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VTSRRWGRFRSECFGQIRGGPTASAPTRKETVLARCLVTGATGYVGGRLTPLLVAAGHDVRVLARTPEKL SGVPWRDDVEVARGDLSDLDSLRSAFTGIDVLYYLVHSMGTATDFADSEREAAANVAEVAKDAGVRRIVY LGGLHPDDAQLSPHLASRTLVGETLMASGVETVVLQAGVVVGSGSASFEMIRHLTDRLPVMTTPKWVHNR IQPIAVRDILHYLVQSASVPFPTTRAWDVGGPDVLKYGDMMQVYAEEAGLRRRRMVVLPWLTPTIASWWV GLVTPIPSGLARPLVESLHCDAICGEHDIDAVIPPPEGGLTSYRDAVALALACQSRPDTGAAWFNEPADS LPSDPDWSGAPAEVAEFRTPSRGADPTATLRNVAEAAWERQGWRVLPDDPSGPLTLTKDARLGRAWLQFT AEGDGAVVHRSVLRPRGLLGQVYAATVWPLRRRMLHRRADALFSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5799 | - | - | 100% (465) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_5189 | - | 2e-60 | 40.36% (337) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5504 | - | 3e-18 | 32.47% (231) | hypothetical protein MSMEG_5504 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 1e-10 | 36.05% (147) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1635 | - | 1e-127 | 70.92% (306) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 1e-10 | 36.05% (147) | oxidoreductase |
| M. leprae Br4923 | MLBr_01942 | - | 2e-09 | 31.11% (135) | putative cholesterol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3360c | - | 6e-10 | 26.29% (213) | hypothetical protein MAB_3360c |
| M. marinum M | MMAR_4310 | - | 1e-129 | 56.32% (451) | oxidoreductase |
| M. avium 104 | MAV_1281 | - | 1e-65 | 43.15% (336) | hypothetical protein MAV_1281 |
| M. thermoresistible (build 8) | TH_0069 | - | 1e-106 | 67.65% (272) | nucleoside-diphosphate-sugar epimerase |
| M. ulcerans Agy99 | MUL_0982 | - | 2e-53 | 44.57% (258) | hypothetical protein MUL_0982 |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | 1e-119 | 69.21% (302) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3752|M.bovis_AF2122/97 --------------------------------MQNATMRVLVTGGTGFVG
Rv3725|M.tuberculosis_H37Rv --------------------------------MQNATMRVLVTGGTGFVG
Mflv_1635|M.gilvum_PYR-GCK --------------------------------MPGNDVRCVVTGATGYIG
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------MSTEQVRCLVTGATGYIG
MSMEG_5799|M.smegmatis_MC2_155 --MTSRRWGRFRSECFGQIRGGPTASAPT--RKETVLARCLVTGATGYVG
TH_0069|M.thermoresistible__bu ---------------------------------MPDLPRCLVTGATGYIG
MMAR_4310|M.marinum_M --------------------------------MSAGQVNCLVTGATGYIG
MAV_1281|M.avium_104 -------------------------------------MRVLVTGATGYVG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
MAB_3360c|M.abscessus_ATCC_199 -------------------------------------MKITVVGATGQIG
MLBr_01942|M.leprae_Br4923 -----------------------MLRGVGNASLTTELGRVLVTGGSGFVG
. *.*.:* :*
Mb3752|M.bovis_AF2122/97 GWTAKAIADAGHSVRFLVRNPARLKTSVAKLGVDVSDFAVADISDRDSVR
Rv3725|M.tuberculosis_H37Rv GWTAKAIADAGHSVRFLVRNPARLKTSVAKLGVDVSDFAVADISDRDSVR
Mflv_1635|M.gilvum_PYR-GCK GRLVPELLARGLQVRAMARTPSKLDR---TEWRDRVEVVRGDLTEADSLT
Mvan_5113|M.vanbaalenii_PYR-1 RRLVPELLDRGHTVRAMARTPAKLDD---AAWRDRVEVVRGDLTEPDSLA
MSMEG_5799|M.smegmatis_MC2_155 GRLTPLLVAAGHDVRVLARTPEKLSG---VPWRDDVEVARGDLSDLDSLR
TH_0069|M.thermoresistible__bu GRLIPRLLDRGHPVQAMARNPEKLAG---APWRDRVDVVQGDLTDGDSLT
MMAR_4310|M.marinum_M ARLVPRLLDEGHRVRALARDPGKLAD---VPWRDRAEVVRGDLGDTDSLE
MAV_1281|M.avium_104 SRLVTALLAGGHDVLAATRNPLRLKR---FGWFDEITPVPLDAADPASLR
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMARLSR---LAWFDDVTPVILDATDRASAQ
MAB_3360c|M.abscessus_ATCC_199 SRVVSLLIADGHDVVAASLSSG------------------ANVLTGEGLV
MLBr_01942|M.leprae_Br4923 ANLVTALLERGYQVRSFDRAPMPLPQ------HPQLEVLQGDITDATVCT
: * * :
Mb3752|M.bovis_AF2122/97 EALNGCDAVVHSAALVATDPRETS------RMLSTNMAGAQNVLGQAVEL
Rv3725|M.tuberculosis_H37Rv EALNGCDAVVHSAALVATDPRETS------RMLSTNMAGAQNVLGQAVEL
Mflv_1635|M.gilvum_PYR-GCK AAFNG----ADVVYYLVHSMGTSR------DFVAEERRSAHNVVEAAKKA
Mvan_5113|M.vanbaalenii_PYR-1 SAFDG----VDVIYYLVHSMGTSR------DFVAEEARSARNVVAAAEKA
MSMEG_5799|M.smegmatis_MC2_155 SAFTG----IDVLYYLVHSMGTAT------DFADSEREAAANVAEVAKDA
TH_0069|M.thermoresistible__bu AAFAG----VDVVYYLVHSMGSAD------DFAAEEARSAREVVAAARRT
MMAR_4310|M.marinum_M AAFAG----MDVVYYLVHSMGSAK------HFADEEARAAHNVVLAARRS
MAV_1281|M.avium_104 SAFAGC-GPVEVVYYLVHAIGQP-------GFRDADKAAAANLAAAAKDA
MUL_0982|M.ulcerans_Agy99 AAMNAA-GQIDVVYYLVHGIGQP-------DFRDRDKTAAANLAVAARDT
MAB_3360c|M.abscessus_ATCC_199 DALTGSAVVIDVVNSPSFEDGPVM------DFFT---ASARNLVDAAKAT
MLBr_01942|M.leprae_Br4923 TAMDSIDTVFHTAAIIELMGGASVTDEYRQRSYTVNVGGTENLLRAGQKS
*: . . .: :: .
Mb3752|M.bovis_AF2122/97 GMDPIVHVSSFTALFRPNLAT---------------LSADLPVAGGTDGY
Rv3725|M.tuberculosis_H37Rv GMDPIVHVSSFTALFRPNLAT---------------LSADLPVAGGTDGY
Mflv_1635|M.gilvum_PYR-GCK GVRRIVYLSGLHPD-RKELSR---------------HLASRVEVGEILMQ
Mvan_5113|M.vanbaalenii_PYR-1 GVRRLVYLGGLHPQGKTDLSR---------------HLASRVEVGDILLG
MSMEG_5799|M.smegmatis_MC2_155 GVRRIVYLGGLHPD-DAQLSP---------------HLASRTLVGETLMA
TH_0069|M.thermoresistible__bu GVRRLVYLGGLHPP-GTGLST---------------HLESRVEVGDILLD
MMAR_4310|M.marinum_M GVRRVVYLSGLHPE-QSKLSP---------------HLQSRMAVGDALIG
MAV_1281|M.avium_104 GVRRIVYLGGFVPA-GEVLSE---------------HLTSRAEVAEALAV
MUL_0982|M.ulcerans_Agy99 GVRRIVYLGGFVPE-CEALSQ---------------HLSSRAVVAEALAV
MAB_3360c|M.abscessus_ATCC_199 GVGHYVALS-IVGADGLPESG---------------YMRAKVAQEKIIVG
MLBr_01942|M.leprae_Br4923 GVKRFVYTASNSVVMGGTPITGGDETMPYTKRFNDLYTETKVVAEKFVLS
*: * .
Mb3752|M.bovis_AF2122/97 GQSKAQIEIYARGLQDA----GAP-----VNITYPGMVLGPPVGDQFG--
Rv3725|M.tuberculosis_H37Rv GQSKAQIEIYARGLQDA----GAP-----VNITYPGMVLGPPVGDQFG--
Mflv_1635|M.gilvum_PYR-GCK S-GIETVVLQAGIVIGS----GSASFEMVRHLTDRLPVMTTPKWVHNK--
Mvan_5113|M.vanbaalenii_PYR-1 S-TVETVVLQAGIVVGS----GSASFEMVRHLTDRLPVMTTPKWVHNT--
MSMEG_5799|M.smegmatis_MC2_155 S-GVETVVLQAGVVVGS----GSASFEMIRHLTDRLPVMTTPKWVHNR--
TH_0069|M.thermoresistible__bu S-GIETVVLQAGIVIGS----GSASFEMIRHLTDRLPVMTTPKWVRNR--
MMAR_4310|M.marinum_M S-GIETIVLQAGVVVGS----GSASFEMIRHLTDRLPVMTTPKWVHNR--
MAV_1281|M.avium_104 PDGPELVWLGAAMIIGA----GSTSFEMMRYVGDRFPLMPIPSWMDNP--
MUL_0982|M.ulcerans_Agy99 DDGAELVWLGAAMIIGA----GSTLFEMLRYVGDRFPVLPMPDWMYNP--
MAB_3360c|M.abscessus_ATCC_199 S-GLPYTIVRATQFQEF----AEA-------ITDTLVVGDEVRVPDAR--
MLBr_01942|M.leprae_Br4923 QNGVPDGETMLTCSIRPSGIWGRGDQTMFRKAFESVVSGHVKVLIGSKNA
.
Mb3752|M.bovis_AF2122/97 -EAGEGVRSALWMHVIPGRGAAWLIVD-VRDVAALHAALLESGRGPRRYT
Rv3725|M.tuberculosis_H37Rv -EAGEGVRSALWMHVIPGRGAAWLIVD-VRDVAALHAALLESGRGPRRYT
Mflv_1635|M.gilvum_PYR-GCK -IQPISISDVLHYLAEAATAEFGE----SRTWDIGGPDVMEYGDAMQGYA
Mvan_5113|M.vanbaalenii_PYR-1 -IQPIAIADVLYYLAEAATAEVPE----SRTWDIGGPDVMEYGEAMQIYA
MSMEG_5799|M.smegmatis_MC2_155 -IQPIAVRDILHYLVQSASVPFPT----TRAWDVGGPDVLKYGDMMQVYA
TH_0069|M.thermoresistible__bu -IQPIAVDDVLHYLAEAATAAVPG----SRAWDVGGPDVLEYGEAIQVYA
MMAR_4310|M.marinum_M -IQPIAIRDVLHYLVAAATATVPDTAR-ARTWDVGGPDVLEYGDMMRVYA
MAV_1281|M.avium_104 -IDPISIRDVLHYLLAAADRDLVP----AGAYDIAGPDTTSYRRLLKTYA
MUL_0982|M.ulcerans_Agy99 -IDPISIRDVLHYLVAAADVDQVP----AGAYDICGPDTTSYRELLKTYA
MAB_3360c|M.abscessus_ATCC_199 -IQLIAVDDVSTQVAHAAAAAPRN-----GIINIGGPEKFSFADMAGAVL
MLBr_01942|M.leprae_Br4923 KLDNSYVHNLVHGLILAAEHLVPGGTAPGQAYFINDGEPINFFDFMGPII
: . .. .
Mb3752|M.bovis_AF2122/97 -AGGHRIPVPELAKILGEVAGTTMLAVPVPDSALRVAGSVLDQAGPYLPF
Rv3725|M.tuberculosis_H37Rv -AGGHRIPVPELAKILGGSPAPRCWPSRCPIPRCVSRDRCWIKPGP----
Mflv_1635|M.gilvum_PYR-GCK DVAGLRRRVMVVLPFLTPTIASWWVGLVTPIPSGLARPLVESLECDAICH
Mvan_5113|M.vanbaalenii_PYR-1 DIAHLRRRVMVVLPFLTPTIASLWVGLVTPIPSGLARPLVESLECDAVAH
MSMEG_5799|M.smegmatis_MC2_155 EEAGLRRRRMVVLPWLTPTIASWWVGLVTPIPSGLARPLVESLHCDAICG
TH_0069|M.thermoresistible__bu EEAGRRRRVIVPLPWLTPRIASWWVGLVTPLPPGLAPPX---PRCSATCR
MMAR_4310|M.marinum_M EVAGLHRRYLIVLPFLTPTIASLWVGTVTPIPPGLARPLIESLECDAVMR
MAV_1281|M.avium_104 RLSG-RWHTGLPVGRVDTGLASLVTGVALPVPPGLAGDLVESLDHPMVAS
MUL_0982|M.ulcerans_Agy99 RIRG-RWHAALPVGRLDTAVASRIT----------AG-------HPAGPA
MAB_3360c|M.abscessus_ATCC_199 AARGDDRPVVVDSGATYFGTPVDDFSLVTGDDGVLTQTRFADWMARR---
MLBr_01942|M.leprae_Br4923 KACGENWPRVRISGRLVRNVMAVWQRLHFGFGLPKPPMEPLAVERVYLDN
Mb3752|M.bovis_AF2122/97 NTPFTAAGMQYYTQMPEPDDSPSEKELGITYRDPRDTVADTVTALRGLGS
Rv3725|M.tuberculosis_H37Rv ---------ICLSILRSPRQVCS-----TTHRCRSPTIRRAKKN------
Mflv_1635|M.gilvum_PYR-GCK EHDIDAVIPPPKGGLIGYREAVAKELRSEGGSS-AGRRHLLR---FSPAA
Mvan_5113|M.vanbaalenii_PYR-1 EHDIDTVIPPPEGGVTGYRDAVTQALRDDGTAAKGGRRHLLR---FSKVV
MSMEG_5799|M.smegmatis_MC2_155 EHDIDAVIPPPEGGLTSYRDAVALALACQSRPDTGAAWFNEP---ADSLP
TH_0069|M.thermoresistible__bu S-------PPSS-------SAPAWSRSGSGCSSAAS--------------
MMAR_4310|M.marinum_M NSDIDTIIAPPAGGLTNYRRAVELALNRAAHGLPDATWASLQSEPAEPLP
MAV_1281|M.avium_104 GSDLRQRVPDPPGGLLGVDDAIARALDDRSYRRPRPVNALADPHHLADTD
MUL_0982|M.ulcerans_Agy99 WSGRR------PGGIAGSPDGGIRGRPAR--QGPRATRRTTEYRRCHYVG
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01942|M.leprae_Br4923 YFSIEKAHKELGYRPLFTTEQAMAECLPYYTELFEQIKVAAKPHLASIAA
Mb3752|M.bovis_AF2122/97 --------------------------------------------------
Rv3725|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK SD------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 PQ------------------------------------------------
MSMEG_5799|M.smegmatis_MC2_155 SDPDWS--------------GAPAEVAEFRTPSRGADPTATLRNVAEAAW
TH_0069|M.thermoresistible__bu --------------------------------------------------
MMAR_4310|M.marinum_M SDPRWAGEIVYTDVRDATTTAAPEAVWKATERAINSRRWYSLALAPRRRH
MAV_1281|M.avium_104 P----------------------------GWAGGDARRIRQLAGRVTPAI
MUL_0982|M.ulcerans_Agy99 A----------------------------GRP-----RERAPVARRRPDR
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01942|M.leprae_Br4923 TPRPE---------------------------------------------
Mb3752|M.bovis_AF2122/97 --------------------------------------------------
Rv3725|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5799|M.smegmatis_MC2_155 ERQGWRVLPDDPSGPLTLTKDARLGRAWLQFTAEGDGAV----VHRSVLR
TH_0069|M.thermoresistible__bu --------------------------------------------------
MMAR_4310|M.marinum_M RAPRWRVAQRTPTTLRLGAGTRVPGPTWLEVTLTPRGTAGSTYHQRAIFF
MAV_1281|M.avium_104 ARPTLGLVNKVPGPVAGAVRTGLDILIALTPKVRPA--------------
MUL_0982|M.ulcerans_Agy99 SPPTR------------IHRSGVGRR------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01942|M.leprae_Br4923 --------------------------------------------------
Mb3752|M.bovis_AF2122/97 ---------------------------------
Rv3725|M.tuberculosis_H37Rv ---------------------------------
Mflv_1635|M.gilvum_PYR-GCK ---------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_5799|M.smegmatis_MC2_155 PRGLLGQVYAATVWPLRRRMLHRRADALFSG--
TH_0069|M.thermoresistible__bu ---------------------------------
MMAR_4310|M.marinum_M PRGIPGRLSWLVLRHLYAAALRALARDVTAADR
MAV_1281|M.avium_104 ---------------------------------
MUL_0982|M.ulcerans_Agy99 ---------------------------------
MAB_3360c|M.abscessus_ATCC_199 ---------------------------------
MLBr_01942|M.leprae_Br4923 ---------------------------------