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TETSSHALAQRMAELARTVASPRRVEDVLSDVTREVMGLIPGVDAAGVLFVGAQGRFESVAGTSELPHRL DELQMKYRQGPCLEAALDSLIVRTDDFRTEQRWPLYSAAAAELGVLSGLSFKLYTSARTAGALNLFALKP NAFDADAETIGAVFAAHAAAAIMASRENEQLQSALSTRDRIGQAKGIIMERYDVDDVTAFEMLRRLSQDS NTKLVEVAAKVIETRGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4938 | - | - | 100% (228) | response regulator receiver/ANTAR domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2553 | - | 7e-39 | 40.40% (198) | response regulator receiver/ANTAR domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1050 | - | 9e-23 | 31.82% (220) | response regulator receiver/ANTAR domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1652 | - | 3e-06 | 26.98% (215) | two-component system transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1809 | - | 2e-99 | 79.39% (228) | response regulator receiver/ANTAR domain-containing protein |
| M. tuberculosis H37Rv | Rv1626 | - | 3e-06 | 26.98% (215) | two-component system transcriptional regulator |
| M. leprae Br4923 | MLBr_01286 | - | 1e-05 | 29.03% (124) | putative two-component response regulatory protein |
| M. abscessus ATCC 19977 | MAB_2534c | - | 2e-46 | 41.33% (225) | hypothetical protein MAB_2534c |
| M. marinum M | MMAR_1808 | - | 8e-25 | 32.57% (218) | hypothetical protein MMAR_1808 |
| M. avium 104 | MAV_5172 | - | 2e-74 | 62.78% (223) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6741 | - | 6e-80 | 65.49% (226) | ANTAR domain-containing protein |
| M. thermoresistible (build 8) | TH_2526 | - | 5e-19 | 28.77% (219) | PUTATIVE putative response regulator receiver and ANTAR domain |
| M. ulcerans Agy99 | MUL_1608 | - | 2e-05 | 29.17% (120) | two-component system transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 MTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFV
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LSHEQFRTDRLVAHAQAAERAGFTHGWASDHIQPWQDNEGHSMFPWLTLA
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVGTGE
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 RLNEQATTNGYGNYTERHDRLAEAIALIRQLWSGSRISFSGRYFQTNSLK
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LYDVPATPPPIFVAAGGPKSAKLAGQFGDGWITQSGDVTNPKLLAAFGAG
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 AQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFTAGAVDQPDPVDIQ
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 RAAESNPTDKVLGGWTGRHRRGSARRGRAAGPRRGRRSLPALSAGRPDGR
MAB_2534c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1808|M.marinum_M --------------------------------------------------
Mb1652|M.bovis_AF2122/97 --------------------------------------------------
Rv1626|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1608|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01286|M.leprae_Br4923 --------------------------------------------------
TH_2526|M.thermoresistible__bu --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 ------------------------------------------MTETSSHA
Mflv_1809|M.gilvum_PYR-GCK ------------------------------------------MNPMPTHE
MSMEG_6741|M.smegmatis_MC2_155 ------------------------------------------MGESRNHE
MAV_5172|M.avium_104 HRLLPGQCLTEIALNPLRATPVSPLPATNSRRIGQNRDVMDAVDPDSRHQ
MAB_2534c|M.abscessus_ATCC_199 -----------------------------------------MTDEAAAGA
MMAR_1808|M.marinum_M ------------------------------MTATPKDSNPDSVPGGTTAD
Mb1652|M.bovis_AF2122/97 ----------------------------------------------MTGP
Rv1626|M.tuberculosis_H37Rv ----------------------------------------------MTGP
MUL_1608|M.ulcerans_Agy99 -------------------------------------------MSVMTGP
MLBr_01286|M.leprae_Br4923 ----------------------------------------------MTGP
TH_2526|M.thermoresistible__bu ------------------------------------------------MG
Mvan_4938|M.vanbaalenii_PYR-1 LAQRMAELARTVASPRR-VEDVLSDVTREVMGLIPGVDAAGVLFVGAQGR
Mflv_1809|M.gilvum_PYR-GCK LARRMAELARQVASPRR-VEDVLSDVTAEARTLIPGVDAAGVLLVGTAGR
MSMEG_6741|M.smegmatis_MC2_155 LAMRMADLARAVASPRS-LADVLTGVTTAAKELIPGVDTAGVLLIGPGNT
MAV_5172|M.avium_104 LAVRMAELVRGMAAPRR-LDQVLAEVTAAAVEVIPGADIAGVLLVRKGGE
MAB_2534c|M.abscessus_ATCC_199 FSAKIADAARRMQQEHSSVEMTLRSITTAALETVPGVEQAGITLVTGRYE
MMAR_1808|M.marinum_M PATVFAALAEIIYQGAQ-PAEMYSAICIAATLIVPGCDHA-SLLVRTNDR
Mb1652|M.bovis_AF2122/97 TTDADAAVPRRVLIAED---EALIRMDLAEMLREEGYEIVGEAGDGQ--E
Rv1626|M.tuberculosis_H37Rv TTDADAAVPRRVLIAED---EALIRMDLAEMLREEGYEIVGEAGDGQ--E
MUL_1608|M.ulcerans_Agy99 TTDADAAKTRRVLIAED---EALIRMDLAEMLREEGYDIVGEAGDGQ--E
MLBr_01286|M.leprae_Br4923 TTDADAATPHRVLIAED---EALIRLDLAEMLRDEGYDIVGEAADGQ--E
TH_2526|M.thermoresistible__bu LNATVEKLIRKARASGADTCAVLTELTRSAVGDWPSIQHAGITVVEDGDV
. : . : .
Mvan_4938|M.vanbaalenii_PYR-1 FESVAGTSELPHRLDELQMKYRQGPCLEAALDSLIVRTDDFRTEQRWPLY
Mflv_1809|M.gilvum_PYR-GCK FESVAGTSELPHRLDELQMRFKEGPCLDAALDQTVVRTDDFRSEARWPQY
MSMEG_6741|M.smegmatis_MC2_155 FESLAALDELPHALDELQMRFDEGPCRQAALADLVVRTEDFRAEQRWPRY
MAV_5172|M.avium_104 FETLADTDSLAARLDVLQHDFGEGPCAQAALQETIVRSDDLRREPRWPCY
MAB_2534c|M.abscessus_ATCC_199 IESRAATSETPRKLDDIQQELREGPCVQSAWEHETVYAEDLAQTTPWPRF
MMAR_1808|M.marinum_M YITVGASDRLAQHVDELERKAGDGPCIDAIEEETPQIETDLTTPTQWPKF
Mb1652|M.bovis_AF2122/97 AVELAELHKPDLVIMDVKMPRRDG----------IDAASEIASKRIAPIV
Rv1626|M.tuberculosis_H37Rv AVELAELHKPDLVIMDVKMPRRDG----------IDAASEIASKRIAPIV
MUL_1608|M.ulcerans_Agy99 AVELAELHKPDLVIMDVKMPRRDG----------IDAASEIATKRIAPIV
MLBr_01286|M.leprae_Br4923 AVELAERHKPDLVIMDVKMPRRDG----------IDAASEIASKRIAPIV
TH_2526|M.thermoresistible__bu VRSIAATDGHVLVVDNIARRLSTGPGIDAALDEDSYRIDDLRADSRWPLF
. : : * :: *
Mvan_4938|M.vanbaalenii_PYR-1 SAAAAELG-VLSGLSF------------KLYTSARTAGALNLFALKPNAF
Mflv_1809|M.gilvum_PYR-GCK APAAAEIG-VLSGLSF------------KLYTSEQAAGALNLFGLRANAF
MSMEG_6741|M.smegmatis_MC2_155 SPASVELG-VLSGLSF------------KLYTADRTAGALNLFGFSPMNW
MAV_5172|M.avium_104 APAAVQLG-VLSSLSF------------KLYTADRTAGALNLFSHRPDAW
MAB_2534c|M.abscessus_ATCC_199 AEAAVKLG-VRSMLSF------------QLFTFGENLGALNLYAQSPGAF
MMAR_1808|M.marinum_M AAALLAQTPVRGAMGF------------RLLVDKRKGAALNLFSETPNSF
Mb1652|M.bovis_AF2122/97 VLTAFSQR--------------------DLVERARDAGAMAYLVKP---F
Rv1626|M.tuberculosis_H37Rv VLTAFSQR--------------------DLVERARDAGAMAYLVKP---F
MUL_1608|M.ulcerans_Agy99 VLTAFSQR--------------------DLVERARDAGAMAYLVKP---F
MLBr_01286|M.leprae_Br4923 VLTAFSQR--------------------DLVERARDAGAMAYLVKP---F
TH_2526|M.thermoresistible__bu ADKVAASTPIRSVIAIPVGNPIRNPIRNPIASAGTVRAALSLYSDLPGAF
: .*: :
Mvan_4938|M.vanbaalenii_PYR-1 DADAETIGAVFAAHAAAAIMASRE--------NEQLQSALSTRDRIGQAK
Mflv_1809|M.gilvum_PYR-GCK DDEAETIGAILAAHAAAAIIAGRQ--------SEQLESALSTRDRIGQAK
MSMEG_6741|M.smegmatis_MC2_155 DEDAVTTGTVLAAHAASAIVASRQ--------EEQLKTALLSRDRIGQAK
MAV_5172|M.avium_104 DTEAETIGSVFAAHAAAAILAGSR--------AEQLYSAVSTRDRIGQAK
MAB_2534c|M.abscessus_ATCC_199 GADSYDAGLALATHAAIVLVAAQR--------ESQWASALASRDVIGQAK
MMAR_1808|M.marinum_M DTESAGRAAVLASFASVAVNAIAHGE-----DAASLRRGLLSNREIGKAV
Mb1652|M.bovis_AF2122/97 SISDLIPAIELAVSRFREITALEG-------EVATLSERLETRKLVERAK
Rv1626|M.tuberculosis_H37Rv SISDLIPAIELAVSRFREITALEG-------EVATLSERLETRKLVERAK
MUL_1608|M.ulcerans_Agy99 TVSDLVPAIELAVSRFSEISALEN-------EVATLSDRLETRKLVERAK
MLBr_01286|M.leprae_Br4923 TISDLIPAIALAMSRFSELTALER-------EVATLADRLETRKLVERAK
TH_2526|M.thermoresistible__bu DDEVEAVAATYAEHIGRVLTARRGRRRAPVSGSARAQGSVRGQDAIETSK
. . * : * : . : :
Mvan_4938|M.vanbaalenii_PYR-1 GIIMERYDVDDVTAFEMLRRLSQDSNTKLVEVAAKVIETRGT--------
Mflv_1809|M.gilvum_PYR-GCK GIIMERYDVDDVAAFDMLRRLSQDSNTKLTEVAAKVIETRGT--------
MSMEG_6741|M.smegmatis_MC2_155 GIIMERYKVDDVQAFEMMRQLSQHSNTRLVDIAGQIIESR----------
MAV_5172|M.avium_104 GIIMERFGVDDVRAFDLLRRLSQESQVKLVEIAQQIIDTRGQGA------
MAB_2534c|M.abscessus_ATCC_199 GMLMERFSINAAEAFTVIRTLSQDFNTKLVEIARAIVEDRPLG-------
MMAR_1808|M.marinum_M GMLMLLNGFTEEEAFDLLRHHSQSLNIKLADVARTVIENRGQLPPEALET
Mb1652|M.bovis_AF2122/97 GLLQTKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT----
Rv1626|M.tuberculosis_H37Rv GLLQTKHGMTEPDAFKWIQRAAMDRRTTMKRVAEVVLETLGTPKDT----
MUL_1608|M.ulcerans_Agy99 GLLQAKQGMTEPEAFKWIQRAAMDRRTTMKRVAEVVLETLDTPDEA----
MLBr_01286|M.leprae_Br4923 GLLQVKQGMTEPEAFKWIQRAAMDRRTTMKRVAEVVLETLDTPKDT----
TH_2526|M.thermoresistible__bu AQLMKHFGVDPAAALTVLLRLSRECNRSLEDVARLLVGPRPVAEPPSQAT
. : . *: : : . : :* ::
Mvan_4938|M.vanbaalenii_PYR-1 --------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------
MAV_5172|M.avium_104 --------------------
MAB_2534c|M.abscessus_ATCC_199 --------------------
MMAR_1808|M.marinum_M DDTVNPTVSG----------
Mb1652|M.bovis_AF2122/97 --------------------
Rv1626|M.tuberculosis_H37Rv --------------------
MUL_1608|M.ulcerans_Agy99 --------------------
MLBr_01286|M.leprae_Br4923 --------------------
TH_2526|M.thermoresistible__bu ATATPDHAGGRPPVWAEGAA