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VNSRWCFRAVRDRGCPFGESGAMRSRMVQTNGVTLRVTEAGEPGAPVVVLCHGFPELAFTWRHQVRALAD AGFHVLAPDQRGYGGSDKPDAVDSYNVAELTADVVGLLDDLGAERAALVGHDFGAVVAWAAPLLQPDRFS SVAGLSLPPVPRPKVPTTQAFRRIFADRFFYILYFQDRGPADAELARDPAGTFRRLFAMDVADEQSALRM TEPGPAGFLDRIPDPGRLPDWISPPDFAVYVDEFRRGGFTAPLNWYRCFDLNWELTADPPAPTIGVPALF VGGTADATLAYTPRHRVREVVTGDYREVMIDGAGHWLTEERPDEVSRILLEFLTAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5373 | - | - | 100% (337) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4002 | - | 6e-48 | 34.59% (344) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_3998 | - | 2e-45 | 35.09% (342) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 8e-47 | 33.71% (350) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1415 | - | 1e-151 | 81.59% (315) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3617 | ephA | 1e-115 | 62.34% (316) | epoxide hydrolase EphA |
| M. leprae Br4923 | MLBr_02297 | - | 2e-20 | 28.57% (329) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 1e-94 | 53.38% (311) | epoxide hydrolase EphA |
| M. marinum M | MMAR_5114 | ephA | 1e-113 | 61.94% (310) | epoxide hydrolase EphA |
| M. avium 104 | MAV_0539 | - | 1e-108 | 60.07% (303) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 1e-106 | 58.52% (311) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_0992 | ephA | 1e-106 | 57.61% (309) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 1e-113 | 61.94% (310) | epoxide hydrolase EphA |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5373|M.vanbaalenii_PYR-1 MNSRWCFRAVRDRGCPFGESGAMRSRMVQTNGVTLRVTEAG---------
Mflv_1415|M.gilvum_PYR-GCK ----------------------MQSRMVHTNGITLRVFEAG---------
MMAR_5114|M.marinum_M ------------------MVATSTERLVDTNGVRLRVTEAG---------
MUL_4193|M.ulcerans_Agy99 ------------------MVATSTERLVDTNGVRLRVTEAG---------
Rv3617|M.tuberculosis_H37Rv -------------------MGAPTERLVDTNGVRLRVVEAG---------
MAV_0539|M.avium_104 --------------------------------MRLRVTEAG---------
MSMEG_6106|M.smegmatis_MC2_155 -------------------MITPTERSVETNGVTLRVTEAG---------
TH_0992|M.thermoresistible__bu -------------------VITPSERSVETNGVRLRLVEAG---------
MAB_0528c|M.abscessus_ATCC_199 ---------------MTDAAVDIRERDIATNGVHLRIVEAG---------
Mb1973|M.bovis_AF2122/97 --------------------MSQVHRILNCRGTRIHAVADSP--------
MLBr_02297|M.leprae_Br4923 --------MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDC
::
Mvan_5373|M.vanbaalenii_PYR-1 ---EPGAPVVVLCHGFPELAFTWRHQVRALADAGFHVLAPDQRGYGGSDK
Mflv_1415|M.gilvum_PYR-GCK ---ERSAPVVVLCHGFPELAFTWRHQISALAAAGFHVLAPDQRGYGGSDK
MMAR_5114|M.marinum_M ---ERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
MUL_4193|M.ulcerans_Agy99 ---ERGAPVVILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSR
Rv3617|M.tuberculosis_H37Rv ---EPGAPVVILAHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSR
MAV_0539|M.avium_104 ---DRGAPVVILAHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDR
MSMEG_6106|M.smegmatis_MC2_155 ---ERGNPVVVLAHGFPELAYSWRHQIPALAAAGYHVLAPDQRGYGGSSR
TH_0992|M.thermoresistible__bu ---ERGDPLVVLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSA
MAB_0528c|M.abscessus_ATCC_199 ---EPGQPAVILSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSSM
Mb1973|M.bovis_AF2122/97 --PDQQGPLVVLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSK
MLBr_02297|M.leprae_Br4923 APSATARPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
* *:* *** . ::****: *. * :::* * **** *.
Mvan_5373|M.vanbaalenii_PYR-1 PDAVDSYNVAELTADVVGLLDDLGAERAALVGHDFGAVVAWAAPLLQPDR
Mflv_1415|M.gilvum_PYR-GCK PGDAGVYNVAELTADVVGLLDDVGAERAALVGHDFGAVVAWGAPLLEPDR
MMAR_5114|M.marinum_M PEAIEDYDIHQLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDR
MUL_4193|M.ulcerans_Agy99 PEAIEDYDIHQLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDR
Rv3617|M.tuberculosis_H37Rv PEAIEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADR
MAV_0539|M.avium_104 PDAVEAYDIHQLTADLVGLLDDVGAQRAVWVGHDWGAAVVWNAPLLHPDR
MSMEG_6106|M.smegmatis_MC2_155 PESIDDYDITKLTGDVVGLLDDIGAEHAAVIGHDWGAVVAWNAAQLHPDR
TH_0992|M.thermoresistible__bu PEAIEAYDITRLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDR
MAB_0528c|M.abscessus_ATCC_199 PAHIDDYNIEALSDDLLGILDDVGAGKATFVGHDWGAVVTWHTALAVPER
Mb1973|M.bovis_AF2122/97 YRVQKAYRIKELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDR
MLBr_02297|M.leprae_Br4923 PP--RGYDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATALLHPRL
* * * *:: * * :** *. . * . .
Mvan_5373|M.vanbaalenii_PYR-1 FSSVAGLSLPPVPR----------PKVPTTQAFRRIFADR-FFYILYFQD
Mflv_1415|M.gilvum_PYR-GCK FSAVAGLSLPPVPR----------PQVPTTQAFRRVFGDR-FMYILYFQE
MMAR_5114|M.marinum_M VAAVAGLSVPVLPR----------AQVPPIQAFRQRFGEH-FFYILYFQQ
MUL_4193|M.ulcerans_Agy99 VAAVAGLSVPVLPR----------AQVPPIQAFRQRFGEH-FFYILYFQQ
Rv3617|M.tuberculosis_H37Rv VAAVAALSVPALPR----------AQVPPTQAFRSRFGEN-FFYILYFQE
MAV_0539|M.avium_104 VAAVAAMSVPVTPR----------PRLAPTQAWRKMFGEN-FFYILYFQE
MSMEG_6106|M.smegmatis_MC2_155 VAAVGGLSVPPTPR----------STRPPTQAFRELVGEGKFFYILHFQE
TH_0992|M.thermoresistible__bu VAAVAGLSVPPVPR----------SLTRPTEAFRALVGEDNFFYILYFQE
MAB_0528c|M.abscessus_ATCC_199 VSGVVGLSVPFTRR----------SQVPPTQAWNKLFGDN-FFYILYFQE
Mb1973|M.bovis_AF2122/97 CAGVVGISVPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAV
MLBr_02297|M.leprae_Br4923 VRAIALINSPHPAA------------LRRSMLTHRNQGYALLPTLLRYQL
.: :. * . . :
Mvan_5373|M.vanbaalenii_PYR-1 RGPADAELARDP---------AGTFRRLFAMDVAD--E------QSALRM
Mflv_1415|M.gilvum_PYR-GCK PGPADAELARDP---------ATTFRRLFALTTG-----------GAEMV
MMAR_5114|M.marinum_M PGVADAELNGDP---------ARTMRRMIGGQRSPTDQ------GAALRM
MUL_4193|M.ulcerans_Agy99 PGVADAELNGDP---------ARTMRRMIGGQRSPTDQ------GAALRM
Rv3617|M.tuberculosis_H37Rv PGIADAELNGDP---------ARTMRRMIGGLRPPGDQ------SAAMRM
MAV_0539|M.avium_104 PGVADAELNADP---------AQVMRRMMGSLRTDGDK------AAGLRM
MSMEG_6106|M.smegmatis_MC2_155 PGVADAEFDGDP---------ARALRRMFGGLLPPENE------EAAMRM
TH_0992|M.thermoresistible__bu PGVADAELDGDP---------ARTMRRMFGGLTS--DP------DAAHRM
MAB_0528c|M.abscessus_ATCC_199 PGVADADLNRDP---------ATTMRRMMAGMAR----------IDGATM
Mb1973|M.bovis_AF2122/97 QDGIITEIEEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDV
MLBr_02297|M.leprae_Br4923 PIWPERLLTRNN---------AAEIERLVRSRSS------------AKWQ
: : : . :.
Mvan_5373|M.vanbaalenii_PYR-1 TEPGPAGFLD--RIPD----PGRLPDWISPPDFAVYVDEFRRGGFTAPLN
Mflv_1415|M.gilvum_PYR-GCK GDAGPQGFLD--RIPE----PGGLPDWISQADFDVYVDEFTRGGFTGPLN
MMAR_5114|M.marinum_M VAPGPEGFID--RLPE----PDTPPSWISRDELDHYISEFTRTGFTGGLN
MUL_4193|M.ulcerans_Agy99 VAPGPEGFID--RLPE----PDAPPSWISRDELDHYISEFTRTGFTGGLN
Rv3617|M.tuberculosis_H37Rv LAPGPDGFID--RLPE----PAGLPAWISQEELDHYIGEFTRTGFTGGLN
MAV_0539|M.avium_104 VAPGPEGFLE--RLPE----PDGLPEWISQDELDHYIAEFSRTGFTGGLN
MSMEG_6106|M.smegmatis_MC2_155 LRPGPEGLID--RLPE----PSALPDWISTGEFDHYVDAFTRTGFTGGLN
TH_0992|M.thermoresistible__bu LQPGPAGFID--RLPE----PEALPDWLTAEELDHYIAEFTRTGFTGGLN
MAB_0528c|M.abscessus_ATCC_199 IAPGPAGFVE--RMPD----PGELPEWLSQDELDHYITEFARTGFTGGLN
Mb1973|M.bovis_AF2122/97 IRAGPLCMAEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLS
MLBr_02297|M.leprae_Br4923 ACEDFAVTID------------HLRIAIQIPAAAHCALEYQRWAVRS---
. : : : * .. .
Mvan_5373|M.vanbaalenii_PYR-1 WYRCFDLNWELTADPPAPTIGVPALFVGGTADA--TLAYTPRHRVREVVT
Mflv_1415|M.gilvum_PYR-GCK WYRCFDRNWELTAETPAPTIEVPALFVGGTEDA--TLAYTPRDRVREVVT
MMAR_5114|M.marinum_M WYRNFDRNWETTADLEGATITVPSLFMAGTKDP--VLSFARSDRASEVIT
MUL_4193|M.ulcerans_Agy99 WYRNFDRNWETTADLEGATITVPSLFMAGTKDP--VLSFARSDRASEVIT
Rv3617|M.tuberculosis_H37Rv WYRNFDRNWETTADLAGKTISVPSLFIAGTADP--VLTFTRTDRAAEVIS
MAV_0539|M.avium_104 WYRNFDRNWETTPELDGAKIAVPCLFIGGTADP--VLSFTRADRAAEVIS
MSMEG_6106|M.smegmatis_MC2_155 WYRNFDRNWELTAHLADAKITVPALFLAGAADP--VLGFARPDRARDLIA
TH_0992|M.thermoresistible__bu WYRNMDRNWELTEHLAGATITAPALFLAGAADP--VLGFMRPERATEVAV
MAB_0528c|M.abscessus_ATCC_199 WYRNFDRNWALTERLAGANVVVPSLFIAGAADP--VLGFTDHAGSAKYRT
Mb1973|M.bovis_AF2122/97 FYHNIDNDWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQAIERAHEVMP
MLBr_02297|M.leprae_Br4923 ---QLRNEGRKFMKSMSRPFSVPLLHVRGDADP--YLLADSVDRTRRYAP
: : . * *.: * *
Mvan_5373|M.vanbaalenii_PYR-1 GDYREVMIDGAGHWLTEERPDEVSRILLEFLTAAR-----
Mflv_1415|M.gilvum_PYR-GCK GDYREVMIDGAGHWLTEERPDEVSRVLVDFLTTVR-----
MMAR_5114|M.marinum_M GPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
MUL_4193|M.ulcerans_Agy99 GPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW----
Rv3617|M.tuberculosis_H37Rv GPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR---
MAV_0539|M.avium_104 GPYRHVMIDGAGHWLQQERPAEVNAALLDFLNGLELR---
MSMEG_6106|M.smegmatis_MC2_155 GPYTEILLDGAGHWVQQERAEEVNAALIGFLHGLELQ---
TH_0992|M.thermoresistible__bu GPYRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ---
MAB_0528c|M.abscessus_ATCC_199 DNRGDLLIDGAGHWIQQERPLEVNAALLAFLREVVH----
Mb1973|M.bovis_AF2122/97 NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP----
MLBr_02297|M.leprae_Br4923 HG-RYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
: ..**: :* . * . * **