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AVDPRTPVIVGVGQFTERIDDPAYRGMSAVELATAAVQAALVDTGADAAVVAAAIDTVFGLRQFEISGPM PATLGKSNNYPRSVMKRVGGDPARVVLEPVGGQGPQKLVTEAGNLIVAGDADVVMIMGSEPGSTAKYFAG RDDKPDFTEHVDGQLEDRGHQIYNYIDEYTVTHGLTGAPVQYGLLDNARRSRLGLGVGPYRHLMAELFAP MSKVAAKNPFSASLVERSVEEVETVTGENRMICDPYPRFLVARDTVNQGAAAVLTSVEAARKLGVPEEKW VYLHGHSDLVEQALLERVDLGASPAAVAAAHEALRVAGLGVDDIATFDLYSCFPFPVFVICEALGLSADD PRGLTLTGGLPYFGGPGNSYSLHGIAETVAQMRDRPGQFGFVGANGGIMSKYSVGIYSTEPVGWRTSRSA ELTAEVAERPRVAVTKSPEGAATIETYSVRHDWPVRTGIIVGRLDADGSRFMATSEDADLVALMTEADPL GANITVTPTDNGNRAVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4866 | - | - | 100% (509) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3068 | - | 7e-57 | 32.47% (502) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0899 | - | 2e-10 | 27.75% (400) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1898 | - | 9e-56 | 32.87% (505) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1869 | - | 0.0 | 86.42% (508) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1867 | - | 9e-56 | 32.87% (505) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3826c | - | 1e-63 | 34.19% (506) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4547 | - | 0.0 | 65.03% (509) | thiolase |
| M. avium 104 | MAV_1076 | - | 0.0 | 67.52% (508) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5521 | - | 0.0 | 67.59% (506) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_1768 | - | 1e-179 | 68.22% (450) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_4717 | - | 0.0 | 65.23% (509) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4866|M.vanbaalenii_PYR-1 MAVDPRTPVIVGVGQFTERIDDPAYRGMSAVELATAAVQAALVDTGADAA
Mflv_1869|M.gilvum_PYR-GCK MAVDSRTPVIVGVGQFTERIGDPDYRGMSAVDLATAAARAALTDTGADTA
MSMEG_5521|M.smegmatis_MC2_155 -MVDPRTPVIVGVGQFTERIDLDGYRGMSSVELATEAAKAALHDCGADAD
TH_1768|M.thermoresistible__bu --------------------------------------------------
MAV_1076|M.avium_104 MNLDPNTPVIVGVGQFTERIEDSGYRGMSSVKLATEAARAALHDCGADAT
MMAR_4547|M.marinum_M MDLDPGTPVIVGVGQAVERIDDPDYQGMSAVELAAAAAQAALEDCAAD--
MUL_4717|M.ulcerans_Agy99 MDLDPGTPVIVGVGQAVERMDDPDYQGMSAVELAAAAAQAALEDCAAD--
Mb1898|M.bovis_AF2122/97 MPVDPRTPVLIGYGQVNHRGDIDAEKQSI-EPVDLMAAAARKAADST---
Rv1867|M.tuberculosis_H37Rv MPVDPRTPVLIGYGQVNHRGDIDAEKQSI-EPVDLMAAAARKAADST---
MAB_3826c|M.abscessus_ATCC_199 MAFDPRTPVLVGTGQVNQRTDADTPFSEIPEPIDLMEQAARLAAGDAGAT
Mvan_4866|M.vanbaalenii_PYR-1 VVAAAIDTVFGLRQFEISGPMP-ATLGKSNNYPRSVMKRVGGDPARVVLE
Mflv_1869|M.gilvum_PYR-GCK AVASAIDTIFGLRQFEISGPMP-AVLGKSNNYPRSVANRLGADPARVVLE
MSMEG_5521|M.smegmatis_MC2_155 TVARAIDTVAGTRQFEISGPAS-APLGVSSNYPRSVARNIGADPAHAVLE
TH_1768|M.thermoresistible__bu --------VAGVRQFEISGLAP-APLGKSDNYPRSVARRIGADPRRAVLE
MAV_1076|M.avium_104 AVAAAVDTVGAIRQFELSGRTP-APMGKSNNYPRSVARRIGAAPARAVLE
MMAR_4547|M.marinum_M -VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARAILE
MUL_4717|M.ulcerans_Agy99 -VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARAILE
Mb1898|M.bovis_AF2122/97 -VLEAVDSIRVVHMLSAHYRNPGQLLG----------ERIKARTFTTGYS
Rv1867|M.tuberculosis_H37Rv -VLEAVDSIRVVHMLSAHYRNPGQLLG----------ERIKARTFTTGYS
MAB_3826c|M.abscessus_ATCC_199 ELLGAIDTISVANIFSWRYRDPGVLLG----------ERLGAVPKRTFYT
: . :. . :* ..: . . .
Mvan_4866|M.vanbaalenii_PYR-1 PVGGQGPQKLVTEAGNLIVAGDADVVMIMGSEPGSTAKYFAGRDDKPDFT
Mflv_1869|M.gilvum_PYR-GCK PVGGQSPQKLVTEAGALIVGGRADVVMIMGSEPGSTAKYFADREDKPDFT
MSMEG_5521|M.smegmatis_MC2_155 VIGGQSPQHLATEFGGKIAAGENDVVLIFGSENTSTLRHFSKAENKPDHS
TH_1768|M.thermoresistible__bu VIGGQSPQRLVTEFAGAIAAGEADVVLVMGSENTSTLRYFADRDDKPDHS
MAV_1076|M.avium_104 PIGGQGPQHLVTEFAGVIAAGDAEVVMIFGSENTSSIRYFADRE-KPDHS
MMAR_4547|M.marinum_M IVGGQGPQHLITELAGAIAAGRSEVAMVFGSDATSTSRHFAGRADKPDFT
MUL_4717|M.ulcerans_Agy99 IVGGQGPQHLITELAGAIAAGSSEVAMVFGSDATSTSRHFAGRADKPDFT
Mb1898|M.bovis_AF2122/97 GVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWT
Rv1867|M.tuberculosis_H37Rv GVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWT
MAB_3826c|M.abscessus_ATCC_199 GPSGNSPQLLVNHAAADILAGDADVVLIGGAEMWRSRNKMMATGVQPTWT
.*: ** * .. * * *.:: *:: : : : :
Mvan_4866|M.vanbaalenii_PYR-1 EHVDGQLEDRGHQIYN-YIDEYTVTHGLTGAPVQYGLLDNARRSRLGLGV
Mflv_1869|M.gilvum_PYR-GCK EHVDGQLEDRGHQIYS-YIDEYTVTHGLTGAPVQYGLLDNARRSRLGLGV
MSMEG_5521|M.smegmatis_MC2_155 ETVDGQLEDRGYGYDG-IFDEYTIRHGLIGAPVQYGLLENARRARLGLSV
TH_1768|M.thermoresistible__bu ETVGGQLEDRGYGYDG-IIDDYSVTHGLVGAPPQYALLENARRARVGLSA
MAV_1076|M.avium_104 ETVEGSLEDRGFGYEG-LFDDYTVAHGLIGAPAQYGLLENARRARLGLSV
MMAR_4547|M.marinum_M EIVDGELQDRGPGIDG-LITRYTIIHGLVDAPTQYGLLENAHRAATGLGP
MUL_4717|M.ulcerans_Agy99 EIVDGELQDRGPGIDG-LITRYTIIHGLVDAPIQYGLLENARRAATGLGP
Mb1898|M.bovis_AF2122/97 VQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYGESI
Rv1867|M.tuberculosis_H37Rv VQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYGESI
MAB_3826c|M.abscessus_ATCC_199 IQDESVAEATVLGGRMDQVGGAETAIGLISPGHVYPLFEEAIRIAGGVSI
. .* . * ::::* * * .
Mvan_4866|M.vanbaalenii_PYR-1 GPYRHLMAELFAPMSKVAAKNPFSASLVERSVEEVETVTGENRMICDPYP
Mflv_1869|M.gilvum_PYR-GCK AEYRHTMAQLFAPMSKVAAKNPFSSSPVERSVEEVETVTGENRMICDPYP
MSMEG_5521|M.smegmatis_MC2_155 ADYRLAMAELFAPFSKVAAKNPYSSAPTERSVEELLTVTASNRMIVDPYP
TH_1768|M.thermoresistible__bu DDYRLAMAELFAPFSKVAAKNPYSSSPVERSVQELATVTDSNRMISDPYP
MAV_1076|M.avium_104 ADYRRRMGELFAPFTKVAAKNPFASAPVERSVDELITVTPSNRMICDPYP
MMAR_4547|M.marinum_M ADYLRRMGELFAPFTKIAAGNPFAAAPIERTIEELITVTDRNRMIAEPYP
MUL_4717|M.ulcerans_Agy99 ADYLRRMGELFAPFTKIAAGNPFAAAPIERTVEELITVTDRNRMIAEPYP
Mb1898|M.bovis_AF2122/97 ENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQPGPQNRMVSWPYT
Rv1867|M.tuberculosis_H37Rv ENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQPGPQNRMVSWPYT
MAB_3826c|M.abscessus_ATCC_199 ADHRAAMSQLWQRFNAVAVTNGHAWSNDAYTAEEIATPGPDNRWISSPYT
: :.:*: :. :*. * .: : :*: ** : **.
Mvan_4866|M.vanbaalenii_PYR-1 RFLVARDTVNQGAAAVLTSVEAARKLGVPEEKWVYLHGHSDLVEQ-ALLE
Mflv_1869|M.gilvum_PYR-GCK RLLVARDTVNQGAAAVLMSVESARRLGVPESKWVYLHGHSDLVEQ-PLLA
MSMEG_5521|M.smegmatis_MC2_155 RLMVARDQVNQGAALLMMSVESARKLGVPEEKWVYLRGHADMKEP-KLLE
TH_1768|M.thermoresistible__bu RLMVARDQVNQGAAAVLMSVEAARRLGVPEDNWVYLHGHADLKEQ-PLLE
MAV_1076|M.avium_104 RLLVARDQVNQGAAALLMSVAAARRFRVPEERWVFLHGHADMVDQ-PLLD
MMAR_4547|M.marinum_M RLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-ALLQ
MUL_4717|M.ulcerans_Agy99 RLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-ALLQ
Mb1898|M.bovis_AF2122/97 KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
Rv1867|M.tuberculosis_H37Rv KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
MAB_3826c|M.abscessus_ATCC_199 KLMNSNNMVEQGAVVLLTSVETALRLGISKDRWIFPLAGAQANDTFALSE
::: :.: *:***. :: ** * :: :. ..*:: . :: : :
Mvan_4866|M.vanbaalenii_PYR-1 RVDLGASPAAVAAAHEALRVAGLGVDDIATFDLYSCFPFPVFVICEALGL
Mflv_1869|M.gilvum_PYR-GCK RVDLGASPAAVHAIDEALRVAGIGVDDIATFDLYSCFPFPVFVACEALGL
MSMEG_5521|M.smegmatis_MC2_155 RADIGASPASVTAVNEALRVAGIGLDDVAAFDLYSCFPFPVFNICDGTGL
TH_1768|M.thermoresistible__bu RPDLGAGPASVLAVQEALRVAGIGLDQVAAFDLYSCFPFPVFNICDGTGL
MAV_1076|M.avium_104 RLDLTYNSASVLAVQEALVGAGIGIDDVSTFDLYSCFPVPVFNFCDGTSL
MMAR_4547|M.marinum_M RPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICDGLGI
MUL_4717|M.ulcerans_Agy99 RPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICDGLGI
Mb1898|M.bovis_AF2122/97 RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
Rv1867|M.tuberculosis_H37Rv RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
MAB_3826c|M.abscessus_ATCC_199 RHELHRSPAIRLAGRRAFEIAGLGTDDVELVDIYSCFPSAVQVAAAELGL
* : .: * .*: **:* *:: .*:***** .* . .:
Mvan_4866|M.vanbaalenii_PYR-1 SADDP-RGLTLTGGLPYFGGPGNSYSLHGIAETVAQMRDRPGQFGFVGAN
Mflv_1869|M.gilvum_PYR-GCK AGDDP-RGVTLTGGLPYFGGPGNSYSLHAIAETVTAMRDRPGQFGFVGAN
MSMEG_5521|M.smegmatis_MC2_155 ATDDP-RGLTLTGGLPFFGGLGNNYSMHGIAEAVNEMRDKPGQFALVGAN
TH_1768|M.thermoresistible__bu ATDDP-RGLTLTGGLPFFGGPGNNYSLHAIAEAVTEMRGRPGQFALVGAN
MAV_1076|M.avium_104 ATDDP-RGLTLTGGLPYFGGPGNNYSLHGIAETVSEMRDRPGQFGLVAAN
MMAR_4547|M.marinum_M ATDDP-RGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGLVGAN
MUL_4717|M.ulcerans_Agy99 ATDDP-RGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGLVGAN
Mb1898|M.bovis_AF2122/97 DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
Rv1867|M.tuberculosis_H37Rv DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
MAB_3826c|M.abscessus_ATCC_199 ALDDPARPLTVTGGLTFAGGPWCNYVTHSIATMAERLRERPGAKGLITAN
*** * :*:****.: ** .* *.:* . : .** .:: **
Mvan_4866|M.vanbaalenii_PYR-1 GGIMSKYSVGIYSTEPVGWRTSRSAELTAEVAERPRVAVTKSPEGAATIE
Mflv_1869|M.gilvum_PYR-GCK GGIMSKYSVGVYSTEPVEWRSCRSAELTAQVAELPTVAVTKTPEGTGTIE
MSMEG_5521|M.smegmatis_MC2_155 GGIASKYSVGIYSTEPADWVADNSAQLQAEHDAQPKVAITEKADGTGTIE
TH_1768|M.thermoresistible__bu GGFASKYSVGIYSTEPAEWRPDRSADLQEQIAAMPKVAITERADGAATVE
MAV_1076|M.avium_104 GGIMSKYSVGVYSTTPVNWKPDNSAALRAEVAARPTVPVTVRADGRATIE
MMAR_4547|M.marinum_M GGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGASQPVTEQADGPATIE
MUL_4717|M.ulcerans_Agy99 GGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGASRPVIEQADGPATIE
Mb1898|M.bovis_AF2122/97 GGYLTKHSFGVYGTEPPSE--FRWEDMQPAVDREPTGDGLVEWEGIGTVE
Rv1867|M.tuberculosis_H37Rv GGYLTKHSFGVYGTEPPSE--FRWEDMQPAVDREPTGDGLVEWEGIGTVE
MAB_3826c|M.abscessus_ATCC_199 GGYLTKHAFGIYGTEPPASG-FAYEDVQADVDQEPRTEAADGYTGTAAVE
** :*::.*:*.* * : . * .::*
Mvan_4866|M.vanbaalenii_PYR-1 TYSVRHDWPVRTG-IIVGRLDADGSRFMATSEDADLVALMTEADPLGANI
Mflv_1869|M.gilvum_PYR-GCK TYSVRYDWPVRTG-IIVGRLDSDGSRFMATSEDHELVALMSDGDPLGAKV
MSMEG_5521|M.smegmatis_MC2_155 TYTVRYDWTPHTG-IIIGRLD-DGSRFLAKTKDEDLVKLLSEGDPIGAKI
TH_1768|M.thermoresistible__bu TYTVRYGRKGRTG-IIVGRLDADNSRFLATTRDDDMLALLCEGEPLGAAF
MAV_1076|M.avium_104 TYTVRYDWPVRTG-IIIGRLDDDGSRFLALTEDPELVGLLSDGEPLGASI
MMAR_4547|M.marinum_M TYTVRHDGGRLTG-IVIGRLADDGRRFLASTEDDELIGLLTDGDPLGQAI
MUL_4717|M.ulcerans_Agy99 TYTVRHDGGRLTG-IVIGRLAADGRRFLASTEDDELIGLLTDGDPLGQAI
Mb1898|M.bovis_AF2122/97 AWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKV
Rv1867|M.tuberculosis_H37Rv AWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKV
MAB_3826c|M.abscessus_ATCC_199 AWTVNYGRDGSPFQTFVSVRTPTGARTFAKIDDRDASAHIADTDIAGASI
:::. . . .:. . * :* * : * .
Mvan_4866|M.vanbaalenii_PYR-1 TVTPTDNGNRAVLR
Mflv_1869|M.gilvum_PYR-GCK AVTNTDNGNRATLA
MSMEG_5521|M.smegmatis_MC2_155 VVTPGEKSNRAVLA
TH_1768|M.thermoresistible__bu TVRSTEKGNRASL-
MAV_1076|M.avium_104 VVTATEKDNRATLA
MMAR_4547|M.marinum_M RVRSFDYGNRCVL-
MUL_4717|M.ulcerans_Agy99 RVRSFDYGNRCVL-
Mb1898|M.bovis_AF2122/97 AVAPDGTATLR---
Rv1867|M.tuberculosis_H37Rv AVAPDGTATLR---
MAB_3826c|M.abscessus_ATCC_199 EVAADGSARLN---
*