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TGRETLVGRYELRGLLGCGGMAEVRDGWDIRLDRPVAVKLLHPNFNADADARARFCDEARSAAALSHPNI VAVHDFGEHDGRPFIVMERLPGRTLADLIAQGPMAPAQVRAMLDDVLAALDVAHTAGVVHRDIKPGNILL SATGDRMQVADFGIAKSGGAAHTMTGQIVGTLCYMSPERVSGAPASVADDLYAVGVMGYEALLARRAFPQ ESPVALVRAIVDAPPPALAGLTGGADPVLAAVIDRAMSRDPRRRFGSAAQMRAALAGDVTALSTAAEPRP LTKVLAAPLPPSAAYPAPAPRRPATRARRYVVGAAAVMTAFVISALALAMDPFSSSAPRPEPVSTSTSAP SPTTPPPPPITTPPPSPAPAVTAATQQPEPQQGRDDKGPRGNGRGNGKGKGEKKD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5401 | - | - | 100% (406) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_5082 | - | 9e-81 | 49.10% (332) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 2e-56 | 36.68% (398) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2115 | pknJ | 3e-53 | 37.31% (386) | transmembrane serine/threonine-protein kinase J |
| M. gilvum PYR-GCK | Mflv_1389 | - | 1e-145 | 66.83% (416) | protein kinase |
| M. tuberculosis H37Rv | Rv2088 | pknJ | 3e-53 | 37.31% (386) | transmembrane serine/threonine-protein kinase J |
| M. leprae Br4923 | MLBr_00897 | - | 7e-50 | 40.53% (301) | serine-threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_0034c | - | 9e-50 | 32.78% (421) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_0016 | pknB | 4e-50 | 37.11% (353) | serine/threonine-protein kinase B PknB |
| M. avium 104 | MAV_3463 | - | 2e-53 | 35.83% (360) | protein kinase/peptidyl-prolyl cis-trans isomerase, |
| M. smegmatis MC2 155 | MSMEG_6206 | - | 1e-102 | 53.65% (397) | serine/threonine protein kinase PksC |
| M. thermoresistible (build 8) | TH_2610 | - | 2e-48 | 40.20% (306) | PUTATIVE serine/threonine protein kinase |
| M. ulcerans Agy99 | MUL_0018 | pknB | 3e-50 | 37.39% (353) | serine/threonine-protein kinase B PknB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5401|M.vanbaalenii_PYR-1 --------MTGRETLVGRYELRGLLGCGGMAEVRDGWDIRLDRPVAVKLL
Mflv_1389|M.gilvum_PYR-GCK --------MT-AEMLAGRYELRGLLGRGGMAEVRDGWDTRLDRSVAVKLL
MSMEG_6206|M.smegmatis_MC2_155 ----MGSAERFQRLLGDRYELRGVLGRGGMAEVRDGWDTRLARPVAIKLL
MMAR_0016|M.marinum_M --------MTTPQHLSDRYELGDILGFGGMSEVHLARDLRLHRDVAVKVL
MUL_0018|M.ulcerans_Agy99 --------MTTPQHLSDRYELGDILGFGGMSEVHLARDLRLHRDVAVKVL
MLBr_00897|M.leprae_Br4923 -------------MLDGRYLLKAKIGNGGTATVYRGVDIRLDRPVAVKVM
TH_2610|M.thermoresistible__bu VETYQQSDPFAGTVLDGRYRIDTLIATGGMSAVYRGLDLRLDRPVAVKVM
MAB_0034c|M.abscessus_ATCC_199 ------MTVRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVKVL
MAV_3463|M.avium_104 --------MTLDPDSFGHYRILELLGRGGMGRVYRAYDATTDRVVALKVL
Mb2115|M.bovis_AF2122/97 -----MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVL
Rv2088|M.tuberculosis_H37Rv -----MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVL
* : :. ** . * . : * *:*::
Mvan_5401|M.vanbaalenii_PYR-1 HPNFNADADARARFCDEARSAAALSHPNIVAVHDFG-----EHDGRPFIV
Mflv_1389|M.gilvum_PYR-GCK YPSQSSDDSVRRRFEDEARSAARLSHPNIVAIHDFG-----EHDSAPFIV
MSMEG_6206|M.smegmatis_MC2_155 YPALAADADLRARFEREARAAAALTHPHVVAVHDCG-----EHAGTPYIV
MMAR_0016|M.marinum_M RADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGE-AETPSGPLPYIV
MUL_0018|M.ulcerans_Agy99 RADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGE-AETPSGPLPYIV
MLBr_00897|M.leprae_Br4923 DSRYTGDEQLLTRFQLEARSVARLKDPGLVAVYDQG---IDARHP--FLV
TH_2610|M.thermoresistible__bu DSRYAGDQQFLTRFQREARAAARLKDPGLVAVYDQGP-GSPASHPP-YLV
MAB_0034c|M.abscessus_ATCC_199 KAEFSSDPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAYLV
MAV_3463|M.avium_104 PPHLAEDQDFQQRFRREARIAAGLNDPHVVPIHGYG-----EIDGQLYVD
Mb2115|M.bovis_AF2122/97 AAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRG-----QFEGRLWIA
Rv2088|M.tuberculosis_H37Rv AAELSRDLDFRARFVREADVAAGLDHPNIVAVHQRG-----QFEGRLWIA
. * . ** ** .* * .* :..:: * ::
Mvan_5401|M.vanbaalenii_PYR-1 MERLPGRTLADLIAQ--GPMAPAQVRAMLDDVLAALDVAHTAGVVHRDIK
Mflv_1389|M.gilvum_PYR-GCK MERLPGRTLADVIEQ--GPMPAPQVRRVLDEVLAALSVAHAAGVLHRDIK
MSMEG_6206|M.smegmatis_MC2_155 MERLSGATLADEIAA--GPLPQERVAELLDQILSALIAAHAAGIVHRDIK
MMAR_0016|M.marinum_M MEYVNGVTLRDIVHTD-GPMAPTRAIEIIADACQALNFSHQNGIIHRDVK
MUL_0018|M.ulcerans_Agy99 MEYVNGFTLRDIVHTD-GPMAPTRAIEIIADACQALNFSHQNGIIHRDVK
MLBr_00897|M.leprae_Br4923 MELIEGGTLRELLAER-GPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVK
TH_2610|M.thermoresistible__bu MELIEGGTLRELLRER-GPMPPHAAAAVLAPVLGGLAVAHRAGLVHRDIK
MAB_0034c|M.abscessus_ATCC_199 MELIHGEPLNSVLKRT-GRLSLRHSLDMLEQTGRALQVAHAAGLVHRDVK
MAV_3463|M.avium_104 MRLIEGRDLAHYITENGGRLSPQRAVAVIEQVAAALDSAHRAGLIHRDVK
Mb2115|M.bovis_AF2122/97 MQFVDGGNAEDALRAA--TMTTARAVYVIGEVAKALDYAHQQGVIHRDIK
Rv2088|M.tuberculosis_H37Rv MQFVDGGNAEDALRAA--TMTTARAVYVIGEVAKALDYAHQQGVIHRDIK
*. : * : :. :: .* :* *::***:*
Mvan_5401|M.vanbaalenii_PYR-1 PGNILLSATGD---RMQVADFGIAKSGGAAH---TMTGQIVGTLCYMSPE
Mflv_1389|M.gilvum_PYR-GCK PANILLTTAGD---SVKVADFGIAKSAGAAH---TATGQIVGTLCYLSPE
MSMEG_6206|M.smegmatis_MC2_155 PGNILIGHTG----QAKLADFGIAKTDGVPH---TQAGQILGTMAYLSPQ
MMAR_0016|M.marinum_M PANIMISTTN----AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE
MUL_0018|M.ulcerans_Agy99 PANIMISTTN----AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE
MLBr_00897|M.leprae_Br4923 PENILISDDG----DVKIADFGLVRAVAAAG--ITSTSVILGTVAYLSPE
TH_2610|M.thermoresistible__bu PENVLISDDG----EVKIADFGLVRAVAEAK--ITSDSVILGTAAYLSPE
MAB_0034c|M.abscessus_ATCC_199 PGNILITPTG----QVKLTDFGIAKAVDAAP--VTQTGMVMGTAQYIAPE
MAV_3463|M.avium_104 PMNVLVTTARD---FVYLIDFGLARAQADTA--LTQTGATMGTVAYMAPE
Mb2115|M.bovis_AF2122/97 PANFLLSRAAGGDERVLLSDFGIARALGDTG--LTSTGSVLATLAYAAPE
Rv2088|M.tuberculosis_H37Rv PANFLLSRAAGGDERVLLSDFGIARALGDTG--LTSTGSVLATLAYAAPE
* *.:: : ***:.:: . * . :.* * :*:
Mvan_5401|M.vanbaalenii_PYR-1 RVSGAPASVADDLYAVGVMGYEALLARRAFPQES--PVALVRAIVDAPPP
Mflv_1389|M.gilvum_PYR-GCK RVMGAPASVADDLYAVGVMGYEALLGRRAFPQDN--PAALARAIIDVPPP
MSMEG_6206|M.smegmatis_MC2_155 RVTGQPAGFADDLYAVGVVGYEALTGRRPFDRDN--PAAMVRAILDDVPV
MMAR_0016|M.marinum_M QARGDSVDARSDVYSLGCVLYEILTGEPPFTGDS--PVAVAYQHVREDPI
MUL_0018|M.ulcerans_Agy99 QARGDSVDARSDVYSLGCVLYEILTGEPPFTGDS--PVAVAYQHVREDPI
MLBr_00897|M.leprae_Br4923 QVRDGDASPRSDVYSAGIMTYELLTGHTPFTGDS--ALSIAYQRLEIDVP
TH_2610|M.thermoresistible__bu QVATGDATPRSDVYAVGILTYEMLTGNTPFTGDN--ALALAYQRLDNDVP
MAB_0034c|M.abscessus_ATCC_199 QALGHDATPASDVYSLGVVGYEAVSGKRPFSGDG--ALTVAMKHIKET--
MAV_3463|M.avium_104 RFTG-TTDHRADVYSLACVLHECLTGKRPFAGDS--LEEQLNAHLNTAPP
Mb2115|M.bovis_AF2122/97 VLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPP
Rv2088|M.tuberculosis_H37Rv VLAGQGFDGRADLYSLGCALFRLLTGEAPFAAGAGAAVAVVAGHLHQPPP
*:*: . .. : .. .* :
Mvan_5401|M.vanbaalenii_PYR-1 ALAGLTGGADPVLAAVIDRAMSRDPRRRFGSAAQMRAALAG---------
Mflv_1389|M.gilvum_PYR-GCK PLRALSVTADPALVAVIDRAMSRDPRLRFGSAPQMRAALAG---------
MSMEG_6206|M.smegmatis_MC2_155 PIASVRSDVAPGLIHVIDMAMAREVAFRYPDAATMRAALTG---------
MMAR_0016|M.marinum_M PPSERHEGISAELDAVVLKALAKNPDNRYQTAAEMRADLVRVHNGESPEA
MUL_0018|M.ulcerans_Agy99 PPSERHEGIFAELDAVVLKALAKNPDNRYQTAAEMRADLVRVHNGEAPEA
MLBr_00897|M.leprae_Br4923 RASTVITGVPQQFDELVARATVRDPSGRYADAIEMAAQVD----------
TH_2610|M.thermoresistible__bu PPSSAISGVPPQFDELVATATARDPADRFADAHDMAAAVA----------
MAB_0034c|M.abscessus_ATCC_199 -PSPLPADLPPNVRELIEITLVKNPQNRYTSGGPFADAVAAVR-------
MAV_3463|M.avium_104 RPSATAPEVPAAFDAVIARGMAKDPERRYQSVTELAEAARAALAPG----
Mb2115|M.bovis_AF2122/97 TVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDG
Rv2088|M.tuberculosis_H37Rv TVSDRVPGLSAAMDAVIATAMAKDPMRRFTSAGEFAHAAAAALYGGATDG
. :: :: *: :
Mvan_5401|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1389|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0016|M.marinum_M PKVLTGAERRSLTASSPSSPAAPRTDPLPRQTLDDTDRDRSTPSVGRWVA
MUL_0018|M.ulcerans_Agy99 PKVLTGAERRSLTTSSPSSPAAPRTDPLPRQTLDDTDRDRSTPSVGRWVA
MLBr_00897|M.leprae_Br4923 --------------------------------------------------
TH_2610|M.thermoresistible__bu --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3463|M.avium_104 --------------------------------------------------
Mb2115|M.bovis_AF2122/97 WVPPSPAPHVISQGAVPGSPWWQHPVG----------------------S
Rv2088|M.tuberculosis_H37Rv WVPPSPAPHVISQGAVPGSPWWQHPVG----------------------S
Mvan_5401|M.vanbaalenii_PYR-1 ---------DVTALSTAAEPRP----LTKVLAAPLPPSA-------AYPA
Mflv_1389|M.gilvum_PYR-GCK ---------DPLALNNAPPPAPPPRAGTRVLAQPLPPSAGFTSAPVGYPT
MSMEG_6206|M.smegmatis_MC2_155 ---------AEPPTQRVG-RRQ-----TKVLAAPLPPIP---------PP
MMAR_0016|M.marinum_M VVAVLAVLTIVVTIAINTFGGNTRNVQVPNVRGQASADAIAALQNRGFKT
MUL_0018|M.ulcerans_Agy99 VVAVLAVLTIVVTIAINTFGGNTRNVQVPNVRGQASADAIAALQNRGFKT
MLBr_00897|M.leprae_Br4923 --------SIAEELALPPFR-----VPAPRNTAQYRSAALHRGHMVERPV
TH_2610|M.thermoresistible__bu --------DLVAELELPPFR-----VPAPRNSAQHLSAIRQH--------
MAB_0034c|M.abscessus_ATCC_199 --------AGRRPPRPNQAPTISRATPAAIPPATQVRPAVGAPSRVAPPT
MAV_3463|M.avium_104 --------AVEKPSAPTPQPRAARRVRAAVVGASALTLAVVAAVVVAMVT
Mb2115|M.bovis_AF2122/97 VTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTMT
Rv2088|M.tuberculosis_H37Rv VTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTMT
Mvan_5401|M.vanbaalenii_PYR-1 PAPRRPATRARRYVVGAAAVMT---------------------------A
Mflv_1389|M.gilvum_PYR-GCK AAPP-PPTRARMYLMAVAAVL----------------------------A
MSMEG_6206|M.smegmatis_MC2_155 PVLPSPRHWRTRLILAVLGIV----------------------------S
MMAR_0016|M.marinum_M RTLLKPDSTIPPDHVIGTDPAANASVSAGDQITINVSTGPEQRELPDVSS
MUL_0018|M.ulcerans_Agy99 RTLLKPDSTIPPDHVIGTDPAANASVSAGDQITINVSTGPEQRELPDVSS
MLBr_00897|M.leprae_Br4923 EQQVQPVVNAPMPHSTRQFTRR----------------------------
TH_2610|M.thermoresistible__bu SQSARPTTTLQPPXXX----------------------------------
MAB_0034c|M.abscessus_ATCC_199 SRTRQPTGSHRPPPPRRGTFSPGQK------------------------A
MAV_3463|M.avium_104 HGHGSHGATPKTPGSPAPGRTAPPLPAFVAPPDLG--------------V
Mb2115|M.bovis_AF2122/97 SHQPRTATPPSAAALSPTSSSTTPPQP----------------------P
Rv2088|M.tuberculosis_H37Rv SHQPRTATPPSAAALSPTSSSTTPPQP----------------------P
Mvan_5401|M.vanbaalenii_PYR-1 FVISALALAMDPFSSSAPRPEPVSTSTSAPSPTTPPPP-----PITTPPP
Mflv_1389|M.gilvum_PYR-GCK FTVAALALALDPFSSPPP-MQTVGTSTTAPPPPTSVPP-----PTSAAPL
MSMEG_6206|M.smegmatis_MC2_155 TLILVLVLALARGSSGLTSPTSTPTATTVPPATSAVVP-----PPVPSTP
MMAR_0016|M.marinum_M MTYAEAVKKLTAAGFGRFKEAKSPSTPELMGKVIGTNP-----PANQTSA
MUL_0018|M.ulcerans_Agy99 MTYAEAVKKLTAAGFGRFKEAKSPSTPELMGKVIGTNP-----PANQTSA
MLBr_00897|M.leprae_Br4923 LRDCSAPRRPARPDIDSPEEYEYEPVPDRFAGIAISEF-----IWAR-QH
TH_2610|M.thermoresistible__bu ---GAGGRARVATEIG-----------DRIG--IVDQP-----PTARGRH
MAB_0034c|M.abscessus_ATCC_199 LMWAAAVLGIFAIIIAALILLQASEKKNQTPSIPATVS-----GSETPSS
MAV_3463|M.avium_104 NCQYRAVPDPSSRPVSPPPSGRVPTTPGQIGAVIATNLGDIG-ISLANSE
Mb2115|M.bovis_AF2122/97 IVTRSRLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPA
Rv2088|M.tuberculosis_H37Rv IVTRSRLPGLLPPLDDVKNFVGIQNLVAHEPMLQPQTPNGSINPAECWPA
Mvan_5401|M.vanbaalenii_PYR-1 SP--APAVTAAT---QQPEPQQGRDDKGPRGNGRGNGKGKGEKKD-----
Mflv_1389|M.gilvum_PYR-GCK PPPIVPVTQAPP---PDNGPKKGPDKKGEKGN---NGRGNGNKPD-----
MSMEG_6206|M.smegmatis_MC2_155 VPAAVPEEPRGPGRGPGPGPGPGKGKGHEKGHGPKGPKGPPHP-------
MMAR_0016|M.marinum_M ITNVITIIVGSGPATKQIPDVAGQSVEEAEQNLNVYGFTKFSQASVDSPK
MUL_0018|M.ulcerans_Agy99 ITNVITIIVGSGPATKQIPDVAGQSVEEAQQNLNVYGFTKFSQASVDSPK
MLBr_00897|M.leprae_Br4923 ARRMVLIWVGVVVAIAGLVATVAWTIGSHLSGLL----------------
TH_2610|M.thermoresistible__bu AN----------------AVRTAFRNDE----------------------
MAB_0034c|M.abscessus_ATCC_199 PGSASPGALAPANIVALLPDAEPDPIPGTKSP------------------
MAV_3463|M.avium_104 SPCAVNSFISLARQRFFDNTQCARLVDSPDGGSLLCGGPDVDGSGGPGYE
Mb2115|M.bovis_AF2122/97 VGGGVPSAYDLGTVIGFYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRH
Rv2088|M.tuberculosis_H37Rv VGGGVPSAYDLGTVIGFYGLTIDEPPTGTAPNQVGQLIVAFRDAATAQRH
Mvan_5401|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1389|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0016|M.marinum_M PAGSVIATNPPAGTTVPIDSVIELQVSKGNQFVMPDLSGMFWTDAEPRLR
MUL_0018|M.ulcerans_Agy99 PAGSVIATNPPAGTTVPIDSVIELQVSKGNQFVMPDLSGMFWTDAEPRLR
MLBr_00897|M.leprae_Br4923 --------------------------------------------------
TH_2610|M.thermoresistible__bu --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3463|M.avium_104 FADEYPANQYRPDDPALRATLLYPRGTVVMATEGPNTNGSQFALIFHDSE
Mb2115|M.bovis_AF2122/97 LADLASIWRRCGGRTVTLFRSEWRRPVELSTSVPEVVDGITTMVLTAQGP
Rv2088|M.tuberculosis_H37Rv LADLASIWRRCGGRTVTLFRSEWRRPVELSTSVPEVVDGITTMVLTAQGP
Mvan_5401|M.vanbaalenii_PYR-1 ------------------------------------------------
Mflv_1389|M.gilvum_PYR-GCK ------------------------------------------------
MSMEG_6206|M.smegmatis_MC2_155 ------------------------------------------------
MMAR_0016|M.marinum_M ALGWTGSLDKGPDVDAGGSQHNRVVYQNPPAGAGVNRDGIVTLKFGQ-
MUL_0018|M.ulcerans_Agy99 ALGWTGSLDKGPDVDGGGSQHNRVVYQNPPAGAGVNRDGIVTLKFGQ-
MLBr_00897|M.leprae_Br4923 ------------------------------------------------
TH_2610|M.thermoresistible__bu ------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 ------------------------------------------------
MAV_3463|M.avium_104 MDPQSTVLGTIDPAGLATLDKIARAGIAGNRPSGPPANPVTITSVRIG
Mb2115|M.bovis_AF2122/97 VLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAVIGITNYILAKIPG-
Rv2088|M.tuberculosis_H37Rv VLRVREDHAIAAKNNVLVDVDIMTPDTSRGQQAVIGITNYILAKIPG-