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QAPELIGGRYELRGVLGRGGMAEVRDAWDKRLGRPVAVKLLYPSVSAHPDTRRRFAIEARAAAALNHPHV VAVHDSGVHDGRHYIVLERLPGQSLADVLAHHGPLPVDHVRAIMRDVLSALRAAHTSGVLHRDIKPANIL FTHFGGVKIADFGVAKSADTPQTLTNRVFGTMAYLPADRIAGRPATPSDDLYALGVVAYEALTARRAYPQ ENLTALADAIAAGHLAPVATLRPDVDPALATTIERSMARDPRWRFATADQMLACLDGPAQRPQRTGVVLA AAALLAVFVLAALLVVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5082 | - | - | 100% (298) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_5401 | - | 6e-81 | 49.10% (332) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_3539 | - | 3e-44 | 38.22% (259) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0015c | pknA | 7e-47 | 39.29% (280) | transmembrane serine/threonine-protein kinase A PKNA |
| M. gilvum PYR-GCK | Mflv_1671 | - | 1e-140 | 82.83% (297) | protein kinase |
| M. tuberculosis H37Rv | Rv0015c | pknA | 7e-47 | 39.29% (280) | transmembrane serine/threonine-protein kinase A PKNA |
| M. leprae Br4923 | MLBr_00017 | pknA | 9e-46 | 39.15% (258) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_0034c | - | 1e-45 | 38.30% (282) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_0017 | pknA | 5e-46 | 39.29% (280) | serine/threonine-protein kinase a PknA |
| M. avium 104 | MAV_0019 | - | 1e-45 | 38.93% (280) | serine/threonine protein kinases Drp72 |
| M. smegmatis MC2 155 | MSMEG_6206 | - | 7e-80 | 55.51% (272) | serine/threonine protein kinase PksC |
| M. thermoresistible (build 8) | TH_2631 | - | 2e-43 | 37.87% (272) | PUTATIVE serine/threonine protein kinase |
| M. ulcerans Agy99 | MUL_0019 | pknA | 3e-46 | 39.29% (280) | serine/threonine-protein kinase a PknA |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0017|M.marinum_M --MSPRVGMTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKQEF
MUL_0019|M.ulcerans_Agy99 --MSPIVGMTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKQEF
MAV_0019|M.avium_104 --------MTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKQEF
Mb0015c|M.bovis_AF2122/97 --MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEF
Rv0015c|M.tuberculosis_H37Rv --MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEF
MLBr_00017|M.leprae_Br4923 --MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEF
MAB_0034c|M.abscessus_ATCC_199 --MTVRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVKVLKAEF
Mvan_5082|M.vanbaalenii_PYR-1 ----MQAPELIGGRYELRGVLGRGGMAEVRDAWDKRLGRPVAVKLLYPSV
Mflv_1671|M.gilvum_PYR-GCK -MEGMQAPEVLGGRYRLGPVLGRGGMAEVRDAWDQRLGRPVAVKLLYPSV
MSMEG_6206|M.smegmatis_MC2_155 MGSAERFQRLLGDRYELRGVLGRGGMAEVRDGWDTRLARPVAIKLLYPAL
TH_2631|M.thermoresistible__bu ----MTTPQHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADL
:..**.* ::. ***.:* . * ** * **:*:* .
MMAR_0017|M.marinum_M SSDPEFIERFRAEARTTAMLNHPGIAAVHDYGESQMNGEGRTAYLVMELV
MUL_0019|M.ulcerans_Agy99 SSDPEFIERFRAEARTTAMLNHPGIAAVHDYGESQMNGEGRTAYLVMELV
MAV_0019|M.avium_104 SQDPEFIERFRAEARTTAMLNHPGIAAVHDYGESQLDGEGRTAYLVMELV
Mb0015c|M.bovis_AF2122/97 SSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELV
Rv0015c|M.tuberculosis_H37Rv SSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELV
MLBr_00017|M.leprae_Br4923 SSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELV
MAB_0034c|M.abscessus_ATCC_199 SSDPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAYLVMELI
Mvan_5082|M.vanbaalenii_PYR-1 SAHPDTRRRFAIEARAAAALNHPHVVAVHDSGVHDG-----RHYIVLERL
Mflv_1671|M.gilvum_PYR-GCK STQPDTRRRFATEARAAAALNHPHVVAVHDTGVHEG-----RHYIVLERL
MSMEG_6206|M.smegmatis_MC2_155 AADADLRARFEREARAAAALTHPHVVAVHDCGEHAG-----TPYIVMERL
TH_2631|M.thermoresistible__bu ARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETP-TGPLPYIVMEYV
: ... ** **: .* *.** :.:*:* * *:*:* :
MMAR_0017|M.marinum_M NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNIL
MUL_0019|M.ulcerans_Agy99 NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNIL
MAV_0019|M.avium_104 NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNIL
Mb0015c|M.bovis_AF2122/97 NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNIL
Rv0015c|M.tuberculosis_H37Rv NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNIL
MLBr_00017|M.leprae_Br4923 NGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNIL
MAB_0034c|M.abscessus_ATCC_199 HGEPLNSVLKRTGRLSLRHSLDMLEQTGRALQVAHAAGLVHRDVKPGNIL
Mvan_5082|M.vanbaalenii_PYR-1 PGQSLADVLAHHGPLPVDHVRAIMRDVLSALRAAHTSGVLHRDIKPANIL
Mflv_1671|M.gilvum_PYR-GCK PGQNLADLLARHGPLPVEQVRAILRDVLSALSAAHLSGVLHRDIKPANIL
MSMEG_6206|M.smegmatis_MC2_155 SGATLADEIA-AGPLPQERVAELLDQILSALIAAHAAGIVHRDIKPGNIL
TH_2631|M.thermoresistible__bu DGVTLRDIVHTDGPMEPKRAIEVIADACQALNFSHQHGIIHRDVKPANIM
* * . : * : : :: : ** :* *::***:**.**:
MMAR_0017|M.marinum_M ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGQDASPS
MUL_0019|M.ulcerans_Agy99 ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGQDASPS
MAV_0019|M.avium_104 ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGHDATPA
Mb0015c|M.bovis_AF2122/97 ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGHDASPA
Rv0015c|M.tuberculosis_H37Rv ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGHDASPA
MLBr_00017|M.leprae_Br4923 ITPTGQVKITDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGHDATPA
MAB_0034c|M.abscessus_ATCC_199 ITPTGQVKLTDFGIAK-AVDAAPVTQTGMVMGTAQYIAPEQALGHDATPA
Mvan_5082|M.vanbaalenii_PYR-1 FTHFGGVKIADFGVAK--SADTPQTLTNRVFGTMAYLPADRIAGRPATPS
Mflv_1671|M.gilvum_PYR-GCK FTEFGGVKIADFGVAK--SPDTPQTLTNRVFGTMAYLPSDRIAGRPATPS
MSMEG_6206|M.smegmatis_MC2_155 IGHTGQAKLADFGIAK--TDGVPHTQAGQILGTMAYLSPQRVTGQPAGFA
TH_2631|M.thermoresistible__bu ISKTGAVKVMDFGIARAIADSNSVTQTAAVIGTAQYLSPEQARGETVDAR
: * .*: ***:*: . * : ::** *:..:: *. .
MMAR_0017|M.marinum_M SDVYSLGVVGYEAVSGKRPFTGDGALTVAMKHIKEPPPP---LPAELPPN
MUL_0019|M.ulcerans_Agy99 SDVYSLGVVGYEAVSGKRPFTGDGALTVAMKHIKEPPPP---LPAELPPN
MAV_0019|M.avium_104 SDVYSLGVVGYEVVSGKRPFSGDGALTVAMKHIKEPPPP---LPAELPPN
Mb0015c|M.bovis_AF2122/97 SDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPP---LPPDLPPN
Rv0015c|M.tuberculosis_H37Rv SDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPP---LPPDLPPN
MLBr_00017|M.leprae_Br4923 SDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPP---LPADLPPN
MAB_0034c|M.abscessus_ATCC_199 SDVYSLGVVGYEAVSGKRPFSGDGALTVAMKHIKETPSP---LPADLPPN
Mvan_5082|M.vanbaalenii_PYR-1 DDLYALGVVAYEALTARRAYPQENLTALADAIAAGHLAPVATLRPDVDPA
Mflv_1671|M.gilvum_PYR-GCK DDLYALGVVAYEALTGRRAYPQDNLSALADAIAAGRLAPLTSVRPDVDPA
MSMEG_6206|M.smegmatis_MC2_155 DDLYAVGVVGYEALTGRRPFDRDNPAAMVRAILDDVPVPIASVRSDVAPG
TH_2631|M.thermoresistible__bu SDVYSLGCVLYEILTGEPPFVGDSPVAVAYQHVREDPVPPSRRNPAVSPE
.*:*::* : ** ::.. .: :. ::. * . : *
MMAR_0017|M.marinum_M VRELIEITLVKNPGLRYRSGGPFADAVAAVRAGRRPPRPSQSPPAGRAAP
MUL_0019|M.ulcerans_Agy99 VRELIEITLVKNPGLRYRSGGPFADAVAAVRAGRRPPRPSQSPPAGRAAP
MAV_0019|M.avium_104 VRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQSPPPGRASP
Mb0015c|M.bovis_AF2122/97 VRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAP
Rv0015c|M.tuberculosis_H37Rv VRELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAP
MLBr_00017|M.leprae_Br4923 VRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRPNQTPSSGRASP
MAB_0034c|M.abscessus_ATCC_199 VRELIEITLVKNPQNRYTSGGPFADAVAAVRAGRRPPRPNQAPTISRATP
Mvan_5082|M.vanbaalenii_PYR-1 LATTIERSMARDPRWRFATADQMLACLD----------------------
Mflv_1671|M.gilvum_PYR-GCK LAATIERAIARDPRWRFATAEQMRRSLD----------------------
MSMEG_6206|M.smegmatis_MC2_155 LIHVIDMAMAREVAFRYPDAATMRAALT----------------------
TH_2631|M.thermoresistible__bu LDAVVLKALAKNPDNRYQTAAEMRADLVRVHSGEQPEAPKVLTDAERTSL
: : ::.:: *: . : :
MMAR_0017|M.marinum_M AAIPSSAPARIAPAPTTRTTTPR-RTRPATGGHRPPPA-RRTFSSGQRAL
MUL_0019|M.ulcerans_Agy99 AAIPSSAPARIAPAPTTRTTTPR-RTRPATGGHRPPPS-RRTFSSGQRAL
MAV_0019|M.avium_104 AAIPSSPTTRAAAVSSGRTAAPR-RTRPATGGHRPPPA-RRTFSSGQRAL
Mb0015c|M.bovis_AF2122/97 AAIPSGTTARVAANSAGRTAASR-RSRPATGGHRPP---RRTFSSGQRAL
Rv0015c|M.tuberculosis_H37Rv AAIPSGTTARVAANSAGRTAASR-RSRPATGGHRPP---RRTFSSGQRAL
MLBr_00017|M.leprae_Br4923 TTIPSSTQARAAVACGTKTPAPR-RSRPSTSGNRPPPA-RNTFSSGQRAL
MAB_0034c|M.abscessus_ATCC_199 AAIPPATQVRPAVGAPSRVAPPTSRTRQPTGSHRPPPPRRGTFSPGQKAL
Mvan_5082|M.vanbaalenii_PYR-1 -GPAQRPQRTG-----------------------------VVLAAAALLA
Mflv_1671|M.gilvum_PYR-GCK -PPPPRAGRAG-----------------------------AVLAVAAILL
MSMEG_6206|M.smegmatis_MC2_155 -GAEPPTQRVGRRQTKVLAAPLPPIPPPPVLPSPRHWRTRLILAVLGIVS
TH_2631|M.thermoresistible__bu LASGPAHDRTQPTDAVIDPVIPRYTGSDRGGSVGRWVAAVAVLAVLTVVV
::
MMAR_0017|M.marinum_M LWAAGVLG------------------ALAIIIAVLIVINSRAD-SQQQPP
MUL_0019|M.ulcerans_Agy99 LWAAGVLG------------------ALAIIIAVLIVINSRAD-SQQQSP
MAV_0019|M.avium_104 LWAAGVLG------------------ALAIIIAVLIVINSRAD-QQQQ--
Mb0015c|M.bovis_AF2122/97 LWAAGVLG------------------ALAIIIAVLLVIKAPGDNSPQQAP
Rv0015c|M.tuberculosis_H37Rv LWAAGVLG------------------ALAIIIAVLLVIKAPGDNSPQQAP
MLBr_00017|M.leprae_Br4923 LWAAGMLG------------------ALAIIIAVLIVINSYAGNEQHQPP
MAB_0034c|M.abscessus_ATCC_199 MWAAAVLG------------------IFAIIIAALILLQASEKKNQTPSI
Mvan_5082|M.vanbaalenii_PYR-1 VFVLAAL-------------------LVVV--------------------
Mflv_1671|M.gilvum_PYR-GCK IVALVAL-------------------LVVA--------------------
MSMEG_6206|M.smegmatis_MC2_155 TLILVLV-------------------LALARGSSGLTSPTSTPTATTVPP
TH_2631|M.thermoresistible__bu TVAINMIGGNPRNVQVPDVSGQASADAIAALQNRGFKTRTQQQPDNSVPP
:
MMAR_0017|M.marinum_M PPTVTQTTTAHQTPTGQGPRLNWTEGKAIGNPGLQSNQPDLVDDAGRNRP
MUL_0019|M.ulcerans_Agy99 PPTVTQTTTAHQTPTGQGPRLNWTDGQSIGNPGLQSNQPDLVDDAGRNRP
MAV_0019|M.avium_104 PPTVTDTG----TPPASAPPPTKTPSGSGAHPGLRLDWP----DDGTIGA
Mb0015c|M.bovis_AF2122/97 TPTVTTTG----NPPASN------TGGTDASP--RLNWT----ERGETRH
Rv0015c|M.tuberculosis_H37Rv TPTVTTTG----NPPASN------TGGTDASP--RLNWT----ERGETRH
MLBr_00017|M.leprae_Br4923 TPTVTDTG----TPPATKT----LSGFPAAYCEYRVNWT----NHKEISN
MAB_0034c|M.abscessus_ATCC_199 PATVSGSE----TPSSPGS----ASPGALAPANIVALLP----DAEPDPI
Mvan_5082|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1671|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 ATSAVVPPPVPSTPVP-----------AAVPEEPRGPGRGPGPGPGPGKG
TH_2631|M.thermoresistible__bu DRVISTDPPADTSVSAGDEITVNVSTGPQQREIPDVSSLTYAEAVRRLSA
MMAR_0017|M.marinum_M IGNR-GSATSWNVTVTPQHLAALARFEMQR--------------------
MUL_0019|M.ulcerans_Agy99 IGNR-DSATSWNVTVTPQHRAALARFEMQR--------------------
MAV_0019|M.avium_104 SGFRDGPARHWTSQ------------------------------------
Mb0015c|M.bovis_AF2122/97 SGLQ-----SWVVPPTPHSRASLARYEIAQ--------------------
Rv0015c|M.tuberculosis_H37Rv SGLQ-----SWVVPPTPHSRASLARYEIAQ--------------------
MLBr_00017|M.leprae_Br4923 SGLP-----KQAARAQLAGAIDISPVAGQT--------------------
MAB_0034c|M.abscessus_ATCC_199 PGTK--------SP------------------------------------
Mvan_5082|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1671|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 KGHEKGHGPKGPKGPPHP--------------------------------
TH_2631|M.thermoresistible__bu AGFEKFRQSESPSTPELRGKVVATNPPANQTAAITNEITVVVGTGPATRE
MMAR_0017|M.marinum_M --------------------------------------------------
MUL_0019|M.ulcerans_Agy99 --------------------------------------------------
MAV_0019|M.avium_104 --------------------------------------------------
Mb0015c|M.bovis_AF2122/97 --------------------------------------------------
Rv0015c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5082|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1671|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 --------------------------------------------------
TH_2631|M.thermoresistible__bu VPDITGQTVELAERNLSVYGFTKFTQSAVDSTAPAGQVVGTNPPAGTTVS
MMAR_0017|M.marinum_M --------------------------------------------------
MUL_0019|M.ulcerans_Agy99 --------------------------------------------------
MAV_0019|M.avium_104 --------------------------------------------------
Mb0015c|M.bovis_AF2122/97 --------------------------------------------------
Rv0015c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5082|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1671|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 --------------------------------------------------
TH_2631|M.thermoresistible__bu LDSVIELEVSKGNQFVMPDLIGMFWTDAEPRLRALGWTGVLDKGADIPNS
MMAR_0017|M.marinum_M ------------------------------
MUL_0019|M.ulcerans_Agy99 ------------------------------
MAV_0019|M.avium_104 ------------------------------
Mb0015c|M.bovis_AF2122/97 ------------------------------
Rv0015c|M.tuberculosis_H37Rv ------------------------------
MLBr_00017|M.leprae_Br4923 ------------------------------
MAB_0034c|M.abscessus_ATCC_199 ------------------------------
Mvan_5082|M.vanbaalenii_PYR-1 ------------------------------
Mflv_1671|M.gilvum_PYR-GCK ------------------------------
MSMEG_6206|M.smegmatis_MC2_155 ------------------------------
TH_2631|M.thermoresistible__bu GQRANAVVRQNPSPGAGVNYDARITLNFAS