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M. thermoresistible (build 8) TH_1768 (-)

annotation: acetyl-CoA acetyltransferase
coordinates: 3430186 - 3431538
length: 451

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1768--100% (451)acetyl-CoA acetyltransferase
M. thermoresistible (build 8)TH_1434-5e-5037.85% (325) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_3402-1e-0924.53% (375) PUTATIVE putative thiolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1898-8e-5034.54% (414) acetyl-CoA acetyltransferase
M. gilvum PYR-GCKMflv_1869-0.068.89% (450) acetyl-CoA acetyltransferase
M. tuberculosis H37RvRv1867-8e-5034.54% (414) acetyl-CoA acetyltransferase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3826c-7e-6136.24% (425) acetyl-CoA acetyltransferase
M. marinum MMMAR_4547-1e-17966.74% (451) thiolase
M. avium 104MAV_1076-0.072.44% (450) acetyl-CoA acetyltransferase
M. smegmatis MC2 155MSMEG_5521-0.077.33% (450) acetyl-CoA acetyltransferase
M. ulcerans Agy99MUL_4717-1e-18067.18% (451) acetyl-CoA acetyltransferase
M. vanbaalenii PYR-1Mvan_4866-1e-17968.22% (450) acetyl-CoA acetyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


TH_1768|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5521|M.smegmatis_MC2_155      -MVDPRTPVIVGVGQFTERIDLDGYRGMSSVELATEAAKAALHDCGADAD
MAV_1076|M.avium_104                MNLDPNTPVIVGVGQFTERIEDSGYRGMSSVKLATEAARAALHDCGADAT
MMAR_4547|M.marinum_M               MDLDPGTPVIVGVGQAVERIDDPDYQGMSAVELAAAAAQAALEDCAAD--
MUL_4717|M.ulcerans_Agy99           MDLDPGTPVIVGVGQAVERMDDPDYQGMSAVELAAAAAQAALEDCAAD--
Mflv_1869|M.gilvum_PYR-GCK          MAVDSRTPVIVGVGQFTERIGDPDYRGMSAVDLATAAARAALTDTGADTA
Mvan_4866|M.vanbaalenii_PYR-1       MAVDPRTPVIVGVGQFTERIDDPAYRGMSAVELATAAVQAALVDTGADAA
Mb1898|M.bovis_AF2122/97            MPVDPRTPVLIGYGQVNHRGDIDAEKQSI-EPVDLMAAAARKAADST---
Rv1867|M.tuberculosis_H37Rv         MPVDPRTPVLIGYGQVNHRGDIDAEKQSI-EPVDLMAAAARKAADST---
MAB_3826c|M.abscessus_ATCC_199      MAFDPRTPVLVGTGQVNQRTDADTPFSEIPEPIDLMEQAARLAAGDAGAT
                                                                                      

TH_1768|M.thermoresistible__bu      --------VAGVRQFEISGLAP-APLGKSDNYPRSVARRIGADPRRAVLE
MSMEG_5521|M.smegmatis_MC2_155      TVARAIDTVAGTRQFEISGPAS-APLGVSSNYPRSVARNIGADPAHAVLE
MAV_1076|M.avium_104                AVAAAVDTVGAIRQFELSGRTP-APMGKSNNYPRSVARRIGAAPARAVLE
MMAR_4547|M.marinum_M               -VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARAILE
MUL_4717|M.ulcerans_Agy99           -VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARAILE
Mflv_1869|M.gilvum_PYR-GCK          AVASAIDTIFGLRQFEISGPMP-AVLGKSNNYPRSVANRLGADPARVVLE
Mvan_4866|M.vanbaalenii_PYR-1       VVAAAIDTVFGLRQFEISGPMP-ATLGKSNNYPRSVMKRVGGDPARVVLE
Mb1898|M.bovis_AF2122/97            -VLEAVDSIRVVHMLSAHYRNPGQLLG----------ERIKARTFTTGYS
Rv1867|M.tuberculosis_H37Rv         -VLEAVDSIRVVHMLSAHYRNPGQLLG----------ERIKARTFTTGYS
MAB_3826c|M.abscessus_ATCC_199      ELLGAIDTISVANIFSWRYRDPGVLLG----------ERLGAVPKRTFYT
                                            :   . :.     .   :*          ..: . .  .   

TH_1768|M.thermoresistible__bu      VIGGQSPQRLVTEFAGAIAAGEADVVLVMGSENTSTLRYFADRDDKPDHS
MSMEG_5521|M.smegmatis_MC2_155      VIGGQSPQHLATEFGGKIAAGENDVVLIFGSENTSTLRHFSKAENKPDHS
MAV_1076|M.avium_104                PIGGQGPQHLVTEFAGVIAAGDAEVVMIFGSENTSSIRYFADRE-KPDHS
MMAR_4547|M.marinum_M               IVGGQGPQHLITELAGAIAAGRSEVAMVFGSDATSTSRHFAGRADKPDFT
MUL_4717|M.ulcerans_Agy99           IVGGQGPQHLITELAGAIAAGSSEVAMVFGSDATSTSRHFAGRADKPDFT
Mflv_1869|M.gilvum_PYR-GCK          PVGGQSPQKLVTEAGALIVGGRADVVMIMGSEPGSTAKYFADREDKPDFT
Mvan_4866|M.vanbaalenii_PYR-1       PVGGQGPQKLVTEAGNLIVAGDADVVMIMGSEPGSTAKYFAGRDDKPDFT
Mb1898|M.bovis_AF2122/97            GVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWT
Rv1867|M.tuberculosis_H37Rv         GVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKLEWT
MAB_3826c|M.abscessus_ATCC_199      GPSGNSPQLLVNHAAADILAGDADVVLIGGAEMWRSRNKMMATGVQPTWT
                                      .*: ** * ..    *  *   *.:: *::   :   :     :   :

TH_1768|M.thermoresistible__bu      ETVGGQLEDRGYGYDG-IIDDYSVTHGLVGAPPQYALLENARRARVGLSA
MSMEG_5521|M.smegmatis_MC2_155      ETVDGQLEDRGYGYDG-IFDEYTIRHGLIGAPVQYGLLENARRARLGLSV
MAV_1076|M.avium_104                ETVEGSLEDRGFGYEG-LFDDYTVAHGLIGAPAQYGLLENARRARLGLSV
MMAR_4547|M.marinum_M               EIVDGELQDRGPGIDG-LITRYTIIHGLVDAPTQYGLLENAHRAATGLGP
MUL_4717|M.ulcerans_Agy99           EIVDGELQDRGPGIDG-LITRYTIIHGLVDAPIQYGLLENARRAATGLGP
Mflv_1869|M.gilvum_PYR-GCK          EHVDGQLEDRGHQIYS-YIDEYTVTHGLTGAPVQYGLLDNARRSRLGLGV
Mvan_4866|M.vanbaalenii_PYR-1       EHVDGQLEDRGHQIYN-YIDEYTVTHGLTGAPVQYGLLDNARRSRLGLGV
Mb1898|M.bovis_AF2122/97            VQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYGESI
Rv1867|M.tuberculosis_H37Rv         VQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYGESI
MAB_3826c|M.abscessus_ATCC_199      IQDESVAEATVLGGRMDQVGGAETAIGLISPGHVYPLFEEAIRIAGGVSI
                                        .                     .*  .   * ::::* *   * . 

TH_1768|M.thermoresistible__bu      DDYRLAMAELFAPFSKVAAKNPYSSSPVERSVQELATVTDSNRMISDPYP
MSMEG_5521|M.smegmatis_MC2_155      ADYRLAMAELFAPFSKVAAKNPYSSAPTERSVEELLTVTASNRMIVDPYP
MAV_1076|M.avium_104                ADYRRRMGELFAPFTKVAAKNPFASAPVERSVDELITVTPSNRMICDPYP
MMAR_4547|M.marinum_M               ADYLRRMGELFAPFTKIAAGNPFAAAPIERTIEELITVTDRNRMIAEPYP
MUL_4717|M.ulcerans_Agy99           ADYLRRMGELFAPFTKIAAGNPFAAAPIERTVEELITVTDRNRMIAEPYP
Mflv_1869|M.gilvum_PYR-GCK          AEYRHTMAQLFAPMSKVAAKNPFSSSPVERSVEEVETVTGENRMICDPYP
Mvan_4866|M.vanbaalenii_PYR-1       GPYRHLMAELFAPMSKVAAKNPFSASLVERSVEEVETVTGENRMICDPYP
Mb1898|M.bovis_AF2122/97            ENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQPGPQNRMVSWPYT
Rv1867|M.tuberculosis_H37Rv         ENHRKRIGELWARFSAVAADNPHAWIRNPVTADEIWQPGPQNRMVSWPYT
MAB_3826c|M.abscessus_ATCC_199      ADHRAAMSQLWQRFNAVAVTNGHAWSNDAYTAEEIATPGPDNRWISSPYT
                                      :   :.:*:  :. :*. * .:      : :*:      ** :  **.

TH_1768|M.thermoresistible__bu      RLMVARDQVNQGAAAVLMSVEAARRLGVPEDNWVYLHGHADLKEQ-PLLE
MSMEG_5521|M.smegmatis_MC2_155      RLMVARDQVNQGAALLMMSVESARKLGVPEEKWVYLRGHADMKEP-KLLE
MAV_1076|M.avium_104                RLLVARDQVNQGAAALLMSVAAARRFRVPEERWVFLHGHADMVDQ-PLLD
MMAR_4547|M.marinum_M               RLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-ALLQ
MUL_4717|M.ulcerans_Agy99           RLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-ALLQ
Mflv_1869|M.gilvum_PYR-GCK          RLLVARDTVNQGAAAVLMSVESARRLGVPESKWVYLHGHSDLVEQ-PLLA
Mvan_4866|M.vanbaalenii_PYR-1       RFLVARDTVNQGAAAVLTSVEAARKLGVPEEKWVYLHGHSDLVEQ-ALLE
Mb1898|M.bovis_AF2122/97            KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
Rv1867|M.tuberculosis_H37Rv         KLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTPAVAD
MAB_3826c|M.abscessus_ATCC_199      KLMNSNNMVEQGAVVLLTSVETALRLGISKDRWIFPLAGAQANDTFALSE
                                    ::: :.: *:***. :: **  * :: :. ..*::  . ::  :   :  

TH_1768|M.thermoresistible__bu      RPDLGAGPASVLAVQEALRVAGIGLDQVAAFDLYSCFPFPVFNICDGTGL
MSMEG_5521|M.smegmatis_MC2_155      RADIGASPASVTAVNEALRVAGIGLDDVAAFDLYSCFPFPVFNICDGTGL
MAV_1076|M.avium_104                RLDLTYNSASVLAVQEALVGAGIGIDDVSTFDLYSCFPVPVFNFCDGTSL
MMAR_4547|M.marinum_M               RPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICDGLGI
MUL_4717|M.ulcerans_Agy99           RPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICDGLGI
Mflv_1869|M.gilvum_PYR-GCK          RVDLGASPAAVHAIDEALRVAGIGVDDIATFDLYSCFPFPVFVACEALGL
Mvan_4866|M.vanbaalenii_PYR-1       RVDLGASPAAVAAAHEALRVAGLGVDDIATFDLYSCFPFPVFVICEALGL
Mb1898|M.bovis_AF2122/97            RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
Rv1867|M.tuberculosis_H37Rv         RHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAIELGL
MAB_3826c|M.abscessus_ATCC_199      RHELHRSPAIRLAGRRAFEIAGLGTDDVELVDIYSCFPSAVQVAAAELGL
                                    *  :   .:   *  .*:  **:* *::  .*:***** .*   .   .:

TH_1768|M.thermoresistible__bu      ATDDP-RGLTLTGGLPFFGGPGNNYSLHAIAEAVTEMRGRPGQFALVGAN
MSMEG_5521|M.smegmatis_MC2_155      ATDDP-RGLTLTGGLPFFGGLGNNYSMHGIAEAVNEMRDKPGQFALVGAN
MAV_1076|M.avium_104                ATDDP-RGLTLTGGLPYFGGPGNNYSLHGIAETVSEMRDRPGQFGLVAAN
MMAR_4547|M.marinum_M               ATDDP-RGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGLVGAN
MUL_4717|M.ulcerans_Agy99           ATDDP-RGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGLVGAN
Mflv_1869|M.gilvum_PYR-GCK          AGDDP-RGVTLTGGLPYFGGPGNSYSLHAIAETVTAMRDRPGQFGFVGAN
Mvan_4866|M.vanbaalenii_PYR-1       SADDP-RGLTLTGGLPYFGGPGNSYSLHGIAETVAQMRDRPGQFGFVGAN
Mb1898|M.bovis_AF2122/97            DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
Rv1867|M.tuberculosis_H37Rv         DTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGLITAN
MAB_3826c|M.abscessus_ATCC_199      ALDDPARPLTVTGGLTFAGGPWCNYVTHSIATMAERLRERPGAKGLITAN
                                      *** * :*:****.: **   .*  *.:*  .  :  .**  .:: **

TH_1768|M.thermoresistible__bu      GGFASKYSVGIYSTEPAEWRPDRSADLQEQIAAMPKVAITERADGAATVE
MSMEG_5521|M.smegmatis_MC2_155      GGIASKYSVGIYSTEPADWVADNSAQLQAEHDAQPKVAITEKADGTGTIE
MAV_1076|M.avium_104                GGIMSKYSVGVYSTTPVNWKPDNSAALRAEVAARPTVPVTVRADGRATIE
MMAR_4547|M.marinum_M               GGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGASQPVTEQADGPATIE
MUL_4717|M.ulcerans_Agy99           GGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGASRPVIEQADGPATIE
Mflv_1869|M.gilvum_PYR-GCK          GGIMSKYSVGVYSTEPVEWRSCRSAELTAQVAELPTVAVTKTPEGTGTIE
Mvan_4866|M.vanbaalenii_PYR-1       GGIMSKYSVGIYSTEPVGWRTSRSAELTAEVAERPRVAVTKSPEGAATIE
Mb1898|M.bovis_AF2122/97            GGYLTKHSFGVYGTEPPSE--FRWEDMQPAVDREPTGDGLVEWEGIGTVE
Rv1867|M.tuberculosis_H37Rv         GGYLTKHSFGVYGTEPPSE--FRWEDMQPAVDREPTGDGLVEWEGIGTVE
MAB_3826c|M.abscessus_ATCC_199      GGYLTKHAFGIYGTEPPASG-FAYEDVQADVDQEPRTEAADGYTGTAAVE
                                    **  :*::.*:*.* *          :       .         * .::*

TH_1768|M.thermoresistible__bu      TYTVRYGRKGRTG-IIVGRLDADNSRFLATTRDDDMLALLCEGEPLGAAF
MSMEG_5521|M.smegmatis_MC2_155      TYTVRYDWTPHTG-IIIGRLD-DGSRFLAKTKDEDLVKLLSEGDPIGAKI
MAV_1076|M.avium_104                TYTVRYDWPVRTG-IIIGRLDDDGSRFLALTEDPELVGLLSDGEPLGASI
MMAR_4547|M.marinum_M               TYTVRHDGGRLTG-IVIGRLADDGRRFLASTEDDELIGLLTDGDPLGQAI
MUL_4717|M.ulcerans_Agy99           TYTVRHDGGRLTG-IVIGRLAADGRRFLASTEDDELIGLLTDGDPLGQAI
Mflv_1869|M.gilvum_PYR-GCK          TYSVRYDWPVRTG-IIVGRLDSDGSRFMATSEDHELVALMSDGDPLGAKV
Mvan_4866|M.vanbaalenii_PYR-1       TYSVRHDWPVRTG-IIVGRLDADGSRFMATSEDADLVALMTEADPLGANI
Mb1898|M.bovis_AF2122/97            AWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKV
Rv1867|M.tuberculosis_H37Rv         AWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVREDIAGVKV
MAB_3826c|M.abscessus_ATCC_199      AWTVNYGRDGSPFQTFVSVRTPTGARTFAKIDDRDASAHIADTDIAGASI
                                    :::.  .    .   .:.     . * :*   *          :  *  .

TH_1768|M.thermoresistible__bu      TVRSTEKGNRASL-
MSMEG_5521|M.smegmatis_MC2_155      VVTPGEKSNRAVLA
MAV_1076|M.avium_104                VVTATEKDNRATLA
MMAR_4547|M.marinum_M               RVRSFDYGNRCVL-
MUL_4717|M.ulcerans_Agy99           RVRSFDYGNRCVL-
Mflv_1869|M.gilvum_PYR-GCK          AVTNTDNGNRATLA
Mvan_4866|M.vanbaalenii_PYR-1       TVTPTDNGNRAVLR
Mb1898|M.bovis_AF2122/97            AVAPDGTATLR---
Rv1867|M.tuberculosis_H37Rv         AVAPDGTATLR---
MAB_3826c|M.abscessus_ATCC_199      EVAADGSARLN---
                                     *