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METYQRSSPLTGAVLDGRYRVDSLIATGGMSAVYRGLDQRLDRPVALKIMDSRYAGDQDFLTRFQREARA VARLKDPGLVAVYDQGIDGQHPFLVMELVEGGTLRELLRERGPMPPHAVAAVLRPVLSGLAAAHSAGLVH RDIKPENVLISDDGEVKIADFGLVRAVAEAKITSTSVILGTAAYLSPEQVATGETDSRGDVYSVGILVYE LLTGRTPFTGDTALAVAYQRMDRDVAPPSTVIDGVPRQFDDLVLCATSRDPADRFADAAEMAEELETIVR ELALPQFRVPAPRNSALHNSANTSTVSQDAHDTTVHLDKPDPAGPVNRDTRVFSRDELPVDDGYDDEYRS TAGRFAGIELDEFYWARQRSRRVLFFWVVAVITLAALAAAGAWTLGTNLSNLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3539 | - | - | 100% (403) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_0023 | - | 9e-60 | 43.82% (267) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_0024 | - | 2e-55 | 37.42% (318) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2198 | pknL | 1e-143 | 65.25% (400) | transmembrane serine/threonine-protein kinase L |
| M. gilvum PYR-GCK | Mflv_2972 | - | 1e-179 | 77.72% (413) | protein kinase |
| M. tuberculosis H37Rv | Rv2176 | pknL | 1e-143 | 65.50% (400) | transmembrane serine/threonine-protein kinase L |
| M. leprae Br4923 | MLBr_00897 | - | 1e-136 | 62.00% (400) | serine-threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_1988c | - | 1e-138 | 61.12% (427) | serine/threonine protein kinase |
| M. marinum M | MMAR_3211 | pknL | 1e-146 | 66.50% (403) | transmembrane serine/threonine-protein kinase L PknL |
| M. avium 104 | MAV_2318 | - | 1e-145 | 64.65% (413) | serine-threonine protein kinase |
| M. smegmatis MC2 155 | MSMEG_4243 | - | 1e-155 | 68.50% (419) | serine/threonine-protein kinase PK-1 |
| M. thermoresistible (build 8) | TH_2610 | - | 1e-134 | 75.23% (331) | PUTATIVE serine/threonine protein kinase |
| M. ulcerans Agy99 | MUL_3519 | pknL | 1e-148 | 66.25% (403) | transmembrane serine/threonine-protein kinase L PknL |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2198|M.bovis_AF2122/97 -------------------MVEAGTRDPLESALLDSRYLVQAKIASGGTS
Rv2176|M.tuberculosis_H37Rv -------------------MVEAGTRDPLESALLDSRYLVQAKIASGGTS
MMAR_3211|M.marinum_M MARAEFPGSFADRVGPHRGRIEAGIGDQLDGALLDGRYLVGARIASGGTS
MUL_3519|M.ulcerans_Agy99 MARAEFPGSFADRVGPHRGRIEAGIGDQLDGALLDGRYLVGARIASGGTS
MLBr_00897|M.leprae_Br4923 --------------------------------MLDGRYLLKAKIGNGGTA
MAV_2318|M.avium_104 MAQAESPGSSSGRPGPHRRQAQAESPGSFAGTLLDGRYLIESKIASGGTS
Mvan_3539|M.vanbaalenii_PYR-1 -------------------METYQRSSPLTGAVLDGRYRVDSLIATGGMS
Mflv_2972|M.gilvum_PYR-GCK ----------------MIPMETYQQPSPLTGVVLDGRYQVDTLIAAGGTS
MSMEG_4243|M.smegmatis_MC2_155 ---------------------MEQQSDPLVGSLLDGRYRVDMPIATGGMS
TH_2610|M.thermoresistible__bu -------------------VETYQQSDPFAGTVLDGRYRIDTLIATGGMS
MAB_1988c|M.abscessus_ATCC_199 ---------------MTSPKSPTGRLDPMIGAVLDGRYRIEAPIATGGMS
:**.** : *. ** :
Mb2198|M.bovis_AF2122/97 TVYRGLDVRLDRPVALKVMDARYAGDEQFLTRFRLEARAVARLNNRALVA
Rv2176|M.tuberculosis_H37Rv TVYRGLDVRLDRPVALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVA
MMAR_3211|M.marinum_M TVYRGLDVRLDRPVALKVMDSRYAGDQQFLTRFQLEARTVARLKNPGLVA
MUL_3519|M.ulcerans_Agy99 TVYRGLDVRLDRPVALKVMDSRYAGDQQFLTRFQLEARTVARLKNPGLVA
MLBr_00897|M.leprae_Br4923 TVYRGVDIRLDRPVAVKVMDSRYTGDEQLLTRFQLEARSVARLKDPGLVA
MAV_2318|M.avium_104 TVYRGVDTRLDRPVAVKVMDPRYAGDEQFLTRFQREARAVARLKDPGLVA
Mvan_3539|M.vanbaalenii_PYR-1 AVYRGLDQRLDRPVALKIMDSRYAGDQDFLTRFQREARAVARLKDPGLVA
Mflv_2972|M.gilvum_PYR-GCK DVYRGLDLRLDRPVALKIMDSRYAGDEHFMTRFQREARAVARLKDPGLVA
MSMEG_4243|M.smegmatis_MC2_155 TVYRGLDTRLDRPVALKVMDSRYAGDEHFLTRFQREARAVARLKAPGLVA
TH_2610|M.thermoresistible__bu AVYRGLDLRLDRPVAVKVMDSRYAGDQQFLTRFQREARAAARLKDPGLVA
MAB_1988c|M.abscessus_ATCC_199 TVYRGLDTRLDRPVAVKVMDSRYASDSGFLARFRLEARAVARLRHPGLVA
****:* *******:*:**.**:.*. :::**: ***:.***. .***
Mb2198|M.bovis_AF2122/97 VYDQGKDG----RHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVL
Rv2176|M.tuberculosis_H37Rv VYDQGKDG----RHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVL
MMAR_3211|M.marinum_M VYDQGLDA----RHPFLVMELIEGGTLRELLSERGPMPPHAVAAVLRPVL
MUL_3519|M.ulcerans_Agy99 VYDQGLDA----RHPFLVMELIEGGTLRELLSERGPMPPHAVAAVLRPVL
MLBr_00897|M.leprae_Br4923 VYDQGIDA----RHPFLVMELIEGGTLRELLAERGPMPPHAVVAVLRPVL
MAV_2318|M.avium_104 VYDQGLDA----RHPFLVMELIEGGTLRELLGERGPMPPYAVAAVLRPVL
Mvan_3539|M.vanbaalenii_PYR-1 VYDQGIDG----QHPFLVMELVEGGTLRELLRERGPMPPHAVAAVLRPVL
Mflv_2972|M.gilvum_PYR-GCK VYDQGLDG----RHPFLVMELIEGGTLRELLRERGPMPPHAVAAVLRPVL
MSMEG_4243|M.smegmatis_MC2_155 VYDQGLDRRSERQYPFLVMELIEGGTLRELLTERGPMPPHAVAAVLEPVL
TH_2610|M.thermoresistible__bu VYDQGPGS-PASHPPYLVMELIEGGTLRELLRERGPMPPHAAAAVLAPVL
MAB_1988c|M.abscessus_ATCC_199 VFDQGMDG----RHPFLVMELIDGGTLRELLRERGPMPPHAVAAVFNPLL
*:*** . : *:*****::******** *******:*..**: *:*
Mb2198|M.bovis_AF2122/97 GGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGV
Rv2176|M.tuberculosis_H37Rv GGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGV
MMAR_3211|M.marinum_M GGLATAHRAGLVHRDVKPENILISDDGDVKIADFGLVRAVAAAGITSTSV
MUL_3519|M.ulcerans_Agy99 GGLATAHRAGLVHRDVKPENILISDDGDVKIADFGLVRAVAAAGITSTSV
MLBr_00897|M.leprae_Br4923 GGLAAAHRAGLVHRDVKPENILISDDGDVKIADFGLVRAVAAAGITSTSV
MAV_2318|M.avium_104 GGLAAAHRAGLVHRDVKPENVLISDDGEVKIADFGLVRAVAAAGITSASV
Mvan_3539|M.vanbaalenii_PYR-1 SGLAAAHSAGLVHRDIKPENVLISDDGEVKIADFGLVRAVAEAKITSTSV
Mflv_2972|M.gilvum_PYR-GCK GGLAAAHAAGLVHRDIKPENVLISDDGDVKIADFGLVRAVAEAKITSTSV
MSMEG_4243|M.smegmatis_MC2_155 GGLAVAHRNGLVHRDIKPENVLISDDGEVKIADFGLVRAVAEAKITSTSV
TH_2610|M.thermoresistible__bu GGLAVAHRAGLVHRDIKPENVLISDDGEVKIADFGLVRAVAEAKITSDSV
MAB_1988c|M.abscessus_ATCC_199 GGLAVAHRSGLVHRDVKPENVLISDDGEVKLADFGLVRAVAEAGITSTSV
.***.** ******:****:******:**:********** * *** .*
Mb2198|M.bovis_AF2122/97 ILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIA
Rv2176|M.tuberculosis_H37Rv ILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIA
MMAR_3211|M.marinum_M ILGTAAYLSPEQVRDGNAGPRSDVYSAGILTYELLTGATPFTGDTALSIA
MUL_3519|M.ulcerans_Agy99 ILGTAAYLSPEQVRDGNAGPRSDVYSAGILTYELLTGATPFTGDTALSIA
MLBr_00897|M.leprae_Br4923 ILGTVAYLSPEQVRDGDASPRSDVYSAGIMTYELLTGHTPFTGDSALSIA
MAV_2318|M.avium_104 ILGTAAYLSPEQVRDGAATPRSDVYAAGILAYELLTGRTPFTGDSTLAIA
Mvan_3539|M.vanbaalenii_PYR-1 ILGTAAYLSPEQVATGETDSRGDVYSVGILVYELLTGRTPFTGDTALAVA
Mflv_2972|M.gilvum_PYR-GCK ILGTAAYLSPEQVATGETDSRGDVYSVGVMVYELLTGRTPFTGDSSLAVA
MSMEG_4243|M.smegmatis_MC2_155 ILGTAAYLSPEQVATGDADPRSDVYAVGILTFELLTGTTPFTGDSALAVA
TH_2610|M.thermoresistible__bu ILGTAAYLSPEQVATGDATPRSDVYAVGILTYEMLTGNTPFTGDNALALA
MAB_1988c|M.abscessus_ATCC_199 ILGTAAYLSPEQVRTGSAGPRSDVYSAGILMYELLTGSTPFTGDTPLALA
****.******** * : .*.***:.*:: :*:*** ******..*::*
Mb2198|M.bovis_AF2122/97 YQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEA
Rv2176|M.tuberculosis_H37Rv YQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEA
MMAR_3211|M.marinum_M YQRLDHDVPPASAVITGVPTQFDEFVACATARDPGERYADAIEMAADLDA
MUL_3519|M.ulcerans_Agy99 YQRLDHDVPPASAVITGVPTQFDEFVACATARDPSERYADAIEMAADLDA
MLBr_00897|M.leprae_Br4923 YQRLEIDVPRASTVITGVPQQFDELVARATVRDPSGRYADAIEMAAQVDS
MAV_2318|M.avium_104 YRRLDADVPPPSAAIDGVPAQFDDFVQRATARDPADRYADAVEMGADLDA
Mvan_3539|M.vanbaalenii_PYR-1 YQRMDRDVAPPSTVIDGVPRQFDDLVLCATSRDPADRFADAAEMAEELET
Mflv_2972|M.gilvum_PYR-GCK YQRMDRDVPPPSAAIRGVPRQFDDLVHCATARDPAGRFADAAEMADQLDV
MSMEG_4243|M.smegmatis_MC2_155 YQRMDHDVPPPSTRIAGVPRQFDDLVRRAATRDPAGRYADAGEMVAALDV
TH_2610|M.thermoresistible__bu YQRLDNDVPPPSSAISGVPPQFDELVATATARDPADRFADAHDMAAAVAD
MAB_1988c|M.abscessus_ATCC_199 YQRIDRDVQAPSEAIDGVPEEFDELVLRATSRDPDARYADAAQFGAELDA
*:*:: ** .* * *** :**::* *: *:* *:*** : :
Mb2198|M.bovis_AF2122/97 IAEELALPEFRVPAPRNSAQHRSAALYRSRITQQ----------GQLGAK
Rv2176|M.tuberculosis_H37Rv IAEELALPEFRVPAPRNSAQHRSAALYRSRITQQ----------GQLGAK
MMAR_3211|M.marinum_M IVEELALPEFRVPAPRNSAQHRSAALQHSRVNQHRPFEA----SAQVSAS
MUL_3519|M.ulcerans_Agy99 IVEELALPEFRVPAPRNSAQHRSAALQHSRVNQHRPFEA----SDQVSAS
MLBr_00897|M.leprae_Br4923 IAEELALPPFRVPAPRNTAQYRSAALHRGHMVERPVEQQ----VQPVVNA
MAV_2318|M.avium_104 IADELALPGFRVPAPRNSALHRSAALHREAGRRAP------------GAE
Mvan_3539|M.vanbaalenii_PYR-1 IVRELALPQFRVPAPRNSALHNSANTSTVSQDAHD------------TT-
Mflv_2972|M.gilvum_PYR-GCK IVRELDLPHFRVPAPKVSASHSSADTTAVTARTNQ------------PTN
MSMEG_4243|M.smegmatis_MC2_155 IIDELGLPPFRVPAPRNSAQHLAATRFHNRPQPDL------------ETT
TH_2610|M.thermoresistible__bu LVAELELPPFRVPAPRNSAQHLSAIRQHSQSAR---------------PT
MAB_1988c|M.abscessus_ATCC_199 ISSELRLPPFRVPAPRDSKQHVAEQLYRSRLIDSGGNTTGNLSAPGQADA
: ** ** ******: : : :
Mb2198|M.bovis_AF2122/97 P-VHHPTRQLTRQPGDCSEP-----------ASGSEP----------EHE
Rv2176|M.tuberculosis_H37Rv P-VHHPTRQLTRQPGDCSEP-----------ASGSEP----------EHE
MMAR_3211|M.marinum_M PHGRQPTRELPREPENHNEPP-----GADFDDESDEY----------EYE
MUL_3519|M.ulcerans_Agy99 PHGRQPTRELPREPENHNEPH-----GSDFDDESDEY----------EYE
MLBr_00897|M.leprae_Br4923 P-MPHSTRQFTRRLRDCSAPRR---PARPDIDSPEEY----------EYE
MAV_2318|M.avium_104 PPARHPTRHLTRGPEEWPQPEPPAHVGAEPDDDEDDY----------EYQ
Mvan_3539|M.vanbaalenii_PYR-1 VHLDKPDPAGP-----VNRDTRVFSRDELPVDDGYDD----------EYR
Mflv_2972|M.gilvum_PYR-GCK TRVFSRDELPA-----FDDDT----DDDSEADTEYD-----------EYP
MSMEG_4243|M.smegmatis_MC2_155 AEVAPPPPAPATVPRQHTREITRDQQDWAPIPAAPADDEYAGEYDEYDYS
TH_2610|M.thermoresistible__bu TTLQPPXXXGAGGRARVATEIG----DRIGIVDQPP--------------
MAB_1988c|M.abscessus_ATCC_199 ADAASAAAALGVSARPSTPPRPRVPNPTRMMDPVPAYDAG-YDEEFDGEP
Mb2198|M.bovis_AF2122/97 PITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNL
Rv2176|M.tuberculosis_H37Rv PITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNL
MMAR_3211|M.marinum_M PVSGQFAGISMNEFAWARQHARRTVLIWVAVVLAITGMVAAAAWTIGSNL
MUL_3519|M.ulcerans_Agy99 PVSGQFAGISLNEFAWARQHARRTVLIWVAVVLAITGMVAAAAWTIGSNL
MLBr_00897|M.leprae_Br4923 PVPDRFAGIAISEFIWARQHARRMVLIWVGVVVAIAGLVATVAWTIGSHL
MAV_2318|M.avium_104 SVTGEFAGIPISEFVWARQHNRRMVLVWLALVLAVTGMVATAAWTIGRNL
Mvan_3539|M.vanbaalenii_PYR-1 STAGRFAGIELDEFYWARQRSRRVLFFWVVAVITLAALAAAGAWTLGTNL
Mflv_2972|M.gilvum_PYR-GCK SHTGHFAGVELEHFYWARQRARRALLFWVIAVITLAGLAAAGAWTLGANL
MSMEG_4243|M.smegmatis_MC2_155 TVSGQFAGIDMAEFYWARQRAKRMVLMWVIAVLTVTGLTAAAAWTLGSNI
TH_2610|M.thermoresistible__bu ---------------------------------TARGRHANAVRTAFRND
MAB_1988c|M.abscessus_ATCC_199 DESAFFADIDDSDYRYERQQSRRAIFIWLVIVLILTSSVAAGCWSLGANI
. * : :
Mb2198|M.bovis_AF2122/97 SGLL-
Rv2176|M.tuberculosis_H37Rv SGLL-
MMAR_3211|M.marinum_M SGLL-
MUL_3519|M.ulcerans_Agy99 SGLL-
MLBr_00897|M.leprae_Br4923 SGLL-
MAV_2318|M.avium_104 NGLF-
Mvan_3539|M.vanbaalenii_PYR-1 SNLL-
Mflv_2972|M.gilvum_PYR-GCK PNLI-
MSMEG_4243|M.smegmatis_MC2_155 ATLIQ
TH_2610|M.thermoresistible__bu E----
MAB_1988c|M.abscessus_ATCC_199 TNLL-