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PRVVKPKDVRRAEVLDRALALFLERGYENVSLNDLLAVSGTSKGAFYHYFPSKEALVVALAQRSAGEAFE VLRPVFDQPGKNALERLNAGLAASYQVKLGMGVPEPIAAMRSLLMPENQALFRKIVTIWEDLFRPVLTEV ITQGVREGVFDTFDPEGVGDMIQGFAASIQDYLVRMFDAADAKSRRKTIDDCVKRLKLYGIATDRILGLP DGATVVLERKQVEAMMTLFMPSRPAGSLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4729 | - | - | 100% (240) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 5e-09 | 38.57% (70) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1640 | - | 5e-09 | 24.77% (214) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3587c | - | 3e-09 | 29.68% (155) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4802 | - | 2e-07 | 30.23% (86) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3557c | - | 3e-09 | 29.68% (155) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00717 | - | 5e-07 | 25.64% (117) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3586c | - | 4e-82 | 65.50% (229) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3438 | - | 2e-08 | 29.23% (195) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0603 | - | 1e-09 | 31.17% (154) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2195 | - | 5e-08 | 29.58% (142) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2855 | - | 9e-12 | 30.67% (150) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2714 | - | 1e-08 | 29.23% (195) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4729|M.vanbaalenii_PYR-1 ------------------------------MPRVVKPKDVRRAEVLDRAL
MAB_3586c|M.abscessus_ATCC_199 ------------------------------MPRVVKHPELRRTELLDLAM
Mb3587c|M.bovis_AF2122/97 ------------------------------MDRVAGQVNSRRGELLELAA
Rv3557c|M.tuberculosis_H37Rv ------------------------------MDRVAGQVNSRRGELLELAA
MAV_0603|M.avium_104 ---------------------------------MTGPANSRRDELLELAA
Mflv_4802|M.gilvum_PYR-GCK ----------------------------MAEARRRLSPDDRRNELLALGA
MLBr_00717|M.leprae_Br4923 ----------------------------MTTARRRLSPEDRRAELLALGA
MMAR_3438|M.marinum_M -----------------------MPDDHPPTGLRQRKKADTRRALSDAAL
MUL_2714|M.ulcerans_Agy99 -----------------------MPDDHPPTGLRQRKKADTRRALSDAAL
TH_2855|M.thermoresistible__bu LSQSPDNATSSSRAGSGAGSGAGSGAEPIGRDTPRRRPRIRPEEIVSAAA
MSMEG_2195|M.smegmatis_MC2_155 -----------------------------MTEQLDRRADLTRLQILQAAS
: .
Mvan_4729|M.vanbaalenii_PYR-1 ALFLERGYENVSLNDLLAVSGTSKGAFYHYFPSKEALVVALAQRSAGEAF
MAB_3586c|M.abscessus_ATCC_199 TLFLERGYERVSLNDLIATSGMSKGAFYHYFSSKEALVSALAARSADQAF
Mb3587c|M.bovis_AF2122/97 AMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLF
Rv3557c|M.tuberculosis_H37Rv AMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLF
MAV_0603|M.avium_104 AMFAERGLRATTVRDIADSAGILSGSLYHHFSSKEEMVDEVLRSFLDWLF
Mflv_4802|M.gilvum_PYR-GCK EVFGQRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVRAESERLF
MLBr_00717|M.leprae_Br4923 EVFGKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLY
MMAR_3438|M.marinum_M ALAFERGLDNVTREDIANVAGVSLRTFNNYFTGKYEALAYRQTERMRRSI
MUL_2714|M.ulcerans_Agy99 ALAFERGLDNVTREDIANVAGVSLRTFNNYFTGKYEALAYRQTERMRRSI
TH_2855|M.thermoresistible__bu EFFAREGYANVGMRDVAEAVGIRGASLYHHFGSKEEILYAICLTVTKEPN
MSMEG_2195|M.smegmatis_MC2_155 RQFARTPYSLVSLDDILADAQVTKGALYFHFRSKHALACAIVEYHAAQAR
. . :: : :* .*
Mvan_4729|M.vanbaalenii_PYR-1 EVL-------RPVFDQPGKNALERLNAGLAASYQVKLGMGVPEPIAAMRS
MAB_3586c|M.abscessus_ATCC_199 EAL-------RPVFEAQGRGALERLNSGLRAGYEVKMALGAPESIGAMAS
Mb3587c|M.bovis_AF2122/97 ARY-------RDIVDSTA-NPLERLQGLFMASFEAIEHHHAQVVIYQDEA
Rv3557c|M.tuberculosis_H37Rv ARY-------RDIVDSTA-NPLERLQGLFMASFEAIEHHHAQVVIYQDEA
MAV_0603|M.avium_104 ARY-------REIIDSES-NPLERLKGLFMASFEAIEHRHAQVVIYQDEA
Mflv_4802|M.gilvum_PYR-GCK DATNTPAQPGQTLFTQVRAGVLAYLRYDELHPHGAWAAYMGMSRSDPVLR
MLBr_00717|M.leprae_Br4923 AATNIPPPAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLL
MMAR_3438|M.marinum_M AALRERP-AGEPLWTAIAHAVLEPLQADLHEATADEDRLPSRGELAEVRK
MUL_2714|M.ulcerans_Agy99 AALRERP-AGEPLWTAIAHAVLEPLQADLHEATADEDRLPSRGELAEVRK
TH_2855|M.thermoresistible__bu ELN-------LPLLDAAG-TPAERLSALIRAHLEHLIRRRVEHLVALHDI
MSMEG_2195|M.smegmatis_MC2_155 DTT-------EDVAARNLSGLETLIDISYQLAVDDVSDPMTRAGLNLIES
: :
Mvan_4729|M.vanbaalenii_PYR-1 LLMPENQALFRKIVTIWEDLFRPVLTEVITQGVREGVFDTFDPEGVGDMI
MAB_3586c|M.abscessus_ATCC_199 MMRPENQSLLRRISAIWEDRFRPVLTEVIAQGVAEGVFDTFDPEGVGDMI
Mb3587c|M.bovis_AF2122/97 QRLASQPRFS--YIEDRNKQQRKMWVDVLNQGIEEGYFR---PDLDVDLV
Rv3557c|M.tuberculosis_H37Rv QRLASQPRFS--YIEDRNKQQRKMWVDVLNQGIEEGYFR---PDLDVDLV
MAV_0603|M.avium_104 KRLLSQPRFS--YIEDMNRQQRKMWLEVLNQGVDEGYFR---PDLDVDLV
Mflv_4802|M.gilvum_PYR-GCK GIDDHDNDRQANRIIDRV--TAGVEP---LDAKVERDLRAAVYGWLAFTF
MLBr_00717|M.leprae_Br4923 GIDDEAKNRQMEHIMSRIGDVVSVVPESKLHPDIERDLRVIVHGWLAFTF
MMAR_3438|M.marinum_M LLMNPQIREAASRELLED----------WRDAIAERTGTDPENDMYPRLV
MUL_2714|M.ulcerans_Agy99 LLMNPQIREAASRELLED----------WRDAIAERTGTDPENDMYPRLV
TH_2855|M.thermoresistible__bu NSLTPEHRAI---IDDLRRYYQRRVRDVIVAGVRSGEFDVPDPKLAALLI
MSMEG_2195|M.smegmatis_MC2_155 IGRTENLGAK--VVTDWVARFSAIGRRAVSEGDLTPDSDPDVVARLLVSL
.
Mvan_4729|M.vanbaalenii_PYR-1 QGFAASIQDYLVRMFDAADAKSRRKTIDDCVKRLKLYGIATDRILGLPDG
MAB_3586c|M.abscessus_ATCC_199 QGLAATMGTAVQRIIAAPDAPARAQAIDAAVLRQRLYGIATDRILGLPDG
Mb3587c|M.bovis_AF2122/97 YRFIRDTTWVSVRWYR-PGGPLTAQQVGQQYLAIVLGGITKEGV------
Rv3557c|M.tuberculosis_H37Rv YRFIRDTTWVSVRWYR-PGGPLTAQQVGQQYLAIVLGGITKEGV------
MAV_0603|M.avium_104 YRFIRDTTWVSVRWYQ-PGGPLTAEQVGQQYLAIVLGGITVDAKKD----
Mflv_4802|M.gilvum_PYR-GCK EMCRQRLMDASLDADYLGDLCAHALMDALARVPGIPADLAEAVAPDRR--
MLBr_00717|M.leprae_Br4923 EVCRQRIMDPSTDADRLADSCAHALLDAIARVPEISKELADAMAIARQPP
MMAR_3438|M.marinum_M VAVVRAVGDAAMDTYATADPPVAITELIRAGFASVAAGLPEPAKPGEQRG
MUL_2714|M.ulcerans_Agy99 VAVVRAVGDAAMDTYATADPPVAITELIRAGFASVAAGLPEPAKPGEQRG
TH_2855|M.thermoresistible__bu LDALN-----GVSGWFHPDRGHSLPDVIAAYTEMIVERVLRARIS-----
MSMEG_2195|M.smegmatis_MC2_155 YLGVRQTSELEDPQRFLQDLERSWQLVLPGIANPDRLGYLRQFIRRRTTL
.
Mvan_4729|M.vanbaalenii_PYR-1 ATVVLERKQVEAMMTLFMPSRPAGSLP
MAB_3586c|M.abscessus_ATCC_199 TVEVLDRDQIEALVAML----------
Mb3587c|M.bovis_AF2122/97 ---------------------------
Rv3557c|M.tuberculosis_H37Rv ---------------------------
MAV_0603|M.avium_104 ---------------------------
Mflv_4802|M.gilvum_PYR-GCK ---------------------------
MLBr_00717|M.leprae_Br4923 Q--------------------------
MMAR_3438|M.marinum_M ---------------------------
MUL_2714|M.ulcerans_Agy99 ---------------------------
TH_2855|M.thermoresistible__bu ---------------------------
MSMEG_2195|M.smegmatis_MC2_155 TARKAVPLHPEPPAHTRAGSA------