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VTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFVLSHEQFRTDRLVAHAQAAER AGFTHGWASDHIQPWQDNEGHSMFPWLTLALVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPG RVFLGVGTGERLNEQATTNGYGNYTERHDRLAEAIALIRQLWSGSRISFSGRYFQTNSLKLYDVPATPPP IFVAAGGPKSAKLAGQFGDGWITQSGDVTNPKLLAAFGAGAQAAGRDVATLGKRAEMFAVVGDDAVAARA ATLWRFTAGAVDQPDPVDIQRAAESNPTDKVLGGWTGRHRRGSARRGRAAGPRRGRRSLPALSAGRPDGR HRLLPGQCLTEIALNPLRATPVSPLPATNSRRIGQNRDVMDAVDPDSRHQLAVRMAELVRGMAAPRRLDQ VLAEVTAAAVEVIPGADIAGVLLVRKGGEFETLADTDSLAARLDVLQHDFGEGPCAQAALQETIVRSDDL RREPRWPCYAPAAVQLGVLSSLSFKLYTADRTAGALNLFSHRPDAWDTEAETIGSVFAAHAAAAILAGSR AEQLYSAVSTRDRIGQAKGIIMERFGVDDVRAFDLLRRLSQESQVKLVEIAQQIIDTRGQGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5172 | - | - | 100% (622) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. avium 104 | MAV_4761 | - | 4e-52 | 40.14% (279) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. avium 104 | MAV_0425 | - | 9e-39 | 37.12% (264) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 1e-134 | 75.08% (317) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1809 | - | 9e-77 | 63.44% (227) | response regulator receiver/ANTAR domain-containing protein |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 1e-135 | 75.39% (317) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00269 | - | 2e-51 | 39.07% (279) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4230c | - | 4e-50 | 39.86% (281) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. marinum M | MMAR_0709 | fgd1 | 2e-50 | 38.35% (279) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. smegmatis MC2 155 | MSMEG_6741 | - | 1e-70 | 61.36% (220) | ANTAR domain-containing protein |
| M. thermoresistible (build 8) | TH_2304 | - | 3e-54 | 40.86% (279) | PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1 |
| M. ulcerans Agy99 | MUL_2814 | fgd1 | 1e-50 | 38.71% (279) | F420-dependent glucose-6-phosphate dehydrogenase Fgd1 |
| M. vanbaalenii PYR-1 | Mvan_4938 | - | 8e-74 | 62.78% (223) | response regulator receiver/ANTAR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 MTGISRRTLGRLAVGAGVLASAVQACAKPGAGHGRSGAPPAPAGKGVGFV
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LSHEQFRTDRLVAHAQAAERAGFTHGWASDHIQPWQDNEGHSMFPWLTLA
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LVGSSTSHVSFGTGVTCPTYRYHPATVAQAFASLAILNPGRVFLGVGTGE
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 RLNEQATTNGYGNYTERHDRLAEAIALIRQLWSGSRISFSGRYFQTNSLK
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 LYDVPATPPPIFVAAGGPKSAKLAGQFGDGWITQSGDVTNPKLLAAFGAG
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 AQAAGRDVATLGKRAEMFAVVGDDAVAARAATLWRFTAGAVDQPDPVDIQ
MMAR_0709|M.marinum_M --------------------------------------------------
MUL_2814|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00269|M.leprae_Br4923 --------------------------------------------------
TH_2304|M.thermoresistible__bu --------------------------------------------------
MAB_4230c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0137c|M.bovis_AF2122/97 --------------------------------------------------
Rv0132c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1809|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4938|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6741|M.smegmatis_MC2_155 --------------------------------------------------
MAV_5172|M.avium_104 RAAESNPTDKVLGGWTGRHRRGSARRGRAAGPRRGRRSLPALSAGRPDGR
MMAR_0709|M.marinum_M -----------------------------------------MAELKLGYK
MUL_2814|M.ulcerans_Agy99 -----------------------------------------MAELKLGYK
MLBr_00269|M.leprae_Br4923 -----------------------------------------MAELRLGYK
TH_2304|M.thermoresistible__bu -----------------------------------------VAELKLGYK
MAB_4230c|M.abscessus_ATCC_199 ----------------------------------------MARELKLGYK
Mb0137c|M.bovis_AF2122/97 ---MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVV
Rv0132c|M.tuberculosis_H37Rv ---MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVV
Mflv_1809|M.gilvum_PYR-GCK ------------------------------------------MNPMPTHE
Mvan_4938|M.vanbaalenii_PYR-1 ------------------------------------------MTETSSHA
MSMEG_6741|M.smegmatis_MC2_155 ------------------------------------------MGESRNHE
MAV_5172|M.avium_104 HRLLPGQCLTEIALNPLRATPVSPLPATNSRRIGQNRDVMDAVDPDSRHQ
MMAR_0709|M.marinum_M ASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMT
MUL_2814|M.ulcerans_Agy99 ASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGGHAPFSLAWMT
MLBr_00269|M.leprae_Br4923 ASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMT
TH_2304|M.thermoresistible__bu ASAEQFAPRELVELGVAAEEHGMDSATVSDHFQPWRHKGGHAPFSLAWMT
MAB_4230c|M.abscessus_ATCC_199 ASAEQFAPRELVELAVATESHGFDSATVSDHFQPWRYNGGHAPFSLAWMT
Mb0137c|M.bovis_AF2122/97 LSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLA
Rv0132c|M.tuberculosis_H37Rv LSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLA
Mflv_1809|M.gilvum_PYR-GCK LARRMAELARQVASPRRVEDVLSDVTAEARTLIPGVDAAG--------VL
Mvan_4938|M.vanbaalenii_PYR-1 LAQRMAELARTVASPRRVEDVLSDVTREVMGLIPGVDAAG--------VL
MSMEG_6741|M.smegmatis_MC2_155 LAMRMADLARAVASPRSLADVLTGVTTAAKELIPGVDTAG--------VL
MAV_5172|M.avium_104 LAVRMAELVRGMAAPRRLDQVLAEVTAAAVEVIPGADIAG--------VL
: . . : . . * * :
MMAR_0709|M.marinum_M AVGERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGE
MUL_2814|M.ulcerans_Agy99 AVGERTKRMQLGTSVLTPTFRYNPAVIAQAFATMGCLYPNRIFLGVGTGE
MLBr_00269|M.leprae_Br4923 AVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGE
TH_2304|M.thermoresistible__bu AVGERTKRITLGTSVLTPTFRYNPAVIAQAFATMACLYPDRIFLGVGTGE
MAB_4230c|M.abscessus_ATCC_199 AVGERTQRLQLGTSVLTPTFRYNPAVTAQAFATMGCLYPGRIFLGVGTGE
Mb0137c|M.bovis_AF2122/97 LVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGK
Rv0132c|M.tuberculosis_H37Rv LVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGE
Mflv_1809|M.gilvum_PYR-GCK LVGTAGR---FESVAGTSELPHRLDELQMRFKEGPCLDAALDQTVVRTDD
Mvan_4938|M.vanbaalenii_PYR-1 FVGAQGR---FESVAGTSELPHRLDELQMKYRQGPCLEAALDSLIVRTDD
MSMEG_6741|M.smegmatis_MC2_155 LIGPGNT---FESLAALDELPHALDELQMRFDEGPCRQAALADLVVRTED
MAV_5172|M.avium_104 LVRKGGE---FETLADTDSLAARLDVLQHDFGEGPCAQAALQETIVRSDD
: : : . : . : : .
MMAR_0709|M.marinum_M ALNEVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRG
MUL_2814|M.ulcerans_Agy99 ALNEVATGYQGVWPEFKERFARLRESVRLMRELWRGDRVDFDGEYYRLRG
MLBr_00269|M.leprae_Br4923 ALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDRVDFDGDYYQLKG
TH_2304|M.thermoresistible__bu ALNEIATGYEGEWPEFKERFARLREAVRLMRELWLGDRVDFDGEYYRTKG
MAB_4230c|M.abscessus_ATCC_199 ALNEIATGYIGEWPEFKERFARLRESVRLMRELWTGERVDFEGEYYRTQG
Mb0137c|M.bovis_AF2122/97 RLNEQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDE
Rv0132c|M.tuberculosis_H37Rv RLNEQAA--TDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDE
Mflv_1809|M.gilvum_PYR-GCK FR------SEARWPQYAPAAAEIGVLSGLSFKLYTSEQAAGALNLFGLRA
Mvan_4938|M.vanbaalenii_PYR-1 FR------TEQRWPLYSAAAAELGVLSGLSFKLYTSARTAGALNLFALKP
MSMEG_6741|M.smegmatis_MC2_155 FR------AEQRWPRYSPASVELGVLSGLSFKLYTADRTAGALNLFGFSP
MAV_5172|M.avium_104 LR------REPRWPCYAPAAVQLGVLSSLSFKLYTADRTAGALNLFSHRP
: : .: * :*: . : . :
MMAR_0709|M.marinum_M ASIYDVPEGGVPVYIAAGGPAVAKYAGRAGDGFICTSGKGEELYSEKLMP
MUL_2814|M.ulcerans_Agy99 ASIYDVPEGGVPVYTAAGGPAVAKYAGRAGDGFICTSGKGEDLYSEKLMP
MLBr_00269|M.leprae_Br4923 ASIYDVPEGGVPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEKLIP
TH_2304|M.thermoresistible__bu ASIYDVPEGGVPVYIAAGGPVVAKYAGRAGDGFICTSGKGAELYQDKLIP
MAB_4230c|M.abscessus_ATCC_199 AAIYDVPEGGIPVYIAAGGAVVAKYAGRAGDGFICTSGKGEELYSGKLIP
Mb0137c|M.bovis_AF2122/97 LKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLA
Rv0132c|M.tuberculosis_H37Rv LKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQAR---DINDAKLLA
Mflv_1809|M.gilvum_PYR-GCK NAFDDEAET-----------------------------------IGAILA
Mvan_4938|M.vanbaalenii_PYR-1 NAFDADAET-----------------------------------IGAVFA
MSMEG_6741|M.smegmatis_MC2_155 MNWDEDAVT-----------------------------------TGTVLA
MAV_5172|M.avium_104 DAWDTEAET-----------------------------------IGSVFA
. ::.
MMAR_0709|M.marinum_M AVREGAAINNRNIDDIDKMIEIKISYDPDPELALNNTRFWAPLSLSAEQK
MUL_2814|M.ulcerans_Agy99 AVREGAAINNRNIDDIDKMIEIKISYDPDPELALNNTRFWAPLSLSAEQK
MLBr_00269|M.leprae_Br4923 AVLEGAAVAGRDADDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAAEQK
TH_2304|M.thermoresistible__bu AVAEGAAAAGRDADEIDKMIEIKISYDPDPELALENTRFWAPLSLTAEQK
MAB_4230c|M.abscessus_ATCC_199 AVREGAALAERSFDDIDRMIEIKISYDPDPDKALENTRFWAPLSLTPEQK
Mb0137c|M.bovis_AF2122/97 AFAAGAQAAGRDPTTLGKRAELFAVVG-DDKAAARAADLWRFTAGAVDQP
Rv0132c|M.tuberculosis_H37Rv AFAAGAQAAGRDPTTLGKRAELFAVVG-DDKAAARAADLWRFTAGAVDQP
Mflv_1809|M.gilvum_PYR-GCK AHAAAAIIAGRQSEQLESALSTRDRIG-----------------------
Mvan_4938|M.vanbaalenii_PYR-1 AHAAAAIMASRENEQLQSALSTRDRIG-----------------------
MSMEG_6741|M.smegmatis_MC2_155 AHAASAIVASRQEEQLKTALLSRDRIG-----------------------
MAV_5172|M.avium_104 AHAAAAILAGSRAEQLYSAVSTRDRIG-----------------------
* .* : .
MMAR_0709|M.marinum_M RSIGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLNHLV
MUL_2814|M.ulcerans_Agy99 RSIGDPIEMEAAAEALPIEQIAKRWIVASDPDEAVEKVGQYVAWGLNHLV
MLBr_00269|M.leprae_Br4923 HSIDDPIEMEKVADALPIEQVAKRWIVVSDPDEAVARVGQYVTWGLNHLV
TH_2304|M.thermoresistible__bu HSIDDPIEMERAADELPIEQVAKRWIVASDPDEAVEQVAQYVKWGLNHLV
MAB_4230c|M.abscessus_ATCC_199 HSIHDPIEMERAADELPIEQVAKRWIVASDPDEAVEKVADYVGWGLNHLV
Mb0137c|M.bovis_AF2122/97 ----NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA-VPF
Rv0132c|M.tuberculosis_H37Rv ----NPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGA-VPF
Mflv_1809|M.gilvum_PYR-GCK -----------QAKGIIMERYDVDDVAAFD------------------ML
Mvan_4938|M.vanbaalenii_PYR-1 -----------QAKGIIMERYDVDDVTAFE------------------ML
MSMEG_6741|M.smegmatis_MC2_155 -----------QAKGIIMERYKVDDVQAFE------------------MM
MAV_5172|M.avium_104 -----------QAKGIIMERFGVDDVRAFD------------------LL
*. :*: : .
MMAR_0709|M.marinum_M LHAPGHDQLRFLELFEKDLAPRLRRLG
MUL_2814|M.ulcerans_Agy99 LHAPGHDQLRFLELFEKDLAPRLRRLG
MLBr_00269|M.leprae_Br4923 FHAPGHNQRRFLELFEKDLAPRLRRLG
TH_2304|M.thermoresistible__bu FHAPGHDQRRFLELFRTDLEPRLRRLG
MAB_4230c|M.abscessus_ATCC_199 FHAPGHDQKRFLELFKTDLEPRLRKLG
Mb0137c|M.bovis_AF2122/97 LHFPQDDPITAIDFYRTNVLPELR---
Rv0132c|M.tuberculosis_H37Rv LHFPQDDPITAIDFYRTNVLPELR---
Mflv_1809|M.gilvum_PYR-GCK RRLSQDSNTKLTEVAAKVIETRGT---
Mvan_4938|M.vanbaalenii_PYR-1 RRLSQDSNTKLVEVAAKVIETRGT---
MSMEG_6741|M.smegmatis_MC2_155 RQLSQHSNTRLVDIAGQIIESR-----
MAV_5172|M.avium_104 RRLSQESQVKLVEIAQQIIDTRGQGA-
: . .. :. : ..