M.marinum_M ADEAVGELVNTMGSGFFTGYYNDPGANAERMR-HGMYWSGDLAYRDSQGW
Mvan_4341|M.vanbaalenii_PYR-1 ADDAIGELVNTQGAGMFAGYYNDQGATDERMR-HGMFWSGDLAYRDADGW
Mflv_2305|M.gilvum_PYR-GCK GDDAIGELVNTQGAGMFAGYYNDQDATDDRMR-HGMFWSGDLAYRDADGW
MSMEG_4952|M.smegmatis_MC2_155 PDAAIGELVNTAGGGLFRGYYNDQGATDQRMR-HGMYWSGDLAYRDADGW
TH_4470|M.thermoresistible__bu PDEAIGELVNTAGAGLFRGYYNDPQATDERMR-HGMYWSGDLAYRDADGW
MAV_3000|M.avium_104 FEEAVGELVNTQGAGPFVGYYNDPEATAERMR-HGMYWSGDLAYRDADGW
MAB_2609|M.abscessus_ATCC_1997 PADAVGELVNTQGAGFFSGYYNDDDATGERMR-HGMYWSGDLAYRDADGW
MUL_4069|M.ulcerans_Agy99 ---AVGELVNTAGPGRFEGYYNDEAASAQRMS-GGVYHSGDLAYRDAAGY
MLBr_01051|M.leprae_Br4923 YDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGM
::. . * ** * *. : : * : :**:* *: *
Mb1779c|M.bovis_AF2122/97 IYLAGR-TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQ
Rv1750c|M.tuberculosis_H37Rv IYLAGR-TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQ
MMAR_2625|M.marinum_M IYLAGR-TADWMRVDGENLAAAPIERILLRDNSVNRVAVYAVPDARVGDQ
Mvan_4341|M.vanbaalenii_PYR-1 IYLAGR-TADWMRVDGENMTSAPIERILIRLPAISMAAVYPVPDEFVGDQ
Mflv_2305|M.gilvum_PYR-GCK IYLAGR-TADWMRVDGENMTAAPIERILIRLPAISMAAVYPVPDEFVGDQ
MSMEG_4952|M.smegmatis_MC2_155 IYLAGR-TADWMRVDGENLTAAPIERILLRLDAVNRVAVYPVPDEYVGDQ
TH_4470|M.thermoresistible__bu IYLAGR-TADWMRVDGENLTAAPIERILLRLPAINRAAVYPVPDELVGDQ
MAV_3000|M.avium_104 IYLAGR-TADWMRVDGENLAAAPIERILARLPDISQVAVYAVPDERVGDQ
MAB_2609|M.abscessus_ATCC_1997 IYLAGR-TPDWMRINGENLAAAPIERVLQRHPAISQAAVYAVRDEHGGDA
MUL_4069|M.ulcerans_Agy99 AYFAGR-LGDWMRVDGENLGTAPIERVLLRYPDAIEVAVYAIPDPVVGDQ
MLBr_01051|M.leprae_Br4923 HRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQR
:.** * :::.* .: :. ** * .** : * *:
Mb1779c|M.bovis_AF2122/97 VMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHK
Rv1750c|M.tuberculosis_H37Rv VMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYIRIAADLPSTATHK
MMAR_2625|M.marinum_M VMAAVVPHRDQRFTPESLEAFLRAQPDLSAKAWPRYVRIAADLPSTATHK
Mvan_4341|M.vanbaalenii_PYR-1 VMAALVLQDEATLTPDEFARFLAAQPDLSPKAWPRHVWIADALPSTATNK
Mflv_2305|M.gilvum_PYR-GCK VMAAIVVQDEATLTPQEFGTFLSEQPDLSPKAWPRYVWIADELPSTATNK
MSMEG_4952|M.smegmatis_MC2_155 VMAAIVLQDGATLTPGEFEEFLAAQRDLSPKAWPRYVWIAEDLPTTATNK
TH_4470|M.thermoresistible__bu VMAAVVLQD--ELTPRQFADFLAAQTDLSPKAWPRYVWVADDLPVTATNK
MAV_3000|M.avium_104 VMAALVLRAGAQLSPEEFGRFLASQPDLSPKAWPRYVRINDRLPTTATNK
MAB_2609|M.abscessus_ATCC_1997 VMAALVLRAPLTYLG--LAEFLSAQQDLPRIGWPRYIRLSENLPTTATNK
MUL_4069|M.ulcerans_Agy99 VMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRICSALPRTETFK
MLBr_01051|M.leprae_Br4923 IVAFVVGAEA--LDADELINYVAQQLSIHKR--PREVRFVDALPRNAMGK
::* :* : :: * .: * : . ** . *
Mb1779c|M.bovis_AF2122/97 VLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI-----------
Rv1750c|M.tuberculosis_H37Rv VLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI-----------
MMAR_2625|M.marinum_M VLKRQLVAEGTAIGPDEALWVREQRGTRYRIASDESR-------------
Mvan_4341|M.vanbaalenii_PYR-1 VLKRELVAMGVEPA-GRTLWRRD--GGTYRTVSAQE--------------
Mflv_2305|M.gilvum_PYR-GCK VLKRELVAMGTTPA-GRTLWTRD--GSGYRTVAEE---------------
MSMEG_4952|M.smegmatis_MC2_155 ILKRELVATGTDPA-GRVLWHRD--GTRFTDLSAASAPGAAPGISPA---
TH_4470|M.thermoresistible__bu VLKRELIARGTAPD-GRVLWRRD--GAQYHVYAESDE-------------
MAV_3000|M.avium_104 ILKRALISAGVTAH-DGVLWSRAPRGTRYAVAGENADGPAASVIARQ---
MAB_2609|M.abscessus_ATCC_1997 ILKRVLISEGLDIA-DETLWYRAERGAEYIDFDPVGHSPHLIAPRLRSIG
MUL_4069|M.ulcerans_Agy99 VLKRQLAADGVDCG--DPVWPIRDQS------------------------
MLBr_01051|M.leprae_Br4923 VLKKQLLFEG----------------------------------------
:**: * *
Mb1779c|M.bovis_AF2122/97 ----------
Rv1750c|M.tuberculosis_H37Rv ----------
MMAR_2625|M.marinum_M ----------
Mvan_4341|M.vanbaalenii_PYR-1 ----------
Mflv_2305|M.gilvum_PYR-GCK ----------
MSMEG_4952|M.smegmatis_MC2_155 ----------
TH_4470|M.thermoresistible__bu ----------
MAV_3000|M.avium_104 ----------
MAB_2609|M.abscessus_ATCC_1997 AAAPPSEPTR
MUL_4069|M.ulcerans_Agy99 ----------
MLBr_01051|M.leprae_Br4923 ----------