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VSTEQVRCLVTGATGYIGRRLVPELLDRGHTVRAMARTPAKLDDAAWRDRVEVVRGDLTEPDSLASAFDG VDVIYYLVHSMGTSRDFVAEEARSARNVVAAAEKAGVRRLVYLGGLHPQGKTDLSRHLASRVEVGDILLG STVETVVLQAGIVVGSGSASFEMVRHLTDRLPVMTTPKWVHNTIQPIAIADVLYYLAEAATAEVPESRTW DIGGPDVMEYGEAMQIYADIAHLRRRVMVVLPFLTPTIASLWVGLVTPIPSGLARPLVESLECDAVAHEH DIDTVIPPPEGGVTGYRDAVTQALRDDGTAAKGGRRHLLRFSKVVPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | - | 100% (327) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4583 | - | 2e-57 | 43.38% (302) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4635 | - | 2e-14 | 40.16% (127) | 3-beta hydroxysteroid dehydrogenase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1136c | - | 2e-15 | 38.21% (123) | cholesterol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1635 | - | 1e-146 | 81.39% (317) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv1106c | - | 2e-15 | 38.21% (123) | cholesterol dehydrogenase |
| M. leprae Br4923 | MLBr_01942 | - | 3e-13 | 33.06% (124) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 4e-12 | 37.39% (115) | NAD-dependent epimerase/dehydratase |
| M. marinum M | MMAR_4310 | - | 1e-123 | 70.03% (307) | oxidoreductase |
| M. avium 104 | MAV_1281 | - | 2e-60 | 44.26% (305) | hypothetical protein MAV_1281 |
| M. smegmatis MC2 155 | MSMEG_5799 | - | 1e-119 | 69.21% (302) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_0069 | - | 1e-112 | 76.92% (260) | nucleoside-diphosphate-sugar epimerase |
| M. ulcerans Agy99 | MUL_0982 | - | 4e-46 | 44.64% (233) | hypothetical protein MUL_0982 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------MSTEQVRCLVTGATGYIG
Mflv_1635|M.gilvum_PYR-GCK --------------------------------MPGNDVRCVVTGATGYIG
MSMEG_5799|M.smegmatis_MC2_155 --MTSRRWGRFRSECFGQIRGGPTASAPT--RKETVLARCLVTGATGYVG
TH_0069|M.thermoresistible__bu ---------------------------------MPDLPRCLVTGATGYIG
MMAR_4310|M.marinum_M --------------------------------MSAGQVNCLVTGATGYIG
MAV_1281|M.avium_104 -------------------------------------MRVLVTGATGYVG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
Mb1136c|M.bovis_AF2122/97 -----------------------MLRRMGDASLTTELGRVLVTGGAGFVG
Rv1106c|M.tuberculosis_H37Rv -----------------------MLRRMGDASLTTELGRVLVTGGAGFVG
MLBr_01942|M.leprae_Br4923 -----------------------MLRGVGNASLTTELGRVLVTGGSGFVG
MAB_0718c|M.abscessus_ATCC_199 -------------------------------------MKTAVTGAAGFIG
. ***.:*::*
Mvan_5113|M.vanbaalenii_PYR-1 RRLVPELLDRGHTVRAMARTPAKLDDAAWRDRVEVVRGDLTEPDSLASAF
Mflv_1635|M.gilvum_PYR-GCK GRLVPELLARGLQVRAMARTPSKLDRTEWRDRVEVVRGDLTEADSLTAAF
MSMEG_5799|M.smegmatis_MC2_155 GRLTPLLVAAGHDVRVLARTPEKLSGVPWRDDVEVARGDLSDLDSLRSAF
TH_0069|M.thermoresistible__bu GRLIPRLLDRGHPVQAMARNPEKLAGAPWRDRVDVVQGDLTDGDSLTAAF
MMAR_4310|M.marinum_M ARLVPRLLDEGHRVRALARDPGKLADVPWRDRAEVVRGDLGDTDSLEAAF
MAV_1281|M.avium_104 SRLVTALLAGGHDVLAATRNPLRLKRFGWFDEITPVPLDAADPASLRSAF
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMARLSRLAWFDDVTPVILDATDRASAQAAM
Mb1136c|M.bovis_AF2122/97 ANLVTTLLDRGHWVRSFDRAPSLLPAHPQLEVLQGDITDADVCAAAVDGI
Rv1106c|M.tuberculosis_H37Rv ANLVTTLLDRGHWVRSFDRAPSLLPAHPQLEVLQGDITDADVCAAAVDGI
MLBr_01942|M.leprae_Br4923 ANLVTALLERGYQVRSFDRAPMPLPQHPQLEVLQGDITDATVCTTAMDSI
MAB_0718c|M.abscessus_ATCC_199 TNLVNLLVDNGHEVIAIDRVVP--ASPETREAVTWVSGDVLDPDSMTKAL
.* *: * * * : * : .:
Mvan_5113|M.vanbaalenii_PYR-1 DG---VDVIYYLVHSMGTSRDFVAE----EARSARNVVAAAEKAGVRRLV
Mflv_1635|M.gilvum_PYR-GCK NG---ADVVYYLVHSMGTSRDFVAE----ERRSAHNVVEAAKKAGVRRIV
MSMEG_5799|M.smegmatis_MC2_155 TG---IDVLYYLVHSMGTATDFADS----EREAAANVAEVAKDAGVRRIV
TH_0069|M.thermoresistible__bu AG---VDVVYYLVHSMGSADDFAAE----EARSAREVVAAARRTGVRRLV
MMAR_4310|M.marinum_M AG---MDVVYYLVHSMGSAKHFADE----EARAAHNVVLAARRSGVRRVV
MAV_1281|M.avium_104 AGCGPVEVVYYLVHAIGQP-GFRDA----DKAAAANLAAAAKDAGVRRIV
MUL_0982|M.ulcerans_Agy99 NAAGQIDVVYYLVHGIGQP-DFRDR----DKTAAANLAVAARDTGVRRIV
Mb1136c|M.bovis_AF2122/97 DTIFHTAAIIELMGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFV
Rv1106c|M.tuberculosis_H37Rv DTIFHTAAIIELMGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFV
MLBr_01942|M.leprae_Br4923 DTVFHTAAIIELMGGASVTDEYRQRSYTVNVGGTENLLRAGQKSGVKRFV
MAB_0718c|M.abscessus_ATCC_199 DG---VEVVYHLVAVITLKHEDELCWR-INTEGARTVAQAALTVGARRMV
.: *: : .: : .. *.:*.*
Mvan_5113|M.vanbaalenii_PYR-1 YLGG---------------LHPQGKTDLSRHLASRVEVGDILLGS-TV--
Mflv_1635|M.gilvum_PYR-GCK YLSG---------------LHPD-RKELSRHLASRVEVGEILMQS-GI--
MSMEG_5799|M.smegmatis_MC2_155 YLGG---------------LHPD-DAQLSPHLASRTLVGETLMAS-GV--
TH_0069|M.thermoresistible__bu YLGG---------------LHPP-GTGLSTHLESRVEVGDILLDS-GI--
MMAR_4310|M.marinum_M YLSG---------------LHPE-QSKLSPHLQSRMAVGDALIGS-GI--
MAV_1281|M.avium_104 YLGG---------------FVPA-GEVLSEHLTSRAEVAEALAVPDGP--
MUL_0982|M.ulcerans_Agy99 YLGG---------------FVPE-CEALSQHLSSRAVVAEALAVDDGA--
Mb1136c|M.bovis_AF2122/97 YTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTETKVVAERFVLAQNGV-D
Rv1106c|M.tuberculosis_H37Rv YTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTETKVVAERFVLAQNGV-D
MLBr_01942|M.leprae_Br4923 YTASNSVVMGGTPITGGDETMPYTKRFNDLYTETKVVAEKFVLSQNGVPD
MAB_0718c|M.abscessus_ATCC_199 HCSSIDSYSN---SVATIDEKSPRSAAADLPVYQRSKWGGEVAVRETIAS
: .. . . : :
Mvan_5113|M.vanbaalenii_PYR-1 ----ETVVLQAGIVVGSGS-ASFEMVRHLTDRLPVMTTPKWVHNTIQPIA
Mflv_1635|M.gilvum_PYR-GCK ----ETVVLQAGIVIGSGS-ASFEMVRHLTDRLPVMTTPKWVHNKIQPIS
MSMEG_5799|M.smegmatis_MC2_155 ----ETVVLQAGVVVGSGS-ASFEMIRHLTDRLPVMTTPKWVHNRIQPIA
TH_0069|M.thermoresistible__bu ----ETVVLQAGIVIGSGS-ASFEMIRHLTDRLPVMTTPKWVRNRIQPIA
MMAR_4310|M.marinum_M ----ETIVLQAGVVVGSGS-ASFEMIRHLTDRLPVMTTPKWVHNRIQPIA
MAV_1281|M.avium_104 ----ELVWLGAAMIIGAGS-TSFEMMRYVGDRFPLMPIPSWMDNPIDPIS
MUL_0982|M.ulcerans_Agy99 ----ELVWLGAAMIIGAGS-TLFEMLRYVGDRFPVLPMPDWMYNPIDPIS
Mb1136c|M.bovis_AF2122/97 G--MLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSY
Rv1106c|M.tuberculosis_H37Rv G--MLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSY
MLBr_01942|M.leprae_Br4923 GETMLTCSIRPSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNAKLDNSY
MAB_0718c|M.abscessus_ATCC_199 G--LDAVICNPTGVYGPVDLPNLSRINQLLFDSARGRLPGMVNSQYDLVD
. : * . . : :
Mvan_5113|M.vanbaalenii_PYR-1 IADVLYYLAEAATAEVPE----SRTWDIGGPDVMEYGEAMQIYADIAHLR
Mflv_1635|M.gilvum_PYR-GCK ISDVLHYLAEAATAEFGE----SRTWDIGGPDVMEYGDAMQGYADVAGLR
MSMEG_5799|M.smegmatis_MC2_155 VRDILHYLVQSASVPFPT----TRAWDVGGPDVLKYGDMMQVYAEEAGLR
TH_0069|M.thermoresistible__bu VDDVLHYLAEAATAAVPG----SRAWDVGGPDVLEYGEAIQVYAEEAGRR
MMAR_4310|M.marinum_M IRDVLHYLVAAATATVPDTAR-ARTWDVGGPDVLEYGDMMRVYAEVAGLH
MAV_1281|M.avium_104 IRDVLHYLLAAADRDLVP----AGAYDIAGPDTTSYRRLLKTYARLSG-R
MUL_0982|M.ulcerans_Agy99 IRDVLHYLVAAADVDQVP----AGAYDICGPDTTSYRELLKTYARIRG-R
Mb1136c|M.bovis_AF2122/97 VHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQR
Rv1106c|M.tuberculosis_H37Rv VHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQR
MLBr_01942|M.leprae_Br4923 VHNLVHGLILAAEHLVPGGTAPGQAYFINDGEPINFFDFMGPIIKACGEN
MAB_0718c|M.abscessus_ATCC_199 ARDVAAGLYLAGEKGRTG-----ENYLLGG-HMGSLLQVCRLAARRAGKR
:: : :. : : . . . .
Mvan_5113|M.vanbaalenii_PYR-1 RRVMVVLPFLTPTIASLWVGLVTPIPSGLARPLVESLECDAVAHEHDIDT
Mflv_1635|M.gilvum_PYR-GCK RRVMVVLPFLTPTIASWWVGLVTPIPSGLARPLVESLECDAICHEHDIDA
MSMEG_5799|M.smegmatis_MC2_155 RRRMVVLPWLTPTIASWWVGLVTPIPSGLARPLVESLHCDAICGEHDIDA
TH_0069|M.thermoresistible__bu RRVIVPLPWLTPRIASWWVGLVTPLPPGLAPPX---PRCSATCRS-----
MMAR_4310|M.marinum_M RRYLIVLPFLTPTIASLWVGTVTPIPPGLARPLIESLECDAVMRNSDIDT
MAV_1281|M.avium_104 WHTGLPVGRVDTGLASLVTGVALPVPPGLAGDLVESLDHPMVASGSDLRQ
MUL_0982|M.ulcerans_Agy99 WHAALPVGRLDTAVASRIT----------AG-------HPAGPAWSGRR-
Mb1136c|M.bovis_AF2122/97 WPKMRISGPAVRWVMTGWQRLHFR--FGFPAPLLEPLAVERLYLDNYFSI
Rv1106c|M.tuberculosis_H37Rv WPKMRISGPAVRWVMTGWQRLHFR--FGFPAPLLEPLAVERLYLDNYFSI
MLBr_01942|M.leprae_Br4923 WPRVRISGRLVRNVMAVWQRLHFG--FGLPKPPMEPLAVERVYLDNYFSI
MAB_0718c|M.abscessus_ATCC_199 GPRFAVP----MGLLNAAIPVIEPIGKLLKNDALSRAAFNKLTVSPAVDI
:
Mvan_5113|M.vanbaalenii_PYR-1 VIPPPEGGVTGYRDAVTQALRDDGTAAKGGRRHLLR---FSKVVPQ----
Mflv_1635|M.gilvum_PYR-GCK VIPPPKGGLIGYREAVAKELRSEGGSS-AGRRHLLR---FSPAASD----
MSMEG_5799|M.smegmatis_MC2_155 VIPPPEGGLTSYRDAVALALACQSRPDTGAAWFNEP---ADSLPSDPDWS
TH_0069|M.thermoresistible__bu --PPSS-------SAPAWSRSGSGCSSAAS--------------------
MMAR_4310|M.marinum_M IIAPPAGGLTNYRRAVELALNRAAHGLPDATWASLQSEPAEPLPSDPRWA
MAV_1281|M.avium_104 RVPDPPGGLLGVDDAIARALDDRSYRRPRPVNALADPHHLADTDP-----
MUL_0982|M.ulcerans_Agy99 -----PGGIAGSPDGGIRGRPAR--QGPRATRRTTEYRRCHYVGA-----
Mb1136c|M.bovis_AF2122/97 AKARRDLGYEPLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP
Rv1106c|M.tuberculosis_H37Rv AKARRDLGYEPLFTTQQALTECLPYYVSLFEQMKNEAR--AEKTAATVKP
MLBr_01942|M.leprae_Br4923 EKAHKELGYRPLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAATPRP
MAB_0718c|M.abscessus_ATCC_199 TKARTELGYEPRSTETTVNEFVDFLLGSGRL-------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5799|M.smegmatis_MC2_155 --------------GAPAEVAEFRTPSRGADPTATLRNVAEAAWERQGWR
TH_0069|M.thermoresistible__bu --------------------------------------------------
MMAR_4310|M.marinum_M GEIVYTDVRDATTTAAPEAVWKATERAINSRRWYSLALAPRRRHRAPRWR
MAV_1281|M.avium_104 -----------------------GWAGGDARRIRQLAGRVTPAIARPTLG
MUL_0982|M.ulcerans_Agy99 -----------------------GRP-----RERAPVARRRPDRSPPTR-
Mb1136c|M.bovis_AF2122/97 --------------------------------------------------
Rv1106c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01942|M.leprae_Br4923 E-------------------------------------------------
MAB_0718c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5799|M.smegmatis_MC2_155 VLPDDPSGPLTLTKDARLGRAWLQFTAEGDGAV----VHRSVLRPRGLLG
TH_0069|M.thermoresistible__bu --------------------------------------------------
MMAR_4310|M.marinum_M VAQRTPTTLRLGAGTRVPGPTWLEVTLTPRGTAGSTYHQRAIFFPRGIPG
MAV_1281|M.avium_104 LVNKVPGPVAGAVRTGLDILIALTPKVRPA--------------------
MUL_0982|M.ulcerans_Agy99 -----------IHRSGVGRR------------------------------
Mb1136c|M.bovis_AF2122/97 --------------------------------------------------
Rv1106c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01942|M.leprae_Br4923 --------------------------------------------------
MAB_0718c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 ---------------------------
Mflv_1635|M.gilvum_PYR-GCK ---------------------------
MSMEG_5799|M.smegmatis_MC2_155 QVYAATVWPLRRRMLHRRADALFSG--
TH_0069|M.thermoresistible__bu ---------------------------
MMAR_4310|M.marinum_M RLSWLVLRHLYAAALRALARDVTAADR
MAV_1281|M.avium_104 ---------------------------
MUL_0982|M.ulcerans_Agy99 ---------------------------
Mb1136c|M.bovis_AF2122/97 ---------------------------
Rv1106c|M.tuberculosis_H37Rv ---------------------------
MLBr_01942|M.leprae_Br4923 ---------------------------
MAB_0718c|M.abscessus_ATCC_199 ---------------------------