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KSAQVVGRVGALAVALGVGAAVFTGSGVAWATEDAAGETTAESGATTSEPADDGDAVEPADDGDTVEQVE SDDDDEAVGQVEPEEEAEADEDEAVVEPDEDEVAPDVEEAADADGAPSEDGDGGFQVPAAPREDDAPPTE PDEDTGSAAAVASSETGSSEADGVEPAVDTVAVQRLTVEPTAAVSTTVASPPEVPSWRPWPTAFDLRSAV TYVVDLATSFVDALLSPFAAGPPRPPADPSGWALLAWVRREFFNGTPAPVENPLPHTQSLTADGGVVITG NVGVVDPDGDALTYSVIGRPHNGGTVAVDADGNFVYRPMNAMAAVGGTDTFTVAVSDEHDGLHVHGLFGW LQFVPILGNLLNPGGGHGRTVTIAVTVTPVDGIDLSLPDDFRWGVAHSGFQAEGGPGSPVDTRSDWYRWV HDPVNRLLGLVKGVPEDGPGAYVSYDGDAALARDELGMNTFRMGIEWSRIFPESTAAVDISDEGGALSLA DLEALDELADQDEVAHYRAVFAALRRRGLDPFVTVNHFTLPVWVHDPIVARPLIQLGLPAPAAGWLSSNT AEEFEKYAAYVAWKYGDQVDNWATLNEPFPPVLTEFLAIPWVVPNWPPGVLRPDLASTFVVNQAIGHVAA YDAIHTWDTTAAAADGPAAFVGFTHNMIPARPANPVNPLDVQAADAWNHFYNKWFPNAVIDGWVDANFDG VKTADEIHPEMAGKVDFLGVQYYGSQPMVGFGVAPLPGFPFLRGFPIRCSGEEPTCSDFNQPTDPGGFRE VLELAGSYGKPLWVTENGIADADDSKRPSYIVNHVAVVQDLVAHGADIRGYTYWSFVDNLEWSEGYELQF GLYGSDPETPELERIPKPASIAALSGITTANGLPVSLLQTYIPS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5030 | - | - | 100% (885) | glycoside hydrolase family protein |
M. vanbaalenii PYR-1 | Mvan_1597 | - | 6e-36 | 31.90% (395) | hypothetical protein Mvan_1597 |
M. vanbaalenii PYR-1 | Mvan_5057 | - | 4e-32 | 30.15% (544) | hypothetical protein Mvan_5057 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0912 | - | 5e-09 | 36.36% (132) | hypothetical protein Mb0912 |
M. gilvum PYR-GCK | Mflv_1722 | - | 0.0 | 73.90% (889) | glycoside hydrolase family protein |
M. tuberculosis H37Rv | Rv0888 | - | 5e-09 | 36.36% (132) | hypothetical protein Rv0888 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3192c | - | 3e-27 | 26.67% (510) | putative glycosyl hydrolase (beta-glucosidase) |
M. marinum M | MMAR_2416 | lgt | 1e-08 | 29.52% (166) | prolipoprotein diacylglyceryl transferases Lgt |
M. avium 104 | MAV_3172 | - | 5e-06 | 31.25% (112) | prolipoprotein diacylglyceryl transferase |
M. smegmatis MC2 155 | MSMEG_5142 | - | 2e-38 | 29.73% (528) | beta-glucosidase A |
M. thermoresistible (build 8) | TH_0997 | rne | 7e-06 | 26.26% (198) | POSSIBLE RIBONUCLEASE E RNE |
M. ulcerans Agy99 | MUL_3715 | rne | 2e-06 | 28.10% (153) | ribonuclease E Rne |
CLUSTAL 2.0.9 multiple sequence alignment Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1722|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTSSRRVLDALSALDGR MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1722|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 IRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEDQQAPDAVAAEVPDAPGE MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1722|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 PAEPESRLMLETQETVQVVETWVERPHYMPLFVAPQPISEPVAGDDADDE MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1722|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 SGDEGDDDEEQADRPGNRRRRRGRRGRGRGRGEQGANDGQDQPGDDGDEA MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1722|M.gilvum_PYR-GCK ------------MGGGTWRSQSTDRHLASDAVGRGAVRQVCRVGADGVRQ MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 PQKAGGNSTSSDDSEAQDGADSEESDNGDDDNGSADGASRRRRRRRRRKS MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------MDYAKRIGQVGALAVVLGVGAAVTT-HAIGS Rv0888|M.tuberculosis_H37Rv -------------------MDYAKRIGQVGALAVVLGVGAAVTT-HAIGS Mvan_5030|M.vanbaalenii_PYR-1 -------------------MKSAQVVGRVGALAVALGVGAAVFTGSGVAW Mflv_1722|M.gilvum_PYR-GCK NDGFGQSAHRAARRRYSRFMDSAQFVGRVGGLAVALGVGAALVTGSGVAW MMAR_2416|M.marinum_M -------------MTATVLAYFPSPPRGVWHLGPLPIRAYAFFIIIGIVM MAV_3172|M.avium_104 --------------MTKLLAYFPSPPQGVWHLGPVPIRAYALFIIAGIVA TH_0997|M.thermoresistible__bu ---------VSPDDPPNTVVHERVPRTEKEER------DQAHSEIQGITG MUL_3715|M.ulcerans_Agy99 GAGDDGDEGPAPDDPPNTVVHERAPRSGDKSGNSDSGDDSGGNEIKGIDG MSMEG_5142|M.smegmatis_MC2_155 ----------------------------MSQPDRTLGFPDGFVWGTATAS MAB_3192c|M.abscessus_ATCC_199 ----MKWMNAVMASAAVVALGLTACSPRQEAPKEDAGWDRGFYWGTATAG . . Mb0912|M.bovis_AF2122/97 AAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVD----- Rv0888|M.tuberculosis_H37Rv AAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVD----- Mvan_5030|M.vanbaalenii_PYR-1 ATEDAAGETTAESGATTSEPADDGDAVEPADDGDTVEQVESDDDDEAVGQ Mflv_1722|M.gilvum_PYR-GCK ATEDSG--SSASAGAESSTARTSSQDRQAASPSKPARDRAGGRDDAEGGG MMAR_2416|M.marinum_M GLMIGDRRFAARGGERGVIYDIALWMVPFGLIGGRLYHLSTDWQTYFG-- MAV_3172|M.avium_104 ALLIGDRRWEARGGERGVIYDIALWTVPFGLVGGRLYHLATDWRTYWG-- TH_0997|M.thermoresistible__bu STRLEAKRQRRRDGRDAGRRRPPILSEAEFLARREAVERVMVVRDKVR-- MUL_3715|M.ulcerans_Agy99 STRLEAKRQRRRDGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRVR-- MSMEG_5142|M.smegmatis_MC2_155 YQIEGAVTAGGRAPSIWDTFSHKPGAVHNGDNGDVADDHYHRYREDVG-- MAB_3192c|M.abscessus_ATCC_199 YQVEGSAPDSNWRRYVERSAGKPVHPDESNLLADGPVDPYKQADDFRHR- . Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 VEPEEEAEADEDEAVVEPDEDEVAPDVEEAADADGAPSEDGDGGFQVPAA Mflv_1722|M.gilvum_PYR-GCK AE-DRDAQAQDD-ATPETGGETGAPD-DASVDASG-PDTGGTTGDASAED MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 PREDDAPPTEPDEDTGSAAAVASSETGSSEADGVEPAVDTVAVQRLTVEP Mflv_1722|M.gilvum_PYR-GCK DDPDEAEERAAWADTGADTDADPDADPDADAS-AATDVATAAVP-SGAGP MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- TH_0997|M.thermoresistible__bu -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -----------PGSIP-----------DDLLNALIDFLAAVRNGLVPIIE Rv0888|M.tuberculosis_H37Rv -----------PGSIP-----------DDLLNALIDFLAAVRNGLVPIIE Mvan_5030|M.vanbaalenii_PYR-1 TAAVSTTVAS-PPEVPSWRPWPTAFDLRSAVTYVVDLATSFVDALLSPFA Mflv_1722|M.gilvum_PYR-GCK TAVVTTEVTVDPPRVPSWRPWPTAFDLRGAVTYVVDLAVSVVDALFHPFA MMAR_2416|M.marinum_M -----------EGGAGLG---AALRIWDGGLGIWGAVTLGTVGAWIGCRR MAV_3172|M.avium_104 -----------PGGAGFG---AAVRIWDGGLGIWGAVALGAVGAWIGCRR TH_0997|M.thermoresistible__bu -----------TEPPHQGARYTQIAVLEDGVVVEHFVTSSASASLVGNIY MUL_3715|M.ulcerans_Agy99 -----------TEPPHPGSRYTQIAVLEDGIVVEHFVTSAASASLVGNIY MSMEG_5142|M.smegmatis_MC2_155 --------------------------------LLADLGVTHYRFSLAWPR MAB_3192c|M.abscessus_ATCC_199 --------------------------YAEDIANAHAMGVNTFRFGLEWSR . . Mb0912|M.bovis_AF2122/97 NRTP--------------------------VANPQ---QVSVPEGGTVGP Rv0888|M.tuberculosis_H37Rv NRTP--------------------------VANPQ---QVSVPEGGTVGP Mvan_5030|M.vanbaalenii_PYR-1 AGPPRPPADPSGWALLAWVRREFFNGTPAPVENPLPHTQSLTADGGVVIT Mflv_1722|M.gilvum_PYR-GCK AGPPPPPGDPSAWGLLAWVRRELFNSTPDEVDNPLPYTQSL-VDGDVVIT MMAR_2416|M.marinum_M RGIPLP-----------------------AFLDAVAPGVVMGQAIG---- MAV_3172|M.avium_104 HGIPLP-----------------------AFADALAPGIILAQAIG---- TH_0997|M.thermoresistible__bu LGIVQN-----------------------VLPSMEAAFVDIGRGRNGVLY MUL_3715|M.ulcerans_Agy99 LGIVQN-----------------------VLPSMEAAFVDIGRGRNGVLY MSMEG_5142|M.smegmatis_MC2_155 LQPDGK-------------------------------------------- MAB_3192c|M.abscessus_ATCC_199 VMPEP--------------------------------------------- Mb0912|M.bovis_AF2122/97 VRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVG Rv0888|M.tuberculosis_H37Rv VRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVG Mvan_5030|M.vanbaalenii_PYR-1 GNVGVVDPDGDALTYSVIGRPHNGG--TVAVDADGNFVYRPMNAMAAVGG Mflv_1722|M.gilvum_PYR-GCK GNVGVEDRDGDPLTYEVIGRPRFGG--EVTVDADGNFVYRPMNAMAAVGG MMAR_2416|M.marinum_M -RLGNYFNQELYGRETTVPWGLE------IFYRRDPSGFVDVHSLDGVST MAV_3172|M.avium_104 -RLGNYFNQELYGRETTLPWGLE------IFYRRDPSGYIDPHSLDGVST TH_0997|M.thermoresistible__bu AGEVNWEAAGLGGQNRKIEQALKPGDYVVVQVSKDPVGHKGARLTTQLSL MUL_3715|M.ulcerans_Agy99 AGEVNWDAAGLGGADRKIEQALKPGDYIVVQVSKDPVGHKGARLTTQVSL MSMEG_5142|M.smegmatis_MC2_155 ---GPINTEGLDFYQR-------------LVDELLAHDIQPWVTLYHWDL MAB_3192c|M.abscessus_ATCC_199 ---GKWDEKELAYYDS-------------VVATLRENGMTPMITLMHWVY Mb0912|M.bovis_AF2122/97 TDTFSVNVS-----------DDTS-LHVHGLAGYLG----------PFHG Rv0888|M.tuberculosis_H37Rv TDTFSVNVS-----------DDTS-LHVHGLAGYLG----------PFHG Mvan_5030|M.vanbaalenii_PYR-1 TDTFTVAVS-----------DEHDGLHVHGLFGWLQFVPILGNLLNPGGG Mflv_1722|M.gilvum_PYR-GCK TDEFTVAVT-----------DDAAGLHVHGLLGWLQFVPILGSFLNPGGG MMAR_2416|M.marinum_M GQVAVVVQP----------------TFLYELIWNLLVFAALIYLDRR--- MAV_3172|M.avium_104 GQVALVVQP----------------TFLYELLWNLLIFVALLYADRR--- TH_0997|M.thermoresistible__bu AGRYLVYVPGATSTGISRKLPDTERQRLKEILREVVPPDAGVIIRTASEG MUL_3715|M.ulcerans_Agy99 AGRYLVYVAGASSTGISRKLPDTERQRLKEILREVVPSDAGVIIRTASEG MSMEG_5142|M.smegmatis_MC2_155 PQTLEDAGG----------------------------------------- MAB_3192c|M.abscessus_ATCC_199 PGWVADSGG----------------------------------------- Mb0912|M.bovis_AF2122/97 HDDVATVTVFVG----------------------------NTPTDTISGD Rv0888|M.tuberculosis_H37Rv HDDVATVTVFVG----------------------------NTPTDTISGD Mvan_5030|M.vanbaalenii_PYR-1 HGRTVTIAVTVTPVDGIDLSLPDDFRWGVAHSGFQAEGGPGSPVDTRSDW Mflv_1722|M.gilvum_PYR-GCK HGITRTITVTVEPVDGIDLSLPDGFKWGVAHSGFQAEGGPGSPVDTGSDW MMAR_2416|M.marinum_M ------FTIGHGRLFASY------------------VALYCVGRFCVELL MAV_3172|M.avium_104 ------LTLGHGRLFALY------------------VAGYCVGRFCVELL TH_0997|M.thermoresistible__bu V-KEEDIRADVNRLQERWTQIEAKAAELTEKKAGQAVALYEEPDVLVKVI MUL_3715|M.ulcerans_Agy99 V-KEDDIRADVTRLQERWNQIEAKAVEIKQKAAGAAVALYEEPDVLVKVI MSMEG_5142|M.smegmatis_MC2_155 ---------------------------------WPARDTAQRFADYAAMT MAB_3192c|M.abscessus_ATCC_199 ---------------------------------------FMNNLPAFEEF Mb0912|M.bovis_AF2122/97 FSMLTYNIAGLPFPLS---------------------------------- Rv0888|M.tuberculosis_H37Rv FSMLTYNIAGLPFPLS---------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 YRWVHDPVNRLLGLVKGVPEDGPGAYVSYDGDAALARDELGMNTFRMGIE Mflv_1722|M.gilvum_PYR-GCK YRWVHDPLNRLLGLVKGVPENGPGAYVSYEDDARLAREELGVNTFRMGIE MMAR_2416|M.marinum_M RDDTATHIAGIRIN---SFTSTFVFIGAVVYIILAPKGREDPASVR---- MAV_3172|M.avium_104 RDDTATHIAGIRIN---SFTSTFVFIGAVVYLMAAPKGREDPESLR---- TH_0997|M.thermoresistible__bu RDLFNEDFSRLIVSGDHAWNTINEYVSTVAPDLMPRLTKYEPASED---- MUL_3715|M.ulcerans_Agy99 RDLFNEDFAGLVVSGDDAWDTINEYVSSVAPDLVSKLSKYEPAVGSEGQV MSMEG_5142|M.smegmatis_MC2_155 HGKLHDRIR----------------------------------------- MAB_3192c|M.abscessus_ATCC_199 AKAITKRYAG---------------------------------------- Mb0912|M.bovis_AF2122/97 -SAILPRFFYTKEIGKR--------LNAYYVANVQEDFAYHQFLIKKSKM Rv0888|M.tuberculosis_H37Rv -SAILPRFFYTKEIGKR--------LNAYYVANVQEDFAYHQFLIKKSKM Mvan_5030|M.vanbaalenii_PYR-1 WSRIFPESTAAVDISDEGGALSLADLEALDELADQDEVAHYRAVFAALRR Mflv_1722|M.gilvum_PYR-GCK WSRIFPDSTASVDISDEGGTVSLADLQALDALANADEVAHYRDVFAALRF MMAR_2416|M.marinum_M -----GTAAAAEEVPEPEPAGEVATAAAPAGDTEGDEPTGLAETAKAAEV MAV_3172|M.avium_104 -----GNQYVEEEPAEPEPATVAATTEAAT--------EGVAAPADG--- TH_0997|M.thermoresistible__bu GPDVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTVIDVNTGKFTG MUL_3715|M.ulcerans_Agy99 GPDVFAVHRIDEHLAKAMDRKVWLPSGGTLVIDRTEAMTVVDVNTGKFTG MSMEG_5142|M.smegmatis_MC2_155 ---------HWTTLNEPWCSAFLGYAAGAHAPGRTEPAAALAAAHHLMFG MAB_3192c|M.abscessus_ATCC_199 ------QGVLWVSINEPLAFGAMEVRTGAIKPDQFNGFLDRVADAHRAVY . . Mb0912|M.bovis_AF2122/97 PSQTP---------------PEPPTLLWPIGVPFSDG----LNTLSEFKV Rv0888|M.tuberculosis_H37Rv PSQTP---------------PEPPTLLWPIGVPFSDG----LNTLSEFKV Mvan_5030|M.vanbaalenii_PYR-1 RGLDPFVTVNHFTLPVWVHDPIVARPLIQLGLPAPAAGWLSSNTAEEFEK Mflv_1722|M.gilvum_PYR-GCK HGLDPMVTVNHFTLPVWVHDPVLARPLIQLGLPVAAAGWLSTETAVEFEK MMAR_2416|M.marinum_M AEPETVGSAVAGDESTADTEASDAVESEVGEAAEAEAPEAEAEEAEVGEV MAV_3172|M.avium_104 -----------------------------AEAAGADATAQRPEESAEPDV TH_0997|M.thermoresistible__bu SGGNLEQTVTRNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVL MUL_3715|M.ulcerans_Agy99 SGGNLEQTVTKNNLEAAEEIVRQLRLRDIGGIVVIDFIDMVLESNRDLVL MSMEG_5142|M.smegmatis_MC2_155 HG---------------------------LAVAAMRAQDGDSQLGITVNL MAB_3192c|M.abscessus_ATCC_199 R-------------------------------AAHEADPEAKVTTNEAYI Mb0912|M.bovis_AF2122/97 QRLDRQTWYECTSDNCLTLKG---------------------------FT Rv0888|M.tuberculosis_H37Rv QRLDRQTWYECTSDNCLTLKG---------------------------FT Mvan_5030|M.vanbaalenii_PYR-1 YAAYVAWKYGDQVDNWATLNEPFPPVLTEFLAIPWVVPNWPPGVLRPDLA Mflv_1722|M.gilvum_PYR-GCK YAAYLAWKYGDQVDNWATLNEPFPPVLTEFLAIPWVVPNWPPGVLRPDLA MMAR_2416|M.marinum_M E-VAEAVEGEVEEAEEAEPGE---------VEVAEAVEGEVEAAAEAEEA MAV_3172|M.avium_104 E-KPESEETEAEAAEEPE-------------------------------S TH_0997|M.thermoresistible__bu RRLTEALARDRTRHQVSEVTS---------LGLVQLTRKRLGTGLLEAFS MUL_3715|M.ulcerans_Agy99 RRLTEALARDRTRHQVSEVTS---------LGLVQLTRKRLGTGLIEAFS MSMEG_5142|M.smegmatis_MC2_155 TPVSPATEEPADVD-----------------------------------A MAB_3192c|M.abscessus_ATCC_199 PPDVLAQFAGFGVKG---------------------------------IE Mb0912|M.bovis_AF2122/97 YSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVT Rv0888|M.tuberculosis_H37Rv YSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVT Mvan_5030|M.vanbaalenii_PYR-1 STFVVNQAIGHVAAYDAIHTWDTTAAAADGPAAFVGFTHNMIPARPANPV Mflv_1722|M.gilvum_PYR-GCK STFLVNQAIGHVAAYDAIHAWDTTSAVEGGPAAFVGFTHNMIPARPANPV MMAR_2416|M.marinum_M EEAEEAEEAEEAEEAEPGEIEVAEAVEGEVEAAAEAEEAEVGEVEAVDEA MAV_3172|M.avium_104 EETEAAEEPGEPEAEEP-------------------------------EE TH_0997|M.thermoresistible__bu TTCTHCNGRGIVLHTDPVDSAQPS-RRSDSGSRRSKRSKRSRSDD----V MUL_3715|M.ulcerans_Agy99 TSCPHCSGRGILLHADPVDSAPTTGRKADSGGRRNRRSKKNRAEEPSEKE MSMEG_5142|M.smegmatis_MC2_155 ARRVDAVSNRLFLDALLRGRYPADLSADVAMISDFGFVQPGDEAVIAAPL MAB_3192c|M.abscessus_ATCC_199 GSFFDRVAGSLDYLGFDYYTGTAADNPASAQSMAARWNIKLQPEDIYYVS Mb0912|M.bovis_AF2122/97 GDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECE Rv0888|M.tuberculosis_H37Rv GDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECE Mvan_5030|M.vanbaalenii_PYR-1 NPLDVQAADAWNHFYNKWFPNAVIDGWVDANFDGVKTADEIHPEMAGKVD Mflv_1722|M.gilvum_PYR-GCK NALDVGAAEAWNHYYNHWFPNAVIDGWIDLDFDGIKSADEIRPDMADKVD MMAR_2416|M.marinum_M AEAEAPEVGEIEAAEAVEGEVEVAAEAEEAEAGEDEPKEAEEVAEAEGSE MAV_3172|M.avium_104 PEAEEPEE----------------PETEEPEADSDE-------------- TH_0997|M.thermoresistible__bu QVVKVPPHPPGEHPLFKAMAAASERADSEAKDDTEETGDGGKDAAKVAAK MUL_3715|M.ulcerans_Agy99 AVAKVPTYAPGEHPMFKAMAASSSSEAEHGDGEVEESGE------ELTAA MSMEG_5142|M.smegmatis_MC2_155 DFLGVNYYFRETVRFGTGAPSDNPHARAWVGSTDVEPVRTGLPTTAMGWE MAB_3192c|M.abscessus_ATCC_199 RHYAQRYPGLPIYIVENGMVTDNGKPRADGVTRSQYLSDTVFWLQRAKAD Mb0912|M.bovis_AF2122/97 LLDKIFYRSGQGVTLQAVSYG----------------------------- Rv0888|M.tuberculosis_H37Rv LLDKIFYRSGQGVTLQAVSYG----------------------------- Mvan_5030|M.vanbaalenii_PYR-1 FLGVQYYGSQPMVGFGVAPLPGFPFLRGFPIRCS---------------- Mflv_1722|M.gilvum_PYR-GCK FLGVQYYGSQPMVGFGVAPLPGFPFLRGFPIRCS---------------- MMAR_2416|M.marinum_M AEDKTVQAIDGGQTGVDDAGEADAEPDDDSTAAEPEVVVEQADIEEIEPQ MAV_3172|M.avium_104 ------------------------EPE----------------------- TH_0997|M.thermoresistible__bu VKEKVAAEDRAKVGAQDGVEEATPDGVETEAAAATRAERVRTAVSGDAQA MUL_3715|M.ulcerans_Agy99 VDDQTAVQVALDLGETE--------------------------------- MSMEG_5142|M.smegmatis_MC2_155 IDPTGLYDVLSWVHREYGPVP----------------------------- MAB_3192c|M.abscessus_ATCC_199 GIPIVGYNYWSLVDN----------------------------------- Mb0912|M.bovis_AF2122/97 ---------------------------------NEAPKFFNSKGEPLSDH Rv0888|M.tuberculosis_H37Rv ---------------------------------NEAPKFFNSKGEPLSDH Mvan_5030|M.vanbaalenii_PYR-1 ---------------GEEPTCSDFNQPTDPGGFREVLELAGSYGKPLWVT Mflv_1722|M.gilvum_PYR-GCK ---------------AEETTCSDFNQPIDPGGFREVLEVAASYGKPLWVT MMAR_2416|M.marinum_M EPEAEAVAAAEATDADEGDGEPAEPASDDLDAVAAEDADVDVDATATEAE MAV_3172|M.avium_104 -------------------------------------------------E TH_0997|M.thermoresistible__bu SAGDLDDEDLANGDLEDEYLDDEDEDEDLEDGDLENGDLDDEDDDEDLED MUL_3715|M.ulcerans_Agy99 ---------------ESEETDGTDETDDFDDDSDDSDDSDEDDDTDETND MSMEG_5142|M.smegmatis_MC2_155 -------------------------------------IYVTENGAAFDDD MAB_3192c|M.abscessus_ATCC_199 ---------------------------------------YEWGSYRPRFG Mb0912|M.bovis_AF2122/97 SPAVVGFH------YVADNVAVR--------------------------- Rv0888|M.tuberculosis_H37Rv SPAVVGFH------YVADNVAVR--------------------------- Mvan_5030|M.vanbaalenii_PYR-1 ENGIADADDSKRPSYIVNHVAVVQDLVAHGADIRGYTYWSFVDNLEWSEG Mflv_1722|M.gilvum_PYR-GCK ENGIADAGDAKRPPYLVNHVAVVQDLVAHGLDIRGYTYWSFVDNLEWSEG MMAR_2416|M.marinum_M ESGDESPEPAADSEEPEADESAPEDSAEDTSSGESDTQSELEQSQTIEQG MAV_3172|M.avium_104 ESGEAPEQPVAE--EPEPAPQQPE-------------------------- TH_0997|M.thermoresistible__bu GEIDVDLDEDLDDDIEVLNGDPDDEEADEDVDSYEDPYDADADADSDSDA MUL_3715|M.ulcerans_Agy99 TDVDADEDEDTDDDSDEDEDTEDDDELDDDLDDELDDDDSDSDDE-DSES MSMEG_5142|M.smegmatis_MC2_155 AEADGSIRDDDRITFLDSHFRATLRAIDDGADIRGYFVWSLLDNFEWAYG MAB_3192c|M.abscessus_ATCC_199 LYTVDALGDPALKRVPTDAVATYTQITRDAGTVPGYRPVIPAAKCSTTVG Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- Mvan_5030|M.vanbaalenii_PYR-1 YELQFGLYGSDPETPELERIPKPASIAALSGITTANGLPVSLLQTYIPS- Mflv_1722|M.gilvum_PYR-GCK YDLQFGLYGSDPDTPELERIPKVASIAALKGITTANGLPVALLQNYLPG- MMAR_2416|M.marinum_M SDQTSAGDGEGPPPSAAVDGDTGPTRQGWRGRLRNRMRRSGR-------- MAV_3172|M.avium_104 ------------------------TKRRWGARLRDRL--SGR-------- TH_0997|M.thermoresistible__bu DADDEDSGDDRAAGRYAAPTVTRRPRRRAAVRPAGPPVQS---------- MUL_3715|M.ulcerans_Agy99 ELTEPAAG--RPAALEVTTIAERPRRRRAAGRPAGPPIHLG--------- MSMEG_5142|M.smegmatis_MC2_155 YAKRFGLIHVDYATQVRTP---KASARWFAEVTRRNGVPHVFRQNDAPAD MAB_3192c|M.abscessus_ATCC_199 QDSCAPLDPNGPTVALR--------------------------------- Mb0912|M.bovis_AF2122/97 -- Rv0888|M.tuberculosis_H37Rv -- Mvan_5030|M.vanbaalenii_PYR-1 -- Mflv_1722|M.gilvum_PYR-GCK -- MMAR_2416|M.marinum_M -- MAV_3172|M.avium_104 -- TH_0997|M.thermoresistible__bu -- MUL_3715|M.ulcerans_Agy99 -- MSMEG_5142|M.smegmatis_MC2_155 IR MAB_3192c|M.abscessus_ATCC_199 --