For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KPVRTLVAGATGYIGSRLVTALLHDGHQVVAASRDPARLTEFGWYKDVSTVTLDAHDEISARQAFTDAGP VDVVYYLVHGIGQPGFREADNRAAANVASAAKAAGVRRIVYLGGFVPDDDSLSEHLTSRAEVAAALTVDG GPDVVWLGAAIVIGAGSTSFEMLRYVGDRFLLLPMPEWSANPIDPIAISDALHYLVAAADADTVPPGAYD ISGPETTTYGDLLRTYARVAGVWRAPVAVYGVDIATVSKLTGVVLPVPAGLASDLVESLDYPMMASAEGL RGRVPDPPGGLVGVEDAIRRAAASPARRPVDELTDPHHLADTDPDWAGGDALRLRQLAGAVTPPVARPFL GLIGFVPGPVAAAVRTGLDAVIGLVPKVIPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4583 | - | - | 100% (382) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | 2e-57 | 43.38% (302) | NAD-dependent epimerase/dehydratase |
| M. vanbaalenii PYR-1 | Mvan_2101 | - | 3e-08 | 27.49% (251) | dTDP-4-dehydrorhamnose reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 5e-07 | 34.75% (118) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_2122 | - | 0.0 | 83.64% (379) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 6e-07 | 34.75% (118) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-08 | 35.48% (124) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_3360c | - | 2e-08 | 26.89% (264) | hypothetical protein MAB_3360c |
| M. marinum M | MMAR_4312 | - | 1e-139 | 63.95% (380) | hypothetical protein MMAR_4312 |
| M. avium 104 | MAV_1281 | - | 1e-147 | 67.54% (382) | hypothetical protein MAV_1281 |
| M. smegmatis MC2 155 | MSMEG_5189 | - | 1e-146 | 68.00% (375) | oxidoreductase |
| M. thermoresistible (build 8) | TH_4331 | - | 1e-163 | 73.77% (385) | PUTATIVE NAD-dependent epimerase/dehydratase |
| M. ulcerans Agy99 | MUL_0982 | - | 7e-92 | 64.68% (252) | hypothetical protein MUL_0982 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4583|M.vanbaalenii_PYR-1 ----------------------------------MKPVRTLVAGATGYIG
Mflv_2122|M.gilvum_PYR-GCK -------------------------------------MRTLVTGASGYIG
TH_4331|M.thermoresistible__bu ----------------------------------VKNLRVLVTGATGYVG
MSMEG_5189|M.smegmatis_MC2_155 -------------------------------------MRMMVTGATGYVG
MAV_1281|M.avium_104 -------------------------------------MRVLVTGATGYVG
MMAR_4312|M.marinum_M -------------------------------------MRILVTGATGYVG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
Mb3658c|M.bovis_AF2122/97 -------------------------------------MRALVTGAAGFIG
Rv3634c|M.tuberculosis_H37Rv -------------------------------------MRALVTGAAGFIG
MLBr_00204|M.leprae_Br4923 --------------------------------MYGEPVRALVTGAAGFIG
MAB_3360c|M.abscessus_ATCC_199 -------------------------------------MKITVVGATGQIG
:: *.**:* :*
Mvan_4583|M.vanbaalenii_PYR-1 SRLVTALLHDGHQVVAASRDPA-RLTEFGWYKDVSTVTLDAHDEISARQA
Mflv_2122|M.gilvum_PYR-GCK SRLVTALLDDGHQVVAASRDPS-RLADFGWYHDVSTVTLDAHDEISAQQA
TH_4331|M.thermoresistible__bu SRLVTSLLAAGHDVVAASRNPR-RLTDFGWYDRVTPVALDAHDEDSVSAA
MSMEG_5189|M.smegmatis_MC2_155 SRLVTALLAHDHDVVVASRNTV-RLTDFGWFPDVRAVRLDAGDADSVRDA
MAV_1281|M.avium_104 SRLVTALLAGGHDVLAATRNPL-RLKRFGWFDEITPVPLDAADPASLRSA
MMAR_4312|M.marinum_M SRLVTALLADGHEVLAATRNMA-RLSRLAWFDDVTPVILDATDRASAQAA
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMA-RLSRLAWFDDVTPVILDATDRASAQAA
Mb3658c|M.bovis_AF2122/97 STLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLH
Rv3634c|M.tuberculosis_H37Rv STLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLH
MLBr_00204|M.leprae_Br4923 STLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQ
MAB_3360c|M.abscessus_ATCC_199 SRVVSLLIADGHDVVAASLSSGANVLTGEGLVDALTGSAVVIDVVNSPSF
* :* *: .* *: . . * .
Mvan_4583|M.vanbaalenii_PYR-1 FTDAG----PVDVVYYLVHGIGQ------PGFREADNRAAAN-VASAAKA
Mflv_2122|M.gilvum_PYR-GCK FTEAG----PIDVVYYLVHGIGQ------PDFREADNRAAAN-VAAAAKA
TH_4331|M.thermoresistible__bu LARAGSGARPVDVIYYLVHGIGQ------DGFREADNRAAAN-VAAAAKY
MSMEG_5189|M.smegmatis_MC2_155 FGAAG----PVDVVYYLLHGIGE------PGFREADNRAATN-LATAARD
MAV_1281|M.avium_104 FAGCG----PVEVVYYLVHAIGQ------PGFRDADKAAAAN-LAAAAKD
MMAR_4312|M.marinum_M MNAAG----QIDVVYYLVHGIGQ------PDFRDRDKTAAAN-LAVAARD
MUL_0982|M.ulcerans_Agy99 MNAAG----QIDVVYYLVHGIGQ------PDFRDRDKTAAAN-LAVAARD
Mb3658c|M.bovis_AF2122/97 AILEQH---RPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQ
Rv3634c|M.tuberculosis_H37Rv AILEQH---RPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQ
MLBr_00204|M.leprae_Br4923 TILDEH---RPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARH
MAB_3360c|M.abscessus_ATCC_199 EDG--------PVMDFFTASARN--------------------LVDAAKA
*: .: :. **:
Mvan_4583|M.vanbaalenii_PYR-1 AGVRRIVYLGGFVPDDDSLSEHLTSRAEVAAALTVDGGPDVVWLGAAIVI
Mflv_2122|M.gilvum_PYR-GCK AGVRRIVYLGGFVPDEDSLSEHLTSRAEVAAALTIDDGPDVVWLGAAIVI
TH_4331|M.thermoresistible__bu AGVRRIVYLGGFVPDGEALSEHLSSRAEVAHALHVDGGADVVWLGAAMII
MSMEG_5189|M.smegmatis_MC2_155 AGVRRIVYLGGFVPEDDTLSDHLAGRAEVAHALGVDGGPEVVWLGAAMII
MAV_1281|M.avium_104 AGVRRIVYLGGFVPAGEVLSEHLTSRAEVAEALAVPDGPELVWLGAAMII
MMAR_4312|M.marinum_M TGVRRIVYLGGFVPECEALSQHLSSRAEVAEALAVDDGAELVWLGAAMII
MUL_0982|M.ulcerans_Agy99 TGVRRIVYLGGFVPECEALSQHLSSRAVVAEALAVDDGAELVWLGAAMII
Mb3658c|M.bovis_AF2122/97 TGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAG----------K
Rv3634c|M.tuberculosis_H37Rv TGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAG----------K
MLBr_00204|M.leprae_Br4923 TGVRKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAG----------K
MAB_3360c|M.abscessus_ATCC_199 TGVGHYVALSIVGADGLPESGYMRAKVAQEKIIVGSGLP--------YTI
:** : * . . . : ..
Mvan_4583|M.vanbaalenii_PYR-1 GAGSTSFEMLRYVGDRFLLLPMPEWSANPIDPIAISDALHYLVAAADADT
Mflv_2122|M.gilvum_PYR-GCK GAGSTSFEMLRYVADRFLLLPMPEWSVNPIDPIAISDVLHYLVASADPD-
TH_4331|M.thermoresistible__bu GAGSTSFEMLRYVGDRFLVLPLPEWSANPIDPISISDVLYYLVAAADADS
MSMEG_5189|M.smegmatis_MC2_155 GAGSTSFEILRYVADRFPVMPLPSWLSNPMDPISIRDVLHYLVAAADTDK
MAV_1281|M.avium_104 GAGSTSFEMMRYVGDRFPLMPIPSWMDNPIDPISIRDVLHYLLAAADRDL
MMAR_4312|M.marinum_M GAGSTSFEMLRYVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVDQ
MUL_0982|M.ulcerans_Agy99 GAGSTLFEMLRYVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVDQ
Mb3658c|M.bovis_AF2122/97 VAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSG
Rv3634c|M.tuberculosis_H37Rv VAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSG
MLBr_00204|M.leprae_Br4923 VAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSD
MAB_3360c|M.abscessus_ATCC_199 VRATQFQEFAEAITDTLVVGDEVRVPDARIQLIAVDDVSTQVAHAAAAAP
. : . : . : : *
Mvan_4583|M.vanbaalenii_PYR-1 VPPGAY--DISGPETTTYGDLLRTYARVAGVWRAPVAVYGVDIATVSKLT
Mflv_2122|M.gilvum_PYR-GCK VPAGAY--DIRGPETTTYGDLLRAYARIAGIWRAPVAVYGIDTSLVSKVT
TH_4331|M.thermoresistible__bu VPAGAY--DICGPDTTTYGDLLHTYARIAGKWRADLPIRGVDTAVVSRLS
MSMEG_5189|M.smegmatis_MC2_155 VPAGAY--DICGPETTTYRGVLAAYSRLAGKRRFGVPVCGVATGLASRVS
MAV_1281|M.avium_104 VPAGAY--DIAGPDTTSYRRLLKTYARLSGRWHTGLPVGRVDTGLASLVT
MMAR_4312|M.marinum_M VPAGAY--DICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRIT
MUL_0982|M.ulcerans_Agy99 VPAGAY--DICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRIT
Mb3658c|M.bovis_AF2122/97 KPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFN-IGTGKET---
Rv3634c|M.tuberculosis_H37Rv KPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFN-IGTGKET---
MLBr_00204|M.leprae_Br4923 RPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGGGQRFN-IGTGIET---
MAB_3360c|M.abscessus_ATCC_199 RNGIIN---IGGPEKFSFADMAGAVLAARGD-------------------
: : : .
Mvan_4583|M.vanbaalenii_PYR-1 GVVLPVPAGLASDLVESLDYPMMASAEGLRGRVPDPPGGLVGVEDAIRRA
Mflv_2122|M.gilvum_PYR-GCK GLILPVPGGLAADLVESLDFPMIASANGLREFVADPPDGPVSVDDAIRRA
TH_4331|M.thermoresistible__bu AAMLPVPGGLAADLVESLDYPMVASADRLHGLVPDPPGGLVGVDDAIARA
MSMEG_5189|M.smegmatis_MC2_155 AVALPVPDGLTADLTVSLEYPMTADGDGIRHVVPDPPGGLLGVDDAIRRA
MAV_1281|M.avium_104 GVALPVPPGLAGDLVESLDHPMVASGSDLRQRVPDPPGGLLGVDDAIARA
MMAR_4312|M.marinum_M AVTLPVPHGLVADLVESLDHPMRASGAGLQDKVPEPPGGLLSIEDAITLA
MUL_0982|M.ulcerans_Agy99 AG-----------------HPAGPAWSGRR------PGGIAGSPD-----
Mb3658c|M.bovis_AF2122/97 ------------------------SDRQLHSAVAAAVGG-----------
Rv3634c|M.tuberculosis_H37Rv ------------------------SDRQLHSAVAAAVGG-----------
MLBr_00204|M.leprae_Br4923 ------------------------SDRQLHTAVSAAVGG-----------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_4583|M.vanbaalenii_PYR-1 AASP---ARRPVDELTDPHHLADTDPDWAGGDALRLRQLAGAVTPPVARP
Mflv_2122|M.gilvum_PYR-GCK VGTP---PRRPVNELIDPHHLADTDPDWAGGDVLRLRQLAGAVTPPLVHP
TH_4331|M.thermoresistible__bu LSSR---EARPVDDLLDPHHLATTDPQWAGGDALRIQRLARSVTPSVIHP
MSMEG_5189|M.smegmatis_MC2_155 LAGG---RRKPVNMLPDPHHLADTDPVWAGGDPARLRQLAGAVLPSVTRP
MAV_1281|M.avium_104 LDDRSYRRPRPVNALADPHHLADTDPGWAGGDARRIRQLAGRVTPAIARP
MMAR_4312|M.marinum_M LAGHANGPPLPVDALTDPHQLAATDPVWAGGDALRIRRIAEAMTPPIARP
MUL_0982|M.ulcerans_Agy99 --GGIRGRPARQGPRATRRTTEYRRCHYVGAGRPRER-------APVARR
Mb3658c|M.bovis_AF2122/97 ----------PDDPEFHPPRLGDLKRSCLDIG--------------LAER
Rv3634c|M.tuberculosis_H37Rv ----------PDDPEFHPPRLGDLKRSCLDIG--------------LAER
MLBr_00204|M.leprae_Br4923 ----------PDDPEFHPPRLGDLKRSCLDIG--------------LATT
MAB_3360c|M.abscessus_ATCC_199 ----------------DRPVVVDSGATYFGTP------------------
.
Mvan_4583|M.vanbaalenii_PYR-1 FLGLIGFVPGPVAAAVRTGLDAVIGLVPKVIPA
Mflv_2122|M.gilvum_PYR-GCK VLGLIGFVPRPVAAAVRTGLDTFLGMVPRVIPA
TH_4331|M.thermoresistible__bu ALGMIDVVPGPVAGAVRTGLDTVLGLAPRVLP-
MSMEG_5189|M.smegmatis_MC2_155 ALALLGLLPGPVAGAVRTGLDTMIGLVPKGAR-
MAV_1281|M.avium_104 TLGLVNKVPGPVAGAVRTGLDILIALTPKVRPA
MMAR_4312|M.marinum_M TLRWVNIVPGPLAGALRSSLDILIALTPKVLFA
MUL_0982|M.ulcerans_Agy99 RPDRS-----PPTRIHRSGVGRR----------
Mb3658c|M.bovis_AF2122/97 VLGWRP--QIELADGVRRTVEYFRHKHTD----
Rv3634c|M.tuberculosis_H37Rv VLGWRP--QIELADGVRRTVEYFRHKHTD----
MLBr_00204|M.leprae_Br4923 VLGWSP--QVQLDDGVRRTVEYFRAAQRS----
MAB_3360c|M.abscessus_ATCC_199 -VDDFSLVTGDDGVLTQTRFADWMARR------
: .