For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRVLVTGATGYVGSRLVTALLAGGHDVLAATRNPLRLKRFGWFDEITPVPLDAADPASLRSAFAGCGPVE VVYYLVHAIGQPGFRDADKAAAANLAAAAKDAGVRRIVYLGGFVPAGEVLSEHLTSRAEVAEALAVPDGP ELVWLGAAMIIGAGSTSFEMMRYVGDRFPLMPIPSWMDNPIDPISIRDVLHYLLAAADRDLVPAGAYDIA GPDTTSYRRLLKTYARLSGRWHTGLPVGRVDTGLASLVTGVALPVPPGLAGDLVESLDHPMVASGSDLRQ RVPDPPGGLLGVDDAIARALDDRSYRRPRPVNALADPHHLADTDPGWAGGDARRIRQLAGRVTPAIARPT LGLVNKVPGPVAGAVRTGLDILIALTPKVRPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1281 | - | - | 100% (382) | hypothetical protein MAV_1281 |
| M. avium 104 | MAV_2451 | - | 7e-15 | 27.00% (237) | hypothetical protein MAV_2451 |
| M. avium 104 | MAV_4609 | - | 2e-07 | 34.92% (126) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3752 | - | 6e-08 | 35.29% (119) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2122 | - | 1e-138 | 64.40% (382) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv3725 | - | 7e-08 | 35.29% (119) | oxidoreductase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 3e-07 | 34.17% (120) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 1e-07 | 35.00% (120) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_4312 | - | 1e-159 | 73.35% (379) | hypothetical protein MMAR_4312 |
| M. smegmatis MC2 155 | MSMEG_5189 | - | 1e-147 | 67.72% (378) | oxidoreductase |
| M. thermoresistible (build 8) | TH_4331 | - | 1e-148 | 68.31% (385) | PUTATIVE NAD-dependent epimerase/dehydratase |
| M. ulcerans Agy99 | MUL_0982 | - | 1e-108 | 73.95% (261) | hypothetical protein MUL_0982 |
| M. vanbaalenii PYR-1 | Mvan_4583 | - | 1e-146 | 67.54% (382) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2122|M.gilvum_PYR-GCK -------------------------------------MRTLVTGASGYIG
Mvan_4583|M.vanbaalenii_PYR-1 ----------------------------------MKPVRTLVAGATGYIG
TH_4331|M.thermoresistible__bu ----------------------------------VKNLRVLVTGATGYVG
MSMEG_5189|M.smegmatis_MC2_155 -------------------------------------MRMMVTGATGYVG
MAV_1281|M.avium_104 -------------------------------------MRVLVTGATGYVG
MMAR_4312|M.marinum_M -------------------------------------MRILVTGATGYVG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
Mb3752|M.bovis_AF2122/97 --------------------------------MQNATMRVLVTGGTGFVG
Rv3725|M.tuberculosis_H37Rv --------------------------------MQNATMRVLVTGGTGFVG
MLBr_00204|M.leprae_Br4923 --------------------------------MYGEPVRALVTGAAGFIG
MAB_0503|M.abscessus_ATCC_1997 -------------------------------------MRAMVTGAAGFIG
:* :*:*.:*::*
Mflv_2122|M.gilvum_PYR-GCK SRLVTALLDDGHQVVA----ASRDPSRLADFGWYHDVSTVTLDAHDEISA
Mvan_4583|M.vanbaalenii_PYR-1 SRLVTALLHDGHQVVA----ASRDPARLTEFGWYKDVSTVTLDAHDEISA
TH_4331|M.thermoresistible__bu SRLVTSLLAAGHDVVA----ASRNPRRLTDFGWYDRVTPVALDAHDEDSV
MSMEG_5189|M.smegmatis_MC2_155 SRLVTALLAHDHDVVV----ASRNTVRLTDFGWFPDVRAVRLDAGDADSV
MAV_1281|M.avium_104 SRLVTALLAGGHDVLA----ATRNPLRLKRFGWFDEITPVPLDAADPASL
MMAR_4312|M.marinum_M SRLVTALLADGHEVLA----ATRNMARLSRLAWFDDVTPVILDATDRASA
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLA----ATRNMARLSRLAWFDDVTPVILDATDRASA
Mb3752|M.bovis_AF2122/97 GWTAKAIADAGHSVR----FLVRNPARLKTSVAKLGVDVSDFAVADISDR
Rv3725|M.tuberculosis_H37Rv GWTAKAIADAGHSVR----FLVRNPARLKTSVAKLGVDVSDFAVADISDR
MLBr_00204|M.leprae_Br4923 STLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQ
MAB_0503|M.abscessus_ATCC_1997 STLVDRLLADGHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLD
. . : .* * . .* .
Mflv_2122|M.gilvum_PYR-GCK QQAFTEAG----PIDVVYYLVHGIGQPDFREADNRAAAN-VAAAAKAAGV
Mvan_4583|M.vanbaalenii_PYR-1 RQAFTDAG----PVDVVYYLVHGIGQPGFREADNRAAAN-VASAAKAAGV
TH_4331|M.thermoresistible__bu SAALARAGSGARPVDVIYYLVHGIGQDGFREADNRAAAN-VAAAAKYAGV
MSMEG_5189|M.smegmatis_MC2_155 RDAFGAAG----PVDVVYYLLHGIGEPGFREADNRAATN-LATAARDAGV
MAV_1281|M.avium_104 RSAFAGCG----PVEVVYYLVHAIGQPGFRDADKAAAAN-LAAAAKDAGV
MMAR_4312|M.marinum_M QAAMNAAG----QIDVVYYLVHGIGQPDFRDRDKTAAAN-LAVAARDTGV
MUL_0982|M.ulcerans_Agy99 QAAMNAAG----QIDVVYYLVHGIGQPDFRDRDKTAAAN-LAVAARDTGV
Mb3752|M.bovis_AF2122/97 DSVREALNGCDAVVHSAALVATDPRETSRMLSTNMAGAQNVLGQAVELGM
Rv3725|M.tuberculosis_H37Rv DSVREALNGCDAVVHSAALVATDPRETSRMLSTNMAGAQNVLGQAVELGM
MLBr_00204|M.leprae_Br4923 TILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGV
MAB_0503|M.abscessus_ATCC_1997 AVVAEYSPEVIFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAGV
: : : : .: : * *:
Mflv_2122|M.gilvum_PYR-GCK RRIVYLGGFVPDEDSLSEHLTSRAEVAAALTIDDGPDVVWLGAAIVIGAG
Mvan_4583|M.vanbaalenii_PYR-1 RRIVYLGGFVPDDDSLSEHLTSRAEVAAALTVDGGPDVVWLGAAIVIGAG
TH_4331|M.thermoresistible__bu RRIVYLGGFVPDGEALSEHLSSRAEVAHALHVDGGADVVWLGAAMIIGAG
MSMEG_5189|M.smegmatis_MC2_155 RRIVYLGGFVPEDDTLSDHLAGRAEVAHALGVDGGPEVVWLGAAMIIGAG
MAV_1281|M.avium_104 RRIVYLGGFVPAGEVLSEHLTSRAEVAEALAVPDGPELVWLGAAMIIGAG
MMAR_4312|M.marinum_M RRIVYLGGFVPECEALSQHLSSRAEVAEALAVDDGAELVWLGAAMIIGAG
MUL_0982|M.ulcerans_Agy99 RRIVYLGGFVPECEALSQHLSSRAVVAEALAVDDGAELVWLGAAMIIGAG
Mb3752|M.bovis_AF2122/97 DPIVHVSSFTALFRPNLATLSADLPVAGGTDGYGQS-----KAQIEIYAR
Rv3725|M.tuberculosis_H37Rv DPIVHVSSFTALFRPNLATLSADLPVAGGTDGYGQS-----KAQIEIYAR
MLBr_00204|M.leprae_Br4923 RKIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAG-----KVAGEIYLN
MAB_0503|M.abscessus_ATCC_1997 RKIVHTSSGGSIYGTPKQIPTSETVPTDPHSPYAAG-----KVAGEIYLN
**: .. . : : . *
Mflv_2122|M.gilvum_PYR-GCK STSFEMLRYVADRFLLLPMPEWSVNPIDPIAISDVLHYLVASADPD-VPA
Mvan_4583|M.vanbaalenii_PYR-1 STSFEMLRYVGDRFLLLPMPEWSANPIDPIAISDALHYLVAAADADTVPP
TH_4331|M.thermoresistible__bu STSFEMLRYVGDRFLVLPLPEWSANPIDPISISDVLYYLVAAADADSVPA
MSMEG_5189|M.smegmatis_MC2_155 STSFEILRYVADRFPVMPLPSWLSNPMDPISIRDVLHYLVAAADTDKVPA
MAV_1281|M.avium_104 STSFEMMRYVGDRFPLMPIPSWMDNPIDPISIRDVLHYLLAAADRDLVPA
MMAR_4312|M.marinum_M STSFEMLRYVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVDQVPA
MUL_0982|M.ulcerans_Agy99 STLFEMLRYVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVDQVPA
Mb3752|M.bovis_AF2122/97 GLQDAG-APVNITYPGMVLGPPVGDQFGEAG------EGVRSALWMHVIP
Rv3725|M.tuberculosis_H37Rv GLQDAG-APVNITYPGMVLGPPVGDQFGEAG------EGVRSALWMHVIP
MLBr_00204|M.leprae_Br4923 TFRHLCGLDCSHIAPANVYGPRQ-DPYGEAGVVAIFVQALLSDRPTKVFG
MAB_0503|M.abscessus_ATCC_1997 TFRHLYGLECSHIAPANVYGPRQ-DPHGEAGVVAIFAQALLSGRSTKVFG
: . . : : *
Mflv_2122|M.gilvum_PYR-GCK GAYDIRGPETTTYGDLLRAYARIAGIWRAPVAVYGIDTSLVSKVTGLILP
Mvan_4583|M.vanbaalenii_PYR-1 GAYDISGPETTTYGDLLRTYARVAGVWRAPVAVYGVDIATVSKLTGVVLP
TH_4331|M.thermoresistible__bu GAYDICGPDTTTYGDLLHTYARIAGKWRADLPIRGVDTAVVSRLSAAMLP
MSMEG_5189|M.smegmatis_MC2_155 GAYDICGPETTTYRGVLAAYSRLAGKRRFGVPVCGVATGLASRVSAVALP
MAV_1281|M.avium_104 GAYDIAGPDTTSYRRLLKTYARLSGRWHTGLPVGRVDTGLASLVTGVALP
MMAR_4312|M.marinum_M GAYDICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRITAVTLP
MUL_0982|M.ulcerans_Agy99 GAYDICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRITAG---
Mb3752|M.bovis_AF2122/97 GRGAAW--LIVDVRDVAALHAALLESGRGPR---RYTAG-GHRIPVP---
Rv3725|M.tuberculosis_H37Rv GRGAAW--LIVDVRDVAALHAALLESGRGPR---RYTAG-GHRIPVP---
MLBr_00204|M.leprae_Br4923 DGTHTR--DYVFVDDVVDAFIKASGDAGGGQ---RFNIGTGIETSDR---
MAB_0503|M.abscessus_ATCC_1997 DGGNTR--DYVFVDDVVEAFVRASGPDGGGQ---RFNVGTGVETSDR---
. . : . . .
Mflv_2122|M.gilvum_PYR-GCK VPGGLAADLVESLDFPMIASANGLREFVADPPDGPVSVDDAIRRAVGTP-
Mvan_4583|M.vanbaalenii_PYR-1 VPAGLASDLVESLDYPMMASAEGLRGRVPDPPGGLVGVEDAIRRAAASP-
TH_4331|M.thermoresistible__bu VPGGLAADLVESLDYPMVASADRLHGLVPDPPGGLVGVDDAIARALSSR-
MSMEG_5189|M.smegmatis_MC2_155 VPDGLTADLTVSLEYPMTADGDGIRHVVPDPPGGLLGVDDAIRRALAGG-
MAV_1281|M.avium_104 VPPGLAGDLVESLDHPMVASGSDLRQRVPDPPGGLLGVDDAIARALDDRS
MMAR_4312|M.marinum_M VPHGLVADLVESLDHPMRASGAGLQDKVPEPPGGLLSIEDAITLALAGHA
MUL_0982|M.ulcerans_Agy99 --------------HPAGPAWSGRR------PGGIAGSPD-------GGI
Mb3752|M.bovis_AF2122/97 ----------------------ELAKILGEVAGTTM--------------
Rv3725|M.tuberculosis_H37Rv ----------------------ELAKILGGSPAPRC--------------
MLBr_00204|M.leprae_Br4923 ----------------------QLHTAVSAAVGGPD--------------
MAB_0503|M.abscessus_ATCC_1997 ----------------------QLHSLVAAAAGAPD--------------
Mflv_2122|M.gilvum_PYR-GCK --PRRPVNELIDPHHLADTDPDWAGGDVLRLRQLAGAVTPPLVHPVLGLI
Mvan_4583|M.vanbaalenii_PYR-1 --ARRPVDELTDPHHLADTDPDWAGGDALRLRQLAGAVTPPVARPFLGLI
TH_4331|M.thermoresistible__bu --EARPVDDLLDPHHLATTDPQWAGGDALRIQRLARSVTPSVIHPALGMI
MSMEG_5189|M.smegmatis_MC2_155 --RRKPVNMLPDPHHLADTDPVWAGGDPARLRQLAGAVLPSVTRPALALL
MAV_1281|M.avium_104 YRRPRPVNALADPHHLADTDPGWAGGDARRIRQLAGRVTPAIARPTLGLV
MMAR_4312|M.marinum_M NGPPLPVDALTDPHQLAATDPVWAGGDALRIRRIAEAMTPPIARPTLRWV
MUL_0982|M.ulcerans_Agy99 RGRPARQGPRATRRTTEYRRCHYVGAGRPRER-------APVARRRPDRS
Mb3752|M.bovis_AF2122/97 ----LAVPVPDSALRVAGSVLDQAGPYLPFNTPFTAAGMQYYTQMPEPDD
Rv3725|M.tuberculosis_H37Rv ----WPSRCPIPRCVSRDRCWIKPGP-------------ICLSILRSPRQ
MLBr_00204|M.leprae_Br4923 ----DPEFHPPRLGDLKRSCLDIGLAT------------TVLGWSPQVQL
MAB_0503|M.abscessus_ATCC_1997 ----DPEFHPPRLGDLRQSCLDVGLAK------------RVLGWEPRVPL
Mflv_2122|M.gilvum_PYR-GCK GFVPRPVAAAVRTGLDTFLGMVPRVIPA--
Mvan_4583|M.vanbaalenii_PYR-1 GFVPGPVAAAVRTGLDAVIGLVPKVIPA--
TH_4331|M.thermoresistible__bu DVVPGPVAGAVRTGLDTVLGLAPRVLP---
MSMEG_5189|M.smegmatis_MC2_155 GLLPGPVAGAVRTGLDTMIGLVPKGAR---
MAV_1281|M.avium_104 NKVPGPVAGAVRTGLDILIALTPKVRPA--
MMAR_4312|M.marinum_M NIVPGPLAGALRSSLDILIALTPKVLFA--
MUL_0982|M.ulcerans_Agy99 -----PPTRIHRSGVGRR------------
Mb3752|M.bovis_AF2122/97 SPSEKELGITYRDPRDTVADTVTALRGLGS
Rv3725|M.tuberculosis_H37Rv VCS-----TTHRCRSPTIRRAKKN------
MLBr_00204|M.leprae_Br4923 DDG-------VRRTVEYFRAAQRS------
MAB_0503|M.abscessus_ATCC_1997 ADG-------IRRTVDFFRS----------
*