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DLDPGTPVIVGVGQAVERIDDPDYQGMSAVELAAAAAQAALEDCAADVAAAIDTVAGVRQFEISGPVPKA PLGRSNNYPRSVAQRIGADPARAILEIVGGQGPQHLITELAGAIAAGRSEVAMVFGSDATSTSRHFAGRA DKPDFTEIVDGELQDRGPGIDGLITRYTIIHGLVDAPTQYGLLENAHRAATGLGPADYLRRMGELFAPFT KIAAGNPFAAAPIERTIEELITVTDRNRMIAEPYPRLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVY LRGHADLQEQALLQRPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICDGLGIATDDPR GLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGLVGANGGIMSKYSVGVYSTAPAQWQPDRSAEL QTQIDSGASQPVTEQADGPATIETYTVRHDGGRLTGIVIGRLADDGRRFLASTEDDELIGLLTDGDPLGQ AIRVRSFDYGNRCVL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4547 | - | - | 100% (506) | thiolase |
| M. marinum M | MMAR_2746 | - | 9e-58 | 33.04% (454) | hypothetical protein MMAR_2746 |
| M. marinum M | MMAR_5027 | ltp2_1 | 3e-06 | 24.87% (394) | acetyl-CoA acetyltransferase (PaaJ-like), Ltp2_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1898 | - | 4e-58 | 33.13% (501) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1869 | - | 0.0 | 63.85% (509) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1867 | - | 4e-58 | 33.13% (501) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2042c | - | 2e-64 | 34.46% (505) | acetyl-CoA acetyltransferase |
| M. avium 104 | MAV_1076 | - | 0.0 | 67.39% (509) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5521 | - | 0.0 | 66.07% (507) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_1768 | - | 1e-179 | 66.74% (451) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_4717 | - | 0.0 | 98.42% (506) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4866 | - | 0.0 | 65.03% (509) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4547|M.marinum_M --MDLDPGTPVIVGVGQAVERID-DPDYQGMSAVELAAAAAQAALEDCAA
MUL_4717|M.ulcerans_Agy99 --MDLDPGTPVIVGVGQAVERMD-DPDYQGMSAVELAAAAAQAALEDCAA
MSMEG_5521|M.smegmatis_MC2_155 ---MVDPRTPVIVGVGQFTERID-LDGYRGMSSVELATEAAKAALHDCGA
TH_1768|M.thermoresistible__bu --------------------------------------------------
MAV_1076|M.avium_104 --MNLDPNTPVIVGVGQFTERIE-DSGYRGMSSVKLATEAARAALHDCGA
Mflv_1869|M.gilvum_PYR-GCK --MAVDSRTPVIVGVGQFTERIG-DPDYRGMSAVDLATAAARAALTDTGA
Mvan_4866|M.vanbaalenii_PYR-1 --MAVDPRTPVIVGVGQFTERID-DPAYRGMSAVELATAAVQAALVDTGA
Mb1898|M.bovis_AF2122/97 --MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAAR---KAADS
Rv1867|M.tuberculosis_H37Rv --MPVDPRTPVLIGYGQVNHRGDIDAEKQSIEPVDLMAAAAR---KAADS
MAB_2042c|M.abscessus_ATCC_199 MPMLVEARTPVVVGVGEVTHRG-----NDFVDPIDLAVEAARRAVKDAGR
MMAR_4547|M.marinum_M D---VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARA
MUL_4717|M.ulcerans_Agy99 D---VAAAIDTVAGVRQFEISGPVPKAPLGRSNNYPRSVAQRIGADPARA
MSMEG_5521|M.smegmatis_MC2_155 DADTVARAIDTVAGTRQFEISGPAS-APLGVSSNYPRSVARNIGADPAHA
TH_1768|M.thermoresistible__bu -----------VAGVRQFEISGLAP-APLGKSDNYPRSVARRIGADPRRA
MAV_1076|M.avium_104 DATAVAAAVDTVGAIRQFELSGRTP-APMGKSNNYPRSVARRIGAAPARA
Mflv_1869|M.gilvum_PYR-GCK DTAAVASAIDTIFGLRQFEISGPMP-AVLGKSNNYPRSVANRLGADPARV
Mvan_4866|M.vanbaalenii_PYR-1 DAAVVAAAIDTVFGLRQFEISGPMP-ATLGKSNNYPRSVMKRVGGDPARV
Mb1898|M.bovis_AF2122/97 T---VLEAVDSIRVVHMLSAHYRNP----------GQLLGERIKARTFTT
Rv1867|M.tuberculosis_H37Rv T---VLEAVDSIRVVHMLSAHYRNP----------GQLLGERIKARTFTT
MAB_2042c|M.abscessus_ATCC_199 P---VERRIDTVATPGILVIPRDNP----------ASRIAEAMHISPARR
: : . : . : .
MMAR_4547|M.marinum_M ILEIVGGQGPQHLITELAGAIAAGRSEVAMVFGSDATSTSRHFAGRADKP
MUL_4717|M.ulcerans_Agy99 ILEIVGGQGPQHLITELAGAIAAGSSEVAMVFGSDATSTSRHFAGRADKP
MSMEG_5521|M.smegmatis_MC2_155 VLEVIGGQSPQHLATEFGGKIAAGENDVVLIFGSENTSTLRHFSKAENKP
TH_1768|M.thermoresistible__bu VLEVIGGQSPQRLVTEFAGAIAAGEADVVLVMGSENTSTLRYFADRDDKP
MAV_1076|M.avium_104 VLEPIGGQGPQHLVTEFAGVIAAGDAEVVMIFGSENTSSIRYFADRE-KP
Mflv_1869|M.gilvum_PYR-GCK VLEPVGGQSPQKLVTEAGALIVGGRADVVMIMGSEPGSTAKYFADREDKP
Mvan_4866|M.vanbaalenii_PYR-1 VLEPVGGQGPQKLVTEAGNLIVAGDADVVMIMGSEPGSTAKYFAGRDDKP
Mb1898|M.bovis_AF2122/97 GYSGVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKL
Rv1867|M.tuberculosis_H37Rv GYSGVGGNMPQSLVNRACLDIQRGRAGVVLLAGAETWRTRTGLRAKGSKL
MAB_2042c|M.abscessus_ATCC_199 ISCPVGGNTPQYLVEVLGGEIREGRADVVLVVGAESGHSARKLQGR-ALL
:**: ** * * * *.:: *:: : :
MMAR_4547|M.marinum_M DFT-EIVDGELQDRGPGIDGLITRYTIIHGLVDAPTQYGLLENAHRAATG
MUL_4717|M.ulcerans_Agy99 DFT-EIVDGELQDRGPGIDGLITRYTIIHGLVDAPIQYGLLENARRAATG
MSMEG_5521|M.smegmatis_MC2_155 DHS-ETVDGQLEDRGYGYDGIFDEYTIRHGLIGAPVQYGLLENARRARLG
TH_1768|M.thermoresistible__bu DHS-ETVGGQLEDRGYGYDGIIDDYSVTHGLVGAPPQYALLENARRARVG
MAV_1076|M.avium_104 DHS-ETVEGSLEDRGFGYEGLFDDYTVAHGLIGAPAQYGLLENARRARLG
Mflv_1869|M.gilvum_PYR-GCK DFT-EHVDGQLEDRGHQIYSYIDEYTVTHGLTGAPVQYGLLDNARRSRLG
Mvan_4866|M.vanbaalenii_PYR-1 DFT-EHVDGQLEDRGHQIYNYIDEYTVTHGLTGAPVQYGLLDNARRSRLG
Mb1898|M.bovis_AF2122/97 EWTVQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYG
Rv1867|M.tuberculosis_H37Rv EWTVQDESVPLPDMAGDDVPMAGAAELRINLDRPAYVYPIFEQALRIAYG
MAB_2042c|M.abscessus_ATCC_199 DSPPPPRSG--DESLGDARPGLSQAELSVGLSWPHEVYPIFESAIAARHG
: . : : .* . * :::.* *
MMAR_4547|M.marinum_M LGPADYLRRMGELFAPFTKIAAGNP-FAAAPIERTIEELITVTDRNRMIA
MUL_4717|M.ulcerans_Agy99 LGPADYLRRMGELFAPFTKIAAGNP-FAAAPIERTVEELITVTDRNRMIA
MSMEG_5521|M.smegmatis_MC2_155 LSVADYRLAMAELFAPFSKVAAKNP-YSSAPTERSVEELLTVTASNRMIV
TH_1768|M.thermoresistible__bu LSADDYRLAMAELFAPFSKVAAKNP-YSSSPVERSVQELATVTDSNRMIS
MAV_1076|M.avium_104 LSVADYRRRMGELFAPFTKVAAKNP-FASAPVERSVDELITVTPSNRMIC
Mflv_1869|M.gilvum_PYR-GCK LGVAEYRHTMAQLFAPMSKVAAKNP-FSSSPVERSVEEVETVTGENRMIC
Mvan_4866|M.vanbaalenii_PYR-1 LGVGPYRHLMAELFAPMSKVAAKNP-FSASLVERSVEEVETVTGENRMIC
Mb1898|M.bovis_AF2122/97 ESIENHRKRIGELWARFSAVAADNP-HAWIRNPVTADEIWQPGPQNRMVS
Rv1867|M.tuberculosis_H37Rv ESIENHRKRIGELWARFSAVAADNP-HAWIRNPVTADEIWQPGPQNRMVS
MAB_2042c|M.abscessus_ATCC_199 RDFDAQREWLGTLMAPFTAEAARHPEQAWFPRARSATELSEVTAENRMVC
. :. * * :: ** :* : : *: ***:
MMAR_4547|M.marinum_M EPYPRLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-
MUL_4717|M.ulcerans_Agy99 EPYPRLLVARDQVNQGAAALVMSVAAARRLGVPEEKWVYLRGHADLQEQ-
MSMEG_5521|M.smegmatis_MC2_155 DPYPRLMVARDQVNQGAALLMMSVESARKLGVPEEKWVYLRGHADMKEP-
TH_1768|M.thermoresistible__bu DPYPRLMVARDQVNQGAAAVLMSVEAARRLGVPEDNWVYLHGHADLKEQ-
MAV_1076|M.avium_104 DPYPRLLVARDQVNQGAAALLMSVAAARRFRVPEERWVFLHGHADMVDQ-
Mflv_1869|M.gilvum_PYR-GCK DPYPRLLVARDTVNQGAAAVLMSVESARRLGVPESKWVYLHGHSDLVEQ-
Mvan_4866|M.vanbaalenii_PYR-1 DPYPRFLVARDTVNQGAAAVLTSVEAARKLGVPEEKWVYLHGHSDLVEQ-
Mb1898|M.bovis_AF2122/97 WPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTP
Rv1867|M.tuberculosis_H37Rv WPYTKLMNSNNMVDQGAALLLTSVERATRLRIPAERWVYPQAGTDAHDTP
MAB_2042c|M.abscessus_ATCC_199 LPYPKLLNSIMSVDMAAAFILMAAEVADELGVARDRWVFPWSAATCNDVY
**.::: : *: .** :: :. * .: :. ..**: . : :
MMAR_4547|M.marinum_M ALLQRPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICD
MUL_4717|M.ulcerans_Agy99 ALLQRPDLGHAPSAVLAAREALRVAGVGVDDIATFDLYSCFPVPVFNICD
MSMEG_5521|M.smegmatis_MC2_155 KLLERADIGASPASVTAVNEALRVAGIGLDDVAAFDLYSCFPFPVFNICD
TH_1768|M.thermoresistible__bu PLLERPDLGAGPASVLAVQEALRVAGIGLDQVAAFDLYSCFPFPVFNICD
MAV_1076|M.avium_104 PLLDRLDLTYNSASVLAVQEALVGAGIGIDDVSTFDLYSCFPVPVFNFCD
Mflv_1869|M.gilvum_PYR-GCK PLLARVDLGASPAAVHAIDEALRVAGIGVDDIATFDLYSCFPFPVFVACE
Mvan_4866|M.vanbaalenii_PYR-1 ALLERVDLGASPAAVAAAHEALRVAGLGVDDIATFDLYSCFPFPVFVICE
Mb1898|M.bovis_AF2122/97 AVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAI
Rv1867|M.tuberculosis_H37Rv AVADRHRLHRSTAIRIAGARALELAGLGLDDIEYVDLYSCFPSAVQVAAI
MAB_2042c|M.abscessus_ATCC_199 FPVERPDLSRSSGIEVAARKALNAGRLTIDDIRWFDLYSCFPSAIEMTAE
* : .. * .** . : :*:: .******* .: .
MMAR_4547|M.marinum_M GLGIATDD-PRGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGL
MUL_4717|M.ulcerans_Agy99 GLGIATDD-PRGLTLTGGLPFFGGAGNNYSMHAVAETVARMRSEPGRFGL
MSMEG_5521|M.smegmatis_MC2_155 GTGLATDD-PRGLTLTGGLPFFGGLGNNYSMHGIAEAVNEMRDKPGQFAL
TH_1768|M.thermoresistible__bu GTGLATDD-PRGLTLTGGLPFFGGPGNNYSLHAIAEAVTEMRGRPGQFAL
MAV_1076|M.avium_104 GTSLATDD-PRGLTLTGGLPYFGGPGNNYSLHGIAETVSEMRDRPGQFGL
Mflv_1869|M.gilvum_PYR-GCK ALGLAGDD-PRGVTLTGGLPYFGGPGNSYSLHAIAETVTAMRDRPGQFGF
Mvan_4866|M.vanbaalenii_PYR-1 ALGLSADD-PRGLTLTGGLPYFGGPGNSYSLHGIAETVAQMRDRPGQFGF
Mb1898|M.bovis_AF2122/97 ELGLDTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGL
Rv1867|M.tuberculosis_H37Rv ELGLDTDDPARPLTVTGGLTFAGGPWSNYVTHSIATMAELLAANPGRRGL
MAB_2042c|M.abscessus_ATCC_199 ALDLDPLD-DRGLTVTGGLPYHGGPGNNYVSHSIVEMVRRCRRDPTDVGL
.: * * :*:****.: ** ..* *.:. . * .:
MMAR_4547|M.marinum_M VGANGGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGAS----QPVTEQ
MUL_4717|M.ulcerans_Agy99 VGANGGIMSKYSVGVYSTAPAQWQPDRSAELQTQIDSGAS----RPVIEQ
MSMEG_5521|M.smegmatis_MC2_155 VGANGGIASKYSVGIYSTEPADWVADNSAQLQAEHDAQPK----VAITEK
TH_1768|M.thermoresistible__bu VGANGGFASKYSVGIYSTEPAEWRPDRSADLQEQIAAMPK----VAITER
MAV_1076|M.avium_104 VAANGGIMSKYSVGVYSTTPVNWKPDNSAALRAEVAARPT----VPVTVR
Mflv_1869|M.gilvum_PYR-GCK VGANGGIMSKYSVGVYSTEPVEWRSCRSAELTAQVAELPT----VAVTKT
Mvan_4866|M.vanbaalenii_PYR-1 VGANGGIMSKYSVGIYSTEPVGWRTSRSAELTAEVAERPR----VAVTKS
Mb1898|M.bovis_AF2122/97 ITANGGYLTKHSFGVYGTEPPSEFRWEDMQPAVDREPTG------DGLVE
Rv1867|M.tuberculosis_H37Rv ITANGGYLTKHSFGVYGTEPPSEFRWEDMQPAVDREPTG------DGLVE
MAB_2042c|M.abscessus_ATCC_199 VTGLGWYSTKHSVGLWSATPPP-TGWRLLDTAVEQAQIDSSRLGVAGVDE
: . * :*:*.*::.: * . :
MMAR_4547|M.marinum_M ADGPATIETYTVRHDGGRLTG-IVIGRLADDGRRFLASTEDDELIGLLTD
MUL_4717|M.ulcerans_Agy99 ADGPATIETYTVRHDGGRLTG-IVIGRLAADGRRFLASTEDDELIGLLTD
MSMEG_5521|M.smegmatis_MC2_155 ADGTGTIETYTVRYDWTPHTG-IIIGRLD-DGSRFLAKTKDEDLVKLLSE
TH_1768|M.thermoresistible__bu ADGAATVETYTVRYGRKGRTG-IIVGRLDADNSRFLATTRDDDMLALLCE
MAV_1076|M.avium_104 ADGRATIETYTVRYDWPVRTG-IIIGRLDDDGSRFLALTEDPELVGLLSD
Mflv_1869|M.gilvum_PYR-GCK PEGTGTIETYSVRYDWPVRTG-IIVGRLDSDGSRFMATSEDHELVALMSD
Mvan_4866|M.vanbaalenii_PYR-1 PEGAATIETYSVRHDWPVRTG-IIVGRLDADGSRFMATSEDADLVALMTE
Mb1898|M.bovis_AF2122/97 WEGIGTVEAWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVR
Rv1867|M.tuberculosis_H37Rv WEGIGTVEAWTTPVNRDGQPEKAFLAVRTPDGSRSLAVITDPASVQATVR
MAB_2042c|M.abscessus_ATCC_199 ATGCATVDGYTVVYDRDGQPRWTPIIAHLSDGRRVVARSDDPQIAEAMGG
* .*:: ::. . . : *. * :* *
MMAR_4547|M.marinum_M GDPLGQAIRVRSFDYGNRCVL-
MUL_4717|M.ulcerans_Agy99 GDPLGQAIRVRSFDYGNRCVL-
MSMEG_5521|M.smegmatis_MC2_155 GDPIGAKIVVTPGEKSNRAVLA
TH_1768|M.thermoresistible__bu GEPLGAAFTVRSTEKGNRASL-
MAV_1076|M.avium_104 GEPLGASIVVTATEKDNRATLA
Mflv_1869|M.gilvum_PYR-GCK GDPLGAKVAVTNTDNGNRATLA
Mvan_4866|M.vanbaalenii_PYR-1 ADPLGANITVTPTDNGNRAVLR
Mb1898|M.bovis_AF2122/97 EDIAGVKVAVAPDGTAT---LR
Rv1867|M.tuberculosis_H37Rv EDIAGVKVAVAPDGTAT---LR
MAB_2042c|M.abscessus_ATCC_199 EMYVGKTVCLRNTGSFTGFELP
* . : . *