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PIDPRTPVLVGYGQVNQHDENPDVEPVDLMVQAARAAADPRLLEAVDAVRVVNLLSWRYRDPGLLLAQRI RADKAVTRYTGIGGNVPQTLVNMACLDIQQGKADVVLIAGAETWRTRSRIRAAGRRPDWTKQDESVPSAP GGDESVPMAAPSDIRINLDRPAYVYPMFEQALRIAAGETPDEHRRRIGELWAQFSAVAADNPHAWNREAL TPEQIWQPSASNRMISWPYTKLMNSNNMVDQGAVLIVASAETARHLQIPSDRWVFPYAGADSHDTYAIAE RAEFHTSPAIRIAGRRALELAGAGVDDMDLVDVYSCFPSAVQVAARELGLPVGKPDRPLTVTGGLTFAGG PWNNYVTHSIATMAERLAAQPGQRGLITANGGYLTKHSFGVYGTEPPKHEFRWEDVQSEVDREPTRTAVV EWSGVGTVESWTTPVDRDGAPEKAFLAVRTPEDARVLAVITDRAGAEATVRDDIAGAAVRVHADGTASLE *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3068 | - | - | 100% (491) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4866 | - | 7e-57 | 32.47% (502) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0916 | - | 7e-09 | 32.67% (150) | acetyl-CoA acetyltransferases |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1898 | - | 0.0 | 68.83% (494) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_3340 | - | 0.0 | 84.69% (490) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1867 | - | 0.0 | 68.83% (494) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 4e-06 | 27.63% (152) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3826c | - | 1e-158 | 56.71% (499) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_2746 | - | 0.0 | 68.62% (494) | hypothetical protein MMAR_2746 |
| M. avium 104 | MAV_2851 | - | 0.0 | 68.08% (495) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_3608 | - | 0.0 | 78.97% (485) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_1434 | - | 1e-159 | 77.78% (342) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3008 | - | 0.0 | 68.02% (494) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3068|M.vanbaalenii_PYR-1 MPIDPRTPVLVGYGQVNQHDEN-----PDVEPVDLMVQAARAAADPR---
Mflv_3340|M.gilvum_PYR-GCK MPIDPRTPVLIGYGQVNQRTED-----PSVEPVDLMAAAAREAADPR---
MSMEG_3608|M.smegmatis_MC2_155 --MN-RTPVLVGYGQVSQYDEN-----PATEPVDLMAEAARNAADPR---
TH_1434|M.thermoresistible__bu --------------------------------------------------
Mb1898|M.bovis_AF2122/97 MPVDPRTPVLIGYGQVNHRGDIDAEK-QSIEPVDLMAAAARKAADST---
Rv1867|M.tuberculosis_H37Rv MPVDPRTPVLIGYGQVNHRGDIDAEK-QSIEPVDLMAAAARKAADST---
MMAR_2746|M.marinum_M MVVDPRTPVLIGYGQVNYRDEIDPTM-PSVEPVDLMLAAAQQAADSR---
MUL_3008|M.ulcerans_Agy99 MAVDPRTPVLIGYGQVNYRDEIDPTM-PSVEPVDLMLAAAQQAADSR---
MAV_2851|M.avium_104 MTVDPRTPVLIGYGQVNHRDDIDPAV-RSVEPVDLMAAAVERAADAA---
MAB_3826c|M.abscessus_ATCC_199 MAFDPRTPVLVGTGQVNQRTDADTPFSEIPEPIDLMEQAARLAAGDAGAT
MLBr_02162|M.leprae_Br4923 MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDLD---
Mvan_3068|M.vanbaalenii_PYR-1 -LLEAVDAVRVVNLLSWRYRDPGLLLAQRIRADKAVTRYTGIGGN----V
Mflv_3340|M.gilvum_PYR-GCK -VLEAVDAVRVVNLLSWRYRDPGLLLAERIGAAKAATRYTGIGGN----V
MSMEG_3608|M.smegmatis_MC2_155 -VLQAVDSVRVVNLLSWRYRDPGLLLAGRIGAAGARTRYTGIGGN----V
TH_1434|M.thermoresistible__bu --------------------------------------------------
Mb1898|M.bovis_AF2122/97 -VLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGN----M
Rv1867|M.tuberculosis_H37Rv -VLEAVDSIRVVHMLSAHYRNPGQLLGERIKARTFTTGYSGVGGN----M
MMAR_2746|M.marinum_M -VLAAVDSIRVVRVLSAHYRNPGQLLGERLQASGFTTSYSSVGGN----T
MUL_3008|M.ulcerans_Agy99 -VLAAVDSMRVVRVLSAHYRNPGQLLGERLQASGFTTSYSSVGGN----T
MAV_2851|M.avium_104 -VIEAVDSIRVVNILSAQYRDPGLLLGQRIGARDFGTLYTPVGGN----V
MAB_3826c|M.abscessus_ATCC_199 ELLGAIDTISVANIFSWRYRDPGVLLGERLGAVPKRTFYTGPSGN----S
MLBr_02162|M.leprae_Br4923 ---ENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCAS
Mvan_3068|M.vanbaalenii_PYR-1 PQTLVNMACLDIQQGKADVVLIAGAETWRTRSRIRAAGRRPDWTKQDESV
Mflv_3340|M.gilvum_PYR-GCK PQTLVNLACLDIQQGRNDVVLIAGAETWRSRTRTRAAGNKMQGTRQDESV
MSMEG_3608|M.smegmatis_MC2_155 PQTLVNHACLDLQAGRAEVVLIAGAETWRTRSRLRARGVRPDWTRQDDTV
TH_1434|M.thermoresistible__bu --------------------------------------------------
Mb1898|M.bovis_AF2122/97 PQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESV
Rv1867|M.tuberculosis_H37Rv PQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWTVQDESV
MMAR_2746|M.marinum_M PQSLVSQACLDVQRGRAGVVLIAGAETWRTRTGLKSKGARLTWTLQDESV
MUL_3008|M.ulcerans_Agy99 PQPLVSQACLDVQRGRAGVVLIAGAETWRTRTGLKSKGARLTWTLQDESV
MAV_2851|M.avium_104 PQSLVNQACLDIQRGRANVVLLAGAETWRTRRGLRAKGGKLVWTEQDRSV
MAB_3826c|M.abscessus_ATCC_199 PQLLVNHAAADILAGDADVVLIGGAEMWRSRNKMMATGVQPTWTIQDESV
MLBr_02162|M.leprae_Br4923 GLEAVNTAAQKVRSGWDDLVLAGGVESMS-RVPMGSDGGAMGLDPATNYD
Mvan_3068|M.vanbaalenii_PYR-1 PSAPGGDESVPMAAPSDIRINLDRPAYVYPMFEQALRIAAG----ETPDE
Mflv_3340|M.gilvum_PYR-GCK PMAPGSDENMPMAGPGDLKIGLDRPAYVYPMFETAVRIAAG----ETPDE
MSMEG_3608|M.smegmatis_MC2_155 PVAPGGDDNVPMAGDAENRIKLDRPAFVYPMFEQALRIAAG----ETPDE
TH_1434|M.thermoresistible__bu -----------MATPADIRIQLDRPSYVYPLFEQALRITAG----EHPDA
Mb1898|M.bovis_AF2122/97 PLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYG----ESIEN
Rv1867|M.tuberculosis_H37Rv PLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYG----ESIEN
MMAR_2746|M.marinum_M PLPRVAGQDVPMAGESEIRIKLDRPAYVYPIFEQALRIANG----ESIED
MUL_3008|M.ulcerans_Agy99 PLPRVAGQDVPMAGESEIRIKLDRAAYVYPMFEQALRIANG----ESIED
MAV_2851|M.avium_104 PMAEVSGEDVAMAGEAEIRISLDRPAYVYPLFEQALRVSTG----ESVED
MAB_3826c|M.abscessus_ATCC_199 AEATVLGGRMDQVGGAETAIGLISPGHVYPLFEEAIRIAGG----VSIAD
MLBr_02162|M.leprae_Br4923 VMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGGYFAKSVVP
: .. * * *
Mvan_3068|M.vanbaalenii_PYR-1 HRRRIGELWAQFSAVAADNP--HAWNREALTPEQIWQPSASNRMISWPYT
Mflv_3340|M.gilvum_PYR-GCK HRRRIGELWAQFSAVAAGNP--HAWSQEARTAEEIYEPSPKNRMVSWPYT
MSMEG_3608|M.smegmatis_MC2_155 HRDRIGALWSRFSAVAARNP--HAWNRDAVTAQQITQVGPDNRMISWPYP
TH_1434|M.thermoresistible__bu HRRRIGELWARFSAVAADNP--HAWNRKALSAEQIWRPGPDNRMISWPYP
Mb1898|M.bovis_AF2122/97 HRKRIGELWARFSAVAADNP--HAWIRNPVTADEIWQPGPQNRMVSWPYT
Rv1867|M.tuberculosis_H37Rv HRKRIGELWARFSAVAADNP--HAWIRNPVTADEIWQPGPQNRMVSWPYT
MMAR_2746|M.marinum_M HRSRVGRLWAGFNAVAVDNP--HAWIRTPMTAEQICRPGPQNRMISWPYT
MUL_3008|M.ulcerans_Agy99 HRSRVGRLWAGFNAVAVDNP--HAWIRTPMTAEQICRPGPQNRMISWPYT
MAV_2851|M.avium_104 HLTRIGRLWARFNAVAVDNP--HAWIRTPHSADDICRAGPHNRMISWPYT
MAB_3826c|M.abscessus_ATCC_199 HRAAMSQLWQRFNAVAVTNG--HAWSNDAYTAEEIATPGPDNRWISSPYT
MLBr_02162|M.leprae_Br4923 VRDQNGLLILDHDEHMRPDTSKEGLAKLKPAFEGLAAMGGFDDVALQKYH
. * .. : .. . : : : . : *
Mvan_3068|M.vanbaalenii_PYR-1 KLMNSNNMVDQGAVLIVASAETARHLQIPSDRWVFPYAGADSHDTYAIAE
Mflv_3340|M.gilvum_PYR-GCK KLMNSNNMVDQGAVLILTSVEKAQHLQIPSERWVFPYAGADAHDTYAIGE
MSMEG_3608|M.smegmatis_MC2_155 KLMNSNNMVDQGAVLILTTVQMATYLQIPMDRWVFPYAGTDSHDTYAIGE
TH_1434|M.thermoresistible__bu KLMNSNNMVDQGAALILTSVQRARELRIPSERWVFPYAGTDAHDTYAIGE
Mb1898|M.bovis_AF2122/97 KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
Rv1867|M.tuberculosis_H37Rv KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
MMAR_2746|M.marinum_M KLMNSNNMVDQGAALILTSVEQATRLRVPTERWVYPQTGTEAHDTFSIAE
MUL_3008|M.ulcerans_Agy99 KLMNSNNMVDQGAALILTSVEQATRLRVPTERWVYPQTGTEAHDTFSSAE
MAV_2851|M.avium_104 KLMNSNNMVDQGAALVLTSVEQARRLKVPPERWVYPLAGTDAHDTASIAE
MAB_3826c|M.abscessus_ATCC_199 KLMNSNNMVEQGAVVLLTSVETALRLGISKDRWIFPLAGAQANDTFALSE
MLBr_02162|M.leprae_Br4923 WVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRARMVATATSG
: : *:: * :. : : : : .
Mvan_3068|M.vanbaalenii_PYR-1 RAEFHTSPAIRIAGRRALELAGAGVDDMDLVDVYSCFPSAVQVAARELGL
Mflv_3340|M.gilvum_PYR-GCK RAEFHASPAIRIAGTRALELAGAGVDDMDLIDVYSCFPSAVQVAARELGL
MSMEG_3608|M.smegmatis_MC2_155 RDELHRSPAIRIAGRRVLELAGADIDAIDFVDVYSCFPSAVQVAAAELGL
TH_1434|M.thermoresistible__bu RYRLDRSPAIRIAGRRVLELAGLGIDDFRFVDVYSCFPSAVQVAAIELGL
Mb1898|M.bovis_AF2122/97 RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
Rv1867|M.tuberculosis_H37Rv RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
MMAR_2746|M.marinum_M RAELHQSPAIRIAGARALELAGLGIDDADYVDLYSCFPSAVQVAAHELGL
MUL_3008|M.ulcerans_Agy99 RAELHQSPAIRIAGARALELAGLGINDADYVDLYSCFPSAVQVAAHELGL
MAV_2851|M.avium_104 RHELHRSAAIRIAGARALQLAGLGIDDVDHVDLYSCFPSAVQVAAAELGL
MAB_3826c|M.abscessus_ATCC_199 RHELHRSPAIRLAGRRAFEIAGLGTDDVELVDIYSCFPSAVQVAAAELGL
MLBr_02162|M.leprae_Br4923 ADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNI
. .. * :.:: ** : .:: ..*.*.* :*.:
Mvan_3068|M.vanbaalenii_PYR-1 PVGKPDRPLTVTGGLTFAGGPWNNYVTHSIATMAERLAAQPGQRGLITAN
Mflv_3340|M.gilvum_PYR-GCK PIGDPDRPLTVTGGLTFAGGPWNNYVTHSIATMAEQLIARPGTRGLITAN
MSMEG_3608|M.smegmatis_MC2_155 PTDDPARPLTVTGGLTFAGGPWNNYVTHSIATMAEKLVAEPGTRGLITAN
TH_1434|M.thermoresistible__bu PLDDPARPLTVTGGLTFAGGPWNNYVTHAIATMAERLIAAPGSRGLVTAN
Mb1898|M.bovis_AF2122/97 DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
Rv1867|M.tuberculosis_H37Rv DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
MMAR_2746|M.marinum_M PVDDADRPLTVTGGLTFAGGPWNNYVTHSIATMAELLAANPGRRGLITAN
MUL_3008|M.ulcerans_Agy99 PVDDADRPLTVTGGLTFAGGPWDNYVTHSIATMAELLAANPGRRGLITAN
MAV_2851|M.avium_104 GLDDPARPLTVTGGLTFAGGPWSNYVMHSIATMAELLVANPGRRGLITAN
MAB_3826c|M.abscessus_ATCC_199 ALDDPARPLTVTGGLTFAGGPWCNYVTHSIATMAERLRERPGAKGLITAN
MLBr_02162|M.leprae_Br4923 PDEK----LNVNGGAIAMGHPLGATGAMILGTMVDELERCNARRALVTLC
. *.*.** * * :.**.: * . :.*:*
Mvan_3068|M.vanbaalenii_PYR-1 GGYLTKHSFGVYGTEPPKHEFRWEDVQSEVDREPTRTAVVEWSGVGTVES
Mflv_3340|M.gilvum_PYR-GCK GGYLTKHSFGVYGTEPPTHEFRWEDVQSEVDAEPTRTALVDWSGVGTVET
MSMEG_3608|M.smegmatis_MC2_155 GGYLTKHSFGVYGTEPPEQEFRWEDVQSVVDAEPTRKLAVEWVGTGTVES
TH_1434|M.thermoresistible__bu GGYLTKHAFGVYSTEPPPVEFRWEDVQSEVDREPVRKVLVEWSGTGTVES
Mb1898|M.bovis_AF2122/97 GGYLTKHSFGVYGTEPPS-EFRWEDMQPAVDREPTGDGLVEWEGIGTVEA
Rv1867|M.tuberculosis_H37Rv GGYLTKHSFGVYGTEPPS-EFRWEDMQPAVDREPTGDGLVEWEGIGTVEA
MMAR_2746|M.marinum_M GGYLTKHSIGVYGTEPPA-EFCWEDVQPLVDREPTRAALVGWDGVGAVEA
MUL_3008|M.ulcerans_Agy99 GGYLTQHSIGVYGTEPPA-EFRWEDVQPLVDREPTRAALVGWDGVGAVEA
MAV_2851|M.avium_104 GGYLTKHSFGVYGTEPPA-EFRWEDTQSAVDREPTTDAAVEWEGVGTVEA
MAB_3826c|M.abscessus_ATCC_199 GGYLTKHAFGIYGTEPPASGFAYEDVQADVDQEPRTEAADGYTGTAAVEA
MLBr_02162|M.leprae_Br4923 IG-------------------AGMGVATIIERV-----------------
* . . ::
Mvan_3068|M.vanbaalenii_PYR-1 WTTPVDRDGAPEKAFLAVRTPEDARVLAVITDRAGAEATVRDDIAGAAVR
Mflv_3340|M.gilvum_PYR-GCK WTTPVDRDGNPEKAFLAVRTPEDARVLAVITDPAGAETTVRDDIAGAQVR
MSMEG_3608|M.smegmatis_MC2_155 WTTPFNRDGAPEKAFLAVRTPDGARTLAVITDESQAAATVREDIAGARVE
TH_1434|M.thermoresistible__bu WTTPFDRDGNPEKAFVAVRTPEDSRALAVIIDPSAAAVTVSEDVAGAPIR
Mb1898|M.bovis_AF2122/97 WTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKVA
Rv1867|M.tuberculosis_H37Rv WTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKVA
MMAR_2746|M.marinum_M WTTPFTRDGQPEKAFVAVRTPTGARTLGVITDPASANATVHEDIAGAKVA
MUL_3008|M.ulcerans_Agy99 WTTPFTRDGQPEKAFVAVRTPTGARTLGVITDPASAHATVHEDIAGAKVA
MAV_2851|M.avium_104 WTTPHDREGEPEKAFLAVRTPDGSRALAVVTDRAAAQATVREDIGGAKVA
MAB_3826c|M.abscessus_ATCC_199 WTVNYGRDGSPFQTFVSVRTPTGARTFAKIDDRDASAHIADTDIAGASIE
MLBr_02162|M.leprae_Br4923 --------------------------------------------------
Mvan_3068|M.vanbaalenii_PYR-1 VHADGTASLE
Mflv_3340|M.gilvum_PYR-GCK VEEDGTASLV
MSMEG_3608|M.smegmatis_MC2_155 VHADGTATLL
TH_1434|M.thermoresistible__bu VHADGTATLG
Mb1898|M.bovis_AF2122/97 VAPDGTATLR
Rv1867|M.tuberculosis_H37Rv VAPDGTATLR
MMAR_2746|M.marinum_M IAADGNATLR
MUL_3008|M.ulcerans_Agy99 IAADGNATLR
MAV_2851|M.avium_104 VAADGSAALQ
MAB_3826c|M.abscessus_ATCC_199 VAADGSARLN
MLBr_02162|M.leprae_Br4923 ----------