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IVDSAIPAAVRPPVSAVQQWWVLTVRMITPTLRNGELATQIVGSIVFTIGYYLPLKQMMGAVQPLSGYAQ YLTPLIVLQAIWFAAISAAFRSATDSVQGINRRFRAMPIPALTPLASRMTASMYRCVVALIVSVACGYVI GFRFDNGVLGIVGFVALVLLIGAALALIGDLIGIATQNPEATAPMMLIPQLTLGLASVGLQPVERFPEWI QGFVRNQPLSQWVYGLQALAGDSSGNAPEATFAVLGPGLAWVLGCIVVALALHTWVSRKRRSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3121 | - | - | 100% (274) | multidrug ABC transporter inner membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4795 | - | 2e-19 | 28.35% (261) | ABC-2 type transporter |
| M. vanbaalenii PYR-1 | Mvan_3120 | - | 3e-18 | 29.39% (245) | multidrug ABC transporter inner membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2962 | drrB | 4e-65 | 45.83% (264) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_3388 | - | 1e-132 | 85.50% (269) | ABC-2 type transporter |
| M. tuberculosis H37Rv | Rv2937 | drrB | 4e-65 | 45.83% (264) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02351 | - | 5e-62 | 48.66% (261) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | MAB_1690 | - | 3e-06 | 22.70% (185) | ABC transporter transmembrane protein |
| M. marinum M | MMAR_1770 | drrB | 6e-70 | 51.18% (254) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. avium 104 | MAV_2004 | - | 2e-34 | 33.33% (237) | ABC-2 type transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 8e-09 | 25.77% (194) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2013 | drrB | 7e-70 | 51.18% (254) | daunorubicin-DIM-transport integral membrane protein ABC |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3121|M.vanbaalenii_PYR-1 --MIVDS---------AIPAAVRPPVSAVQQWWVLTVR-MITPTLRNGEL
Mflv_3388|M.gilvum_PYR-GCK --MTAQSTVKTAPRRAAIPQAVRPRVSAIQQWWVLTVR-MIIPTLRNGEL
MMAR_1770|M.marinum_M MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
MUL_2013|M.ulcerans_Agy99 MSISAVDPTPVPTFKGAGPSAAKPRLSTLQQWWVLVGR-FTKPRLRDPEL
Mb2962|M.bovis_AF2122/97 MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
Rv2937|M.tuberculosis_H37Rv MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRR-FAAPSLLNGEV
MLBr_02351|M.leprae_Br4923 MSMPALAPIPASRWP--STIMAKPRRSTLRQWWALTTRYYTDIKLFVFEK
MAV_2004|M.avium_104 ----------------------------MSALVALTLR-TMSGSRRDADL
MSMEG_6510|M.smegmatis_MC2_155 ----------MSVELVRAPRGLRRVRAVAMRMGAFALVELQKLRHDRTEL
MAB_1690|M.abscessus_ATCC_1997 ------------------------MTALSNTARLFRRYVVVGLRQPVFGF
:
Mvan_3121|M.vanbaalenii_PYR-1 ATQIVGSIVFTIGYYLP----LKQMMGAVQP--LSGYAQYLTPLIVLQAI
Mflv_3388|M.gilvum_PYR-GCK ATQVVGSIVFTVGYYLP----LKQMMGAVQP--LSSYAQYLTPLIVLQAI
MMAR_1770|M.marinum_M ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVASSLGQYIAPLIVLQSI
MUL_2013|M.ulcerans_Agy99 ITMVGAPVVFTVGFYIPFAIPWNHYVGGGASGVPSSLGQYIAPLIVLQSI
Mb2962|M.bovis_AF2122/97 LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
Rv2937|M.tuberculosis_H37Rv LTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAV
MLBr_02351|M.leprae_Br4923 TIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSGIASNLGQYVTPLIVLQSI
MAV_2004|M.avium_104 LFAALAPVGCFLG--------FTLVLGGLIRTGSMSYPQYVLPVVIVQAM
MSMEG_6510|M.smegmatis_MC2_155 FTRMVQPALWLLIFG------QTFSRLHVVDTGGVPYLAFLAPGIIAQSA
MAB_1690|M.abscessus_ATCC_1997 IFPIVFPVVLVIFVR-----SMFQRVADLPGFPLSSYTAYIAPGLIMLIP
. : :: * :
Mvan_3121|M.vanbaalenii_PYR-1 WFAAISAAFRSATDSVQGINRRFRAMPIPALTPLASRMTASMYRCVVALI
Mflv_3388|M.gilvum_PYR-GCK WFAAISAAFRSATDSVQGINRRFRAMPIPSSTPLAARMTASMYRCCIALA
MMAR_1770|M.marinum_M SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
MUL_2013|M.ulcerans_Agy99 SFAAISSAFRAATDSLQGINRRFRYMPIAPLTPVVARVTAAIYRCCVGLT
Mb2962|M.bovis_AF2122/97 SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
Rv2937|M.tuberculosis_H37Rv SFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLV
MLBr_02351|M.leprae_Br4923 AFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMG
MAV_2004|M.avium_104 LFGAMTTADRAARDRLSGFGSRLRTLPLPASVPLGARMLYCLTRALIALA
MSMEG_6510|M.smegmatis_MC2_155 LFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGKAFAAGVRSVVQVI
MAB_1690|M.abscessus_ATCC_1997 MLGAGYGAGTLIDEIRSGFTDRLRLYGVSTGQIMAAKIGFEMFRILPAAV
: : . : *. :: .. : .: *
Mvan_3121|M.vanbaalenii_PYR-1 VSVACGYVIGFRFDNGVLGIVGFVALVLLIGAALALIGDLIGIATQNPEA
Mflv_3388|M.gilvum_PYR-GCK VSVGCGYVIGFRFEAGVLGILGFVGLALLIGAALAIIGDLIGVATQNPEA
MMAR_1770|M.marinum_M VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
MUL_2013|M.ulcerans_Agy99 VALICGYAIGFHFNRGPLYIVGYCLLAIAIGAVLSFGADLLGTGTKNPDA
Mb2962|M.bovis_AF2122/97 ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
Rv2937|M.tuberculosis_H37Rv ISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDA
MLBr_02351|M.leprae_Br4923 VALICGHVIGFQFHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDA
MAV_2004|M.avium_104 ATMAAGWSFGFRMQGGPADAVLFVTIVVVFAMAVCLGADALGSRVGTVES
MSMEG_6510|M.smegmatis_MC2_155 GVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACLSMTLAGLVRKRDR
MAB_1690|M.abscessus_ATCC_1997 IVIGLLAFLDAPLRSGLLTGVFLVLVMFLWSAAYSSLFYLVALRTLNPQA
: :. : . : : . . . :. . :
Mvan_3121|M.vanbaalenii_PYR-1 TAPMMLIPQLTLGLASVGLQPVERFPEWIQGFVRNQPLSQWVYGLQALAG
Mflv_3388|M.gilvum_PYR-GCK TAPMMLIPQLTLGLASVGLQPVEQFPDWIQGFVRNQPLSQWVYALQALAG
MMAR_1770|M.marinum_M MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
MUL_2013|M.ulcerans_Agy99 MLPLLSLPILIFGLLSVGLMPLKLFPHWIHPFVRNQPITQFVVALRALAG
Mb2962|M.bovis_AF2122/97 MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
Rv2937|M.tuberculosis_H37Rv MLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAG
MLBr_02351|M.leprae_Br4923 MLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFVVALRALAG
MAV_2004|M.avium_104 SSQLLLLPQLVLVLLSTGIAPAESFPAWMAPFIRNQPVSQVTEALRGLAT
MSMEG_6510|M.smegmatis_MC2_155 LMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNPLSYEVNALRGLLI
MAB_1690|M.abscessus_ATCC_1997 PVAMLPL-ALPVLFVSQALMPSVFLSDWLRISINANPFSHIVSAASTIMY
: : . : * .: * :. *: :*.: . . :
Mvan_3121|M.vanbaalenii_PYR-1 DSSGNAPEATFAVLGPGLAWVLGCIVVALALHTWVSRKRRSE--------
Mflv_3388|M.gilvum_PYR-GCK DSTDAAPDPTVAVLGSAVAWAVGCIVVALTLHVWVSRRRRS---------
MMAR_1770|M.marinum_M DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP----------
MUL_2013|M.ulcerans_Agy99 DTTKAAIPVTWTVMTPTLAWLAGFALFLVPVSIIVLSRRP----------
Mb2962|M.bovis_AF2122/97 DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP----------
Rv2937|M.tuberculosis_H37Rv DTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP----------
MLBr_02351|M.leprae_Br4923 ETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT----------
MAV_2004|M.avium_104 GHVAGGSLAAALTWCLGLLAVFGVVAVRMQRRVDAGRSRAHRAVRKAPRD
MSMEG_6510|M.smegmatis_MC2_155 GTPTNWVLDITVLVAAAVLGVVAASALLRRLVR-----------------
MAB_1690|M.abscessus_ATCC_1997 GDFDAMLVVKGVLVAIGMFALLQIPIHLVIRRKIGK--------------
:
Mvan_3121|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3388|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1770|M.marinum_M --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02351|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 AAPAGDVGVNPVGKSAECLARQEVTRVGCLKGFVGQSASEAGRLLRRWRR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3121|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3388|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1770|M.marinum_M --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02351|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 DPVVAVQALLFPTLLLVIYKLLVGKSVLAVTGHDSLYGLVPMCAVVGAVF
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3121|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3388|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1770|M.marinum_M --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02351|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 GTIGAGLALPSERESGVLTRLWVQPVHRASPVAGRLVAEAARTVASAFVL
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3121|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3388|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1770|M.marinum_M --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02351|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 TVFGIALGLRFNDGWIAMLAFVLVPVTISAGMATLVTAIAARADGKAMVT
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3121|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3388|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1770|M.marinum_M --------------------------------------------------
MUL_2013|M.ulcerans_Agy99 --------------------------------------------------
Mb2962|M.bovis_AF2122/97 --------------------------------------------------
Rv2937|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02351|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 WLGAGCVVLLFLNTGVAPAEVFPGWLQPVVRYSPISPTIEAMRALAQGGP
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_3121|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_3388|M.gilvum_PYR-GCK -----------------------------------
MMAR_1770|M.marinum_M -----------------------------------
MUL_2013|M.ulcerans_Agy99 -----------------------------------
Mb2962|M.bovis_AF2122/97 -----------------------------------
Rv2937|M.tuberculosis_H37Rv -----------------------------------
MLBr_02351|M.leprae_Br4923 -----------------------------------
MAV_2004|M.avium_104 VLSPLWQAGLWGGVLVAVFAPIAVRGYRAAAEAGC
MSMEG_6510|M.smegmatis_MC2_155 -----------------------------------
MAB_1690|M.abscessus_ATCC_1997 -----------------------------------