For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTARNYDVPDAFDAGAPAYDGLVGANPGYHAHLRLSARRMRLPDQGRGLRLLDIGCGTGASTAALLSAAP LADIVAVDGSAGMLEQARAKTWPPSVTFVHSRAETLAAAGVTGPFDGILAAYLIRNVEDPDSVLGSLRSL LRPGGVLAVHEYSVRDSRLATAVWNLVSTAIIIPAGRLRSGDAGLYRYLRRSVNNFDGAAQFRDRLRRNG FVDVHSESMPGWQHNIVHTFLGRAPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4887 | - | - | 100% (236) | methyltransferase type 11 |
| M. vanbaalenii PYR-1 | Mvan_0983 | ubiE | 6e-11 | 29.07% (172) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 2e-08 | 36.89% (103) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0573 | ubiE | 4e-10 | 27.40% (219) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. gilvum PYR-GCK | Mflv_1845 | - | 1e-107 | 82.68% (231) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0558 | ubiE | 4e-10 | 27.40% (219) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 2e-11 | 27.27% (176) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_1977 | - | 6e-10 | 30.00% (140) | putative methyltransferase |
| M. marinum M | MMAR_0907 | ubiE | 1e-10 | 29.06% (234) | ubiquinone/menaquinone methlytransferase, MenH |
| M. avium 104 | MAV_3889 | - | 4e-82 | 68.00% (225) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_5176 | - | 4e-11 | 36.11% (144) | methyltransferase type 11 |
| M. thermoresistible (build 8) | TH_3050 | - | 1e-89 | 70.13% (231) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_0660 | ubiE | 4e-10 | 28.63% (234) | ubiquinone/menaquinone biosynthesis methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4887|M.vanbaalenii_PYR-1 -------------MTARNYDVPDAFDAGAPAYDGLVGANPGYHAHLRLSA
Mflv_1845|M.gilvum_PYR-GCK ---------------MATYDVPDAFDAGADAYDGLVGANPGYHKHLRLSA
TH_3050|M.thermoresistible__bu --------VTGRRRHLDRAAVPAAFDAGAASYDRLVAANPGYHEHLRLSA
MAV_3889|M.avium_104 --------MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSA
MMAR_0907|M.marinum_M --------MSRAALDKDPRDVASMFDGVARRYDLTNTVLSLGQDRYWRRA
MUL_0660|M.ulcerans_Agy99 --------MSRAALDKDPRDVASMFDGVARRYDLTNTVLSLGQDRYWRRA
Mb0573|M.bovis_AF2122/97 --------MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRA
Rv0558|M.tuberculosis_H37Rv --------MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRA
MLBr_02273|M.leprae_Br4923 MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSLGQDRYWRRA
MAB_1977|M.abscessus_ATCC_1997 -----------MDPAEHARHTRDVYDRLAPVWSATTDDGP-FNGLLERPA
MSMEG_5176|M.smegmatis_MC2_155 ---------------MPPTDAAQPEPVDNPFFAWLWKTLSTHETESVRRM
: . .
Mvan_4887|M.vanbaalenii_PYR-1 RRMRLP---DQGRGLRLLDIGCGTGASTAALLSAAPLADIVAVDGSAGML
Mflv_1845|M.gilvum_PYR-GCK RRMGLP---DGGRGLVLLDIGCGTGASTAALLRAAPHAEIVAVDGSAGML
TH_3050|M.thermoresistible__bu HRMGLPGCAARXRGLRILDAGCGTGASTAALLTYAPDAEIVAVDASAGML
MAV_3889|M.avium_104 RRMRIP---HDGKGLRLLDAGCGTGASTAALLAVAPAADIVAVDASRGML
MMAR_0907|M.marinum_M TRSALR----IGPGDKVLDLAAGTAVSTVELAKSG--AWCVAADFSVGML
MUL_0660|M.ulcerans_Agy99 TRSALR----IGPGDKVLDLAAGTAVSSVELAKSG--AWCVAADFSVGML
Mb0573|M.bovis_AF2122/97 TRSALR----IGPGQKVLDLAAGTAVSTVELTKSG--AWCVAADFSVGML
Rv0558|M.tuberculosis_H37Rv TRSALR----IGPGQKVLDLAAGTAVSTVELTKSG--AWCVAADFSVGML
MLBr_02273|M.leprae_Br4923 TRSALR----IGPGQKVLDLAAGTAVSTAELSKSG--AWCVAADFSVRML
MAB_1977|M.abscessus_ATCC_1997 LRSLIP---RPLAGRSVLDAGCGSGAQCAWLLGEG--ADVTGLDLSPAMV
MSMEG_5176|M.smegmatis_MC2_155 RAENLA-----GLSGRVLEVGAGTGTNFEFYPSTVDEVVAIEPERRLADV
: . :*: ..*:... . : :
Mvan_4887|M.vanbaalenii_PYR-1 EQARAKTWPPSVTFVHSRAETLAAAGVTGPFDGILAAYLIRNVEDPDSVL
Mflv_1845|M.gilvum_PYR-GCK AQARAKRWPPNVRFVHSRVEDLAVNGVTGPFDGILAAYLIRNVADRDGVL
TH_3050|M.thermoresistible__bu AAAAAKPWPATVRFVHSRVEDLAGAGVGGPFDAVFAAYLLRNLPDPDTQL
MAV_3889|M.avium_104 EVALAKRWPASVRFVHAPVQRLAEHGISGPFDGVLAAYLIRNVADRDEQL
MMAR_0907|M.marinum_M AAGHER----KVCKVAGDATRLPFA--DDVFDAVTISFGLRNVVDFSAAL
MUL_0660|M.ulcerans_Agy99 AAGHER----RVCKVAGDATRLPFA--DDVFDAVTISFGLRNVVDFSAAL
Mb0573|M.bovis_AF2122/97 AAGAAR----KVPKVAGDATRLPFG--DDVFDAVTISFGLRNVANQQAAL
Rv0558|M.tuberculosis_H37Rv AAGAAR----KVPKVAGDATRLPFG--DDVFDAVTISFGLRNVANQQAAL
MLBr_02273|M.leprae_Br4923 ATGGAR----KVPKVAADATQLPFS--DGVFDAVTISFGLRNIADYQAAL
MAB_1977|M.abscessus_ATCC_1997 DQARQRCGSAAKLMVADLADDLPLE--PRSFDGVTCSLALHYLRDWQVPL
MSMEG_5176|M.smegmatis_MC2_155 ARQAAAKAPVPVSVTGDTIETFASA---QPFDAVVCSLVLCSVDDPEQVV
. :. **.: : : : : . :
Mvan_4887|M.vanbaalenii_PYR-1 GSLRSLLRPGGVLAV---HEYSVRDSRLATAVWNLVSTAIIIPAGRLRSG
Mflv_1845|M.gilvum_PYR-GCK QELRALLRPGGVFAA---HEYSVRDSRTATALWNLVSSAVIIPAGRLRSG
TH_3050|M.thermoresistible__bu TAFRDLLRPGGILAV---HEYSVRDSAVATAVWNVVCGAVVIPLGRLRTG
MAV_3889|M.avium_104 RRFRTLLRPGATLAV---HEYSVRDSAAATLAWHALCWGIIIPAGWWRSG
MMAR_0907|M.marinum_M REMARVTRPGGRLVV---CEFSTPVSALFATVYKEYLMRALPRVARAVSS
MUL_0660|M.ulcerans_Agy99 REMARVTRPGGRLVV---CEFSTPVSALFATVYKEYLMRALPRVARAVSS
Mb0573|M.bovis_AF2122/97 REMARVTRPGGRLLV---CEFSTPTNALFATAYKEYLMRALPRVARAVSS
Rv0558|M.tuberculosis_H37Rv REMARVTRPGGRLLV---CEFSTPTNALFATAYKEYLMRALPRVARAVSS
MLBr_02273|M.leprae_Br4923 REMARVTRPGGQLVV---CEFSTPTNALVANVYTEYLMRALPQVARLVSS
MAB_1977|M.abscessus_ATCC_1997 ASFARILRPGGWVVISLDHPFGAPLPDQRGGYFQHQLVSDTWNKADVEVT
MSMEG_5176|M.smegmatis_MC2_155 GQLYSLLRPGGELRY-----LEHVAGTGFQARLQRLADATVWPKLFG-GC
: : ***. .
Mvan_4887|M.vanbaalenii_PYR-1 DAGLYRYLRRSVNNFDGAAQFRDRLRRNGFVDVHSESMPGWQHNIVHT--
Mflv_1845|M.gilvum_PYR-GCK DAELYRYLKRSVNEFDGAAEFRNRLQRNGFVDVTSHTMSGWQHDIVHT--
TH_3050|M.thermoresistible__bu DAALYRYLRRSVNTFDGAERFRNRLRACGFTDVRSATMPGWQRDIVHT--
MAV_3889|M.avium_104 DTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHT--
MMAR_0907|M.marinum_M NPEAYVYLAESIRAWPDQAALAQQMSRAGWSAVRWRNLTG---GIVAL--
MUL_0660|M.ulcerans_Agy99 NPEAYVYLAESIRAWPDQAALAQQMSRAGWSAVRWRNLTG---GIVAL--
Mb0573|M.bovis_AF2122/97 NPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTG---GIVAL--
Rv0558|M.tuberculosis_H37Rv NPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTG---GIVAL--
MLBr_02273|M.leprae_Br4923 NPDAYIYLAESIRAWPDQVTLACQLSRTGWASPRWRNLTG---GIVAL--
MAB_1977|M.abscessus_ATCC_1997 QHFWRRPLGQVADAFADAGLLIERISEPRPSAEAIRRFPAELRNVVDSPS
MSMEG_5176|M.smegmatis_MC2_155 HTHRHTEQVIASSGFGVRGRRREQVLPAWVPVPTTEFAIG----------
. : :: .
Mvan_4887|M.vanbaalenii_PYR-1 FLGRAPQ------
Mflv_1845|M.gilvum_PYR-GCK FLGRTPQ------
TH_3050|M.thermoresistible__bu FLARRPG------
MAV_3889|M.avium_104 FLADAPS------
MMAR_0907|M.marinum_M HAGYKP---QPV-
MUL_0660|M.ulcerans_Agy99 HAGYKP---QPV-
Mb0573|M.bovis_AF2122/97 HAGYKPGKQTPQ-
Rv0558|M.tuberculosis_H37Rv HAGYKPGKQTPQ-
MLBr_02273|M.leprae_Br4923 HAADKPVR-----
MAB_1977|M.abscessus_ATCC_1997 FIVYRLRYWGAPA
MSMEG_5176|M.smegmatis_MC2_155 -RAVRP-------